170,737 research outputs found
Application of Hydro-Acoustic and Video Data for the Exploration of Manganese Nodule Fields
No full textKuhn T, Rühlemann C, Wiedicke-Hombach M, Schoening T, Nattkemper TW. Application of Hydro-Acoustic and Video Data for the Exploration of Manganese Nodule Fields. Presented at the ISOPE OMS, Szczecin, Poland
Practical cues for helping develop image and multimodal discourse scholarship
No full textThe Bilder-Sehen-Denken conference at Chemnitz University of Technology witnessed the foundation of the Gesellschaft für interdisziplinäre Bildwissenschaft (GIB). In this paper, I will briefly sketch where I see good opportunities for humanities scholars to contribute to the fledgling discipline. To begin with, humanities scholars have a crucial role in reflecting on the ontology of the image, on the way images help constitute or destroy power relations between (groups of) people, on the ethics of representation, and on other philosophical issues. Secondly, it is essential that humanities scholars write macro- and micro histories of images and their uses.I will not, however, comment on these two scholarly pursuits; others are far more qualified than I am to do so. My proposals pertain to a third issue which I consider indispensable for a healthy image science: the development of ›tools‹ for analysis. I present my program in the form of six suggestions, or cues, that are based on my own experiences in the field. Clearly, six is an arbitrary number, and the list has no pretense to be exhaustive, while there is also some overlap. Furthermore, my orientation is heavily biased toward English-language scholarship - but where appropriate I will briefly refer to chapters from the state-of-the art volume edited by Sachs-Hombach (2005a) in order to help build further bridges between the two language communities. Hopefully this paper provides starting points for getting to work - or else at least food for thought
Practical cues for helping develop image and multimodal discourse scholarship
No full textThe Bilder-Sehen-Denken conference at Chemnitz University of Technology witnessed the foundation of the Gesellschaft für interdisziplinäre Bildwissenschaft (GIB). In this paper, I will briefly sketch where I see good opportunities for humanities scholars to contribute to the fledgling discipline. To begin with, humanities scholars have a crucial role in reflecting on the ontology of the image, on the way images help constitute or destroy power relations between (groups of) people, on the ethics of representation, and on other philosophical issues. Secondly, it is essential that humanities scholars write macro- and micro histories of images and their uses.I will not, however, comment on these two scholarly pursuits; others are far more qualified than I am to do so. My proposals pertain to a third issue which I consider indispensable for a healthy image science: the development of ›tools‹ for analysis. I present my program in the form of six suggestions, or cues, that are based on my own experiences in the field. Clearly, six is an arbitrary number, and the list has no pretense to be exhaustive, while there is also some overlap. Furthermore, my orientation is heavily biased toward English-language scholarship - but where appropriate I will briefly refer to chapters from the state-of-the art volume edited by Sachs-Hombach (2005a) in order to help build further bridges between the two language communities. Hopefully this paper provides starting points for getting to work - or else at least food for thought
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
AhR-agonist-induced transcriptional changes of genes involved in thyroid function in primary porcine thyrocytes
No full textThe Ah receptor (AhR) is a ligand transcription factor mediating toxic effects of chemicals such as dioxins. The 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) and the coplanar polychlorinated biphenyl 126 (PCB 126) are member of the polyhalogenated aromatic hydrocarbons family exerting a variety of toxic effects in a tissue-specific and species-specific manner including thyroid function. In the present study, we aimed to investigate the effects of TCDD (1 and 10 nM) and dioxin-like PCB 126 (306 nM) on the AhR signaling pathway and on the gene expression profiles of key factors involved in thyroid function, including thyroglobulin (TG), thyroid peroxidase (TPO), the sodium iodide symporter (NIS), TSH receptor (TSHR), and cathepsins (Cat B and L), using a primary porcine thyrocyte culture as the experimental model. AhR and ARNT expression was detected both as mRNA and on the protein level. Expression did not vary upon treatment with either TCDD or PCB 126. However, treatment with TCDD and PCB 126 induced an AhR signaling response, as indicated by the expression of the AhR-target gene cytochrome P-450 1A1 (CYP1A1). Both 10 nM TCDD and PCB 126 treatment induced a significant downregulation in the expression of NIS and cathepsin B without affecting any of the other parameters investigated. In conclusion, these data indicate that (a) thyrocytes are targets of TCDD and TCDD-like compounds and (b) there is evidence for two independent most likely AhR-mediated molecular mechanisms, by which these compounds negatively interfere with thyroid function
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
A 0.12mm<sup>2</sup> Wien-Bridge Temperature Sensor with 0.1°C (3σ) Inaccuracy from -40°C to 180°C
No full text Resistor-based temperature sensors can achieve much higher resolution and energy efficiency than conventional BJT-based sensors [1], but they typically occupy more area (> 0.25 mm 2 ) and have lower operating temperatures (le 125 {circ} {C}) [2]-[4]. This work describes a 0.12mm 2 resistor-based sensor that uses a Wien-bridge (WB) filter to achieve 0.1 {circ} {C} (3 sigma) inaccuracy from - 40 {circ} {C} to 180 {circ} {C}. Compared to a state-of-the-art WB sensor [4], it occupies 6 × less area and achieves comparable relative accuracy over a 76% wider operating range. Session 10.3 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
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