1,721,046 research outputs found
JCB887777 Supplementary material - Supplemental material for The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms
No full textSupplemental material, JCB887777 Supplementary material for The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms by Carlos Bas-Orth, Justus Schneider, Andrea Lewen, Jamie McQueen, Kerstin Hasenpusch-Theil, Thomas Theil, Giles E Hardingham, Hilmar Bading and Oliver Kann in Journal of Cerebral Blood Flow & Metabolism</p
Les défis de la signalisation intracellulaire
No full textColloque organisé par Jean-Antoine Girault et Argus C. Nairn du 27 septembre au 2 octobre 2001. Participants Dario Alessi (University of Dundee, Grande-Bretagne), Hilmar Bading (MRC Laboratory of Molecular Biology, Cambridge, Grande-Bretagne), Philippe Bastiaens (European Molecular Biology Laboratory, Heidelberg, Allemagne), Jocelyne Caboche (Université Pierre-et-Marie-Curie, Paris), Isabelle Callebaut (CNRS, universités Paris VI et Paris VII), Ivan Dikic (Ludwig Institute for Cancer Researc..
Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations
No full textActivation of extrasynaptic N-methyl-d-aspartate (NMDA) receptors causes neurodegeneration and cell death. The disease mechanism involves a pathological triad consisting of mitochondrial dysfunction, loss of integrity of neuronal structures and connectivity, and disruption of excitation–transcription coupling caused by CREB (cyclic adenosine monophosphate–responsive element-binding protein) shut-off and nuclear accumulation of class IIa histone deacetylases. Interdependency within the triad fuels an accelerating disease progression that culminates in failure of mitochondrial energy production and cell loss. Both acute and slowly progressive neurodegenerative conditions, including stroke, Alzheimer’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, share increased death signaling by extrasynaptic NMDA receptors caused by elevated extracellular glutamate concentrations or relocalization of NMDA receptors to extrasynaptic sites. Six areas of therapeutic objectives are defined, based on which a broadly applicable combination therapy is proposed to combat the pathological triad of extrasynaptic NMDA receptor signaling that is common to many neurodegenerative diseases.</jats:p
Nuclear calcium-activated gene expression: possible roles in neuronal plasticity and epileptogenesis
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Hirnjogging
No full textWer geistig aktiv ist, z.B. durch Lesen, Rätseln oder angeregte Diskussionen, schützt seine Nervenzellen mittels eines genetischen Schutzprogramms gegen Absterben. Welche Rolle Kalzium dabei spielt, erläutert der Heidelberger Neurowissenschaftler Hilmar Bading.
Der Beitrag über die Auswirkungen geistiger Aktivität auf die Lebenslänge von Nervenzellen erschien in der Sendereihe "Campus-Report" - einer Beitragsreihe, in der über aktuelle Themen aus Forschung und Wissenschaft der Universitäten Heidelberg, Mannheim, Karlsruhe und Freiburg berichtet wird. Zu hören ist "Campus-Report" montags bis freitags jeweils um ca. 19.10h im Programm von Radio Regenbogen. (Empfang in Nordbaden: UKW 102,8. In Mittelbaden: 100,4 und in Südbaden: 101,1
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