1,721,007 research outputs found
ExtraCorporeal Membrane Oxygenation in Newborns. Implications for Brain and Lung.
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59064.pdf (Publisher’s version ) (Open Access)Extracorporeal membrane oxygenation (ECMO) is a rescue treatment for newborns with severe respiratory insufficiency. In veno-arterial ECMO, venous blood is drained from the right atrium, oxygenated in an artificial lung and reinfused in the aorta. For vascular access the right internal jugular vein and right common carotid artery are ligated permanently. This invasive treatment may have major complications. In this thesis we described the results of ECMO treatment in the University Medical Center Nijmegen of 186 newborns over a period of 12.5 years. Survival varied between 65% and 95%, depending on the diagnosis. Major causes of death were respiratory insufficiency and intracranial haemorrhage. In this thesis we studied lung vascular morphology in newborns with pulmonary hypertension treated with ECMO and demonstrated a decrease in the abnormal morphometry that exists in the small pulmonary blood vessels.Furthermore, we studied the effects of ECMO on the brain. We demonstrated that intermittent opening of the so-called bridge, a safety connection in the ECMO circuit, has important negative effects on the cerebral oxygenation and circulation. This can be prevented with adaptation of this bridge. We also demonstrated that a patent ductus arteriosus with left to right shunt can diminish cerebral oxygenation and perfusion and should therefore be identified early. Others suggested that ECMO causes cerebral lesions predominantly in the right cerebral hemisphere, related to ligation of the right common carotid artery. We demonstrated that the initiation of ECMO has effects on the cerebral oxygenation and circulation, but that these effects were equal for both cerebral hemispheres. In veno-venous ECMO, drainage and reinfusion of blood take place both in the right atrium and ligation of the right common carotid artery is not necessary. To optimize the use of veno-venous ECMO it is important to be informed about recirculation. We developed a bedside method to quantify the amount of recirculation during veno-venous ECMO.KUN Katholieke Universiteit Nijmegen, 02 juni 2004Promotor : Sengers, R.C.A. Co-promotores : Liem, K.D., Staak, F.H.J.M. van der195 p
Neonatale adenoviruspneumonie
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20704___.PDF (Publisher’s version ) (Open Access
Myocardial infarction in a neonate with left-sided congenital diaphragmatic hernia.
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79830.pdf (Publisher’s version ) (Closed access)We present a case study of a newborn girl with a left-sided congenital diaphragmatic hernia and a myocardial infarction (MI). The occurrence of MI in newborns has been associated with cardiac malformations and abnormalities of the coronary arteries or thromboembolization. In our patient, echocardiography revealed left ventricular dysfunction, persistent pulmonary hypertension and an inferolateral MI. Within 24 hours cardiac function and oxygenation did not improve and the baby died. Autopsy showed massive MI, a small aortic valve and ascending aorta, and hypoplasia of the distal aortic arch and isthmus. An accessory spleen was also present. The present report underlines the importance of cardiac evaluation in patients with congenital diaphragmatic hernia
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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