762 research outputs found
A Description of St. Patrick's Purgatory in Lough-Derg : and an account of the Pilgrims Busines there
No full textPagination avant numérisation : 163 pages. - Titre provenant de la page de titre du document numérisé. Reproduction numérique de l'édition imprimée à Dublin en 172
Using bacterial biomarkers to identify early indicators of cystic fibrosis pulmonary exacerbation onset
No full textAcute periods of pulmonary exacerbation are the single most important cause of morbidity in cystic fibrosis patients, and may be associated with a loss of lung function. Intervening prior to the onset of a substantially increased inflammatory response may limit the associated damage to the airways. While a number of biomarker assays based on inflammatory markers have been developed, providing useful and important measures of disease during these periods, such factors are typically only elevated once the process of exacerbation has been initiated. Identifying biomarkers that can predict the onset of pulmonary exacerbation at an early stage would provide an opportunity to intervene before the establishment of a substantial immune response, with major implications for the advancement of cystic fibrosis care. The precise triggers of pulmonary exacerbation remain to be determined; however, the majority of models relate to the activity of microbes present in the patient's lower airways of cystic fibrosis. Advances in diagnostic microbiology now allow for the examination of these complex systems at a level likely to identify factors on which biomarker assays can be based. In this article, we discuss key considerations in the design and testing of assays that could predict pulmonary exacerbations
Avaliação do tratamento em pacientes com sintomatologia otorrinolaringológica relacionada à doença do refluxo gastroesofágico.
Get PDFTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Cirúrgica, Curso de Medicina, Florianópolis, 199
Arthur William Upfield: a biography
Get PDFThis dissertation is an exhaustive account of the life and work of Arthur William Upfield (1890-1964). It is presented as a critical biography and narrates the life of the writer, in his socio-cultural milieu, from birth. It also positions Upfield as a writer who dealt with issues of Aboriginality at a time when this was a singularly polemical subject. My work is informed by the theory of Zygmunt Bauman and others and is posited in the context of late-modern biography theory.
English-born, Upfield arrived in Australia in 1911 and took work in the bush, serving overseas with the Australian army at the outbreak of World War I and marrying an Australian army nurse in Egypt. Returning with his wife and son to Australia in 1921 he intermittently carried his swag until he was employed patrolling the Western Australian number 1 rabbit-proof fence for three years to 1931. By that time he had published four novels, including two crime novels featuring his fictional creation, the part-Aboriginal, part-European, Detective-Inspector Napoleon Bonaparte ('Bony'), arguably the first fully-developed character in Australian popular fiction.
Leaving the fence, Upfield settled with his family in Perth and wrote full-time until joining the Melbourne Herald in 1933. Retrenched, he resumed career writing to be further interrupted by a war-time intelligence posting in 1939. In 1943 the first Bony mysteries were published in America, where Upfield's critical success was maintained until his death. In 1945 he left his wife for Jessica Uren, to whom he remained devoted.
Upfield's in all twenty-nine Bony novels, many of which have been translated across eleven languages, afforded him notable success both at home and abroad, in good part due to his descriptive gifts and the uniqueness of his fictional character, the part-Aboriginal Bony
The life and works of James Miller, 1704-1744, with particular reference to the satiric content of his poetry and plays.
No full textPhDJames Miller was born the son of a Dorset rector in 1704. He
was himself ordained, but acquired no benefice until just before his
early death, probably because of a scathing portrayal of the Bishop
of London in one of his verse satires. At Oxford he wrote a vivacious
comedy of humours, set in the University. Its production in 1730
began his dramatic career, at a time when the number of London
theatres had just doubled, and new dramatic forms were being invented.
In 1731 his poem Harlequin-Horace, a witty inversion of
the Ars Poetica, attacked pantomime and opera, but also painted a
lively portrait of the entire theatrical world, in the tradition of
the Dunciad.
After collaborating in a translation of Moliere's works Miller
wrote two plays based on this author. Of all his dramatic works
these were the most successful with his contemporaries, and were
followed by a modernisation of Much Ado, and a ballad-opera adapted
from an afterpiece by Jean-Baptiste Rousseau, and rendered highly
topical. Miller made similar use of a recent French comedy showing
a Red Indian's reactions to civilisation, a satiric "fable" by Walsh
and Voltaire's Mahomet. A large quantity of original material was
incorporated into most of these, and this is generally satirical in
nature. The Indian is made to voice almost egalitarian sentiments.
An afterpiece, "The Camp Visitants", satirised military inaction
in the war, and was apparently banned. The manuscripts of the six
plays produced after the Licensing Act bear the examiner's deletions,
and illustrate the nature of the censorship at this time.
Miller's greatest strength is probably his flexible, vigorously
colloquial dialogue. His political satire is mostly contained in
the poetry, which attacks Walpole's administration with increasing
vehemence through the seventeen-thirties, until its fall. In 1740
two poems that used Pope in symbolic contrast to Walpole caused a
sensation. In both poetry and plays Miller is also a social satirist,
who lays unusually strong emphasis on false taste and the deterioration
of culture
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
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Oxford tracts, 1841.
No full textTitle from spine.[1] Tracts for the times, no. 90 : remarks on certain passages in the Thirty-nine articles. 1841. (83 p.) -- [2] Tracts for the times : [letter to the editor] / T.T. Churton ... [et al.]. 1841. (2 p.) -- [3] [Letters debating the "Thirty-nine Articles] / P. Wynter and John Henry Newman. 1841. (2 p.) -- [4] Tracts for the times : [letter to the editor] / member of the Church of England. (4 p.) -- [5] Strictures on no. 90 of the Tracts for the times / by a member of the University of Oxford. 1841. (75 p.) -- [6] Certain documents, &c., &c. connected with Tracts for the times no. 90. 1841. (18 p.) -- [7] Some papers illustrative of Tracts for the times, no. 90 ... 1841. (24 p.) -- [8] A few words in support of no. 90 of the Tracts for the times : partly with reference to Mr. Wilson's letter. 1841. (48 p.) -- [9] The crisis come : being remarks on Mr. Newman's letter to Dr. Jelf, and on Tract for the times no. 90 / by the Rev. J. Jordan. 1841. (16 p.) -- [10] The articles treated on in Tract 90 reconsidered and their interpretation vindicated in a letter to the Rev. R.W. Jelf, D.D. canon of Christ Church ... / by the Rev. E.B. Pusey. 1841. (217 p.) -- [11] A letter to the Rev. T.T. Churton ... / [H.B. Wilson]. 1841. (37 p.) -- [12] A letter to the Rev. E.B. Pusey ... : on the publication of no. 90 of the Tracts for the times / by William Sewell. 1841. (20 p.) -- [13] A letter respectfully addressed to the Rev. J.H. Newman upon some passages in his letter to the Rev. Dr. Jelf / by N. Wiseman. 1841. (32 p.) -- [14] Letter to the right reverend the Lord Bishop of Ripon : on the state of parties in the Church of England / by Walter Farquhar Hook. 1841. (16 p.) -- [15] A letter addressed to the Rev. R.W. Jelf ... : in explanation of no. 90 in the series called the Tracts for the times / by the author [J.H.N.]. 1841. (30 p.) -- [16] A letter to the right reverend father in God Richard, Lord Bishop of Oxford : on occasion of no. 90 in the series called the Tracts for the times / by J.H. Newman. 1841. (47 p.) -- [17] Some remarks on a letter addressed to the reverend R.W. Jelf ... : in explanation of no. 90 in the series called Tracts for the times / by Ambrose Lisle Phillipps. 1841. (24 p.)Mode of access: Internet
Episodic encoding is more than the sum of its parts: An fMRI investigation of multifeatural contextual encoding
No full textEpisodic memories are characterized by their contextual richness, yet little is known about how the various features comprising an episode are brought together in memory. Here we employed fMRI and a multidimensional source memory procedure to investigate processes supporting the mnemonic binding of item and contextual information. Volunteers were scanned while encoding items for which the contextual features (color and location) varied independently, allowing activity elicited at the time of study to be segregated according to whether both, one, or neither feature was successfully retrieved on a later memory test. Activity uniquely associated with successful encoding of both features was identified in the intra-parietal sulcus, a region strongly implicated in the support of attentionally mediated perceptual binding. The findings suggest that the encoding of disparate features of an episode into a common memory representation requires that the features be conjoined in a common perceptual representation when the episode is initially experienced
Sustaining menstrual regulation policy: a case study of the policy process in Bangladesh
Get PDFBangladesh introduced menstrual regulation (early abortion) into its national
family planning program in 1979, and for more than 20 years women with unwanted
pregnancies have been able to avail themselves of a relatively safe and accessible
service. Over the years, however, concern has been expressed about deficiencies in
the implementation of the policy, and by the mid-1990s, the menstrual regulation
(MR) policy was approaching a critical juncture. The introduction of health sector
reforms and the waning of international and domestic support raised questions
regarding the sustainability of the policy. This study was conducted to determine the
factors that influenced the development of and support for the MR policy in
Bangladesh, in order to explore how far those factors might influence future
sustainability.
The study used an analytic framework based on literature from the policy
field to test what factors were important in the policy process in Bangladesh.
Qualitative data was gathered from interviews and documents in an inductive
approach to determine the development of the MR policy, which was then subjected
to a retrospective analysis of the entire life cycle of the MR policy-how it came to
be placed on the policy agenda, how and why it was formulated the way it was, and
why it was not implemented as well as it could have been. Data gathered from
interviews and document reviews were then used in a political mapping exercise
undertaken in a prospective analysis for the policy, providing insights in relation to
the future sustainability of the MR policy.
The research suggested that the analytic framework used was helpful in
providing a systematic analysis of contextual conditions, agenda-setting
circumstances, and policy characteristics that could explain much of the variability in
the policy process. The role of international donors and attitudes toward religion
were found to be particularly relevant to explaining the policy process. The study
concluded that the MR policy would likely not be sustained in the future unless
purposeful action were taken to mobilise additional bureaucratic and political
resources in support of the policy
A systematic review of evidence on malignant spinal metastases : natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression
Get PDFBackground: Spinal metastases can lead to significant morbidity and reduction in quality of life due to spinal cord compression (SCC). Between 5% and 20% of patients with spinal metastases develop metastatic spinal cord compression during the course of their disease. An early study estimated average survival for patients with SCC to be between 3 and 7 months, with a 36% probability of survival to 12 months. An understanding of the natural history and early diagnosis of spinal metastases and prediction of collapse of the metastatic vertebrae are important.
Objective: To undertake a systematic review to examine the natural history of metastatic spinal lesions and to identify patients at high risk of vertebral fracture and SCC.
Data sources: The search strategy covered the concepts of metastasis, the spine and adults. Searches were undertaken from inception to June 2011 in 13 electronic databases [MEDLINE; MEDLINE In-Process & Other Non-Indexed Citations; EMBASE; Cochrane Database of Systematic Reviews; Cochrane Central Register of Controlled Trials (CENTRAL); Database of Abstracts of Reviews of Effects (DARE), NHS Economic Evaluation Database (NHS EED), HTA databases (NHS Centre for Reviews and Dissemination); Science Citation Index and Conference Proceedings (Web of Science); UK Clinical Research Network (UKCRN) Portfolio Database; Current Controlled Trials; ClinicalTrials.gov].
Review methods: Titles and abstracts of retrieved studies were assessed by two reviewers independently. Disagreement was resolved by consensus agreement. Full data were extracted independently by one reviewer. All included studies were reviewed by a second researcher with disagreements resolved by discussion. A quality assessment instrument was used to assess bias in six domains: study population, attrition, prognostic factor measurement, outcome measurement, confounding measurement and account, and analysis. Data were tabulated and discussed in a narrative review. Each tumour type was looked at separately.
Results: In all, 2425 potentially relevant articles were identified, of which 31 met the inclusion criteria. No study examined natural history alone. Seventeen studies reported retrospective data, 10 were prospective studies, and three were other study designs. There was one systematic review. There were no randomised controlled trials (RCTs). Approximately 5782 participants were included. Sample sizes ranged from 41 to 859. The age of participants ranged between 7 and 92 years. Types of cancers reported on were lung alone (n= 3), prostate alone (n= 6), breast alone (n= 7), mixed cancers (n= 13) and unclear (n= 1). A total of 93 prognostic factors were identified as potentially significant in predicting risk of SCC or collapse. Overall findings indicated that the more spinal metastases present and the longer a patient was at risk, the greater the reported likelihood of development of SCC and collapse. There was an increased risk of developing SCC if a cancer had already spread to the bones. In the prostate cancer studies, tumour grade, metastatic load and time on hormone therapy were associated with increased risk of SCC. In one study, risk of SCC before death was 24%, and 2.37 times greater with a Gleason score 7 than with a score of < 7 (p= 0.003). Other research found that patients with six or more bone lesions were at greater risk of SCC than those with fewer than six lesions [odds ratio (OR) 2.9, 95% confidence interval (CI) 1.012 to 8.35, p= 0.047]. For breast cancer patients who received a computerised tomography (CT) scan for suspected SCC, multiple logistic regression in one study identified four independent variables predictive of a positive test: bone metastases 2 years (OR 3.0 95% CI 1.2 to 7.6; p= 0.02); metastatic disease at initial diagnosis (OR 3.4, 95% CI 1.0 to 11.4; p= 0.05); objective weakness (OR 3.8, 95% CI 1.5 to 9.5; p= 0.005); and vertebral compression fracture on spine radiograph (OR 2.6, 95% CI 1.0 to 6.5; p= 0.05). A further study on mixed cancers, among patients who received surgery for SCC, reported that vertebral body compression fractures were associated with presurgery chemotherapy (OR 2.283, 95% CI 1.064 to 4.898; p= 0.03), cancer type [primary breast cancer (OR 4.179, 95% CI 1.457 to 11.983; p= 0.008)], thoracic involvement (OR 3.505, 95% CI 1.343 to 9.143; p= 0.01) and anterior cord compression (OR 3.213, 95% CI 1.416 to 7.293; p= 0.005).
Limitations: Many of the included studies provided limited information about patient populations and selection criteria and they varied in methodological quality, rigour and transparency. Several studies identified type of cancer (e.g. breast, lung or prostate cancer) as a significant factor in predicting SCC, but it remains difficult to determine the risk differential partly because of residual bias. Consideration of quantitative results from the studies does not easily allow generation of a coherent numerical summary, studies were heterogeneous especially with regard to population, results were not consistent between studies, and study results almost universally lacked corroboration from other independent studies.
Conclusion: No studies were found which examined natural history. Overall burden of metastatic disease, confirmed metastatic bone involvement and immediate symptomatology suggestive of spinal column involvement are already well known as factors for metastatic SCC, vertebral collapse or progression of vertebral collapse. Although we identified a large number of additional possible prognostic factors, those which currently offer the most potential are unclear. Current clinical consensus favours magnetic resonance imaging and CT imaging modalities for the investigation of SCC and vertebral fracture. Future research should concentrate on: (1) prospective randomised designs to establish clinical and quality-of-life outcomes and cost-effectiveness of identification and treatment of patients at high risk of vertebral collapse and SCC; (2) Service Delivery and Organisation research on magnetic resonance imaging (MRI) scans and scanning (in tandem with research studies on use of MRI to monitor progression) in order to understand best methods for maximising use of MRI scanners; and (3) investigation of prognostic algorithms to calculate probability of a specified event using high-quality prospective studies, involving defined populations, randomly selected and clearly identified samples, and with blinding of investigators
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