364 research outputs found
Observations upon a treatise, entitled A description of the Plain of Troy, by Monsieur Le Chevalier /
No full textErrata: p. [1] at end.Signatures: [A]1 B-H⁴.Includes bibliographical references.ESTC(RLIN)Mode of access: Internet.Library copy bound with: Description of the plain of Troy : with a map of that region, delineated from an actual survey : read in French before the Royal Society of Edinburgh, Feb. 21 and 28 and March 21 1791 / by the author, M. Chevalier. Edinburgh : Printed for T. Cadell, 1791. (90-B15413
Remarks and observations on the plain of Troy, made during an excursion in June, 1799 /
No full textSignatures: pi⁴ A-G⁴.Errata: p. [2] at end; p. [1] and [3] at end blank.ESTC(RLIN)Mode of access: Internet.Library copy bound with: Description of the plain of Troy : with a map of that region, delineated from an actual survey : read in French before the Royal Society of Edinburgh, Feb. 21 and 28 and March 21 1791 / by the author, M. Chevalier. Edinburgh : Printed for T. Cadell, 1791. (90-B15413
Some observations upon the Vindication of Homer, and of the ancient poets and historians, who have recorded the siege and fall of Troy, written by I.B.S. Morritt, esq. /
No full textFinal leaf blank, with errata slip attached.Signatures: A² B-N⁴ [M]1.ESTC(RLIN)Mode of access: Internet.Library copy bound with: Description of the plain of Troy : with a map of that region, delineated from an actual survey : read in French before the Royal Society of Edinburgh, Feb. 21 and 28 and March 21 1791 / by the author, M. Chevalier. Edinburgh : Printed for T. Cadell, 1791. (90-B15413
Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation
No full textThe study of protein function in neurons has been hindered by the lack of highly efficient, nontoxic methods of inducing RNA interference in such cells. Here we show that application of synthetic small interfering RNA( siRNA) linked to the vector peptide Penetratin1 results in rapid, highly efficient uptake of siRNA by entire populations of cultured primary mammalian hippocampal and sympathetic neurons. This treatment leads to specific knock-down of targeted proteins within hours without the toxicity associated with transfection. In contrast to current methods, our technique permits study of protein function across entire populations with minimal disturbance of complex cellular networks. Using this technique, we found that protein knock-down ( evident after 6 hr) precedes any decrease in targeted message ( evident after 24 hr), suggesting an early, translational repression by perfectly targeted siRNAs.PT: J; CR: BARTEL DP, 2004, CELL, V116, P281 BERTRAND E, 2001, MOL CELL NEUROSCI, V18, P503 DEROSSI D, 1994, J BIOL CHEM, V269, P10444 DOENCH JG, 2003, GENE DEV, V17, P438 DOSTIE JE, 2003, RNA, V9, P180 ELBASHIR SM, 2001, EMBO J, V20, P6877 FINK CC, 2003, NEURON, V39, P283 FIRE A, 1998, NATURE, V391, P806 GAUDILLIERE B, 2002, J BIOL CHEM, V277, P46442 HANNON GJ, 2002, NATURE, V418, P244 HUTVAGNER G, 2002, SCIENCE, V297, P2056 JOHNSTON RJ, 2003, NATURE, V426, P845 JOLIOT A, 2004, NAT CELL BIOL, V6, P189 KHVOROVA A, 2003, CELL, V115, P209 KIM J, 2004, P NATL ACAD SCI USA, V101, P360 KRICHEVSKY AM, 2002, P NATL ACAD SCI USA, V99, P11926 KRICHEVSKY AM, 2003, RNA, V9, P1274 LAI EC, 2003, CURR BIOL, V13, R925 LLAVE C, 2002, SCIENCE, V297, P2053 MURATOVSKA A, 2004, FEBS LETT, V558, P63 OMI K, 2004, FEBS LETT, V558, P89 RABACCHI SA, 2004, NEUROBIOL AGING, V25, P1057 REYNOLDS A, 2004, NAT BIOTECHNOL, V22, P326 SAXENA S, 2003, J BIOL CHEM, V278, P44312 SCHERER LJ, 2003, NAT BIOTECHNOL, V21, P1457 SCHWARZ DS, 2003, CELL, V115, P199 THEODORE L, 1995, J NEUROSCI, V15, P7158 TOROCSIK B, 2002, J NEUROSCI, V22, P8971 TROY CM, 1994, P NATL ACAD SCI USA, V91, P6384 TROY CM, 1996, J NEUROSCI, V16, P253 TROY CM, 1996, P NATL ACAD SCI USA, V93, P5635 TROY CM, 2001, J NEUROSCI, V21, P5007 TROY CM, 2002, J BIOL CHEM, V277, P34295 VICKERS TA, 2003, J BIOL CHEM, V278, P7108 ZENG Y, 2003, P NATL ACAD SCI USA, V100, P9779; NR: 35; TC: 22; J9: J NEUROSCI; PG: 7; GA: 869ZASource type: Electronic(1
Seven Troy cities
No full textУ статті автор, на базі узагальнення власних досліджень
1980—1990-х рр та з урахуванням останніх результатів
розкопок експедиції М. Корфмана в Трої, доходить висновку, що варто відійти від традиційного уявлення про сім
міст, які після своєї загибелі стали культурними шарами
й утворюють стратиграфічну колонку пагорба Гісарлик.
Натомість, це швидше образи міст, що виступають у
свідомості дослідників під час читання Іліади та сприйнятті археологічних матеріалів. Відтворенню згаданих
образів міст Троя, за якими проступають риси культурних та етнічних спільнот, присвячено дослідження. Мешканці міст Троя стали свідками й учасниками міграційних
рухів, що призвели до індоєвропеїзації Анатолії.В статье автор, обобщив выводы своих исследований 1980—1990-х гг. и учтя последние результаты раскопок экспедиции М. Корфмана в Трое, приходит к выводу, что традиционное представление о семи городах, ставших
после своей гибели культурными слоями холма Гисарлик, требует пересмотра. Это скорее образы городов, возникающих в сознании исследователей при чтении «Илиады» и восприятии археологических материалов. Воссозданию упомянутых образов городов Троя, за коими просматриваются черты археологических культур и этнических
общностей, посвящено исследование. Обитатели городов Троя стали свидетелями и участниками миграционных
потоков, а результатом их стала индоевропеизация Анатолии.In the article the author, summarizing the conclusions of his studies of the 1980-ies and 1990-ies and taking into account
the recent finds of M. Korfmann excavations in Troy, concludes that the traditional idea of seven cities, which have become
cultural layers after the destruction of the Khisarlyk hill, requires reconsideration. These are more likely the images of
cities that arise in minds of researchers when reading the “Iliad” and perceiving archaeological materials. The research is
devoted to the restoration of the mentioned images of Troy cities, in which the features of archaeological cultures and ethnic
communities are traced. The inhabitants of the Troy cities
Correction to: The “Risser+” grade: a new grading system to classify skeletal maturity in idiopathic scoliosis (European Spine Journal, (2019), 28, 3, (559-566), 10.1007/s00586-018-5821-8)
No full textUnfortunately, the affiliation of the author Negrini S has been incorrectly published in the original version. The complete correct affiliation of this author should read as follows
Gq Protein-Coupled Membrane-Initiated Estrogen Signaling Rapidly Excites Corticotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus in Female Mice
No full textCRH neurons in the hypothalamic paraventricular nucleus (PVN) play a central role in regulating the hypothalamus-pituitary-adrenal (HPA) axis and are directly influenced by 17β-estradiol (E2). Although compelling evidence has suggested the existence of membrane-associated estrogen receptors (mERs) in hypothalamic and other central nervous system neurons, it remains unknown whether E2 impacts CRH neuronal excitability through this mechanism. The purpose of the current study is to examine the existence and function of mER signaling in PVN CRH neurons. Whole-cell recordings were made from CRH neurons identified by Alexa Fluor 594 labeling and post hoc immunostaining in ovariectomized female mice. E2 (100nM) rapidly suppressed the M-current (a voltage-dependent K(+) current) and potentiated glutamatergic excitatory postsynaptic currents. The putative Gq-coupled mER (Gq-mER) characterized in hypothalamic proopiomelanocortin neurons initiates a phospholipase C-protein kinase C-protein kinase A pathway; therefore, we examined the involvement of this pathway using selective inhibitors. Indeed, the ER antagonist ICI 182780 and inhibitors of Gq-phospholipase C-protein kinase C-protein kinase A blocked E2's actions, suggesting dependence on the Gq-mER. Furthermore, STX, a selective ligand for the Gq-mER, mimicked E2's actions. Finally, to examine the in vivo effect of Gq-mER activation, E2 or STX injection increased c-fos expression in CRH neurons in the PVN, suggesting CRH neuronal activation. This corresponded to an increase in plasma corticosterone. We conclude that the Gq-mER plays a critical role in the rapid regulation of CRH neuronal activity and the HPA axis. Our findings provide a potential underlying mechanism for E2's involvement in the pathophysiology of HPA-associated mood disorders.Peer reviewe
Cloud top phase characterization of cold sector Southern Ocean clouds and ice production at warm cloud top temperatures: results from the SOCRATES field campaign
No full textDSpace SAF Submission Ingestion Package generated from Vireo submission #15324 on 2020-08-25 at 17:30:51Made available in DSpace on 2020-08-26T23:58:45Z (GMT). No. of bitstreams: 2
ZAREMBA-THESIS-2020.pdf: 11733684 bytes, checksum: b4cb5ef25932712ba0a40e0f9ee1594f (MD5)
LICENSE.txt: 4209 bytes, checksum: 4848dc1974c70c881dc428df1700ba97 (MD5)
Previous issue date: 2020-05-14Low-level cloud cover over the Southern Ocean (SO) has a significant influence on global radiative balance. Climate models have had difficulty in the past reproducing shortwave radiation reflected by these clouds because of the inability to represent low-level cloud top properties, more specifically, they underrepresent cloud top supercooled liquid water concentrations. Past in-situ and satellite studies over the region have emphasized the abundance and importance of supercooled liquid water in cold sector SO clouds, especially at or near cloud top. SO supercooled clouds contribute between 27% and 38% of the total reflected solar radiation between 40ºS and 70ºS and represent a significant source of uncertainty in global climate models. Understanding these cloud’s properties and processes is critical to accurately simulating them in the climate system. Past global climate model studies have found that replacing all mixed-phase clouds with supercooled clouds at temperatures between -35ºC and 0ºC would result in 17 W m-2 more radiation reflected back to space. Ice crystals are typically thinner for the same liquid water content present as a pure supercooled liquid cloud.
This study uses collocated airborne radar, lidar, and thermodynamic data from twelve high-altitude flight legs during the SO Clouds, Radiation, Aerosol Transport Experimental Study (SOCRATES) field campaign to characterize SO cold sector cloud top phase (top 96 m) and cloud precipitation properties as a function of cloud top temperature. Training datasets were developed to create probabilistic phase classifications based on High Spectral Resolution Lidar data and HIAPER Cloud Radar data. These classifications were used to identify cloud top phase. Results indicate that nearly 88.7% of the cloud tops contained liquid, 1.1% contained ice, 0.8% could not be identified based on the training datasets, and 9.4% were unknown (meaning they fell outside of the training datasets). 75.6% of cloud cover had cloud top temperatures less than 0ºC. Considering only these clouds we found that 89.9% had supercooled liquid water at cloud top, 0.4% contained ice, 0.1% could not be identified based on the training datasets and 9.6% were unknown (meaning they fell outside the training datasets). Case studies are also presented illustrating examples of low-level cold sector cloud top phase identification.
Ice production in clouds with warm cloud top temperatures (greater than -5ºC) occurred in several locations during 8 research flights. Case studies showed the clear presence of a melting level even when cloud top temperatures were as warm as -3ºC. 41.0% of clouds sampled had cloud top temperatures between -5ºC and 0ºC. 8.5% of those clouds were precipitating through the 0ºC isotherm. 23.5% of clouds with cloud top temperatures between -5ºC and 0ºC that precipitated through the 0ºC isotherm had a definitive melting level present, implying that primary and/or secondary ice production was occurring.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-05-01The student, Troy Zaremba, accepted the attached license on 2020-05-11 at 13:29.The student, Troy Zaremba, submitted this Thesis for approval on 2020-05-11 at 13:36.This Thesis was approved for publication on 2020-05-14 at 08:25.Embargo set by: Seth Robbins for item 115794
Lift date: 2022-08-26T23:58:55Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemAuthor requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Onl
A transient analysis of a shunt thyristor bridge excitation system for synchronous machines
No full textMay 1976School of EngineeringThe work described analyzes the transient response of a static excitation system for large steam turbine-generators. The transient performance characteristics of the excitation system are important because they relate to: 1. Speed of response of the excitation system and magnitude of the generator field transient forcing which is one of the important aspects of a good excitation system. 2. Maximum possible transient overvoltages, affecting the insulation design of all excitation system components. These points are investigated for a particular case of transient operation of the excitation system. Test results from an actual system are reported and comparison with expected values is indicated.Ph
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Construction and testing of components for the 6.5 m MMT adaptive optics system
No full textIn recent years astronomers have been pushing to build larger ground-based telescopes with apertures greater than 5 m in order to see deeper into space and resolve smaller objects. Realistically, while a larger telescope aperture allows more light to be collected, atmospheric turbulence caused by thermal gradients in the atmosphere limits the achievable resolution to a level comparable with apertures on the order of half a meter or less. Adaptive optics (AO) can be used to counteract the degrading effects of the atmosphere in real time and recover diffraction-limited resolution. With the help of AO, better science can be done, and as more large ground-based telescopes are built, the need for reliable AO systems grows. The 6.5 m upgrade to the Multiple Mirror Telescope (MMT) on Mt. Hopkins is an example of a large telescope project. An infrared adaptive optics system for this telescope is currently under construction at Steward Observatory in the Center for Astronomical Adaptive Optics. This dissertation reports on the design, construction, and testing of various components of this AO system with which the author was involved. These components include the deformable secondary mirror, the wave front sensor, a laboratory testing system, and wavefront reconstruction algorithms.This item was digitized from a paper original and/or a microfilm copy. If you need higher-resolution images for any content in this item, please contact us at [email protected] file replaced with corrected file September 2023
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