196,439 research outputs found
Validation of models that predict Cesarean section after induction of labor
No full textAbstract not availableA. Oudenaarden, M. A. A. Hermus, M. M. Porath, S. G. Oei and B. W. J. Mo
Homocysteine and Venous Thrombosis Epidemiological studies on Causality, Pathophysiology and Risk Prediction.
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51620.pdf (Publisher’s version ) (Open Access)RU Radboud Universiteit Nijmegen, 29 maart 2007Promotor : Hermus, A.R.M.M. Co-promotores : Heijer, M. den, Blom, H.J., Borm, G.F.157 p
Comparison of induction of labour and expectant management in postterm pregnancy: a matched cohort study
No full textAbstract not availableMarieke A.A. Hermus, Corine J.M. Verhoeven, Ben W. Mol, Gideon S. de Wolf, and Cora A. Fiedeldei
Towards an optimal TSH: different goals for different outcomes and for different populations?
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150187.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 27 januari 2016Promotores : Heijer, M. den, Hermus, A.R.M.M. Co-promotor : Netea-Maier, R.T
Molecular genetic analysis of hyperhomocysteinemia.
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30131_molegeano.pdf (Publisher’s version ) (Open Access)Homocysteine is a intermediary product of protein metabolism. A high concentration of homocysteine in the blood is associated with a higher risk of cardiovascular disease, including venous thrombosis. Homocysteine levels are in part determined by genetic factors and vitamin intake (such as vitamin B12). The main goal of the presented research was to identify genetic factors (polymorphisms) that affect homocysteine levels and to assess if these polymorphisms also increased the risk of recurrent venous thrombosis. In addition, we evaluated vitamin B12 as a risk factor of recurrent venous thrombosis. We investigated a polymorphism in the catechol-O-methyltransferase gene, which is involved in so-called 'transmethylation reactions', in relation to homocysteine levels. Individuals carrying this polymorphism had higher homocysteine levels than subjects that did not carry this variant. In addition, this polymorphism was more common in recurrent venous thrombosis cases than the general population. This supports the hypothesis that high homocysteine reflects a disturbed transmethylation, which increases venous thrombosis risk. We also developed a method to study metabolites in the blood that report on the ability of our body to perform transmethylation reactions. It appeared that the way the blood samples were stabilized was of great importance for the reliability of our method. Future studies will have to point out whether a disturbed transmethylation is involved in the aetiology of venous thrombosis. Finally, we show that a low vitamin B12 status, which is a cause of high homocysteine levels, is associated with an increased risk of recurrent venous thrombosis. Measuring methylmalonic acid, a marker of intracellular vitamin B12 availability, seems more suitable for measuring vitamin B12 status than plasma vitamin B12 itself.RU Radboud Universiteit Nijmegen, 11 januari 2007Promotor : Hermus, A.R.M.M. Co-promotores : Heijer, M. den, Blom, H.J.165 p
Genetic epidemiology of homocysteine and related diseases.
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80617.pdf (Publisher’s version ) (Open Access)Homocysteine is a sulphur-containing intermediate in one-carbon metabolism. Plasma total homocysteine (tHcy) concentration is associated to common diseases including venous thrombosis and neural tube defects (NTD). Identification of genetic determinants of plasma tHcy concentration can contribute to clarification of the underlying pathogenic processes. In the last 13 years, a focus on single locus association studies of functional variants has resulted in establishment of the MTHFR677C>T polymorphism as a genetic determinant of plasma tHcy concentrations. In this thesis, we looked beyond the single locus effects of evident candidate DNA variants and beyond the traditional genetic epidemiological study designs. The first part of the thesis describes a linkage study for plasma tHcy and four candidate-gene association studies for plasma tHcy, related metabolites, recurrent venous thrombosis (RVT), and NTD. The genome wide-linkage analysis revealed three regions that might harbour genetic determinants for plasma tHcy. Extensive association studies for over 40 one-carbon metabolism-related genes led to identification of novel candidates and known DNA variants that each had small contributions in plasma tHcy variation (T and CBS variants. Using multi-locus analysis we found a strongly associated five-locus interacting genotype that explained 17% of plasma tHcy variation in our population. Simultaneous analysis of candidate genes for plasma tHcy and folate and methionine concentrations indicated heterogeneity in genetic determinants for the three metabolites. The UCP2 45bp del was found to influence recurrent venous thrombosis risk and variants in CUBN and TRDMT1 were associated with NTD but not via plasma tHcy concentration. In the second part of the thesis, a new hybrid design is proposed which is shown to allow a powerful and flexible identification of both maternal and offspring genetic effects compared to alternative designs. Finally, four different methods to analyse gene-gene interactions are evaluated using simulated data.RU Radboud Universiteit Nijmegen, 30 september 2009Promotores : Kiemeney, L.A.L.M., Hermus, A.R.M.M. Co-promotores : Heijer, M. den, Blom, H.J.224 p
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Durante partu naar het geboortecentrum: een secundaire analyse van het geboortecentrumonderzoek.
No full textRuim 30% van de vrouwen die in een geboortecentrum willen bevallen, komt daar uiteindelijk niet terecht. Dat concludeert Marieke Hermus in haar onderzoek. De vrouwen die er wel komen worden minder snel verwezen naar de tweede lijn wanneer zij eerst thuis getoucheerd worden. (aut. ref.
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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