326,566 research outputs found
Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein
No full textThe regulation of differentiation is particularly important in microbial eukaryotes that inhabit multiple environments. The parasite Trypanosoma brucei is an extreme example of this, requiring exquisite gene regulation during transmission from mammals to the tsetse fly vector. Unusually, trypanosomes rely almost exclusively on post-transcriptional mechanisms for regulated gene expression. Hence, RNA binding proteins are potentially of great significance in controlling stage-regulated processes. We have previously identified TbZFP1 as a trypanosome molecule transiently enriched during differentiation to tsetse midgut procyclic forms. This small protein (101 amino acids) contains the unusual CCCH zinc finger, an RNA binding motif. Here, we show that genetic ablation of TbZFP1 compromises repositioning of the mitochondrial genome, a specific event in the strictly regulated differentiation programme. Despite this, other events that occur both before and after this remain intact. Significantly, this phenotype correlates with the TbZFP1 expression profile during differentiation. This is the first genetic disruption of a developmental regulator in T. brucei. It demonstrates that programmed events in parasite development can be uncoupled at the molecular level. It also further supports the importance of CCCH proteins in key aspects of trypanosome cell function
De Groot (Wim), ed. The Seventh Window. The King 's Window donated by Philip II and Mary Tudor to Sint Janskerk in Gouda (1557).
No full textHendriks Valentine. De Groot (Wim), ed. The Seventh Window. The King 's Window donated by Philip II and Mary Tudor to Sint Janskerk in Gouda (1557). . In: Revue belge de philologie et d'histoire, tome 84, fasc. 4, 2006. Histoire medievale, moderne et contemporaine - Middeleeuwse. moderne en hedendaagse geschiedenis. pp. 1336-1338
Board Networks Among Hospitals In The Netherlands 2008
No full textThis database contains the network of interlocking directorates among Dutch hospitals. Hendriks selected 23 hospitals located in or near Amsterdam (8), Rotterdam (6), Utrecht (5), and Friesland (4). The data were compiled from annual reports. The database contains information on the name, academic title, expertise and (other) function(s) of 201 directors of these hospitals. In addition to their position in the hospital board, these directors hold positions in 876 other organizations. Twenty-two hospitals are interconnected because hospital directors meet each other in these other organizations. At the national and at the regional level there is a social network of hospital elites
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Board Networks Among Hospitals In The Netherlands 2008
No full textThis database contains the network of interlocking directorates among Dutch hospitals. Hendriks selected 23 hospitals located in or near Amsterdam (8), Rotterdam (6), Utrecht (5), and Friesland (4). The data were compiled from annual reports. The database contains information on the name, academic title, expertise and (other) function(s) of 201 directors of these hospitals. In addition to their position in the hospital board, these directors hold positions in 876 other organizations. Twenty-two hospitals are interconnected because hospital directors meet each other in these other organizations. At the national and at the regional level there is a social network of hospital elites
The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count
No full textAbstract not availableSimone L. Broer, Ben Willem J. Mol, Dave Hendriks, and Frank J.M. Broekman
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
ritmische kracht van water
No full textH2O, water. Er zijn weinig stoffen met zo´n eenvoudige chemische samenstelling. Die chemisch eenvoudig lijkende stof heeft echter een nog niet te overzien vermogen om met informatie om te gaan. In Engeland zijn John Wilkes en zjn collega´s al vele jaren actief om stromingsbewegingen in water te analyseren en deze in flowforms vorm te geven. Ruud Hendriks zocht hem op in zijn huis op het terrein van Emerson College in Forest Row en sprak met Nick Weidmann in de net nieuw gebouwde werkplaats
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