1,417 research outputs found
Distinct binding specificity of the multiple PDZ Domains of INADL, a human protein with homology to INAD from Drosophila melanogaster
No full textPhilipp Melanchthon
No full textPhilipp Melanchthon (1497–1560) was, with Martin Luther, the most influential reformer of the church during the 16th century. He was also a reformer of university education, especially theological studies, as well as the school system in Germany. He was responsible for a theological curriculum that included Greek, Hebrew, and philosophy. He, as a professor of Greek at the University of Wittenberg since 1518, was the author of the first generally accepted Protestant confession, known as the Confessio Augustana (1530). He also wrote the first Protestant commentaries on Paul’s letter to the Romans (1519), as well as the first Protestant handbook in systematic theology (1521). He was the main negotiator of the Protestant movement during the diets and religious discussions with the Roman Catholic Church. He is known as the ‘teacher of Germany and Europe’ and is respected as the father of the ecumenical movement. Yet, Melanchthon is not known to South Africans and especially Afrikaans-speaking people who, traditionally, have close links with the reformational tradition. There is not yet one single publication on Melanchthon in Afrikaans or by a South African scholar, making this book, therefore, the first by an Afrikaans-speaking scholar on Melanchthon
#Bitcoin : an analysis of the field of a decentralized virtual currency using twitter data
No full textAuthor Philipp AllerstorferAbstract in englischer SpracheMasterarbeit Universität Linz 201
On Philipp Lersch’s Psychology, Reflection No. 2
No full textАвтор статті зазначає, що у 1930–1970 рр. Ф. Лерш був головним представником гуманітарної течії в німецькомовній психології. Наукову класифікацію людських прагнень і стремлінь було
викладено у головній праці Ф. Лерша «Структура особи» (11-те видання 1970 року). Ф. Лерш зумів
об’єднати у своїм творі інформацію із низки наук (біології, психопатології, із різних психологічних
теорій та концепцій).The author of the article notes that in 1930-1970, Philipp Lersch was the main representative of the
humanitarian direction in German psychology. A scientific classification of human aspirations and ambitions
was described in the main work by Philipp Lersch “Building the Person” (11th ed. of 1970). In his work,
Philipp Lersch managed to combine information from a number of sciences (biology, psychopathology, various
psychological theories and concepts)
Deformation Behavior and Damage Modeling of Polypropylene and Polycarbonate
No full textAuthor Philipp Siegfried StelzerKurzfassungen in deutscher und englischer SpracheMasterarbeit Universität Linz 201
Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster
No full textPDZ domains are protein-protein interaction modules that typically bind to short peptide sequences at the carboxyl terminus of target proteins. Proteins containing multiple PDZ domains often bind to different trans-membrane and intracellular proteins, playing a central role as organizers of multimeric complexes. To characterize the rules underlying the binding specificity of different PDZ domains, we have assembled a novel repertoire of random peptides that are displayed at high density at the carboxyl terminus of the capsid D protein of bacteriophage lambda. We have exploited this combinatorial library to determine the peptide binding preference of the seven PDZ domains of human INADL, a multi-PDZ protein that is homologous to the INAD protein of Drosophila melanogaster. This approach has permitted the determination of the consensus ligand for each PDZ domain and the assignment to class I, class II, and to a new specificity class, class IV, characterized by the presence of an acidic residue at the carboxyl-terminal position. Homology modeling and site-directed mutagenesis experiments confirmed the involvement of specific residues at contact positions in determining the domain binding preference. However, these experiments failed to reveal simple rules that would permit the association of the chemical characteristics of any given residue in the peptide binding pocket to the preference for specific amino acid sequences in the ligand peptide. Rather, they suggested that to infer the binding preference of any PDZ domain, it is necessary to simultaneously take into account all contact positions by using computational procedures. For this purpose we extended the SPOT algorithm, originally developed for SH3 domains, to evaluate the probability that any peptide would bind to any given PDZ domain
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