22 research outputs found
Technical requirements of age-friendly smart home technologies in high-rise residential buildings: A system intelligence analytical approach
No full text<i>Smart home technology (SHT)</i> has been identified as a promising means of helping seniors to remain independent and maintain their quality of life (QoL) while containing spiralling care costs for older people. Despite official pilot schemes in many countries to promote SHT in seniors housing, there is limited understanding of the forms that such SHT interventions should take. This study builds on the analytical model of intelligent building control systems developed by the author; the aim is to provide a systematic approach to understanding the key intelligent attributes of smart-home devices. A qualitative participatory evaluation approach involving focus groups was adopted to investigate the needs of seniors and their SHT preferences. Fourteen features of the SHT technical requirements of four key intelligent attribute types were identified. This study’s insights will help to shape the way SHT is designed and used
B.2. A broad perspective on Estonian haiku as compared to its Japanese origins
No full textThe article aims to give a broad overview of the main formal characteristics of Estonian haiku and to compare it to its Japanese origin. The analysis is based on texts published in the literary magazine "Looming" from 1963-1998, and focuses on two main issues: the openness of the form (in Eco's sense) and the use of tropes. It also touches upon the different mechanisms for meaning generation in Estonian haiku. The use of tropes is analysed in the light of Yuri Lotman's notions of "rhetorical – anti-rhetorical culture" and "meta-trope". The author concludes that while Japanese haiku is an open text and the meanings are created between different texts rather than inside the text, Estonian authors tend to prescribe the possible associations of their text. Thus it can be said that a notion "haiku" refers to considerably different kinds of texts in Japanese and Estonian literature
A.3. Die Bedeutung der Buchgliederung für die kompositionelle Gestaltung der Metamorphosen Ovids
No full textDie Makrostruktur der ovidischen Metamorphosen bildet ein bislang ungelöstes Problem der Forschung. Ältere Gliederungsansätze abstrahieren völlig von der vom Autor vorgegebenen Buchstruktur und nehmen nach genealogischen Kriterien eine der überlieferten Buchgliederung gänzlich fremde Einteilung vor. Dagegen orientieren sich neuere Forscher wieder mehr an der vorgegebenen 15 Bücher Form und suchen vor allem die Buchpentade mit weitreichenden Folgerungen als strukturelles Prinzip zu erweisen. Entgegen diesen Ansätzen wird in der vorliegenden Arbeit versucht, auf die Annahme einer makrostrukturellen Epochengliederung zu verzichten und stattdessen die einzelnen Bücher als autonome Dispositionseinheiten zu verstehen, die ihren Reiz zumeist aus einer Dichotomie von zwei konträren Großteilen erhaben epischen bzw. erotisch elegischen Inhalts beziehen. Die Spannung zwischen solchen konträren Gestaltungsweisen einzelner Großteile bestimmt das Innere der einzelnen Bücher als Lektüreeinheiten wie auch die Grenzen zwischen den einzelnen Büchern. The macrostructure of Ovid's Metamorphoses is a hitherto unsolved problem. Earlier studies entirely ignore the structure of books given by the author and impose a disposition totally alien to the transmitted grouping of books. On the other hand, more recent approaches emphasize the division of the poem into 15 books and try especially to demonstrate that five book groups are the main structural principle in order to draw from this far reaching conclusions. Deviating from these approaches, the present article intends to dismiss the thesis of a macrostructural order of epochs and rather to understand the single books as autonomous structural units which owe their attractiveness to the tension arising between two main parts of either epic or elegiac content. This tension characterizes the whole of the single books as reading units and also the transitions between single books
Aquatic Food Composition Database
No full textWelcome to the Aquatic Food Composition Database! This database synthesizes existing nutrient composition data for aquatic food species. These data originate from disparate sources, including national food composition tables (FCT), international datasets from FAO, and other peer reviewed published sources of nutrient composition. New data are dynamically added to this comprehensive database and this will change summary and regional values based on the version of the database. Please visit this GitHub site for more information on the database, and available code to process data: https://github.com/zachkoehn/aquatic_foods_nutrient_database
Author contributions (* indicates joint first co-authorship)
CDG* created the concept for the AFCD, co-designed the database, and guided data extraction efforts.
JZK* led the data extraction efforts and co-designed the database.
BV co-designed the database.
CD, HK, KM extracted data.
KJF contributed data.
MK performed quality checks on the database.
SHT performed quality checks and facilitated data contributions
Quasi-liquid crystals of electrons and positrons
No full textThis work concerns the discovery of a time-domain "anomaly" in the Infra-Red synchrotron radiation spectra emitted by electrons and positrons from both the DAPHNE -Factory (Frascati National Laboratories, Italy) and HFL (Hefei Light Source at NSRL(National Synchrotron Radiation Laboratory, People’s Republic of China).
The study was conducted with the SHT unconventional statistical category calculus system, developed and patented by the present author for the analysis of complex systems. The anomaly found in the IR synchrotron radiation emission profile of each single bunch of electrons and positrons, has been resolved by SHT analysis in two distinct waveform components, one of which is "delayed" by a few hundred of ps with respect to the other.
A detailed and in-depth analysis excludes that the anomaly is the result of systematic errors.
The measured time differences between the two signals leads to an apparent discrepancy in the value of the speed of light in a vacuum.
A deep time series analysis of the anomaly, based on considerations on the coherent emission of synchrotron radiation (CSR), demonstrates the existence of a distribution of structures and degrees of freedom inside a bunch of particles. This evidence is in contrast with the "rigid bunch" model (J. Schwinger 1945). We therefore propose a model called "CFNM" (Coherent Fractal Nematic Mesophase), which describes the transition from a phase of maximum symmetry to a condensed phase, homologous to the nematic mesophase of liquid crystals.
This model could have significant consequences in the study, modeling and measurement of the operating parameters of future machines and collectors of accelerators, in particular with regard to emission and brightness
A BOOK REVIEW: GRAPmc NOVELS: A FUN & CREATIVE WAY OF WRITING AND READING
No full textThe 21" century is marked for the vast development of digital
media. I fbefore, communicating with people from another country is reached by the sending ofletters or making international phone calls, nowadays people can do all of those in one go with the internet. Whether it is writing to people or speaking to them, all can be done at once with a bonus of even seeing who and what the other end is doing. The chatting facilities of e.g. the Yahoo Messenger or Skype make it
possible. Similarly, ifbefore students would spend hours of research at a library to fmd and read books, nowadays some of those same books can be read digitally in their own homes. Yet, Nancy Frey exclaims: "Readers in the 21 st century need to be able to analyze what they read and understand the motive of the author and the accuracy of the reading. They need to see themselves as active users, not merely vessels to be filled" (in http://www.educationworld.com /a_curr/profdev/profdevl05.sht m1, 2010). To do this, the traditional method of giving books to students to read either inside or outside the classroom, is a fact not to be argued. The problem is, with numerous instant facilities that a student can have now, may make them not patient enough to sit for long hours reading the pages and pages of books assigned by a teacher
Mechanisms of neurodegeneration in a preclinical autosomal dominant retinitis pigmentosa knock-in model with a RhoD190N mutation
No full textD190N, a missense mutation in rhodopsin, causes photoreceptor degeneration in patients with autosomal dominant retinitis pigmentosa (adRP). Two competing hypotheses have been developed to explain why D190N rod photoreceptors degenerate: (a) defective rhodopsin trafficking prevents proteins from correctly exiting the endoplasmic reticulum, leading to their accumulation, with deleterious effects or (b) elevated mutant rhodopsin expression and unabated signaling causes excitotoxicity. A knock-in D190N mouse model was engineered to delineate the mechanism of pathogenesis. Wild type (wt) and mutant rhodopsin appeared correctly localized in rod outer segments of D190N heterozygotes. Moreover, the rhodopsin glycosylation state in the mutants appeared similar to that in wt mice. Thus, it seems plausible that the injurious effect of the heterozygous mutation is not related to mistrafficking of the protein, but rather from constitutive rhodopsin activity and a greater propensity for chromophore isomerization even in the absence of light.We greatly appreciate the assistance of the members of the Bernard & Shirlee Brown Glaucoma laboratory, especially to Chun-Wei Hsu for technical support. SHT is a Burroughs-Wellcome Program in Biomedical Sciences Fellow, and is also supported by the Charles E. Culpeper-Partnership for Cures 07-CS3, Crowley Research Fund, Schneeweiss Stem Cell Fund, New York State N09G-302, Foundation Fighting Blindness [TA-NMT-0116-0692- COLU] (Owings Mills, MD), TS080017 from US Department of Defense, NIH Grants [P30EY019007, R01EY018213, R01EY024698, R01EY026682, R21AG050437], Research to Prevent Blindness (New York, NY), and Joel Hoffmann Scholarship. CSL is the Homer McK. Rees Scholar. JSP is a BEST2016 awardee (BEST/ 2016/030, Conselleria de Educación, Investigación, Cultura y Deporte; Generalitat Valenciana) and his research is supported by a Prometeo Grant (PROMETEO/2016/094; Conselleria de Educación, Investigación, Cultura y Deporte; Generalitat Valenciana) and by internal funds from Universidad Católica de Valencia San Vicente Mártir (2018-128-001). VBM is supported by NIH Grants K08EY020530, R01EY016822, The Doris Duke Charitable Foundation Grant #2013103, and Research to Prevent Blindness (New York, NY); GV is supported by NIH Grants [F30EYE027986 and T32GM007337].Author manuscriptMedicin
Reinforcing Data Integrity in Renewable Hybrid AC-DC Microgrids from Social-Economic Perspectives
No full textThe microgrid (MG) is a complicated cyber-physical system that operates based on interactions between physical processes and computational components, which make it vulnerable to varied cyber-attacks. In this paper, the impact of data integrity attack (DIA) has been considered, as one of the most dangerous cyber threats to MGs, on the steady-state operation of hybrid MGs (HMGs). Additionally, a novel method based on sequential hypothesis testing (SHT) approach, is proposed to detect DIA on the renewable energy sources’ metering infrastructure and improve the data security within the HMGs. The proposed method generates a binary sample, which is used to compute a test statistic that is further used against two thresholds to decide among three alternatives. The performance of the suggested method is examined using an IEEE standard test system. The results illustrated the acceptable performance of the proposed methodology in detection of DIAs. Also, to evaluate the effect of DIA on the operation of the HMGs, DIAs with different severities are launched on the measured power generation of renewable energy resources (RESs) like wind turbine (WT). The results of this part showed that a successful DIA on renewable units can severely affect the operation of electric grids and cause serious damages.© 2022 Copyright held by the owner/author(s), published by Association for Computing Machinery (ACM). This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in ACM Transactions on Sensor Networks, http://dx.doi.org/10.1145/3512891. Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]=vertaisarvioitu|en=peerReviewed
Development and validation of a diagnostic prediction model for pancreatic ductal adenocarcinoma: VAPOR 1, protocol for a prospective multicentre case-control study
No full text\ua9 Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. Introduction: Pancreatic ductal adenocarcinoma (PDAC) continues to have extremely poor patient outcomes, unlike other cancer types which have seen significant improvements in their treatments and survival. A major contributing factor is that PDAC is often detected at an advanced, incurable stage. In the UK, nearly half of patients have stage 4 disease at the time of diagnosis, which has a profound effect on treatment options and, ultimately, survival. To address the challenge of early detection of PDAC, this study aims to develop and validate a clinical prediction model based on a non-invasive breath test. The proposed breath test aims to assist general practitioners in the triaging of patients who present with symptoms that do not meet current criteria for urgent suspected PDAC pathway referral. Methods and analysis: The Volatile organic compound Assessment in Pancreatic ductal adenOcaRcinoma (VAPOR 1) study is a prospective, multicentre, case-control study that aims to recruit 771 participants from England, Wales and Scotland. These include adult participants, aged ≥18 years, in three cohorts: pancreatic ductal adenocarcinoma; benign pancreatic controls (chronic pancreatitis or new-onset diabetes); healthy controls with a normal pancreas on imaging. A one-off breath sample will be obtained from participants who have fasted for at least 6 hours, and participant demographics and clinical data will be recorded. Breath samples will be analysed using gas chromatography-mass spectrometry to identify the volatile organic compounds (VOCs) present. Relationships between VOCs of interest and the presence of PDAC will be explored, and a clinical prediction model will be developed using statistical and machine learning methods and internally validated. Ethics and dissemination: The VAPOR 1 study has received approval from the South East Scotland Research Ethics Committee 02, and from the Health Research Authority and Health and Care Research Wales (REC 22/SS/0061). Results of this study will be published in open-access peer-reviewed journals, and disseminated through pancreatic cancer conference presentations. In addition, lay summaries shared on our website, social media platforms and through our charitable funder, Pancreatic Cancer UK, will enable engagement with patients and the wider public
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