10 research outputs found
The Methodology of interpretation of Qur'ān in "Qur'ānan ‘Ajaban" by Dr. Nighat Hashmi: ڈاکٹر نگہت ہاشمی کاقرآن مجید کی تفسیر ’’قرآناً عجباً‘‘ میں منہج و اسلوب
No full textGreat personalities in the history of nations are not born every day. Centuries later, a personality emerges and organizes scattered crowds. These great people come to the world as the star of the fate of their nation. People with such high objectives are a beacon for their future generations. The poet has said very well about such great personalities. "Don't be easy to know us, the flicks come out of the dust screen for years". If we pick up the history of Islam, we are aware that not only men but women also have a great share in this field, but history introduces us to many women who have served different lying in different walks of life, especially in the field of knowledge. There are vivid examples of this. The role of women in the society in terms of education and training is very clear. Today, I have taken up a pen to write on one such great personality who has done the duty of training women and young girls. He is a great teacher, a commentator, a well-known religious figure as Astaza Nighat Hashmi Hafzaullah
Comparison of Aspiration, Touch and Scrape Preparations Simultaneously Obtained from Surgically Excised Specimens
No full textGlocalism, disguised oppression and parochialism: a study of Karachi You’re Killing Me
No full textUnderscoring concerns related to gender studies, postcolonialism, and glocalism, this paper presents a discussion about how local is being presented in chick lit by a Pakistani female author Imtiaz (2016) in her Anglophonic novel Karachi You’re Killing Me! Applying Dirlik’s (1997) theorization about global and local in The Postcolonial Aura: Third World Criticism in the Age of Global Capitalism, where he asserts how the local gives an illusion of empowering the local, but in reality, local is viewed and presented in a parochial manner and put in a reductive category. The focus on the local, therefore, is a new gimmick of colonizers and imperialists. With this theoretical perspective, in this paper, it is argued that the representation of the locals in the novel is eclipsed by the colonial narrative. By underscoring negative aspects of local the writer seems to be performing the role of a native informant and is a re-endorsing colonial narrative about the orient. It is also argued that this local female author has been empowered to write but the agency she is granted is loaded because it is, in fact, quite restricted
Research on Information Seeking and Use in Pakistan: An Assessment
No full textThe paper describes the beginning of research activity on information needs and presents an analysis of the literature on information needs in Pakistan to discover that no research has so far been published. It reviews 14 student-research projects produced from 1975 to 1982 at the University of the Punjab which have remained unpublished; Laments the loss of impetus given to this topic in 1974-75; and urges the LIS academics and practitioners to promote and conduct research on this critical topic
Exploring Cultural Layers: Code-Mixing in Bepsi Sidhwa’s “Ice-Candy-Man”
No full textThis study delves into the nature and significance of underlying causes of code mixing in Bepsi Sidhwa’s novel “Ice-Candy-Man”. It reveals a notable prevalence of code mixing in English novel, rather than diminishing native dialects, the author highlights importance of non-native variety of Englishes i.e., Pakistani English. It acknowledges instances where English language may inadequately serve communication needs of the local population. It also involves in mixing of translations into other native languages, serving to supplement vocabulary gaps for conveying ideological concepts not easily expressed in English. Importantly, such borrowings are not intended to denigrate code-mixed English but rather to highlight its role in enriching expression. The objectives of this study are to identify and categorize various types of code-mixing utilized in Sidhwa’s “Ice-Candy-Man” and ascertain frequency and context of each category of code-mixing words employed within the narrative to represent cultural and social values. It focuses on the conceptual frameworks established by Kachru (1983) and Modiano’s model of English (1999). Speech Act Theory Austin (1963) has been used as fundamental theoretical framework. A total number of codemixing words is 461, that is 3,8 % of the total amount of words in the novel. They were identified by thematic affiliation, scope of use, and by structural and grammatical characteristics. Each group was assessed in terms of frequency. Mixing words are identified in different categories, including anthroponymes and toponymes; possessive and addressive words, religious and routine words, clothing and food names, verbs and phrases, expressive interjections and invectives, they are used in performative, locutionary, assertive and expressive acts. It concludes that the incorporation of local words serves to emphasize the value of native languages and prompts considerations about the status of English as a lingua franca
Regio- and Diastereoselective Vicinal Aminobromination of Electron Deficient Olefins via Phosphorus-Based GAP Protocol
No full text© 2021 Rahman, Zarshad, Khan, Faiz, Li and Ali. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Chemical synthesis based on Group-Assisted Purification chemistry (GAP) has been prolifically used as a powerful, greener and ecofriendly tool so far. Herein, we report hypervalent iodine (III) mediated regio- and diastereoselective aminobromination of electron-deficient olefins using group-assisted purification (GAP) method. By simply mixing the GAP auxiliary-anchored substrates with TsNH2–NBS as nitrogen/bromine sources and PhI(OAc)2 as a catalyst, a series of vicinal bromoamines with multifunctionalities were obtained in moderate to excellent yields (53–94%). The vicinal bromoamines were obtained without column chromatography and/or recrystallization simply by washing the crude mixtures with cosolvents and thus avoiding wastage of silica, solvents, time, and labor. The GAP auxiliary is recyclable and reusable
Nutraceutical Effect of Resveratrol on the Mammary Gland: Focusing on the NF-κb /Nrf2 Signaling Pathways
No full textThe aim of this study is to evaluate the defensive role of resveratrol, which is antagonistic to the oxidative stress and inflammation that is prompted by LPS in mammary tissue of female mice. Thirty adult mice were distributed into three groups (n = 10) control (CON), lipopolysaccharides at 2.5 mg/kg (LPS), and lipopolysaccharides at 2.5 mg/kg with 2 mg/kg of resveratrol (RES + LPS). The treatments were applied for 15 consecutive days. Spectrophotometry was used to quantify ROS in the blood, and proinflammatory cytokines concentrations were determined through radioimmunoassay. NF-κB, Jnk, IL-1β, Erk, IL-6, Nrf2 and TNF-α were quantified by RT-qPCR, and Western blots were used to quantifyP65 and pP65 protein intensities. MDA production was considerably increased, and the activity of T-AOC declined in the LPS treatment in comparison with the CON group but was significantly reversed in the RES + LPS group. Proinflammatory cytokines production and the genes responsible for inflammation and oxidative stress also showed higher mRNA and pP65 protein intensity in the LPS group, while Nrf2 showed a remarkable decline in mRNA expression in the LPS versus the CON group. All these mRNA intensities were reversed in the RES + LPS group. There were no remarkable changes in P65 protein intensity observed between the CON, LPS, and RES + LPS groups. In conclusion, resveratrol acts as a protective agent to modulate cellular inflammation and oxidative stress caused by LPS in mammary tissue of female mice
Functional genomics analysis of Leptin-Melanocortin system genes reveals candidate genes associated rapid growth and high carcass yield in sheep
No full textThe Leptin-Melanocortin System (LMS) is an important regulatory system involved in appetite and energy balance in many organisms, including sheep. Functional genomics analysis of LMS genes can provide insights into the genetic factors that influence rapid growth and high carcass yield in sheep. However, the genetic potential of sheep growth and reproduction has not been fully exploited. Therefore, identifying genes that regulate growth and reproduction would offer strategies for improving the yield and quality of sheep meat. In this study, to explore the possible molecular mechanisms underlying rapid growth and muscular high-yield carcass in sheep, we screened 14 genes, which were previously claimed to be associated with such traits in humans and rodents. The FST outlier approach implemented in LOSITAN detected the loci under selection. These candidate genes were connected to complicated biological processes, including the regulation of eating behavior, energy balance, and the positive regulation of the cAMP biosynthetic process, according to the gene ontology (GO) study. In addition, the 14 genes' re-sequence data revealed 7,226 SNPs. The MC4R, STAT3, BDNF, and TUB genes were discovered to be an outlier and significantly under positive selection using the fixation index (FST) based technique with the tentative combined allocation of mean heterozygosity and FST. Differentially expressed genes were found, and their functions were assigned using a functional genomics approach. Results showed that these genes are crucial in determining sheep features including size and meat quality. Insights are gained into the molecular mechanisms behind these phenotypic variations, and possible genes for future sheep breeding initiatives are provided. This research proves the value of functional genomics analysis in identifying the heritable components of valuable sheep agriculture traits.The authors extend their appreciation to the Researchers Supporting Project number (RSP2023R27) King Saud University, Riyadh, Saudi Arabia.Peer reviewe
Education Research Gender, Education and Development - A Partially Annotated and Selective Bibliography
No full textCommunity/Rural/Urban Development,
Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial.
No full textBACKGROUND: Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. METHODS: In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15 000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15 000 to 20 000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283. FINDINGS: Between March, 2010, and April, 2016, 20 060 women were enrolled and randomly assigned to receive tranexamic acid (n=10 051) or placebo (n=10 009), of whom 10 036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65-1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52-0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88-1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group. INTERPRETATION: Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset. FUNDING: London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation
