1,387,837 research outputs found
Hashimoto thyreoiditis gyermekkori vonatkozásai
No full textA Hashimoto thyreoiditis az egyik leggyakoribb autoimmun betegség, amely a pajzsmirigy krónikus gyulladásával és alulműködésével jár. A jelentőségét az adja, hogy egyre nagyobb gyakorisággal fordul elő serdülők és gyermekek között is, ahol a megfelelő időben történő felismerés és kezelés kulcsfontosságú, hiszen a hormonális egyensúly fontos szerepet játszik az egészséges növekedésben és fejlődésben. Dolgozatom célja a betegség gyermek- és serdülőkori sajátosságainak összefoglalása a jelenlegi ismereteink alapján.egységes, osztatlanáltalános orvosmagyarnappal
No.328, Joy Hashimoto, interview by Everett L. Cooley
No full textTranscript (89 pages) of interview by Everett L. Cooley with Joy Hashimoto, widow of Dr. Edward Hashimoto, on February 2 and April 9, 1990. This interview is no. 328 in the Everett L. Cooley Oral History Project, and tape nos. 1163, 1164, and 1165. Accompanied by an article about Dr. Hashimoto and text of his convocation address of June 13, 1981In a 1990 interview with Everett L. Cooley, Joy Hashimoto (b. 1927) recalls her family. She describes being interned, 1942-1945 in the Granada Relocation Center (later called Amache) in Colorado, attending college one year at Carleton and finishing her degree at North Dakota. Bound with the interivew are a biographical sketch of Dr. Hashimoto and a copy of the convocation address he gave to the graduating class of 1981 of the College of Medicine. Interviewer: Everett Coole
George Masashi and Mitsuno Hashimoto
No full textOral history interview with George Masashi and Mitsuno Hashimoto. Information on the oral history project is found in: csuf_stp_0012A; Glossary in: csuf_stp_0014.A Japanese American oral history project undertaken in 1979-1980, funded by the National Endowment for the Humanities and archived at the Fresno County Public Library
Einfluss von Hashimoto-Thyreoiditis und Depression auf Hirnstruktur und -funktion
No full textDie Arbeit untersucht strukturelle und funktionelle Hirnveränderungen bei Hashimoto-Thyreoiditis (HT), Hypothyreose und gesunden Kontrollen – jeweils mit und ohne Major Depression (MDD) – mittels GMV-, CT- und fMRT-Analysen. Die deutlichsten Befunde zeigten sich in der funktionellen Aktivierung beim Episodic-Memory-Task: Es trat ein signifikanter Interaktionseffekt zwischen somatischer Diagnose (HT/Hypothyreose/keine SD-Erkrankung) und MDD auf. Besonders die Gruppe mit kombinierter MDD und HT (MDDHa) zeigte konsistent verminderte Aktivierung, u.a. im Gyrus frontalis superior, Parahippocampus und Hippocampus, also in Bereichen des Default-Mode- und Central-Executive-Networks – Netzwerken, die bei Depression typischerweise verändert sind. Trotz hormoneller Substitution wiesen Patient:innen mit HT weiterhin funktionelle Veränderungen auf, und bei MDDHa korrelierten TPO- und TG-Antikörper negativ mit Aktivierung und kortikaler Dicke, was auf einen möglichen autoimmunvermittelten Mechanismus hindeutet. Insgesamt bestätigen die Ergebnisse einen Zusammenhang zwischen HT/Hypothyreose und depressiver Symptomatik, zeigen aber, dass weitere Forschung zu den neurobiologischen Grundlagen dringend erforderlich ist.This study investigates structural and functional brain changes in Hashimoto’s thyroiditis (HT), hypothyroidism, and healthy controls – both with and without major depression (MDD) – using GMV, CT, and fMRI analyses. The most prominent findings were observed in functional activation during the episodic memory task, with a significant interaction effect between somatic diagnosis (HT/hypothyroidism/no thyroid disorder) and MDD. The group with combined MDD and HT (MDDHa) consistently showed reduced activation, particularly in the superior frontal gyrus, parahippocampus, and hippocampus—areas belonging to the Default-Mode and Central-Executive Networks, which are typically altered in depression. Despite hormone replacement therapy, patients with HT still exhibited functional changes, and in the MDDHa group, TPO and TG antibodies negatively correlated with activation and cortical thickness, suggesting a potential autoimmune-mediated mechanism. Overall, the findings confirm a link between HT/hypothyroidism and depressive symptoms but highlight the need for further research into the neurobiological underpinnings of these associations
Einfluss von Hashimoto-Thyreoiditis und Depression auf Hirnstruktur und -funktion
No full textDie Arbeit untersucht strukturelle und funktionelle Hirnveränderungen bei Hashimoto-Thyreoiditis (HT), Hypothyreose und gesunden Kontrollen – jeweils mit und ohne Major Depression (MDD) – mittels GMV-, CT- und fMRT-Analysen. Die deutlichsten Befunde zeigten sich in der funktionellen Aktivierung beim Episodic-Memory-Task: Es trat ein signifikanter Interaktionseffekt zwischen somatischer Diagnose (HT/Hypothyreose/keine SD-Erkrankung) und MDD auf. Besonders die Gruppe mit kombinierter MDD und HT (MDDHa) zeigte konsistent verminderte Aktivierung, u.a. im Gyrus frontalis superior, Parahippocampus und Hippocampus, also in Bereichen des Default-Mode- und Central-Executive-Networks – Netzwerken, die bei Depression typischerweise verändert sind. Trotz hormoneller Substitution wiesen Patient:innen mit HT weiterhin funktionelle Veränderungen auf, und bei MDDHa korrelierten TPO- und TG-Antikörper negativ mit Aktivierung und kortikaler Dicke, was auf einen möglichen autoimmunvermittelten Mechanismus hindeutet. Insgesamt bestätigen die Ergebnisse einen Zusammenhang zwischen HT/Hypothyreose und depressiver Symptomatik, zeigen aber, dass weitere Forschung zu den neurobiologischen Grundlagen dringend erforderlich ist.This study investigates structural and functional brain changes in Hashimoto’s thyroiditis (HT), hypothyroidism, and healthy controls – both with and without major depression (MDD) – using GMV, CT, and fMRI analyses. The most prominent findings were observed in functional activation during the episodic memory task, with a significant interaction effect between somatic diagnosis (HT/hypothyroidism/no thyroid disorder) and MDD. The group with combined MDD and HT (MDDHa) consistently showed reduced activation, particularly in the superior frontal gyrus, parahippocampus, and hippocampus—areas belonging to the Default-Mode and Central-Executive Networks, which are typically altered in depression. Despite hormone replacement therapy, patients with HT still exhibited functional changes, and in the MDDHa group, TPO and TG antibodies negatively correlated with activation and cortical thickness, suggesting a potential autoimmune-mediated mechanism. Overall, the findings confirm a link between HT/hypothyroidism and depressive symptoms but highlight the need for further research into the neurobiological underpinnings of these associations
A Hashimoto-thyreoiditis és a papillaris pajzsmirigy-carcinoma kapcsolata
No full textKutatásunkban a Hashimoto-thyreoiditis (HT) és papillaris pajzsmirigy-carcinoma (PC) közti összefüggéseket vizsgáltuk. Bizonyos szerzők a PC multifocalitását HT-vel kísért esetekben gyakoribbnak találták, mint a HT nélküli PC-seknél, és ez alapján a HT-t a PC alapbetegségének tekintik, mások szerint viszont ez a különbség nem szignifikáns. Vizsgálatunkba a 2007 és 2012 között a DE KK Sebészeti Intézetben operált pajzsmirigy-carcinomás betegeket válogattuk be (43 HT-s és pajzsmirigy-carcinomás beteg, 5 férfi és 38 nő; 219 pajzsmirigy-carcinomás beteg HT nélkül, 48 férfi és 171 nő). Eredményeink szerint a HT-vel együtt jelentkező PC szignifikánsan gyakrabban multifocalis (16 MF (40,0%)/ 24 UF (60,0%)), mint a HT nélküli PC (45 MF (23,7%)/ 145 UF (76,3%), p = 0,034). A pN0 nyirokcsomó stádium szignifikánsan gyakoribb HT-vel kísért PC esetében (7 pN0 (63,6%)/ 4 pN1 (36,4%)), mint HT nélkül (7 pN0 (17,1%)/ 34 pN1 (82,9%), p = 0,002). A PC-ben és HT-ben is érintett betegek között szignifikánsan kisebb a férfiak aránya (4 férfi (10,0%)/ 36 nő (90,0%)), mint a csak PC-ben érintettek között (44 férfi (23,2%)/ 146 nő (76,8%), p = 0,046). Az életkor valamelyest alacsonyabb, a tumor és TNM-stádium pedig kevésbé előrehaladott HT-vel kísért PC esetében, mint HT nélkül, azonban ezek a különbségek nem szignifikánsak. A mindkét betegségben érintettek gyakoribb PC-multifocalitása arra utal, hogy a HT a PC alapbetegségének tekinthető, azonban a két betegség kapcsolatának természete egyelőre nem teljesen tisztázott.általános orvostudományinappalimagyaregységes, osztatla
Hashimoto Encephalopathy Presenting as Schizophrenia-Like Disorder
No full textObjective: Hashimoto encephalopathy (HE) is associated with numerous neuropsychiatric symptoms and responds well to steroid therapy. In the past, only a few cases were reported to present with pure psychiatric syndromes. We describe a case of HE with presenting symptoms like that of schizophrenic patients. Methods: We describe a 73-year-old woman with a history of autoimmune Line thyroiditis. She had psychotic symptoms for 3 years that responded poorly to antipsychotic agents, and she was thus admitted in 2007. Results: The diagnosis of HE was made, although the patient presented neurologic symptoms and signs including abnormal electroencephalography, recent memory impairment, and executive function declination. The psychotic symptoms subsided completely in a few days after high-dose intravenous steroid therapy. Conclusions: The neuropsychiatric manifestation of HE can be similar to typical schizophrenia. Considering the effectiveness of steroid therapy for HE, we suggested HE as an important differential diagnosis for psychotic disorders, particularly for those patients of late onset, with abnormal electroencephalography, history of autoimmune thyroiditis, or poor response to conventional psychiatric treatment, so as to provide prompt and effective treatment for these patients
Hashimoto thyroiditis as a manifestation of struma ovarii
No full textWe describe clinicopathologic features, laboratory data, and imaging and therapeutic management of a rare case of Hashimoto thyroiditis arising in struma ovarii. The patient was a 38-year-old woman with clinical symptoms of hyperthyroidism. Laboratory data showed elevated levels of total and free thyroxine, low thyrotropin level, and positive specific antithyroid antibodies without ultrasound evidence of morphologic abnormalities of the thyroid gland. Pelvic ultrasonography and magnetic resonance imaging of the abdomen showed bilateral solid ovarian masses containing cystic and fat areas diagnostic of teratoma. The performance of a I whole-body scan demonstrated a focus of intense uptake in the pelvis with minimal residual thyroid gland. The patient had a bilateral oophorectomy, and histologic examination revealed thyroid tissue in both masses with all the features of Hashimoto thyroiditis in the right ovary. Symptoms of hyperthyroidism diminished after the surgery, and the thyroid hormone levels and antithyroid antibodies were in the normal range in 1 month. The present case further confirms the rare occurrence of Hashimoto thyroiditis in struma ovarii. This diagnosis should be suggested in the differential diagnosis of patients with symptoms of thyroid disease and a normal thyroid gland. Copyrigh © 2010 by Lippincott Williams & Wilkins
Aspectos quirúrgicos de la enfermedad de Hashimoto
No full textAs regards a retrospective series of 55 patients, 34 ofwhom were operated on, the author analyses thediagnostica/ value of thyroid cytology and antithyroidantibodies dosage for Hashimoto 's disease. In the group ofoperated patients. low sensitivity of cytology stands out.Se analiza el valor diagnóstico de la citología tiroidea y dela dosificación de anticuerpos antitiroideos en laenfermedad de Hashimoto. en una serie retrospectiva de55 enfermos, de los cuales 34 fueron operados. Sedestaca la baja sensibilidad de la citología en el grupo depacientes operados
Hashimoto Sanai: A Japanese Martyr
No full textWelden translates from Japanese and puts into historical context a manuscript, "A Biographical Sketch of Hashimoto Sanai" from the William Elliot Griffis Collection. Hashimoto Sanai (1834-1859) was reformer and martyr in mid-nineteenth-century Japan
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