1,134 research outputs found

    Supplementary_material - Elevated DNA Damage, Oxidative Stress, and Impaired Response Defense System Inflicted in Patients With Myocardial Infarction

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    Supplementary_material for Elevated DNA Damage, Oxidative Stress, and Impaired Response Defense System Inflicted in Patients With Myocardial Infarction by Sumayya Shahzad, Asif Hasan, Abul Faiz Faizy, Somaiya Mateen, Naureen Fatima, and Shagufta Moin in Clinical and Applied Thrombosis/Hemostasis</p

    Hydraulic simulations to evaluate and predict design and operation of the Chashma Right Bank Canal

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    Irrigation systems / Irrigation canals / Flow control / Velocity / Canal regulation techniques / Hydraulics / Simulation models / Design / Operations / Crop-based irrigation / Distributary canals / Water delivery / Policy / Protective irrigation / Water allocation / Water requirements / Sedimentation / Water distribution / Equity / Water conveyance / Pakistan / Chashma Right Bank Canal

    Image based dental impression tray selection from maxillary arches using multifeature with ensemble classifier / Muhammad Asif Hasan

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    Dental impression tray is frequently used in dentistry to record patient’s oral structure for clinical oral diagnosis and treatment planning. Manual procedure of taking impressions is costly, time-consuming, and additionally, no research has been done to select dental impression tray from dental arch images using computer vision in real-life scenarios. In this spirit, an intelligent model is proposed based on computer vision and machine learning to select appropriate dental impression trays from maxillary arch images. A dataset of 52 patients’ maxillary arch images that matches one from 4 sizes of Kurten’s impression tray have been acquired. Various sets features such as, colors, textures, and shapes of the images were extracted to better characterize the maxillary arch images. Considering the importance of the features in describing the maxillary arch object and to improve the classification performance, a method based on multi-feature with ensemble classifier is proposed. Besides, the performance of a deep-learning based multilayer perceptron neural network is also investigated. The proposed multi-feature with ensemble classifier attained 92.31% precision, 91.75% recall, 91.75% accuracy, respectively, on the dataset. This clearly establishes the feasibility of this study. An illustration of a real-life application of the proposed model is also provided

    STUDY FORMS OF FEMINISM IN SHORT STORY COLLECTION PARODIA BY ISTIFARI HASAN

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    The focus of this research actually lies on the descriptive qualitative research model with a socialfeminist approach. By using the object collection of Parodia short stories written by Istifari Hasan, researcherstried to show the forms of feminism contained therein. From sources that have been collected in parallel,researchers found that there are feminism forms contained in a collection of Parodia short stories by IstifariHasan that are full of social values in real community life in socializing, especially for women. In this case,researchers also aim to cultivate the analysis of short stories in the area of Indonesian literature. With theshort story analysis that carries the theme of feminism, it is hoped that readers or literary connoisseurs can getcloser to understanding the meaning or message of the author. After the researcher found a form of feminismin a collection of Parodia short stories written by Istifari Hasan, the researcher tried to look back at the realitythat occurred in the life of the surrounding community which was not much different from the eventscontained in literary works, especially short stories which are indeed often the object of social criticism forwriters.Fokus pada penelitian ini sebenarnya terletak pada model penelitian deskriptif kualitatif denganpendekatan sosialfeminis. Dengan menggunakan obyek kumpulan cerpen Parodia karya Istifari Hasan,peneliti berusaha menunjukkan bentuk-bentuk feminism yang terkandung didalamnya. Dari sumber yangtelah dikumpulkan secara paralel, peneliti menemukan bahwasannya terdapat bentuk-bentuk feminismyang terkandung dalam kumpulan cerpen Parodia karya Istifari Hasan yang sarat akan nilai-nilai sosialdalam kehidupan masyarakat nyata dalam bersosialisasi, terutama bagi kaum perempuan. Dalam hal ini,peneliti juga bertujuan untuk membudayakan analisis karya cerpen diranah kesustraan Indonesia. Denganadanya analisis cerpen yang yang mengangkat tema feminism, diharapakan pembaca ataupun penikmatsastra dapat lebih dekat dalam memahami makna atau pesan penulis. Setelah peneliti menemukan bentukfeminism dalam kumpulan cerpen Parodia karya Istifari Hasan peneliti mencoba melihat kembali realitasyang terjadi pada kehidupan masyarakat sekitar yang tidak jauh berbeda dengan kejadian yang terdapat didalam karya sastra, terutama cerpen yang memang sering menjadi obyek kritik sosial bagi penulis

    Embedding spanning subgraphs into large dense graphs

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    In this thesis we are going to present some results on embedding spanning subgraphs into large dense graphs. Spanning Trees Bollob'as conjectured that if GG is a graph on nn vertices, delta(G)geq(1/2+epsilon)ndelta(G) geq (1/2 + epsilon) n for some epsilon>0epsilon > 0, and TT is a bounded degree tree on nn vertices, then TT is a subgraph of GG. The problem was solved in the affirmative by Koml'os, S'ark"ozy and Szemer'edi for large graphs. They then strengthened their result, and showed that the maximum degree of TT need not be bounded: there exists a constant cc such that TT is a subgraph of GG if Delta(T)leqcn/lognDelta(T) leq cn / log n, delta(G)geq(1/2+epsilon)ndelta(G) geq (1/2 + epsilon) n and nn is large. Both proofs are based on the Regularity Lemma-Blow-up Lemma Method. Recently, using other methods, it was shown that bounded degree trees embed into graphs with minimum degree n/2+Clognn/2 + C log n, where CC is a constant depending on the maximum degree of TT. Here we show that in general n/2+O(Delta(T)cdotlogn)n/2 + O(Delta(T) cdot log n) is sufficient for every Delta(T)leqcn/lognDelta(T) leq cn / log n. We also show that this bound is tight for the two extreme values of mm i.e. when m=Cm = C and when m=cn/lognm = cn / log n. Powers of Hamiltonian Cycles In 1962 P'osa conjectured that if delta(G)geqfrac23ndelta(G) geq frac{2}{3}n then GG contains the square of a Hamiltonian cycle. Later, in 1974, Seymour generalized this conjecture: if delta(G)geq(frack1k)ndelta(G) geq (frac{k-1}{k})n then GG contains the (k1)(k-1)th power of a Hamiltonian cycle. In 1998 the conjecture was proved by Koml'os, S'ark"ozy and Szemer'edi for large graphs using the Regularity Lemma. We present a ``deregularised" proof of the P'osa-Seymour conjecture which results in a much lower threshold value for nn, the size of the graph for which the conjecture is true. We hope that the tools used in this proof will push down the threshold value for nn to around 100 at which point we will be able to verify the conjecture for every nn.Ph.D.Includes bibliographical referencesIncludes vitaby Asif Jamshe

    Characterization of functional protein complexes from Alzheimer’s disease and healthy brain by mass spectrometry-based proteome analysis

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    Abstract Alzheimer’s disease (AD) is a complex neurodegenerative disorder with impaired protein activities. Proteins in the form of complexes have a ubiquitous role in diverse range of cellular functions. The key challenge is to identify novel disease associated protein complexes and their potential role in the progression of AD pathology. Protein complexes were obtained from AD brain prefrontal cortex and age matched controls by Blue Native-Polyacrylamide Gel Electrophoresis. A proteomic analysis was performed using second dimension SDS-PAGE followed by nano LC–MS/MS. Differentially expressed proteins were mapped to existing biological networks by Ingenuity Pathway Analysis (IPA). A total of 13 protein complexes with their interacting proteins were resolved on SDS-PAGE. We identified 34 protein spots and found significant abundance difference between the two experimental samples. IPA analysis revealed degeneration of neurons and cell death as a major consequence of protein dysregulation. Furthermore, focused network analysis suggested an integrated regulation of the identified proteins through APP and MAPT dependent mechanisms. The interacting differentially expressed proteins in AD were found to be part of concomitant signaling cascades terminating in neuronal cell death. The identified protein networks and pathways warrant further research to study their actual contribution to AD pathology

    sj-docx-2-jbm-10.1177_03936155241230968 - Supplemental material for Screening out molecular pathways and prognostic biomarkers of ultraviolet-mediated melanoma through computational techniques

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    Supplemental material, sj-docx-2-jbm-10.1177_03936155241230968 for Screening out molecular pathways and prognostic biomarkers of ultraviolet-mediated melanoma through computational techniques by Md. Arju Hossain, Asif Ahsan, Md. Imran Hasan, Md Sohel, Md. Arif Khan, Pratul Dipta Somadder, Sumaiya Monjur, Md Sipon Miah, K. M. Kaderi Kibria, Kawsar Ahmed and Md Habibur Rahman in The International Journal of Biological Markers</p

    sj-docx-1-jbm-10.1177_03936155241230968 - Supplemental material for Screening out molecular pathways and prognostic biomarkers of ultraviolet-mediated melanoma through computational techniques

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    Supplemental material, sj-docx-1-jbm-10.1177_03936155241230968 for Screening out molecular pathways and prognostic biomarkers of ultraviolet-mediated melanoma through computational techniques by Md. Arju Hossain, Asif Ahsan, Md. Imran Hasan, Md Sohel, Md. Arif Khan, Pratul Dipta Somadder, Sumaiya Monjur, Md Sipon Miah, K. M. Kaderi Kibria, Kawsar Ahmed and Md Habibur Rahman in The International Journal of Biological Markers</p

    Towards Circular Manufacturing Systems implementation : A Complex Adaptive Systems perspective using modelling and simulation as a quantitative analysis tool

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    A transition towards circular manufacturing systems (CMS) has brought awareness of untapped economic and environmental benefits for the manufacturing industry. Conventional manufacturing systems already present a high level of complexity in terms of physical flows of materials and products as well as information and financial flows linked to them. Closing the loop of materials and products through multiple lifecycles, as proposed in CMS, increases this complexity manifold. To support practitioners in implementing CMS through enhanced decision-making, this research studies CMS from a complex adaptive systems (CAS) perspective and proposes to exploit methods and tools used in the study of CAS to characterise, model and analyse CMS. By viewing CMS as CAS composed of autonomous, interacting agents, this research proposes a multi-method model architecture for modelling and simulating CMS. The different CMS stakeholders are modelled individually as autonomous agents by integrating agent-based, discrete-event, and/or system dynamics modules within each agent to capture their diverse and heterogeneous nature. The applicability of the proposed multi-method approach is illustrated through a case study of a white goods manufacturing company implementing CMS in practice. This case study shows the relevance and feasibility of the proposed multi-method approach as a decision support tool for the systemic exploration and quantification of CMS. It also shows how a transition towards CMS necessitates a lifecycle approach in terms of costs, revenues and environmental impacts to identify hotspots and, therefore, design circular systems that are viable in both economic and environmental terms. In fact, the analyses of the simulation results indicate how decisions in terms of business models, product design, and supply chain affected the CMS performance of the case company. For instance, implementing a service-based model led to a high number of usecycles (on average six usecycles per washing machine), which, in turn, led to high lifecycle costs and emissions due to more frequent transportation and recovery operations. Similarly, the deployment of long-lasting washing machines, which is a core principle of CMS, led to high manufacturing costs. Due to the high initial costs and a time mismatch between revenues and costs in the service-based model, it required a longer time for the company to reach the break-even point (approximately 23 months). Overall, the case study shows that multi-method simulation modelling can provide decision-making support for a successful implementation of CMS.</p
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