65 research outputs found
Inhibitory potential of combination of macrolide antibiotic with conventional chemotherapeutic agent sorafenib on growth rate of cancer cell population
No full textOver the past few years great progress has been achieved in anticancer therapy, but development
of resistance and unavoidable side effects have incapacitated these fulfilments. Keeping in view
this demanding condition, numerous drugs with unique antitumor mechanisms are under
investigations including antimicrobials which have been shown to possess anti-inflammatory,
immunomodulatory and cytotoxic effects. In this regard, both conventional and novel antimicrobials
are being studied to explore their anticancer potential along with underlying mechanisms which
may render them as effective anticancer drugs in near future. Moreover, the new approach of drug
repurposing is also being encouraged especially in cancers in order to reduce cost and limit adverse effects. In recent times a cumulative number of studies have laid stress upon the antitumor
properties of antimicrobials. Consequently, this study has been conducted to see comparative
inhibitory effect of Sorafenib and its combination with a macrolide antibiotic Azithromycin on growth
rate HepG2 cell line
Preliminary phytochemical and hepatoprotective studies on trnip brassica rapa L
No full textIn the present study, the pre-treatment of rats with Turnip {Brassica rapa L.), juice protected the
animals against CCl„-induced hepatotoxicity. The treatment significantly reduced the serum GOT, GPT, alkaline
phosphatase (ALP) and bilirubin level at a dose of 16 mL k g - 1 body weight. Besides, the juice also replinished
the lowered nonprotein sulfhydryl (NP-SH) concentration in the liver tissue after CC14 treatment. The preliminary
phytochemical screening showed the presence of flavonoids, anthocyanins and sulfur containing constituents.
The present results reveal that turnip possesses a hepatoprotective action, through its antioxidative potentials.Corresponding Author: Dr. Syed Rafatullah, Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy,
King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia. Email: [email protected]
سر سید احمد خان اور مراد آباد
No full textEvery aspect of Sir Syed Ahmed Khan’s life has been attracting attention of the scholars.In addition to Delhi, where he was born and brought up, Sir Syed stayed in different cities for certain time for certain reasons. But some cities have a special status in Sir Syed’s life and Muradabad is one of them.
This paper surveys and analyses Sir Syed’s connection to Muradabad from different aspects.
Protective effect of swertia chirata against indomethacin and other ulcerogenic agent-induced gastric ulcers
No full textThe effect of Swertia chirata has been studied on experimentally induced gastric ulcers in
rats. The ethanolic extract of chirata significantly reduced the intensity of gastric mucosal damage
induced by indomethacin and necrotizing agents. It produced a significant decrease in gastric secretion
•in pylorus-ligated rats. The extract inhibited acetylcholine-induced contraction of guinea pig ileum,
suggesting its anti-cholinergic activity. Pretreatment of rats with the extract significantly prevented
ethanol-induced gastric wall mucus depletion and restored the non-protein sulfhydryl (NP-SH) content in
the glandular stomachs. These findings support the use of chirata for the treatment of gastric ulcers in
traditional medicine.Corresponding Author:
Dr. Syed Rafatullah, Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University,
P.O. Box 2457, Riyadh-11451, Saudi Arabia.
Email: [email protected]
Pharmacological studies of various extracts and the major constituent, lupeol, obtained from hexane extract of teclea nobilis in rodents
No full textThe pharmacological activities of the acetonitrile (MeCN), hexane extracts and isolated
pure terpenoidal compound Lupeol from the leaves of Teclea nobilis, Delile (TN), on inflammation
induced by carrageenan and implantation of cotton pellets in rats; the nociceptive response using
writhing and tail flick tests and the antipyretic activity in yeast-induced fever were examined in mice.
Oral administration of TN extracts at doses of 150 and 300 mg/kg and lupeol 5 and 10 mg/kg showed a
significant anti-inflammatory activity in rats. The extracts of TN and lupeol significantly decreased the
number of contractions and stretchings induced by acetic acid and heat-induced pain in mice. The
antipyretic effect of extracts and lupeol was also found to be significant. The behavioral observation of
animals showed that the hexane extract and lupeol caused CNS depressant activity and did not produce
any toxic or lethal effects in animals at various dose levels. The results suggest that the Teclea nobilis
extracts and lupeol possesses anti-inflammatory, analgesic and antipyretic activities.Corresponding Author:
Dr. Adnan J. Al-Rehaily, Department of Pharmacognosy and Medicinal, Aromatic and Poisonous Plants Research Center,
College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia.
Email: [email protected]
Grain yield, chlorophyll and protein contents of elite wheat genotypes under drought stress
No full textBackground: Drought stress at different growth stages significantly alters growth, yield, and quality traits of wheat. However, great variability exists among genotypes regarding their response to drought stress. Therefore, determining the impacts of drought stress on yield and quality traits would help to select the superior genotypes.Methods: This study investigated the effects of drought stress on wheat grain yield, chlorophyll, and protein contents. Fourteen (14) recently developed elite bread wheat (Triticum aestivum L.) genotypes were used in this study for evaluation under irrigated (full irrigation) and drought conditions (half of normal irrigation). The data relating to growth, yield and protein contents were recorded.Results: Significant differences (P <= 0.01) were noted among genotypes for all recorded traits. Drought stress significantly reduced the days to 50 % heading, days to 50 % maturity, grain filling, plant height (cm), number of spikes per m2, chlorophyll index (SPAD), peduncle length (cm), number of grains spike1, thousand grain weight (g) and grain yield (kg ha-1). However, protein contents were increased under drought stress. Correlation analysis showed significant positive association of grain yield with thousand grain weight, number of spikes per m2, spike length, chlorophyll index, grain filling period and number of grains spike-1 under both irrigated and drought stress conditions. The protein contents expressed positive and negative relationship with yield under drought stress and irrigated conditions, respectively. Bioplot analysis revealed that genotype 'V-19618' and 'V-19600' proved superior under drought conditions regarding grain yield and related traits, while genotype 'V-19574' proved better under both irrigated and drought conditions.Conclusions: These identified genotypes, i.e., 'V-19618' and 'V-19600' can be utilized in future wheat breeding programs to induce desirable characters for producing drought tolerant wheat genotypes. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Taif University, Taif, Saudi Arabia [TURSP-2020/64]Authors would like to thank Taif University Researchers Sup- porting Project number (TURSP-2020/64) , Taif University, Taif, Saudi Arabia
One Dimensional Graphitic Carbon Nitrides as Effective Metal-Free Oxygen Reduction Catalysts
No full textTo explore the effect of morphology on catalytic properties of graphitic carbon nitride (GCN), we have studied oxygen reduction reaction (ORR) performance of two different morphologies of GCN in alkaline media. Among both, tubular GCN react with dissolved oxygen in the ORR with an onset potential close to commercial Pt/C. Furthermore, the higher stability and excellent methanol tolerance of tubular GCN compared to Pt/C emphasizes its suitability for fuel cells.National Natural Science Foundation of China [23171023, 50972017]; Research Fund for the Doctoral Program of Higher Education of China [20101101110026]; NSFC-RGC Joint Research Scheme [51361165201]; NSFC [51125001, 51172005]; Beijing Natural Science Foundation [2122022]; Aerostatic Science Foundation [2010ZF71003]; Doctoral Program of the Ministry of Education of China [20120001110078]; Deanship of Scientific Research at King Saud University through Prolific Research Group [PRG-1436-25]SCI(E)[email protected]; [email protected]
Effect of commiphora opobalsamum (L.) Engl. (Balessan) on experimental gastric ulcers and secretion in rats
No full textThe ulcer protective potential of an ethanol extract of Commiphora opobalsamum (L.) Engl. (Burseraceae) 'Balessan' was assessed against
different acute gastric ulcer models in rats induced by necrotizing agents (80% ethanol, 0.2 M NaOH and 25% NaCl), hypothermic restraint
stress, pyloric ligation (Shay) and indomethacin. Balessan, 250 and 500mg/kg administered orally (intraperitoneally in Shay rat model)
showed a dose-dependent ulcer protective effects in all the above ulcer models. Besides, the extract offered protection against ethanolinduced
depletion of stomach wall mucus and reduction in nonprotein sulfhydryl (NP-SH) concentration. Ethanol treatment also caused
histopathological lesions of the stomach wall. Pretreatment with Balessan extract provided a complete protection of gastric mucosa through
supporting both the offensive and defensive factors. Balessan extract was also showed a large margin of safety without any apparent adverse
effects in rats.Corresponding author:
S. Rafatullah
Fax: +966-1-467-6383
E-mail address: [email protected]
Biogenic Silver Nanoparticles for Trace Colorimetric Sensing of Enzyme Disrupter Fungicide Vinclozolin
No full textWe report a novel, simple, efficient, and green protocol for biogenic synthesis of silver nanoparticles (AgNPs) in aqueous solution using clove (Syzygium aromaticum) extract as a reducing and protecting agent. Ultraviolet-visible (UV-Vis) spectroscopy was employed to monitor the localized surface plasmon resonance (LSPR) band of clove extract-derived AgNPs prepared under various conditions. Fourier-transform infrared (FTIR) spectroscopy analysis provided information about the surface interaction of the clove extract with the AgNPs. Ultrahigh-resolution transmission electron microscopy (UHRTEM) results confirmed the formation of spherical, uniformly distributed clove extract-capped AgNPs with sizes in the range of 2-20 nm (average size: 14.4 +/- 2 nm). Powder X-ray diffractometry analysis (PXRD) illustrated the formation of pure crystalline AgNPs. These AgNPs were tested as a colorimetric sensor to detect trace amounts of vinclozolin (VIN) by UV-Vis spectroscopy for the first time. The AgNP-based sensor demonstrated very sensitive and selective colorimetric detection of VIN, in the range of 2-16 mu M (R-2 = 0.997). The developed sensor was green, simple, sensitive, selective, economical, and novel, and could detect trace amounts of VIN with limit of detection (LOD) = 21 nM. Importantly, the sensor was successfully employed for the determination of VIN in real water samples collected from various areas in Turkey.TUBITAK [21514107-115.02-188888]; King Saud University, Riyadh, Saudi Arabia [RSP-2019/79]We are thankful to TUBITAK for Fellowship provision to the first author via BIDEB 2216 Research Fellowship Program, Ref: 21514107-115.02-188888. This work was also funded through Researchers Supporting Project number (RSP-2019/79) at King Saud University, Riyadh, Saudi Arabia
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