49 research outputs found
A Case Study on Management of Shwitra Through Ayurveda
No full textIntroduction: Melanocyte degeneration has a connection to vitiligo, an acquired macular depigmentation disorder. It is thought to be brought on by cells\u27 autoimmune destruction of melanocytes. Frequently symmetrical, generalized vitiligo affects the hands, wrists, feet, knees, neck, as well as the skin around bodily orifices. According to Ayurveda all the skin diseases are categorized under the Kushtha Roga. In the classics Shwitra is mentioned under Kushtha Roga Chikitsa. Methodology: The 10-year-old male child, complaint of white discolored spots on his neck and left clavicle region; Shamana Chikitsa was used to cure the condition satisfactorily. Result: Patient showed encouraging result after Shamana Chikitsa, where subjective criteria evaluated using scoring method and objective criteria evaluated using VASI scoring method. Discussion: Patient was treated with Shamana Aushadhis, where white discolored patches turned to pinkish, and after that the patches turned into normal skin color. Subject was observed with 95% improvement in subjective criteria and VASI scoring improved from 0.25 to 0.10. Hence, the present case study highlights the importance of efficacy of Ayurvedic treatment in Shwitra, as mentioned in classics. Conclusion: Ayurvedic medicine\u27s effectiveness in curing Shwitra was confirmed by the current case study
Role of Pathya-Apathya in the Management of Prameha (Type-2 Diabetes Mellitus)
No full textBefore starting management of any disease three important things to be kept in mind that is etiology, well planning, and Pathya-Apathya. Pathya–Apathya plays important role in the management of various disorders. Prameha is one of such disorder in which Pathya-Apathya affect its morbidity. Etiology, etiopathogenesis with clinical manifestation of Prameha are very well described in ancient textbook like Charaka Samhita, Sushruta Samhita, Astanga Hridyam and Astanga Samgraha etc. In all treatise of Ayurveda, Prameha is considered as Santarpanajanya Vikara that is of three types i.e., Vataj, Pittaj and Kaphaja. Madhumeha mentioned under the heading of Vataj Prameha that is closely correlated to diabetes mellitus. Diabetes Mellitus is of two type viz., Type-1 Diabetes & Type-2 Diabetes. Among that, Type-2 diabetes is non-insulin dependent diabetes mellitus that occur in middle age. In this clinical entity insulin resistance was developed. In its management, Pathya–Apathya contributes a major role in controlling blood sugar level. Therefore, author attempted to highlight role of Pathya–Apathya (do’s & don’t) in the management of Type-2 Diabetes Mellitus
Role of Ayurvedic Herbs and Shirodhara Procedure in the Management of Academic Stress in Children
No full textStress is a state of mental strain for a specific person experiencing issues with their social and environmental well-being, which can result in a variety of illnesses. The important phage is when a person is young since this is when their life is going through a lot of change. They are expected to be members of the social elite. Therefore, kids should improve their stress-management skills to live healthy lives after they join the society. Comparing stress to Avasad in Ayurveda (Vatanatamaja vikaras). It\u27s regarded as being among the Manasik Rogas. Ayurveda deals with the mind and body of human beings. Only the conventional system of medicine helps to maintain health in the healthy while also treating the sick. The Ahar vihar, Aushad, and Sanshodhan principles of Ayurveda\u27s therapy are included. Two types of medication internal and external are described in the classical texts of Ayurveda. Many herbal and herbal-mineral concoctions are referred to be "Medhya medicines" in internal medicine. Like Mandukparni Brahmi, Vacha, Shankhpushpi, Giloy, Jyotismati, Ashwagandha, Tagar, etc., the majority of them have been scientifically and therapeutically shown to be effective stress relievers. In terms of external medicine, Panchakarma techniques like Shirodhara are also described. Shirodhara treatment is frequently used to treat psychological disorders. Although Shirodhara\u27s clinical effectiveness has been established, its mode of action is complicated. Shirodhara aids in soothing the anxious mind and relaxing the entire body because the body, mind, and spirit are all interconnected. Shirodhara\u27s therapeutic effectiveness has been established, however, its mode of action is complicated. Since the body, mind, and spirit are all intertwined, Shirodhara helps to quiet a busy mind and rest the entire body
Management of Mixed Cerebral Palsy Through Ayurveda
No full textCerebral Palsy (CP) is the most common cause of developmental and functional disabilities in children. A non-progressive neuromotor condition of posture and movement. Cerebral palsy (CP) is described as the result of improper development of injury to the brain\u27s motor control centers. Due to its multifactorial nature and vast range of clinical symptoms, it cannot be associated with a particular Ayurvedic disease or condition. According to Vagbhaṭa it is classified in the categories of Sahaja (hereditary), Garbhaja (congenital) and Jataja (psychosomatic) disorders. There is no known "cure" for any of the several forms and subtypes of cerebral palsy. A three-year-old male child was reported to pediatric OPD of Sanjeevani Ayurveda Hospital, Dr. S. R. Rajasthan Ayurved University, Jodhpur, Rajasthan with complaints of mixed cerebral palsy. The case was taken up and aim to assess the effectiveness of the Ayurvedic management method in enhancing the child’s quality of life, improving or enhancing his functional capacity to become dependent and facilitating early rehabilitation to avoid subsequent complications
Management of Shwitra (Vitiligo) Through Ayurveda
No full textA condition of acquired macular depigmentation called vitiligo is linked to melanocyte degeneration, caused by the autoimmune destruction of melanocytes cells. This vitiligo can be correlated to Shwitra in Ayurveda because of the disease\u27s resemblance in appearance. In the Ayurveda classics especially Charaka Samhita, Shwitra has been mentioned under the heading of Kushta Roga Chikitsa. Methodology: The present case report is of 11 years old female child, came with complaints of whitish discolored patches on the almost all over body, effectively treated with Shamana and Shodhana Chikitsa. Result: Patient showed encouraging result after Shodhana Chikitsa, where subjective criteria evaluated using scoring method and objective criteria evaluated using VASI scoring method. Discussion: Patient was treated with Shamana Aushadis and Shodhana, where white discolored patches turned to pinkish, and after that the patches turned into normal skin color. Subject was observed with 95% improvement in subjective criteria & VASI scoring improved from 19.85 to 3.2. Conclusion: The present case study validated the efficacy of Ayurveda medicine in treating Shwitra
Efficacy and Safety of Biosimilar Ranibizumab (OPTIMAB®) versus Innovator Ranibizumab in Patients with Neovascular (Wet) Age-Related Macular Degeneration: A Double-Blind, Randomized, Multicenter, Phase III Study
No full textParth J Rana,1 Himanshu Deshmukh,2 Urmil Shah,3 Vinod Kumar,4 Sanghamitra Kanungo,5 Deepika Singhal,6 Santosh Kumar Mahapatra,7 Ira Vakharia,8 Mukesh Jaiswal,9 Ajitkumar Gondane,10 Pooja Vaidya,10 Vinayaka Shahavi,9 Harish Shandilya,11 Dattatray Pawar,10 Akhilesh Sharma12 1Department of Retina and Trauma Surgery, Netralaya Superspeciallity Hospital, Ahmedabad, Gujarat, India; 2Department of Retina; ‘Daulat’ Deshmukh Eye Hospital, Khaparde Gardens, Amravati, Maharashtra, India; 3Department of Retina, P.N. Desai Eye Hospital, Ahmedabad, Gujarat, 380052, India; 4Department of Ophthalmology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India; 5Department of Retina, Kar Vision Eye Hospital, Bhubaneswar, Odisha, 751007, India; 6Department of Ophthalmology, GMERS Medical College and Civil Hospital, Ahmedabad, Gujarat, India; 7Department of Retina, JPM Rotary Club of Cuttack Eye Hospital and Research Institute, Cuttak, Odisha, 753014, India; 8Department of Retina, Nirmal Hospital Pvt Ltd, Surat, Gujarat, 395002, India; 9Clinical Research Department, Alkem Laboratories Ltd., Lower Parel, Mumbai, India; 10Medical Affairs Department, Alkem Laboratories Ltd., Lower parel, Mumbai, India; 11Global Product Development, IPM & Regulatory Affairs, Enzene Biosciences Ltd., Pune, India; 12Medical Affairs and Clinical Research Department, Alkem Laboratories Ltd., Lower Parel, Mumbai, IndiaCorrespondence: Ajitkumar Gondane, Medical Affairs, ALKEM Laboratories Ltd., ALKEM HOUSE, “Devashish”, Adjacent to Matulya Centre, Senapati Bapat Marg, Lower Parel, Mumbai, 400 013, India, Tel +8983375722, Email [email protected]: This study aimed to compare efficacy, safety, and immunogenicity of the biosimilar ranibizumab in comparison with the Innovator Ranibizumab in treatment-naive patients with neovascular (wet) age-related macular degeneration (nAMD or wAMD).Materials and Methods: This comparative, double blind, multicentre, Phase III clinical study randomized eligible patients in a 3:1 ratio to receive either OPTIMAB® (Alkem Laboratories Ltd./ Enzene Biosciences Ltd.) or Innovator Ranibizumab. Intravitreal injections of Innovator Ranibizumab (0.5 mg in 0.05 mL) and OPTIMAB® (0.5 mg in 0.05 mL) were administered every four weeks for 12 weeks (three doses). Primary efficacy endpoints included loss of < 15 letters from baseline, gain of ≥ 15 letters from baseline in visual acuity, mean change in best corrected visual acuity (BCVA) from baseline, and change in central subfoveal thickness (CSFT) from baseline at week 12. Safety was assessed through monitoring of adverse events (AEs) and serious adverse events (SAEs) throughout the study.Results: Overall, of the 152 patients randomized, 141 (92.8%) patients (mean age, 66.6 ± 9.37 years) completed the study. Percentage of patients who lost < 15 letters in BCVA at week 12 from baseline was comparable in both the groups (100.0%, each). On secondary end point analysis, the two groups had comparable mean changes in BCVA (OPTIMAB®, 11.8 ± 9.18; innovator ranibizumab, 12.9 ± 10.29; P = 0.5509); proportion of patients who gained ≥ 15 letters in visual acuity (OPTIMAB®, 32.18%; innovator ranibizumab, 25.74%; P = 0.4785) and mean change in CSFT (OPTIMAB®, − 76.6 ± 89.03; Innovator ranibizumab, − 73.1 ± 92.23 μm; P = 0.8422) at week 12 as compared to baseline. OPTIMAB® and innovator ranibizumab demonstrated comparable safety over the 12-week treatment period and no patient expressed anti-ranibizumab antibody in either group patient.Conclusion: Biosimilar ranibizumab (OPTIMAB®) was non-inferior to innovator ranibizumab in terms of efficacy, safety, and immunogenicity in the patients of nAMD.Keywords: biosimilar ranibizumab, best corrected visual acuity, central subfoveal thickness, nAM
A comparative study of syrup Trayodashanga Kashaya and syrup Vyaghradi Kashaya along with Anu Taila Nasya in the management of Vataj Pratishyaya W.S.R. to allergic rhinitis
No full textIntroduction: Allergic rhinitis (AR) is the most common disease among children which is mentioned in Ayurveda as “Pratishyaya”. This manifests when the Kapha, Rakta, and Pitta migrate from the root of the Nasa Pradesha and get stuck in Shirapradesha which is already vitiated by the Vata Dosha. There are five types of Pratishyaya described in the Ayurveda textbook, out of which Vataj Pratishyaya can be correlated with AR. Methods: Eighty-two children suffering from Vataj Pratishyaya were randomly selected and divided into four groups, namely Group A was treated with Compound A (syrup Trayodashanga Kashaya), Group B was treated with Compound A (syrup Trayodashanga Kashaya) and Anu Taila Nasya, Group C were treated with Compound A-1 (syrup Vyaghradi Kashaya), while Group D was treated with Compound A-1 (syrup Vyaghradi Kashaya) and Anu Taila Nasya. A total of 60 children completed the treatment, 15 in each group. Result: Group B showed extremely significant results in relieving signs and symptoms of Vataj Pratishyaya in comparison to Group A, C, and D. Conclusion: All four groups showed extremely significant results in subjective parameters while no changes were seen in objective parameters
Demographic Study to Evaluate the Morbidity Status of Children in Jodhpur City
No full textEvery nation\u27s foundation is its children, and that nation\u27s top priority is to ensure their health. Their early years of life are characterized by their development and growth. The first few years of life are the most important time because of the fast growth and development that is common at this age and necessitates ongoing observation. During this time, roughly 40% of physical growth and 80% of mental development take place. Any obstacle they face at this age could severely restrict their ability to develop and grow. A child who lacks access to health care during these formative years is denied the chance to develop into a healthy adult, and the harm caused in the early years may be permanent or in the long run. Children under the age of five continue to die from ailments that are treatable or preventable. Despite the significant progress in immunization to strengthen the immune system, medical research has not yet developed a fully effective defense against virulent organisms, and occasionally we fail in the struggle for survival. To understand the primary causes of death and the carers\u27 patterns of seeking medical attention before the deaths of such children, a cross-section study encompassing the area of Jodhpur, Rajasthan, was done. The survey was conducted on 1000 children living in the surroundings of the Post Graduate Institute of Ayurved, Dr. S. R. Rajasthan Ayurved University, Jodhpur. Demographic studies show that Respiratory tract Infection is the main cause of morbidity in children. In Respiratory tract Infection recurrent cough, recurrent running nose, recurrent nasal obstruction, recurrent sore throat, and breathlessness are included. Out of which maximum number of children suffered from recurrent running nose
Hyperuricemia as a risk factor for increase severity of coronary vessel occlusion disease: a cross-sectional study in North Indian population
No full textBackground: Cardiovascular disease (CVD) is the most common cause of death worldwide. The present study was conducted to study uric acid as a potential biomarker in predicting the severity of CVD in terms of vessel involvement.Methods: A cross-sectional study, conducted at Rajiv Gandhi Super Speciality Hospital, Tahirpur, Delhi. A total of 52 consecutive male and female patients age between 30 to 70 years was included in this study. Written informed consent was obtained from all the enrolled patients. Automated analysers were used for the analysis of blood glucose, lipid profile and serum uric acid level. IBM SPSS Statistics (Version 20.0, IBM SPSS, IL, USA) was used for the statistical analyses.Results: In this study, a total of 52 consecutive patients were divided into three groups; single-vessel disease (n=19), double vessel disease (n=19) and triple vessel disease (n=14). Biochemical profile of all the groups was calculated. A group of triple vessel disease patients showing higher amount (164±42 mg/dl) of cholesterol level as compared to the other two groups (157±34 mg/dl). The mean level of serum uric acid levels significantly differed and its mean levels increases as the severity of vessel diseases increases. The receiver operating characteristic curve shows the uric level has 71% sensitivity and 52.5% specificity for detecting the severity of coronary vessel disease.Conclusions: This study demonstrated an increased serum uric acid levels were associated with increased severity of vessel disease, and serum uric acid is an independent risk factor for coronary artery disease
