413 research outputs found
3MT Presentations - Harish Chander
No full textHarish Chander presents his graduate work. Video by Mary Stanton Knight.https://egrove.olemiss.edu/umvideo/1204/thumbnail.jp
Mitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi.
No full textpeer reviewedWe report here that blocking the activity of the 26 S proteasome results in drastic changes in the morphology of the mitochondria and accumulation of intermembrane space (IMS) proteins. Using endonuclease G (endoG) as a model IMS protein, we found that accumulation of wild-type but to a greater extent mutant endoG leads to changes in the morphology of the mitochondria similar to those observed following proteasomal inhibition. Further, we show that wild-type but to a greater extent mutant endoG is a substrate for ubiquitination, suggesting the presence of a protein quality control. Conversely, we also report that wild-type but not mutant endoG is a substrate for the mitochondrial protease Omi but only upon inhibition of the proteasome. These findings suggest that although elimination of mutant IMS proteins is strictly dependent on ubiquitination, elimination of excess or spontaneously misfolded wild-type IMS proteins is monitored by ubiquitination and as a second checkpoint by Omi cleavage when the proteasome function is deficient. One implication of our finding is that in the context of attenuated proteasomal function, accumulation of IMS proteins would contribute to the collapse of the mitochondrial network such as that observed in neurodegenerative diseases. Another implication is that such collapse could be accelerated either by mutations in IMS proteins or by mutations in Omi itself
Mapping the Scholarly Discourse on National Education Policy (NEP) 2020: A Bibliometric Study
No full textThe study aims to identify the growth of research, contributing subject areas, relevant journal sources, prolific authors, affiliations, and map the co-authorship and co-occurrence network of publications on New National Education Policy (NEP) 2020 using a bibliometric approach based on the data retrieved from Scopus. Analysis of dataset and its visualization is performed using multiple tools, including MS Excel, Matplotlib library in Python, Biblioshiny and VOSviewer. Some major findings of the study are that growth of publications on NEP 2020 spiked after 2021 and continued. Additionally, the research on NEP 2020 is fragmented, as many isolated authors work independently or in small, disconnected groups. This study attempts to provide a comprehensive overview of the current state of research on NEP 2020, including an analysis of co-occurrence and co-authorship networks. To the best of the authors' knowledge, no prior study has made an attempt to fill this gap
The Electronic Silk Road: How the Web Binds the World in Commerce
No full textOn the ancient Silk Road, treasure-laden caravans made their arduous way through deserts and mountain passes, establishing trade between Asia and the civilizations of Europe and the Mediterranean. Today’s electronic Silk Roads ferry information across continents, enabling individuals and corporations anywhere to provide or receive services without obtaining a visa. But the legal infrastructure for such trade is yet rudimentary and uncertain. If an event in cyberspace occurs at once everywhere and nowhere, what law applies? How can consumers be protected when engaging with companies across the world?
In this accessible book, cyber-law expert Anupam Chander provides the first thorough discussion of the law that relates to global Internet commerce. Addressing up-to-the-minute examples, such as Google’s struggles with China, the Pirate Bay’s skirmishes with Hollywood, and the outsourcing of services to India, the author insightfully analyzes the difficulties of regulating Internet trade. Chander then lays out a framework for future policies, showing how countries can dismantle barriers while still protecting consumer interests
Influence of military workload on muscle exertion in two types of military footwear
No full textLower extremity muscle activity during balance can be affected by footwear characteristics. A dearth in literature remains regarding minimalist footwear in combination with a military-type workload on muscle activation during balance. The purpose of the study was to assess lower extremity muscular activity during balance tasks before and after a military workload, in two military footwear [standard tactical (STD), minimalist (MIN)]. Twentyour trained males (18-35 years) participated, following a repeated measures counter balanced footwear assignment. Participants performed maximal voluntary contractions (MVC) and balance assessments before and after a military treadmill workload. Muscle activity was collected on tibialis anterior, medial gastrocnemius, tibialis posterior, and peroneus-longus. A repeated measures 2x2 [2(Boot #1 x Boot #2) x 2(Pre-test x Post-test)] RM ANOVA with alpha set at 0.05. Significant differences occurred in mean, root-mean square, and peak muscle activities and in %MVC and co-contraction index, that were attributed to footwear design and physiological workload
Impact of military boots and military workload on balance
No full textThe US Army Annual Injury Epidemiology Report in 2008 reported that 18.4% of all causes of injuries were attributed to falls/near falls (USAPHC, 2008). The purpose of this investigation was to determine the effect of two military type boots (minimalist and standard) on balance prior to and after a physiological workload. Twentyour healthy male adults completed the study following a repeated measures design and a counter balanced footwear assignment. Participants underwent a balance analysis prior to and after completing a military workload. The dependent kinetic variables from balance tests were analyzed using a 2x2 RM-ANOVA independently, p\u3c0.05. Results demonstrated minimalist boots showed superior balance in most conditions likely due to low mass, low heel-midfoot drop, and thin, hard midsoles; however, standard boots demonstrated greater balance on unstable surfaces likely due to a large sole surface area. Optimal balance would likely be a result of a combination of both boots’ characteristics
Manu Samriti Chander\u27s Brown Romantics: Poetry and Nationalism in the Global Nineteenth Century
No full textThe last decade has witnessed increasing critical interest in questions of race, nation, and empire during the Romantic era. Manu Samriti Chander\u27s Brown Romantics: Poetry and Nationalism in the Global Nineteenth Century contributes to this discussion by examining the extensive international impact of Romantic poetry on writers beyond Britain. Part of Bucknell University Press\u27s Transits: Literature, Thought, and Culture series, his work provides a fascinating and unique perspective on global literary relations. He demonstrates how Henry Derozio of India, Egbert Martin of British Guiana, and Henry Lawson of Australia adopted the role of the Romantic author to shape nationalist movements in their countries and mediate their colonial relationship with England. By reading British writers in relation to those of other nations, Brown Romantics questions the privileging of a Eurocentric canon and challenges us to widen our definition of ‘Romantic’ literature
The effects of high-intensity interval training on Division I college 800/1500m runners performance
No full textAssessment of Nitinol-based Arch Wedge Support through Finite Element Analysis
No full textThis study proposes a nitinol-based thin-walled arch wedge support (AWS) and validated its performance in shock absorbing by using finite element analysis (FEA) method. Five human movements, two boundary conditions, and three thicknesses were implemented in FEA models to systematically reveal how those parameters and factors affect the response of the AWS. Due to the lack of data, the FEA models were meshed with elements of different sizes and used for simulations until the results converged. The simulation results showed that the thin-walled nitinol AWS with the selected thicknesses can withstand different human movements under both boundary conditions. In another word, the AWS will retain its original shape give the force conditions with no permanent deformation. Based on the initial numerical results, the AWS design can be further optimized before experimentation and testing. The potential of replacing the plastic AWS with additive manufactured nitinol AWS is verified from this study
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