1,720,953 research outputs found
Advances in ovarian cancer diagnosis: from biomarkers to imaging innovation
Get PDFIntroducere. În ciuda progreselor în oncologie, cancerul ovarian rămâne cea mai letală malignitate ginecologică, din cauza diagnosticului tardiv. Supravieţuirea la 5 ani este de 93% în stadiul I vs. 20% în stadiul IV, evidenţiind nevoia unor metode de diagnostic mai timpurii, eficiente, accesibile şi standardizate. Scop. Acest studiu evaluează metode actuale şi emergente de diagnostic al cancerului ovarian, concentrându-se pe imagistică avansată şi bio-markeri moleculari promiţători pentru detectare precoce. Material şi metode. Am efectuat un review sistematic al literaturii ştiinţifice recenzate publicate între 2016 şi 2025, utilizând baze de date academice majore precum PubMed, ScienceDirect, Elsevier şi ResearchGate. Strategia de căutare a inclus criterii predefinite de selecţie şi s-a concentrat pe studii care abordează progresele în diagnosticul cancerului ovarian. Rezultate. Ecografia transvaginală combinată cu CA-125 oferă o sensibilitate de 84,9% şi o specificitate de 98,2%. RMN-ul caracterizează superior masele anexiale, cu o sensibilitate de 98% şi o specificitate de 91%, iar PET/CT detectează eficient recurenţa şi ghidează tratamentul. Mi-croARN-urile circulante şi autoanticorpii specifici tumorii au demonstrat sensibilităţi de până la 85,7% şi specificităţi de 100%, depăşind CA-125. Instrumentele emergente, precum imagistica asistată de inteligenţă artificială, panourile multi-analitice şi biopsiile lichide cu ADN tumoral circulant (ctDNA), oferă promisiuni importante pentru detectarea ne-invazivă, precoce. Concluzii. Integrarea imagisticii avansate cu biomarkeri noi îmbunătăţeşte diagnosticul precoce al cancerului ovarian. Strategiile viitoare cu ctADN, microARN şi autoanticorpi pot creşte sensibilitatea şi specificitatea, facilitând intervenţii timpurii şi rezultate clinice şi calitatea vieţii pacienţilor.Introduction. Despite ongoing progress in oncology, ovarian cancer remains the most lethal gynecologic malignancy, often diagnosed late due to vague symptoms and limited early detection tools. 5-year survival rates drop from 93% (stage I) to 20% (stage IV), highlighting the need for more accurate diagnostic methods. Objective. This study evaluates current and emerging diagnostic methods for ovarian cancer, focusing on advanced imaging techniques and promising molecular biomarkers for early detection. Material and methods. A comprehensive systematic review of peer-reviewed literature published between 2016 and 2025 was conducted, utilizing major academic databases including PubMed, ScienceDirect, Elsevier, and ResearchGate. The search strategy incorporated predefined inclusion criteria and focused on studies addressing diagnostic advancements in ovarian cancer. Results. Transvaginal ultrasound (TVUS) combined with CA-125 offers a sensitivity of 84.9% and specificity of 98.2%. MRI demonstrates superior characterization of adnexal masses, with 98% sensitivity and 91% specificity, while PET/CT effectively detects recurrence and guides treatment planning. Circulating microRNAs and tumor-specific autoantibodies have shown diagnostic sensitivities up to 85.7% and specificities of 100%, outperforming CA-125 alone. Emerging tools such as AI-assisted imaging, multi-analyte panels, and liquid biopsies using circulating tumor DNA (ctDNA) hold substantial promise for non-invasive, early-stage detection. Conclusion. Combining advanced imaging with novel biomarker panels significantly improves ovarian cancer early detection. Future approaches using ctDNA, microRNAs, and autoantibodies may enhance both sensitivity and specificity, enabling earlier intervention and better patient outcomes
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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