91 research outputs found
Spectrophotometric simultaneous analytical method validation to determine isoniazid and pyridoxine in pure and 3D printed tablet forms
No full textIntroduction: Isoniazid (INH) is the anti-tuberculosis drugs being used to counter tuberculosis since 1952. Patients on INH should be given daily prophylactic pyridoxine (PYR) with 10-50 mg/day to prevent the development of isoniazid-induced neuropathy. Within the framework of this research, the UV-Vis spectrophotometer is used to quantify simultaneously the drug content of INH and PYR. Methods: The standard curve for both INH and PYR were plotted using the concentration of 5 μg/ml, 10 μg/ml, 15 μg/ml, 20 μg/ml, 25 μg/ml, and 30 μg/ml and tablets were analysed using simultaneous equation method. The proposed method was validated by analytical method validation for the linearity, specificity, accuracy, intermediate precision, limit of detection (LOD), and limit of quantification (LOQ). Results: A regression equation of INH standard and sample were found to be y = 0.0279x + 0.0637 and y = 0.0280x + 0.0522 obtained from the calibration curve and linear with correlation coefficient (R2) values of 0.9950 and 0.9964, respectively. A regression equation of PYR standard and sample were y= 0.0267x + 0.0723 and y = 0.0259x + 0.0806 and to be linear with R2 values of 0.9981 and 0.9962, respectively. The result of accuracy obeyed the accepted criteria of percentage recovery in % to 102%. The method exhibited intermediate precision as demonstrated by relative standard deviation <2%. The LOD and LOQ of INH were 0.166 μg/ml and 0.5018 μg/ml while the LOD and LOQ of PYR were 0.122 μg/mL and 0.371 μg/mL, respectively in the pure form. In tablet dosage form, the LOD and LOQ of INH were 0.071μg/ml and 0.215 μg/m while LOD and LOQ of PYR give the result 0.124 μg/ml and 0.375 μg/ml, respectively. Conclusion: This spectrophotometric simultaneous analytical method validation for INH and PYR was successfully conducted with the notion to spearhead the development of INH and PYR in a single dosage form to improve compliance among tuberculosis patients
Keselamatan dan Keberkesanan Ubat-ubatan dalam Merawat Pesakit COVID-19 di Malaysia dan Indonesia
No full textPENGENALAN
Dunia berhadapan dengan pandemik global setelah merebaknya penyakit novel koronavirus 2019 (COVID-19). Pandemik COVID-19 ini menyebabkan sindrom pernafasan akut yang teruk dan boleh membawa kepada kematian (Zhai et al. 2020). Sejak Disember 2019 sehingga 18 Mei 2020, Pertubuhan Kesihatan Sedunia (WHO) melaporkan terdapat lebih daripada 4,600,000 kes positif dan 312,009 kes kematian melibatkan lebih daripada 200 buah negara (World Health Organization, 2020a). Setakat 18 Mei 2020, Malaysia mencatatkan 6,941 kes positif dan 113 kes kematian iaitu bersamaan dengan 1.63%. Di Indonesia pula, sejumlah 18,010 kes positif dan 1,191 kes kematian dilaporkan dengan kadar kematian 6.61% (Outbreak.my, 2020). Berdasarkan padanan genetik, novel koronavirus atau sindrom respiratori akut teruk-koronavirus-2 (SARS-CoV-2) ialah virus daripada keluarga koronavirus yang serupa dengan sindrom respiratori akut teruk-koronavirus (SARS-CoV) dan sindrom pernafasan timur tengah-koronavirus (MERSCoV) (Zhou et al. 2020). SARS-CoV-2 ialah virus yang mengandungi RNA yang diselaputi oleh protein envelop. Di bahagian luar protein envelop ini terdapat tiara protein yang dikenali sebagai S protein. Daripada tiara protein inilah, virus ini mendapat namanya sebagai koronavirus. S protein ini amat penting bagi koronavirus kerana protein ini membolehkan koronavirus melekat kepada Angiotensin Converting Enzyme-2 (ACE-2)
reseptor yang terdapat pada bahagian luar sel (Sanders et al. 2020). Apabila novel koronavirus ini melekat pada ACE-2 reseptor, sel membenarkan virus ini untuk masuk ke dalam secara endositosis. Virus ini kemudian menjadikan sel sebagai tempat untuk membiak dan menghasilkan lebih banyak virus. Apoptosis dan kematian sel berlaku dan merembeskan virus ini untuk menyerang sel-sel badan yang lain (Gurwitz, 2020) the coronavirus COVID-19 epidemic has already resulted in more fatalities compared with the SARS and MERS coronavirus epidemics combined.
Therapeutics that may assist to contain its rapid spread and reduce its high mortality rates are urgently needed. Developing vaccines against the SARS-CoV-2 virus may take many months. Moreover, vaccines based on viral-encoded peptides may not be effective against future coronavirus epidemics, as virus mutations could make them futile. Indeed, new Influenza virus strains emerge every year, requiring new immunizations. A tentative suggestion based on existing therapeutics, which would likely be resistant to new coronavirus mutations, is to use available angiotensin
receptor 1 (AT1R)
Abstract for 3rd World Congress on Integration and Islamicisation 2021: mental health & well being in the 4th Industrial Revolution
No full textStability study of royal jelly in alginate-pectin beads
No full textThe stability of royal jelly (RJ) beads is a critical aspect to ensure the product is safe, efficacious, and possesses an acceptable quality for consumers. This study aims to establish storage duration and condition to ensure the stability of RJ in alginate-pectin bead
A review of black seed extract as an agent in the wound healing process
No full textIntroduction: Nigella Sativa or Black Cumin is an annual flowering plant that can be used for wound treatment. In the treatment for wound healing, this plant contains many beneficial components that can help with the treatment but this plant utilisation in the medical field is still limited. This review will provide an overview of the advantages when this plant is used in the wound healing treatment.
Method: The review was based on the ROSES protocol, and the databases used were ScienceDirect, PubMed, and Google Scholar. After the search, only 11 papers had been chosen to be included in the results and they were divided into four main themes that were used for the analysis of the results.
Results: The themes were gross analysis, microscopic analysis, biochemical analysis and antimicrobial analysis.
Conclusion: In conclusion, the black seed extract contains several valuable properties, such as antimicrobial and antioxidant properties, which help improve the wound healing process. Further study needs to be done to discover more potential of Nigella Sativa in treating the wound
THE ROLE OF ISLAMIC THEOLOGY TEACHERS IN BUILDING CLASS CLIMATE IN STUDENTS SIKKA FLORES REGENCY, EAST NUSA TENGGARA
No full textThis article discusses the role of Theology Teachers in Building a Classroom Climate for Students at Mts Nur Muhammad Pemana, Sikka Flores Regency, NTT. This article uses a qualitative research methodology with a focus on research (Field Research) in obtaining documents related to this issue and using multiple sites. Teachers have a very big role in creating a conducive classroom climate, so teacher competence is needed. A good classroom climate will describe demonstrations, where the teacher's behavior is more active in creating a conducive classroom climate. where a teacher provides opportunities for optimal learning achievement. Students who live in a pleasant classroom atmosphere are expected to be able to produce better performance when compared to children who live in an unpleasant classroom atmosphere. The author has come to the conclusion that the role of the moral theology teacher of class VIII MTs Nur Muhammad starting from the role of class management is both from students and the state of the classroom environment before the lesson begins, then after that hold a little dialogue or story with the aim of conditioning students to learn
Nanotechnology for molecular imaging of atherosclerosis: current design and approaches
No full textAtherosclerosis complications such as myocardial infarction or stroke is still one of the most critical causes of death worldwide. Advance and innovative diagnostic technologies are urgently required to discover an early stage of the disease, such as plaque instability and thrombosis. A combination of molecular imaging probes based on well-designed nanomaterials with leading-edge imaging methods is currently concreting the direction for novel and distinctive approaches to examine the inflammatory growth in atherosclerosis. Over the past several decades, an exceptional understanding of the biological nature of atherosclerosis provides unique opportunities to better treat atherosclerotic disease with targeted imaging and nanomedicines. Consequently, tremendous development has been initiated in the nanotechnology application; the leading engineering tools working at molecular range, which is designed for diagnostic and therapeutic approach, called theranostic. This review underlying ideas involving the potential and development of molecular imaging
technologies that had been invented for studying atherosclerosis. We envisage that many molecular imaging methods will become valuable assistants to the clinical management of targeted treatment in the atherosclerosis disease together with their challenges and future perspective in clinical translation
Optimizing Task Execution: The Impact of Dynamic Time Quantum and Priorities on Round Robin Scheduling
No full textTask scheduling algorithms are crucial for optimizing the utilization of computing resources. This work proposes a unique approach for improving task execution in real-time systems using an enhanced Round Robin scheduling algorithm variant incorporating dynamic time quantum and priority. The proposed algorithm adjusts the time slice allocated to each task based on execution time and priority, resulting in more efficient resource utilization. We also prioritize higher-priority tasks and execute them as soon as they arrive in the ready queue, ensuring the timely completion of critical tasks. We evaluate the performance of our algorithm using a set of real-world tasks and compare it with traditional Round Robin scheduling. The results show that our proposed approach significantly improves task execution time and resource utilization compared to conventional Round Robin scheduling. Our approach offers a promising solution for optimizing task execution in real-time systems. The combination of dynamic time quantum and priorities adds a unique element to the existing literature in this field
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