1,720,957 research outputs found
PENGARUH EKSTRAK KULIT BUAH NAGA SUPER MERAH (HYLOCEREUS COSTARICENCIS) TERHADAP EKSPRESI MDA DAN EKSPRESI MMP-3 PADA KULIT (Studi Eksperimental in vivo pada Tikus Jantan Galur Wistar Akibat Paparan UVB)
Full text linkLatar Belakang: Paparan sinar UVB pada kulit dapat mengakibatkan terakumulasinya Reactive Oxygen Species (ROS) sehingga akan terjadi peningkatan preoksidasi lipid, salah satunya MDA. ROS pada kulit mengakitvasi sitokin pro inflamasi yang kemudian memicu peningkatan produksi MMP-3 yang disekresikan neutrofil untuk mendegradasi kolagen. Hylochereus Costaricencys (buah naga) terutama kulitnya memiliki senyawa aktif berupa antosianin yang berperan sebagai antioksidan dan anti inflamasi. Tujuan penelitian ini untuk mengetahui pengaruh pemberian krim ekstrak kulit buah naga super merah terhadap ekspresi MDA dan ekspresi MMP-3.
Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian krim ekstrak kulit buah naga super merah terhadap ekspresi MDA dan Ekspresi MMP-3 pada kulit tikus yang dipapar sinar UVB.
Metode: Desaign penelitian yang digunakan adalah randomized post test only control group design. Sampel yang diteliti sebanyak 24 ekor tikus yang dibagi menjadi 4 kelompok; yaitu kelompok tikus sehat, K- (tikus dengan paparan sinar UVB dosis 160 mJ/cm2 selama 5 hari dilanjutkan denga pemberian cream base selama 2 minggu), K+ (tikus dengan paparan sinar UVB dosis 160 mJ/cm2 selama 5 hari dilanjutkan denga pemberian cream anti wrinkle selama 2 minggu), P (tikus dengan paparan sinar UVB dosis 160 mJ/cm2 selama 5 hari dilanjutkan denga pemberian krim ekstrak kulit buah naga super merah 10% selama 2 minggu).
Hasil: Hasil penelitian menunjukkan bahwa krim ekstrak kulit buah naga 10% tidak secara signifikan menurunkan ekspresi MDA pada tikus yang dipapar UVB dengan nilai p>0,05. Krim ekstrak kulit buah naga 10% secara signifikan menurunkan ekspresi MMP-3 pada tikus yang dipapar UVB dengan nilai p<0,05.
Kesimpulan: Terdapat penurunan ekspresi MDA dan ekspresi MMP-3 pada tikus model UVB setelah pemberian krim ekstrak kulit buah naga 10%.
Kata Kunci: Paparan UVB, MDA, MMP-3, Hylocereus Costaricenci
Empirical Antibiotics’ Impact on Hospital Stay and Mortality in Community-Acquired Pneumonia
Full text linkIntroduction: Community-acquired pneumonia (CAP) shows a high prevalence rate in adult patients. Bacterial infections are the most common etiology of CAP cases and can lead to patient hospitalization, morbidity, and mortality. Empirical antibiotics can be given to CAP patients to prevent worsening. This study aims to analyze the appropriateness of empirical antibiotics, according to guidelines on length of stay and mortality, in CAP patients.
Methods: This observational retrospective study used medical record data from CAP patients at Sultan Agung Islamic Hospital, Semarang, from January 2023 to December 2024. We evaluated the impact of prescribed antibiotics, based on the 2019 ATS/IDSA guidelines, on length of stay and in-hospital mortality. Data were tested using the Fisher test with a 95% confidence interval (CI).
Result: Significant differences were shown in the type of treatment room and comorbid diseases such as lung disorders, related to patient outcomes (recovery or death). The administration of empirical antibiotics to patients with CAP, as recommended by guidelines on length of hospitalization and patient mortality, demonstrated p-values of 0.683 and 0.166, respectively (p > 0.05). The suitability of empirical antibiotics to the guideline did not affect the length of treatment and outcome of CAP patients.
Conclusion: The administration of empirical therapy in accordance with guidelines did not demonstrate a correlation with reduced duration of hospitalisation or decreased mortality. Nevertheless, a significant association was identified between ICU admission, comorbid lung disease, and patient outcomes
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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