147,285 research outputs found
Composite Wall Panel: Reckitt’s Blue
No full textResearch Background:
D Harding is a descendant of the Bidjara, Ghungalu and Garingbal peoples. Harding’s work Composite Wall Panel: Reckitt’s Blue (2017) was exhibited as part of dOCUMENTA 14 in Kassel, Germany, a major contemporary art exhibition which recurs every five years. The three-panel work is part of a series of wall paintings and murals using Indigenous motifs and traditions of paint application that Harding has constructed as site-specific installations in Australia and overseas.
Contribution:
The panels reproduce segments of complex compositions from rock paintings of the Carnarvon Gorge, the Country of Bidjara, Ghungalu and Garingbal peoples. Harding refers to the reproductions as ‘carbon copy stencils – via silkscreen prints – of historical rock art sites from Aboriginal territories’. These reproductions challenge our understanding of the postmodern art style known as appropriation. Harding uses the term ‘iteration’ to cut across that style of art, the terms calls up seriality and a process of repetition rather than a copy per se. In this way, Harding’s emphasises the role of passing on a tradition, even if it is not possible to practise that tradition of image-making in the original place of execution; the work is framed nonetheless as part of a continuum of cultural practice.
Research Significance:
Documenta is one of the most prestigious art exhibitions in the international art world. Harding exhibited in both locations of dOCUMENTA 14 Athens and Kassel however only the work in Kassel was not previously exhibited. The work has been discussed by critics including Tess Maunder, Susan Best, Hendrik Folkerts.No Full Tex
Structure and heterogeneity of gliadin: A hydrodynamic evaluation
Get PDFA study of the heterogeneity and conformation in solution [in 70% (v/v) aq. ethanol] of gliadin proteins from wheat was undertaken based upon sedimentation velocity in the analytical ultracentrifuge, analysis of the distribution coefficients and ellipsoidal axial ratios assuming quasi-rigid particles, allowing for a range of plausible time-averaged hydration values. All classical fractions (α, γ, ωslow, ωfast) show three clearly resolved components. Based on the weight-average sedimentation coefficient for each fraction and a weight-average molecular weight from sedimentation equilibrium and/or cDNA sequence analysis, all the proteins are extended molecules with axial ratios ranging from ~10 to 30 with α appearing the most extended and γ the least. © 2009 European Biophysical Societies' Association
Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes
No full textSarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA)2a overexpression and phospholamban depletion have been shown to have beneficial effects on contractility in heart failure. However, the high sympathetic tone during development of failure may interact with increases in SERCA2a activity in potentially deleterious ways. We used adenoviral vectors to overexpress SERCA2a or partially downregulate phospholamban in adult rabbit ventricular myocytes in culture and studied the responses of these cells to beta-adrenoceptor stimulation. SERCA2a overexpression and phospholamban depletion had quantitatively similar effects on basal contraction amplitude and in accelerating relaxation. Increasing SERCA2a activity by either strategy had little effect on the increase in contraction amplitude or incidence of arrhythmias with increasing isoproterenol. Maximum acceleration of relaxation by beta-adrenoceptor stimulation was similar to that produced by SERCA2a overexpression. Isoproterenol treatment of SERCA2a-overexpressing or phospholamban-deficient myocytes produced a further modest decrease in relaxation time, with similar final values in both groups. We find no evidence for Ca(2+) overload induced by SERCA2a overexpression alone or in combination with catecholamines
There's no such thing as a journal paper
Get PDFThis is the author accepted manuscript. The final version is available from Palgrave Macmillan via the DOI in this record.Ford, Harding, Gilmore and Richardson’s ‘Becoming the leader: leadership as material presence’, was accepted for publication in Organization Studies in late 2016. The paper conforms with the dominant format for academic journal papers. It: outlines how the idea for the study on which the paper is based was arrived at, lists its aims and objectives, discusses its methodology and methods, has a long section labelled ‘data analysis’, a discussion that develops a theory arising out of the data analysis, and a short conclusion looking forward to future work. It gives the impression of a smooth passage from inception of an idea about a topic that needs to be researched through the fieldwork to the paper’s publication. Because Organization Studies is listed as 4* in the Chartered Association of Business Schools (CABS) journal rankings list, a considerable proportion of the paper is devoted to the methodology of the study, and to its theoretical location. We are quite proud of these – we developed a method for interviewing people that helps them articulate abstract ideas, and we brought together new materialities theory, notably the work of Karen Barad, with psychoanalytical theory, through the work of Christopher Bollas
Dilute Solution Viscometry Studies on a Therapeutic Mixture of Non-digestible Carbohydrates
Get PDFRecent work has shown the beneficial effects of a proprietary mixture of three non-digestible carbohydrates:
konjac glucomannan, xanthan and alginate and these effects have been linked with a synergistic interaction observable
with analytical ultracentrifugation, rheological and NMR measurements. These observations have been supported by
fundamental dilute solution viscosity studies. Preparations of konjac glucomannan, xanthan and alginate have been
checked with regards their molecular integrity (molar mass distribution) using a newly established method based on the
analytical ultracentrifuge. The intrinsic viscosity behaviour for each of the individual polysaccharides were estimated at
low ionic strength I (10-3M) and found to be (2090±120) ml/g, (4430±340) ml/g and (3460±330) ml/g for konjac
glucomannan, xanthan and alginate respectively and at (10-1M) (2350±200) ml/g, (3370±310) ml/g and (1210±50) ml/g
respectively. The intrinsic viscosity [η] was then determined for a proprietary mixture of the three (known as “PGX®”) at
both ionic strengths and compared with the predicted values for a non-interacting mixture. In I=10-3 M solvent a
significant difference was observed (3090+250) ml/g compared with the predicted value (2350+300) ml/g, although at
higher ionic strength the interaction appears to have gone: [η] = (1990+250) ml/g compared with the predicted value of
(2180+300) ml/g. This appears to reinforce the earlier observations that in PGX® there is a synergistic interaction which
is ionic strength sensitive
<i>No se sabe</i>: entrevista a Lucas Gagliardi
No full textEntrevista al Licenciado y Profesor en Letras (UNLP) Lucas Gagliardi. Se especializa en literatura en lengua inglesa y en crítica genética. Se desempeña como profesor en la Universidad Pedagógica (UNIPE), en institutos de formación docente y escuelas secundarias. Ha participado en proyectos de investigación sobre archivos de escritores, publicaciones impresas. Participa en el programa de voluntariado universitario de la Facultad de Trabajo Social (UNLP) en articulación con la Biblioteca Ambulante del Hospital de Niños dictando talleres de lectura y escritura.Al hacer clic en el enlace que figura en "Documentos relacionados", pueden accederse a todos los trabajos de Lucas Gagliardi presentes en el repositorio.Radio Universidad Nacional de La Plat
Posmodern feminism D. J. Haraway and S. Harding. [Spanish]
No full textEn este texto se caracteriza el llamado “Feminismo Postmoderno” y se presentan las posiciones teóricas de dos influyentes pensadoras contemporáneas en el ámbito de la filosofía de la ciencia desde una perspectiva feminista postmoderna. Haraway y Harding debaten en torno a la historia de la ciencia y sus sesgos androcéntricos, así como sobre el concepto identidad desde el paradigma cyborg. Dentro del paradigma postmoderno asumen la herencia postestructuralista y deconstruccionista y defienden la necesidad de una ciencia social crítica y autorreflexiva como modelo de todas las ciencias, pero tienen controversias en cuanto a la estructuración del espacio social generizado. Haraway entiende que el espacio social no es homogéneo, y que las tres dimensiones que detecta Harding: simbolismo genérico, división socio-sexual del trabajo y procesos de identidad individual generizada, se interceptan en múltiples dimensiones.In this text is characterized the “Postmodern. Feminism” and the theoretical positions of two influential contemporary thinkers in Philosophy of Science from a postmodern feminist perspective. Haraway and Harding debate around the History of Science and its andocentric slants, as well as on the concept “identity” from the cyborg paradigm. Within the postmodern paradigm they assume the poststructuralist and deconstructionist inheritance and defend the necessity of a critical and autorreflexive social science like model of all sciences, but they have controversies about the gendered social space. Haraway understands that the social space is not homogenous, and that the three dimensions that Harding detects: generic symbolism, partner-sexual division of the work and processes of gendered individual identity, they are intercepted in multiple dimensions
La literatura popular de Rebecca Harding Davis
Get PDFEsta tesis doctoral contiene un estudio de la literatura de Rebecca Harding Davis, una escritora estadounidense del siglo XIX cuyo trabajo abarcó el periodismo, la novela, el relato y literatura juvenil. Rebecca Harding Davis se lanzó a la fama con la publicación de la novela corta, "Life in the Iron Mills" en Atlantic Monthly, la revista literaria de más prestigio en aquel periodo. Por este trabajo y por su implicación en proyectos de reforma social, se considera pionera del realismo norteamericano. Una escritora olvidada desde entonces, la escritora Tillie Olsen la redescubrió en 1972 publicando "Iron-Mills" en Feminist Press. Sus obras, que incluyen más de 19 novelas, mas de 175 relatos y más de 200 ensayos, vieron la luz todas en las revistas más importantes de los Estados Unidos entre 1861 y 1910.Este estudio analiza a fondo su corpus popular, principalmente las obras que Davis publicó en la revista Petersonś, la publicación periódica de más amplia circulación
Propagation and Cardiac Differentiation of Encapsulated Human Embryonic Stem Cells in a Novel Perfused Bioreactor Capable of Ultrasonic Mechanical Stimulation
No full textTargeting phospholamban by gene transfer in human heart failure
No full textBACKGROUND:
Myocardial cells from failing human hearts are characterized by abnormal calcium handling, a negative force-frequency relationship, and decreased sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) activity. In this study, we tested whether contractile function can be improved by decreasing the inhibitory effects of phospholamban on SERCA2a with adenoviral gene transfer of antisense phospholamban (asPL).
METHODS AND RESULTS:
Myocardial cells isolated from 9 patients with end-stage heart failure and 18 donor nonfailing hearts were infected with adenoviruses encoding for either the antisense of phospholamban (Ad.asPL), the SERCA2a gene (Ad.SERCA2a), or the reporter genes beta-galactosidase and green fluorescent protein (Ad.betagal-GFP). Adenoviral gene transfer with Ad.asPL decreased phospholamban expression over 48 hours, increasing the velocity of both contraction and relaxation. Compared with cardiomyocytes infected with Ad.asPL (n=13), human myocytes infected with Ad.betagal-GFP (n=8) had enhanced contraction velocity (20.3 +/- 3.9% versus 8.7 +/- 2.6% shortening/second; P<0.01) and relaxation velocity (26.0 +/- 6.2% versus 8.6 +/- 4.3% shortening/second; P<0.01). The improvement in contraction and relaxation velocities was comparable to cardiomyocytes infected with Ad.SERCA2a. Failing human cardiomyocytes had decreased contraction and Ca2+ release with increasing frequency (0.1 to 2 Hz). Phospholamban ablation restored the frequency response in the failing cardiomyocytes to normal; increasing frequency resulted in enhanced sarcoplasmic reticulum Ca2+ release and contraction.
CONCLUSION:
These results show that gene transfer of asPL can improve the contractile function in failing human myocardium. Targeting phospholamban may provide therapeutic benefits in human heart failure
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