12,920 research outputs found
Increased Excitatory Synaptic Transmission of Dentate Granule Neurons in Mice Lacking PSD-95-Interacting Adhesion Molecule Neph2/Kirrel3 during the Early Postnatal Period
No full textCopy number variants and point mutations of NEPH2 (also called KIRREL3) gene encoding an immunoglobulin (Ig) superfamily adhesion molecule have been linked to autism spectrum disorders, intellectual disability and neurocognitive delay associated with Jacobsen syndrome, but the physiological roles of Neph2 in the mammalian brain remain largely unknown. Neph2 is highly expressed in the dentate granule (DG) neurons of the hippocampus and is localized in both dendrites and axons. It was recently shown that Neph2 is required for the formation of mossy fiber filopodia, the axon terminal structure of DG neurons forming synapses with GABAergic neurons of CA3. In contrast, however, it is unknown whether Neph2 also has any roles in the postsynaptic compartments of DG neurons. We here report that, through its C-terminal PDZ domain-binding motif, Neph2 directly interacts with postsynaptic density (PSD)-95, an abundant excitatory postsynaptic scaffolding protein. Moreover, Neph2 protein is detected in the brain PSD fraction and interacts with PSD-95 in synaptosomal lysates. Functionally, loss of Neph2 in mice leads to age-specific defects in the synaptic connectivity of DG neurons. Specifically, Neph2−/− mice show significantly increased spontaneous excitatory synaptic events in DG neurons at postnatal week 2 when the endogenous Neph2 protein expression peaks, but show normal excitatory synaptic transmission at postnatal week 3. The evoked excitatory synaptic transmission and synaptic plasticity of medial perforant pathway (MPP)-DG synapses are also normal in Neph2−/− mice at postnatal week 3, further confirming the age-specific synaptic defects. Together, our results provide some evidence for the postsynaptic function of Neph2 in DG neurons during the early postnatal period, which might be implicated in neurodevelopmental and cognitive disorders caused by NEPH2 mutations.
Copyright © 2017 Roh, Choi, Cho, Choi, Park, Cutforth, Chung, Park, Lee, Kim, Lee,
Mo, Rhee, Kim, Ko, Choi, Bae, Shen, Kim and Han. This is an open-access article
distributed under the terms of the Creative Commons Attribution License (CC BY).
The use, distribution and reproduction in other forums is permitted, provided the
original author(s) or licensor are credited and that the original publication in this
journal is cited, in accordance with accepted academic practice. No use, distribution
or reproduction is permitted which does not comply with these terms.
© 2017 Roh, Choi, Cho, Choi, Park, Cutforth, Chung, Park, Lee, Kim, Lee,
Mo, Rhee, Kim, Ko, Choi, Bae, Shen, Kim and Han. This is an open-access article
distributed under the terms of the Creative Commons Attribution License (CC BY).
The use, distribution and reproduction in other forums is permitted, provided the
original author(s) or licensor are credited and that the original publication in this
journal is cited, in accordance with accepted academic practice. No use, distribution
or reproduction is permitted which does not comply with these terms.
Frontiers1321sciescopu
Author Correction: Evaluation of skin cancer resection guide using hyper‑realistic in‑vitro phantom fabricated by 3D printing
No full textThe original version of this Article contained an error in the spelling of the author Taehun Kim which was incorrectly given as Teahun Kim. The original Article has been corrected
Perspective: Uniform switching of artificial synapses for large-scale neuromorphic arrays
No full textResistive random-access memories are promising analog synaptic devices for efficient bio-inspired neuromorphic computing arrays. Here we first describe working principles for phase-change random-access memory, oxide random-access memory, and conductive-bridging random-access memory for artificial synapses. These devices could allow for dense and efficient storage of analog synapse connections between CMOS neuron circuits. We also discuss challenges and opportunities for analog synaptic devices toward the goal of realizing passive neuromorphic computing arrays. Finally, we focus on reducing spatial and temporal variations, which is critical to experimentally realize powerful and efficient neuromorphic computing systems
SiGe epitaxial memory for neuromorphic computing with reproducible high performance based on engineered dislocations
No full textAlthough several types of architecture combining memory cells and transistors have been used to demonstrate artificial synaptic arrays, they usually present limited scalability and high power consumption. Transistor-free analog switching devices may overcome these limitations, yet the typical switching process they rely on-formation of filaments in an amorphous medium-is not easily controlled and hence hampers the spatial and temporal reproducibility of the performance. Here, we demonstrate analog resistive switching devices that possess desired characteristics for neuromorphic computing networks with minimal performance variations using a single-crystalline SiGe layer epitaxially grown on Si as a switching medium. Such epitaxial random access memories utilize threading dislocations in SiGe to confine metal filaments in a defined, one-dimensional channel. This confinement results in drastically enhanced switching uniformity and long retention/high endurance with a high analog on/off ratio. Simulations using the MNIST handwritten recognition data set prove that epitaxial random access memories can operate with an online learning accuracy of 95.1%.
DBLP-derived labeled data for author name disambiguation
No full textThis is a DBLP-derived labeled data originally created by Dr. C. Lee Giles at Penn State University and filtered for duplicate removal and error correction by Dr. Jinseok Kim at University of Michigan. For more details, see references below.1. Kim, Jinseok (2018). Evaluating author name disambiguation for digital libraries: a case of DBLP. Scientometrics. doi:10.1007/s11192-018-2824-5 2. Kim, Jinseok & Kim, Jenna (2018). The impact of imbalanced training data on machine learning for author name disambiguation. Scientometrics. doi: 10.1007/s11192-018-2865-9Each row refers to an author name instance with following feature information separated by tab.author name: full name string extracted from DBLPunique author id: labels assigned manually by Dr. C. Lee Giles's teampaper id: assigned by Dr. Jinseok Kimauthor list: names of authors in the byline of the paperyear: publication yearvenue: conference or journal namestitle: stopwords removed and stemmed by the Porter's stemmerIf you want to use this dataset, please consider to cite papers below.For the original dataset: Han, H., Giles, L., Zha, H., Li, C., & Tsioutsiouliklis, K. (2004). Two Supervised Learning Approaches for Name Disambiguation in Author Citations. JCDL 2004: Proceedings of the Fourth ACM/IEEE Joint Conference on Digital Libraries, 296-305. doi:10.1145/996350.996419For the filtered dataset: 1. Kim, Jinseok (2018). Evaluating author name disambiguation for digital libraries: a case of DBLP. Scientometrics. doi:10.1007/s11192-018-2824-5 or2. Kim, Jinseok & Kim, Jenna (2018). The impact of imbalanced training data on machine learning for author name disambiguation. Scientometrics. doi: 10.1007/s11192-018-2865-9</div
Khoo Kay Kim, professor of Malaysian history : a biobibliometric study
No full textPresents an analysis of the publication productivity, authorship pattern, channels of communication, journal preference and language preference of Professor Dato' Khoo Kay Kim, Professor of Malaysian History in the University of Malaya, Kuala Lumpur. The results of this biobibliometric study indicate that he can be a role model for future Malaysian historians to emulate his various achievements especially in the field of history education
Anxious, Dismal, Giddy, Aggressive: Seth Kim-Cohen interviewed by Mark Peter Wright for Ear Room.
No full textA conversation with author Seth Kim-Cohen
Kim Gordon - no icon
No full textAs cofounder of legendary rock band Sonic Youth, best-selling author, and celebrated artist, Kim Gordon is one of the most singular and influential figures of the modern era. This personally curated scrapbook is an edgy and evocative portrait of Gordon s life, art, and style. Spanning from her childhood on Californian surf beaches in the 60s and 70s to New York s downtown art and music scene in the 80s and 90s where Sonic Youth was born. Through unpublished personal photographs, magazine and newspaper clippings, fashion editorials, and advertising campaigns, interspersed with Gordon s song lyrics, writings, artworks, private objects, and ephemera, this book demonstrates how Kim Gordon has been a role model for generations of women and me
Overview of Recent Progress in Fire Suppression
No full textthis document is published in / Une version de ce document se trouve dans : Invited Keynote Lecture at the 2 nd NRIFD Symposium, Proceedings, Tokyo, Japan, July 17-19, 2002, pp. 1-13 www.nrc.ca/irc/ircpubs NRCC-45690 Title: OVERVIEW OF RECENT PROGRESS IN FIRE SUPPRESSION TECHNOLOGY Author(s): Andrew KIM Corresponding (first) author: Andrew Kim Academic degree: Ph.
A note on Kim-Ma characterization of the Hilbert ball
No full textThis is an open access article under the CC BY license.[No abstract available]Kortney Rose Foundation, KRF, (2002-070-C00005); National Research Foundation of Korea, NRF* Corresponding author. E-mail addresses: [email protected] (K.-T. Kim), [email protected] (D. Ma). 1 Research supported in part by the grant KRF 2002-070-C00005 from The Korea Research Foundation
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