8,952 research outputs found
Han Gyeol Kim
No full text학위논문(석사)아주대학교 일반대학원 :의학계열,2012. 8I. INTRODUCTION 1
II. MATERIALS AND METHODS 2
A. Study subjects 3
B. Questionnaire 3
C. Genotyping 3
D. Statistical analysis 4
III. RESULTS 5
IV. DISCUSSION 9
V. CONCLUSION 12
REFERENCES 13
국문요약 16MasterBackground: G-protein beta3 subunit (GNB3) C825T polymorphism alters intracellular signal transduction, which may lead to motor or sensory abnormalities of the gastrointestinal tract. The aim of the present study was to evaluate the association of the GNB3 C825T polymorphism with susceptibility to overlap syndrome of functional dyspepsia (FD) and irritable bowel syndrome (IBS) in a Korean population.
Methods: One hundred sixty-seven patients with FD alone, 60 patients with IBS alone, 85 patients with the overlap of FD and IBS, and 434 asymptomatic healthy subjects participated in the study. Genotyping for GNB3 C825T polymorphism was performed using their blood samples.
Results: No association of genotype in subjects with FD alone, IBS alone or overlap phenotype compared to that in controls was detected. The frequency of GNB3 C825T CT and TT genotypes relative to the CC genotype for the phenotypes of FD alone, IBS alone, and the coexistence of FD and IBS did not significantly differ. Comparison of the TT genotype with the CC/CT genotype showed no significant association for each phenotype group.
Conclusions: There is no apparent association of the GNB3 C825T polymorphism with the susceptibility to FD, IBS or the overlap of FD and IBS. A larger-scale study and further investigation on other candidate genes are required
Supplemental Material, sj-pdf-1-ojs-10.1177_23259671221145228 - Reliability of the TT-TG Index Versus TT-TG Distance on MRI: Morphometric Analyses in Asian Children and Adolescents
No full textSupplemental Material, sj-pdf-1-ojs-10.1177_23259671221145228 for Reliability of the TT-TG Index Versus TT-TG Distance on MRI: Morphometric Analyses in Asian Children and Adolescents by Sin Hyung Park, Wonchul Choi, Siyeong Yoon, Jeongbae Rhie, Wooyeol Ahn, Jongbeom Oh, Dong Hun Han and Soonchul Lee in Orthopaedic Journal of Sports Medicine</p
Isomorphisms in co-TT graphs
No full text2019 Spring.Includes bibliographical references.A threshold tolerance graph is a graph where each vertex v is assigned a weight wv and a tolerance tv, and there is an edge between two vertices vx and vy if and only if wx + wy ≥ min(tx,ty). A co-TT graph is the complement of a threshold tolerance graph. Recognition of these graphs can be done in O(n2) time; however no polynomial-time algorithm to identify isomorphisms between pairs of TT or co-TT graphs was previously known. We give an algorithm to identify these isomorphisms, which takes O(n2) time
Safety and immunogenicity of a CRM or TT conjugated meningococcal vaccine in healthy toddlers
No full textAbstractBackgroundMenACWY-CRM (Menveo®; GlaxoSmithKline) and MenACWY-TT (Nimenrix®; Pfizer) are two meningococcal vaccines licensed in the European Union for use in both children and adults. While both vaccines target meningococcal serogroups A, C, W and Y, immunogenicity and reactogenicity of these quadrivalent meningococcal conjugate vaccines may differ due to differences in formulation processes and chemical structure. Yet data on the comparability of these two vaccines are limited.MethodsThe reactogenicity and immunogenicity of one dose of either MenACWY-CRM or MenACWY-TT were evaluated in healthy toddlers aged 12–15 months. Immunogenicity was assessed using serum bactericidal antibody assays (SBA) with human (hSBA) and rabbit (rSBA) complement.ResultsA total of 202 children aged 12–15 months were enrolled to receive one dose of MenACWY-CRM or MenACWY-TT. Similar numbers of subjects reported solicited reactions within 7 days following either vaccination. Tenderness at the injection site was the most common local reaction. Systemic reactions reported were similar for both vaccines and mostly mild to moderate in severity: irritability, sleepiness and change in eating habits were most commonly reported. Immunogenicity at 1 month post-vaccination was generally comparable for both vaccines across serogroups. At 6 months post-vaccination antibody persistence against serogroups C, W, and Y was substantial for both vaccines, as measured by both assay methodologies. For serogroup A, hSBA titers declined in both groups, while rSBA titers remained high.ConclusionDespite differences in composition, the MenACWY-CRM and MenACWY-TT vaccines have comparable reactogenicity and immunogenicity profiles. Immediate immune responses and short-term antibody persistence were largely similar between groups. Both vaccines were well-tolerated and no safety concerns were identified
Safety and immunogenicity of a CRM or TT conjugated meningococcal vaccine in healthy toddlers.
No full textBackground MenACWY-CRM (Menveo®; GlaxoSmithKline) and MenACWY-TT (Nimenrix®; Pfizer) are two meningococcal vaccines licensed in the European Union for use in both children and adults. While both vaccines target meningococcal serogroups A, C, W and Y, immunogenicity and reactogenicity of these quadrivalent meningococcal conjugate vaccines may differ due to differences in formulation processes and chemical structure. Yet data on the comparability of these two vaccines are limited. Methods The reactogenicity and immunogenicity of one dose of either MenACWY-CRM or MenACWY-TT were evaluated in healthy toddlers aged 12–15 months. Immunogenicity was assessed using serum bactericidal antibody assays (SBA) with human (hSBA) and rabbit (rSBA) complement. Results A total of 202 children aged 12–15 months were enrolled to receive one dose of MenACWY-CRM or MenACWY-TT. Similar numbers of subjects reported solicited reactions within 7 days following either vaccination. Tenderness at the injection site was the most common local reaction. Systemic reactions reported were similar for both vaccines and mostly mild to moderate in severity: irritability, sleepiness and change in eating habits were most commonly reported. Immunogenicity at 1 month post-vaccination was generally comparable for both vaccines across serogroups. At 6 months post-vaccination antibody persistence against serogroups C, W, and Y was substantial for both vaccines, as measured by both assay methodologies. For serogroup A, hSBA titers declined in both groups, while rSBA titers remained high. Conclusion Despite differences in composition, the MenACWY-CRM and MenACWY-TT vaccines have comparable reactogenicity and immunogenicity profiles. Immediate immune responses and short-term antibody persistence were largely similar between groups. Both vaccines were well-tolerated and no safety concerns were identified
tt*-geometry and pluriharmonic maps
No full textInternational audienceIn this paper we use the real differential geometric definition of a metric (an unimodular oriented metric) tt*-bundle of Cortés and the author to define a map from the space of metric (unimodular oriented metric) tt*-bundles of rank r over a complex manifold M to the space of pluriharmonic maps from M to (respectively ), where (p,q) is the signature of the metric. In the sequel the image of the map is characterized. It follows, that in signature (r,0) the image of is the whole space of pluriharmonic maps. This generalizes a result of Dubrovin
performance of the low-rank TT-SVD for large dense tensors on modern multicore CPUs
No full textThere are several factorizations of multidimensional tensors into lower-dimensional components, known as ``tensor networks."" We consider the popular ``tensor-train"" (TT) format and ask, How efficiently can we compute a low-rank approximation from a full tensor on current multicore CPUs? Compared to sparse and dense linear algebra, kernel libraries for multilinear algebra are rare and typically not as well optimized. Linear algebra libraries like BLAS and LAPACK may provide the required operations in principle but often at the cost of additional data movements for rearranging memory layouts. Furthermore, these libraries are typically optimized for the compute-bound case (e.g., square matrix operations), whereas low-rank tensor decompositions lead to memory bandwidth limited operations. We propose a ``TT singular value decomposition"" (TT-SVD) algorithm based on two building blocks: a ``Q-less tall-skinny QR"" factorization and a fused tall-skinny matrix-matrix multiplication and reshape operation. We analyze the performance of the resulting TT-SVD algorithm using the roofline performance model. In addition, we present performance results for different algorithmic variants for shared-memory as well as distributed-memory architectures. Our experiments show that commonly used TT-SVD implementations suffer severe performance penalties. We conclude that a dedicated library for tensor factorization kernels would benefit the community: Computing a low-rank approximation can be as cheap as reading the data twice from main memory. As a consequence, an implementation that achieves realistic performance will move the limit at which one has to resort to randomized methods that only process part of the data.Numerical Analysi
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