4,977 research outputs found
Austin Papers: Series II, Part II, 1818-1847
No full textCopy of transcript for a letter from Sam Hammond to Moses Austin concerning the completion of a sale
Henry Schley: Upton and Sam Hammond are manumitted by Nathan Hammond, December 1, 1835
No full textReport of Manumissions, Frederick County, December 1, 1835, Henry Schley: Upton and Sam Hammond are manumitted by Nathan Hammond [Frederick County]
Letter from Hayao (Sam) Chuman to the American Friends Service Committee
No full textA letter from Hayao (Sam) Chuman to the American Friends Service Committee, donating a portion of his redress check from the U.S. government to the Committee.The Chuman (Hayao "Sam" and Toshiko) Papers documents the World War II experiences of Hayao "Sam" and Toshiko Chuman, who were Kibei Nisei born in the United States but grew up and completed school in Japan, and then returned to the U.S. prior to the war. It chronicles the Chuman's incarceration from the Santa Anita Assembly Center, through Jerome, Rohwer, Tule Lake camps, and the Santa Fe and Crystal City internment camps as well as their struggle for restoring their U.S. citizenships in the 1960s. The digital collection consists of mostly textual material, including correspondence, affidavits, incarceration camp records, lease agreements, financial documents, receipts, pamphlets, and booklets
Letter from Hayao (Sam) Chuman to Earl Warren and "Attorney General Clark"
No full textA letter from Hayao (Sam) Chuman to Chief Justice of the Supreme Court Earl Warren and "Attorney General Clark". The letter is a request to regain his citizenship after renouncing his U.S. citizenship and requesting repatriation to Japan during his time incarcerated in World War II.The Chuman (Hayao "Sam" and Toshiko) Papers documents the World War II experiences of Hayao "Sam" and Toshiko Chuman, who were Kibei Nisei born in the United States but grew up and completed school in Japan, and then returned to the U.S. prior to the war. It chronicles the Chuman's incarceration from the Santa Anita Assembly Center, through Jerome, Rohwer, Tule Lake camps, and the Santa Fe and Crystal City internment camps as well as their struggle for restoring their U.S. citizenships in the 1960s. The digital collection consists of mostly textual material, including correspondence, affidavits, incarceration camp records, lease agreements, financial documents, receipts, pamphlets, and booklets
Sam "Kangaroo"
No full textabstract: Sam left Sudan when he was six years old. He also witnessed many people die when they tried to cross the Gilo river.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 23Region: Upper Nile (Bor)This picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
the beat report piece detailing author Sam Pfeifle\u27s wishes for local music fo
No full textthe beat report piece detailing author Sam Pfeifle\u27s wishes for local music for 2004, mentioning radio stations WCYY and WCLZ, local band 6gig, and the Musicians Resource League
Izvori informacija u dostupnim EBSCO bazama podataka za istraživanja u visokom školstvu u Srbiji = Academic research in Serbia and available database resources
No full textUniversities in Serbia have access to large amounts of quality information through online full text databases. Specific details regarding the world’s two most comprehensive full text research data-bases, Academic Search Premier and Business Source Premier are provided. The paper examines which databases are strongest in each discipline, and covers issues such as the availability of journals most-cited, full text formats, peer-review status, embargo periods, backfills, and other important facets. Additional information depicts reasons for tremendous increase in the availability of information in the Serbia, and the value that these resources bring to researchers in universities
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Synthesis of S-adenosylmethionine (SAM) Analogs and Development of High-Throughput Screens to Target SAM-I Riboswitches
No full textSynthesis of S-adenosylmethionine (SAM) Analogs and Development of High-Throughput Screens to Target SAM-I RiboswitchesByScott Forsythe HickeyDoctor of Philosophy in ChemistryUniversity of California, BerkeleyProfessor Ming C. Hammond, Chair The understanding of fundamental regulatory mechanisms in bacteria has been aided by the discovery of a class of non-coding RNAs known as riboswitches. Riboswitches are ligand-binding RNAs that control the expression of a wide variety of genes in response to changes in intracellular metabolite concentrations. Bacterial genomes contain riboswitches that can exert control over entire collections of metabolic genes that are important for cell survival, homeostasis, and adapting to environmental changes. Coupled with the presence of riboswitches within the genomes of bacterial human pathogens, these features suggest that riboswitches are promising new targets for therapeutic development. In addition, the unique gene control mechanisms of riboswitches make them well-suited as tools for synthetic biology. However, investigations into riboswitch-ligand interactions has been hindered by the lack of available high-throughput screening tools. The ability to screen riboswitch binding properties in a rapid and scalable fashion will augment drug discovery and target validation efforts for bacterial riboswitches and other RNA targets in general. Here, we describe the development of a series of riboswitch-ligand binding assays with increased throughput and utility as compared to traditional assays. The techniques described are demonstrated for riboswitch model systems, but are also applicable to RNA-ligand interactions in general. Out of the 20 known riboswitch classes that have been described to date, seven of them bind the small molecule S-adenosylmethionine (SAM). The most abundant of these is the SAM-I riboswitch family, which we chose as a model system for our studies. First, a synthetic procedure is described for the preparation of SAM analogs that are of interest for both riboswitch- and protein methyltransferase- drug discovery. SAM analogs prepared using our procedure were profiled against a panel of human protein methyltransferases, and a fluorescently-tagged SAM analog was shown to target the SAM-I riboswitch family. The fluorescent analog was applied to the development of a high-throughput screening approach to identify riboswitch agonists or antagonists by a competitive ligand displacement assay. A similar strategy could be used for identifying protein methyltransferase inhibitors. In addition, the development of a microfluidic mobility shift screening platform is described for the rapid characterization of riboswitch-ligand interactions with extremely low resource consumption. The method is highly scalable, offers significant advantages over traditional methods, and will enable screening efforts for a variety of riboswitch-ligand interactions. Finally, a mechanism-based magnetic bead assay is described with applications both for riboswitch in vitro selection and investigation of kinetically-controlled riboswitch regulatory responses. It is anticipated that the assays described here will forward the development of new riboswitch-ligand pairs for antibiotic discovery as well as increase fundamental understanding of riboswitch binding and selectivity principles
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