1,721,367 research outputs found
Fine-scale mapping at IGAD1 and genome-wide genetic linkage analysis implicate HLA-DQ/DR as a major susceptibility locus in selective IgA deficiency and common variable immunodeficiency.
No full textGenetic linkage of IgA deficiency due to the Major Histocompatibility Complex: evidence for segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA sntibodies in disease predisposition.
No full textMapping genes underlying complex disorders: progress on IgA deficiency and common variable immunodeficiency
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes
No full textHere we correct the nucleotide sequence of a single known variant of the HLA-DRA gene. We show that the coding regions of the HLA-DRA*0101 and HLA-DRA*0102 alleles do not differ at two codons as reported previously, but only in codon 217. Using nucleotide sequencing and DNA samples from individuals homozygous in the major histocompatibility complex, we found that the variant, leucine 217-encoding HLA-DRA*0102 allele was present on the haplotypes HLA-B*0801, DRB1*03011, DQB1*0201 (ancestral haplotype AH8.1), HLA-B*07021, DRB1*15011, DQB1*0602 (AH7.1), HLA-B*1501, DRB1*15011, DQB1*0602, HLA-B*1501, DRB1*1402, DQB1*03011 and HLA-A3, B*07021, DRB1*1301, DQB1*0603. The HLA-DRA*0101 allele coding for valine 217 was observed on the haplotypes HLA-B*5701, DRB1*0701, DQB1*03032 (AH57.1), HLA-DRB1*04011, DQB1*0302, HLA-DRB1*0701, DQB1*0202, and HLA-DRB1*0101, DQB1*05011
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Erratum: From NiMoO4to γ-NiOOH: Detecting the Active Catalyst Phase by Time Resolved in Situ and Operando Raman Spectroscopy (ACS Nano (2021) 15: 8 (13504−13515) DOI: 10.1021/acsnano.1c04126)
No full textAfter our article was published we became aware of the comprehensive and enlightening study by Liu et al.,1 which we would like to accentuate. In their work, they detect the complete reconstruction of NiMoO4·xH2O nanorods into a highly porous and loose γ-NiOOH structure by electrooxidation in 1 M KOH. By high-resolution transmission electron microscopy (HRTEM) and electron tomography analysis, they could observe that molybdenum leaching, before the oxidation of Ni2+ to Ni3+, causes an amorphous Ni−O layer. This agrees with our X-ray diffraction (XRD) data after molybdenum etching, in which no crystalline phase other than the one of flower-NiMoO4 could be detected.2 By HRTEM, they could infer that the formed γ-NiOOH nanorods are built up from nanosheets when the etching and oxidation step occur subsequently and not simultaneously, which confirms our observation of a roughened sheet-like morphology of our nanorods after catalysis. As in our work, the removal of the vibration spectra of the nanorods was detected by timeresolved in situ Raman spectroscopy measured without applied bias. However, in contrast with us, they suggest that it is the vibration environment that is responsible for the shift of the peak at 355 cm−1 to lower wavenumbers, whereas in our work, this lower wavenumber is assigned to the presence of a flower- NiMoO4 sheet structure between the NiMoO4·xH2O nanorod structure and nickel foam. This was confirmed in our study by performing complementary XRD and Raman spectroscopy studies of flower-NiMoO4 and NiMoO4 nanorods by both selective etching and the additional synthesis of samples with domination of one of the allotropes. We also observe a shift of the peak at 948 cm−1 to slightly lower wavenumbers in their spectra, which, again, is consistent with presence of flower- NiMoO4 sheet structures between the rods and the foam. Interestingly, the anhydrous form of NiMoO4·xH2O, which is also known as α-NiMoO4, shows a much slower leaching rate in 1 M KOH compared with the nanorod-shaped NiMoO4· xH2O.3 Eventually, with 30 wt % KOH or an increased temperature to 51.9 °C in 1 M KOH (as shown in an adjacent study3), molybdenum leaching was achieved for α-NiMoO4. They attributed this to a very limited molybdenum leaching rate that was accelerated by higher concentrated KOH or temperature.2 With the same reasoning and instead considering two different crystal structures, one with more dense/closer packed Ni atoms, it would agree with our detected different molybdenum leaching rates among the different nanostructures, which also possess different crystal structures. This addendum is meant to highlight and acknowledge some recent work we missed in our contribution, with the intention that the additional comments and comparisons made here bring a more complete understanding of the structures and processes present in these systems
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Development of passive immunity against SARS-CoV-2 for management of immunodeficient patients—a perspective
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