894 research outputs found
Improving the Preaching Team Model at Brentwood Baptist Church and Its Regional Campuses
No full textThis project was designed to improve a theological and methodological framework for the preaching team model at Brentwood Baptist Church and its regional campuses that would result in greater unity, alignment, and effectiveness in gospel proclamation as well as provide transferable principles for other multi-site churches or networks that would prefer a preaching team model to a video preaching model. Chapter 1 introduces the ministry context regarding Brentwood Baptist Church and the development of its multi-site structure and the preaching team model. Chapter 2 provides the biblical and theological basis for preaching in a multi-site church structure where faithful men are equipped to contextualize the unchanging message of the gospel to their campus and congregation. Key passages examined are Acts 2:17-36, Ephesians 4:1-16, and 1 Timothy 3:1-16. Chapter 3 examines the multi-site movement and how it is an emerging strategy to fulfill the mission of the church that leverages team-based leadership, collaboration, and the ministerial development of pastors. Chapter 4 details the preaching team meeting assessment, a survey of other churches that utilize preaching teams, the development of “points of excellence” for the preaching team, and the sermon self-evaluation rubric introduced to improve preaching. Chapter 5 concludes with an evaluation of the project and suggestions for improvement
The Art of Biography : Finding Timothy Findley
No full textDr. Grace is a prolific scholar specializing in the study of Canadian literature and culture. She is the author of Canada and the Idea of North (2001, 2007), Making Theatre: The Life of Sharon Pollock (2008), On the Art of Being Canadian (2009), the co-edited volume Bearing Witness: Perspectives on War and Peace from the Arts and Humanities (2012), Landscapes of Memory: Representations of the Two World Wars in Canadian Literature and the Arts (2014), and Tiff: A Life of Timothy Findley (2020). Dr. Grace is a fellow of the Royal Society of Canada and awardee of a Royal Society of Canada’s Lorne Pierce Medal for national career achievement, winner of a Canada Council Killam Prize in Humanities, and recipient of a Canadian Association of Theatre Research Lifetime Achievement award, as well as UBC’s Jacob Biely Faculty Research prize and Killam Prize for Graduate Teaching.Arts, Faculty ofEnglish, Department ofUnreviewedFacult
Synthetic biological circuits for continuous signal processing
No full textThesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 169-182).Natural organisms evolved gene networks that measure continuous environmental information and adjust gene expression to maximize fitness. Engineered cells will need to be capable of similar signal processing and computation in order to operate efficaciously in complex environments, like the human body. In this thesis I describe the development of synthetic biological circuits that enable such capabilities. In the first chapter, analog gene networks are engineered to measure the concentration of molecules and to perform mathematical operations such as addition and division. Building on this work, analog gene networks are next engineered to compensate for input-sensor circuit crosstalk. Finally, in the third chapter, analog-to-digital converters are introduced to convert signals from analog gene circuits into discrete regimes of gene expression. This mixed-signal approach merges the benefits of analog signal processing and of digital signal integration to enable robust continuous signal processing. I posit that the computational architecture demonstrated herein will enable novel applications for the field of synthetic biology.by Jacob Rosenblum Rubens.Ph. D
Bedrooms in the Ford Mansion
No full textIn these bedrooms you can see the military beds that were used in encampments by the officers of the American Army. The field camp beds were collapsible and could be set up with ease indoors or in a field. The un-curtained bed in the background is a rare original surviving from the Revolutionary War. Alexander Hamilton, Lafayette, General Von Stueben and other seniors stayed in these rooms.
The bottom picture is of a bedroom on the first floor of the house that normally would have been the library. This first-floor room is believed to have been used as the bedroom for Mrs. Ford�s three sons during General Washington�s stay. Her sons included Timothy (17), Gabriel (15), and Jacob III (8). Adding to the list of sacrifices by the Fords, Timothy volunteered with the Commander-In-Chief�s Guard and was wounded at the Battle of Springfield in June 1780.Original file name 000_Fotor_Collage.jp
The Role of Chtf18 in Sister Chromatid Cohesion and Post-Replicative Genome Maintenance
No full textMitosis is a critical process that all living cells undergo to produce two identical daughter cells. To ensure that each daughter cell contains the same requisite genetic material, cohesion must be established and maintained between sister chromatids. Chromosome Transmission Fidelity factor 18 (CTF18), a protein subunit of the Replication Factor C-like complex (CTF18-RLC), has functions in DNA replication and also helps to establish cohesion between sister chromatids in yeast. Previously, we demonstrated a function for CHTF18 (the mouse ortholog) in meiotic recombination that is consistent with a role in chromosome cohesion during mammalian meiosis. We used Chtf18−/− and wild type murine embryonic fibroblasts (MEFs) to investigate a possible function for CHTF18 in sister chromatid cohesion and post-replicative genome maintenance. Cultured Chtf18−/− MEFs ceased proliferating after the 6th population doubling compared to wild type MEFs, which continued to proliferate until the 11th doubling. Immunofluorescence staining with 53BP1 antibody, a marker of DNA double strand breaks (DSBs) showed that DSBs are increased in Chtf18−/− MEFs. These findings suggest that defects in cellular proliferation of Chtf18−/− MEFs are due to DNA damage. Analysis of chromosome spreads reveals that Chtf18−/− MEFs may have a propensity for increased sister chromatid separation and breakage. Together, our data indicate a role for CHTF18 in sister chromatid cohesion and post-replicative genome maintenance.M.S., Biochemistry -- Drexel University, 201
New Insights into the Bacterial Fitness-Associated Mechanisms Revealed by the Characterization of Large Plasmids of an Avian Pathogenic E. coli
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Extra-intestinal pathogenic E. coli (ExPEC), including avian pathogenic E. coli (APEC), pose a considerable threat to both human and animal health, with illness causing substantial economic loss. APEC strain chi7122 (O78ratioK80ratioH9), containing three large plasmids [pChi7122-1 (IncFIB/FIIA-FIC), pChi7122-2 (IncFII), and pChi7122-3 (IncI(2))]; and a small plasmid pChi7122-4 (ColE2-like), has been used for many years as a model strain to study the molecular mechanisms of ExPEC pathogenicity and zoonotic potential. We previously sequenced and characterized the plasmid pChi7122-1 and determined its importance in systemic APEC infection; however the roles of the other pChi7122 plasmids were still ambiguous. Herein we present the sequence of the remaining pChi7122 plasmids, confirming that pChi7122-2 and pChi7122-3 encode an ABC iron transport system (eitABCD) and a putative type IV fimbriae respectively, whereas pChi7122-4 is a cryptic plasmid. New features were also identified, including a gene cluster on pChi7122-2 that is not present in other E. coli strains but is found in Salmonella serovars and is predicted to encode the sugars catabolic pathways. In vitro evaluation of the APEC chi7122 derivative strains with the three large plasmids, either individually or in combinations, provided new insights into the role of plasmids in biofilm formation, bile and acid tolerance, and the interaction of E. coli strains with 3-D cultures of intestinal epithelial cells. In this study, we show that the nature and combinations of plasmids, as well as the background of the host strains, have an effect on these phenomena. Our data reveal new insights into the role of extra-chromosomal sequences in fitness and diversity of ExPEC in their phenotypes
Usos sociais da escrita empreendidos por adultos alfabetizandos em programa educacional institucionalizado: dimensões extraescolar e escolar
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em LinguísticaA presente pesquisa tem como objeto a modalidade escrita da língua no cotidiano extraescolar e escolar de adultos alfabetizandos, moradores de Florianópolis - SC, inseridos no mercado de trabalho e participantes do Curso de Educação de Jovens e Adultos - I Segmento da Prefeitura Municipal de Florianópolis. O objetivo desse estudo foi compreender como se caracterizam os usos sociais da escrita nos contextos extraescolar e escolar das alfabetizandas adultas participantes desta pesquisa, inseridas em uma sociedade grafocêntrica, bem como identificar quais as motivações de tais mulheres ao recorrerem a uma instituição escolar a fim de participarem de um programa de alfabetização, descrevendo analiticamente em que medida e/ou de que forma o programa de alfabetização do qual as alfabetizandas adultas participantes deste estudo tomam parte tem lhes facultado e/ou favorecido a construção de novas práticas de letramento e, por implicação, sua inserção em novos eventos de letramentos. Nortearam a pesquisa três grandes questões, contando, cada uma delas, com alguns desdobramentos. A primeira delas: Como se caracterizam os usos sociais da escrita nos contextos extraescolar e escolar das alfabetizandas adultas, participantes desta pesquisa, inseridas em uma sociedade grafocêntrica? Já a segunda: O que motiva as mulheres envolvidas neste estudo a recorrerem a uma instituição escolar a fim de participarem de um programa de alfabetização? A terceira: Em que medida o programa de alfabetização do qual tomam parte tem lhes facultado e/ou favorecido a construção de novas práticas de letramento e, por via de consequência, sua inserção em novos eventos de letramento? Teoricamente, este trabalho foi dividido em quatro partes: na primeira delas, foram discutidos aspectos históricos, indicadores e programas relacionados ao analfabetismo adulto (HADDAD; DI PIERRO, 2000; GALVÃO; SOARES, 2010); na segunda, discutiram-se as especificidades conceituais do letramento e as relações com a alfabetização (HAMILTON; BARTON; IVANIC, 1993; STREET, 1984 e 2003); na terceira, abordaram-se a alfabetização e as implicações no que respeita a acessibilidade social, identidade e empoderamento (GRAFF, 1994; VÓVIO, 2010; BRITTO, 2003; STROMQUIST, 2001; KALMAN, 2003); na quarta, por fim, discutiu-se a alfabetização no que compete à questão dos métodos (MORTATTI, 2006; MATENCIO, 2003) e à natureza das ações pedagógicas endereçadas a alfabetizandos adultos (KLEIMAN, 2007 e 2001 [1995]; FREIRE, 2009 [1982] e 2009 [1969]). Tal pesquisa consiste em um estudo de caso do tipo etnográfico realizado com três alunas do primeiro segmento da Educação de Jovens e Adultos de uma escola do Norte da Ilha do município de Florianópolis/SC. Os resultados sinalizam para a não convergência entre as práticas de letramento das alfabetizandas e as práticas de letramento escolares; para motivações à reinserção escolar de duas naturezas: o que se nomeia pragmatismo estreito e o que se nomeia dimensão ontológica da subjetividade; e, no espaço escolar, tais sinalizações apontam para uma preocupação latente com a evasão na EJA e para um movimento embrionário no sentido de atentar para a necessidade de apropriação/implementação dos usos sociais da língua
Quantifying metastatic inefficiency:rare genotypes versus rare dynamics
No full textWe introduce and solve a 'null model' of stochastic metastatic colonization. The model is described by a single parameter ?: the ratio of the rate of cell division to the rate of cell death for a disseminated tumour cell in a given secondary tissue environment. We are primarily interested in the case in which colonizing cells are poorly adapted for proliferation in the local tissue environment, so that cell death is more likely than cell division, i.e. ? 1, we find that the probability of establishment is exponentially rare, as expected, and yet the mean time for such rare events is of the form ~log (N)/(1 - ?) while the standard deviation of colonization times is ~1/(1 - ?). Thus, counter to naive expectation, for ? 1), i.e. the statistics show a duality mapping (1 - ?) --> (? - 1). We conclude our analysis with a study of heterogeneity in the fitness of colonising cells, and describe a phase diagram delineating parameter regions in which metastatic colonization is dominated either by low or high fitness cells, showing that both are plausible given our current knowledge of physiological conditions in human cancer
The Quest for Citations: Drivers of Article Impact
No full textWhy do some articles become building blocks for future scholars, while many others remain unnoticed? We aim to answer this question by contrasting, synthesizing and simultaneously testing three scientometric perspectives – universalism, social constructivism and presentation – on the influence of article and author characteristics on article citations. To do so, we study all articles published in a sample of five major journals in marketing from 1990 to 2002 that are central to the discipline. We count the number of citations each of these articles has received and regress this count on an extensive set of characteristics of the article (i.e. article quality, article domain, title length, the use of attention grabbers and expositional clarity), and the author (i.e. author visibility and author personal promotion). We find that the number of citations an article in the marketing discipline receives, depends upon “what one says†(quality and domain), on “who says it†(author visibility and personal promotion) and not so much on “how one says it†(title length, the use of attention grabbers, and expositional clarity). Our insights contribute to the marketing literature and are relevant to scientific stakeholders, such as the management of scientific journals and individual academic scholars, as they strive to maximize citations. They are also relevant to marketing practitioners. They inform practitioners on characteristics of the academic journals in marketing and their relevance to decisions they face. On the other hand, they also raise challenges towards making our journals accessible and relevant to marketing practitioners: (1) authors visible to academics are not necessarily visible to practitioners; (2) the readability of an article may hurt academic credibility and impact, while it may be instrumental in influencing practitioners; (3) it remains questionable whether articles that academics assess to be of high quality are also managerially relevant.Impact;Citation Analysis;Referencing;Scientometrics;Cite
Disambiguating Descriptions: Mapping Digital Special Collections Metadata into Linked Open Data Formats
No full textIn this poster we describe the Linked Open Data (LOD) for Digital Special Collections project at the University of Illinois at Urbana-Champaign and describe some of the particular challenges that legacy metadata poses for representation in LOD formats. LOD formats are primarily based on the World Wide Web Consortium’s Resource Description Framework standard which demands both that entities be named by opaque universal identifiers whenever possible but also that metadata descriptions for entities be as unambiguous as possible. The challenges for disambiguating those descriptions are illustrated through examples drawn from digital special collections based at four different digital librariesOpen Restriction set for Item 99117 on 2017-04-28T13:15:31Z with date null by [email protected] by Jacob Jett ([email protected]) on 2017-04-28T13:27:28Z
No. of bitstreams: 2
LOD_ASIST2016_posterFinal.pdf: 292161 bytes, checksum: 35c3144eaa4528c55050741123b58ae7 (MD5)
ASIST2016_poster.pdf: 741377 bytes, checksum: 926b35395a88f651961ae14eb707d9eb (MD5)Rejected by Ayla Stein ([email protected]), reason: Hi Jacob,
Since you're the first author on this item and you're a Graduate Research Assistant, I think it makes more sense for this item to be submitted to the Student Publications and Research - Library and Information Sciences collection (https://www.ideals.illinois.edu/handle/2142/151). Please resubmit this item and select the Student Publications and Research - Library and Information Sciences collection from the drop down menu. If it doesn't appear as an option for you, please let me know so I can provide access.
Thanks,
Ayla on 2017-04-30T18:53:10Z (GMT)Open Restriction set for Item 99117 on 2017-06-01T19:04:32Z with date null by [email protected] by Jacob Jett ([email protected]) on 2017-06-01T19:21:34Z
No. of bitstreams: 2
LOD_ASIST2016_posterFinal.pdf: 292161 bytes, checksum: 35c3144eaa4528c55050741123b58ae7 (MD5)
ASIST2016_poster.pdf: 741377 bytes, checksum: 926b35395a88f651961ae14eb707d9eb (MD5)Approved for entry into archive by Ayla Stein ([email protected]) on 2017-06-01T19:25:02Z (GMT) No. of bitstreams: 2
LOD_ASIST2016_posterFinal.pdf: 292161 bytes, checksum: 35c3144eaa4528c55050741123b58ae7 (MD5)
ASIST2016_poster.pdf: 741377 bytes, checksum: 926b35395a88f651961ae14eb707d9eb (MD5)Made available in DSpace on 2017-06-01T19:25:02Z (GMT). No. of bitstreams: 2
LOD_ASIST2016_posterFinal.pdf: 292161 bytes, checksum: 35c3144eaa4528c55050741123b58ae7 (MD5)
ASIST2016_poster.pdf: 741377 bytes, checksum: 926b35395a88f651961ae14eb707d9eb (MD5)
Previous issue date: 2016Ope
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