1,725,928 research outputs found
MARKETING KONTSEPTSIYALARI HAMDA EVOLYUTSIYASI
No full textMaqolada marketing konseptriyasi hamda evolyusiyasi rivojlanish bosqichlari haqida manbalar keltirilga
Hamda Ibrahim and her trophy
No full textTwo color images of Hamda Ibrahim and her trophy. Hamda won second place of Tarbiyah at the competition at Al- Huda Islamic Center. This competition was for knowledge and recitation of the teachings of Islam
O'ZBEK HAMDA INGLIZ TILLARIDAGI FONETIK O'XSHASHLIKLAR VA FARQLANISHLAR HAMDA ULARNING TARJIMAGA TA'SIRI
No full textUshbu maqola orqali dunyodagi muloqot tillari orasida yetakchi o’rinlarda turuvchi jahon tillarining ,,Qiroli’’ deya yuritiladigan ingliz tili hamda ona tilimizning grammatikasdagi fonetik hodisalari, ularning o’xshash va farqli jihatlari hamda ularning tarjimadagi xususiyatlari haqida ma’lumot beriladi
Cadmium Modulates Expression of Vascular Alpha 1 Adrenoceptors and Aortic Smooth Muscle Cells Phenotype
Get PDFCardiovascular diseases (CVDs) remain the leading cause of death worldwide, including Qatar. Hypertension is one of the most common CVDs that contribute to this mortality. Cadmium (Cd) is a well-known pollutant that has been suggested to be a risk factor for hypertension. However, the underlying mechanisms are still lacking. Very little is known about the effect of Cd on the expression of vascular alpha-1 adrenoceptors (α1 ARs) in vascular smooth muscle cells (VSMCs). This study was therefore undertaken to determine the effect of Cd on the expression and sensitivity of vascular α1 ARs in vitro and in vivo. Along with that, there are several phenotypic changes could modulate the VSMCs function and contribute to CVDs including hypertension. These changes include hypertrophy, migration and senescence. The second objective of this study was to determine the effect of Cd on VSMCs phenotype. Human aortic smooth muscle cells (HASMCs) were incubated with different concentrations of cadmium chloride (CdCl2) for varying durations. The results indicated that Cd increases the expression of α1 ARs, cells were pre-incubated with actinomycin D, a DNA-dependent RNA synthesis inhibitor. Interestingly, the Cd-induced α1 ARs protein expression was abolished by actinomycin D. Moreover, this expression of α1 ARs was diminished when cells were pre-incubated with H89, a protein kinase A (PKA) inhibitor. This indicates that PKA plays an important role in mediating the Cd-induced expression of α1 ARs. α1 ARs activity was determined through functional study. Wistar rats were treated with CdCl2 at dose 15mg/kg/day via drinking water for 8 weeks. Blood pressure was measuredd at the baseline and after 30 days of treatment. Cd didn't affect the vascular reactivity of rat mesenteric arteries in response to α1 ARs agonists, phenylephrine and norepinephrine (NE) as well as blood pressure. Antagonizing α1 ARs with prazosin didn't show any response of other alpha's AR. To determine the effect of Cd on VSMCs phenotype, HASMCs were incubated with CdCl2. Our results showed that cadmium induces hypertrophy, migration and senescence. Taken together, our results dissect a novel pathway employed by Cd to increase expression (not the activity) of vascular α1 ARs, a major player in hypertension as well as VSMCs phenotypic modulation. This new paradigm offers a better understanding and thus potential amelioration of pollution-related CVDs
Oila hamda nikohning pedagogik psixologiya va falsafada o’rganilishi
Get PDFMaqolada avvalambor oila hamda nikohga pedagogik-psixologik va falsafiy qarashlar keltirilib, asosan ularga qisqacha ta’riflar, qadimda va hozirda zamonaviy oilalar hamda eng asosiysi oilalar haqida statistik ma’lumotlar yoritilib o’tiladi
IMOM AL-BUXORIY SHAXSI HAMDA MAQBARASIGA NAZAR
No full textMazkur maqolada Imom al-Buxoriy hazratlarining ilmiy hayot yo`li, hamda Samarqanddagi maqbarasining o`ziga xos jihatlari muhokama etiladi
Yashil Iqtisodiyotning Dolzarbligi Hamda Barqaror Taraqqiyotga Ta'siri
No full textUshbu maqolada yashil iqtisodiyotning nazariy asoslari, dasturlarining samaradorligi va ijtimoiy ta'siri tahlilqilingan. Yashil iqtisodiyotning ekologik muammolarni hal etishdagi roli va iqtisodiy barqarorlikni ta'minlashdagi ahamiyatiyoritilgan. Germaniya, Daniya va Xitoy kabi mamlakatlarning yashil iqtisodiyot dasturlarini amalga oshirish bo‘yichatajribalari o‘rganilgan. Shuningdek, yashil iqtisodiyotga o‘tish jarayonida duch kelinadigan muammolar – investitsiyalaryetishmasligi, texnologiyalarning sekin rivojlanishi va ijtimoiy tengsizlik kabi masalalar ko‘rib chiqilgan. Kelajakda yashiliqtisodiyot dasturlarining rivojlanishi hamda ularning iqtisodiy va ijtimoiy ta'siri muhim ahamiyat kasb etishi kutilmoqda.Mazkur maqola akademik va amaliy tadqiqotlar uchun foydali manba bo‘lib xizmat qiladi hamda yashil iqtisodiyotistiqbollari haqida tahliliy mulohazalar berad
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
DIQQAT VA UNING XUSUSIYATI HAMDA TURLARI
No full text<p>Mazkur maqolada diqqat va uning turlari, diqqatning kuchi va barqarorligi hamda uning inson hayotidagi ahamiyati va diqqat turlarida insonda yuzaga keladigan holatlar aks ettirilgan.</p>
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