221 research outputs found
Erna Fergusson
No full textPortrait of a child (full-length), identified as Erna Fergusson (later a well known New Mexican author), in costume for a Washington's Birthday party sponsored by the Ilfeld family. Three different images on printing-out paper; studio mount car
ERNA and Friedman's reverse mathematics
Get PDFElementary Recursive Nonstandard Analysis, in short ERNA, is a constructive system of nonstandard analysis with a PRA consistency proof, proposed around 1995 by Patrick Suppes and Richard Sommer. Recently, the author showed the consistency of ERNA with several transfer principles and proved results of nonstandard analysis in the resulting theories (see [12] and [13]). Here, we show that Weak Konig's lemma (WKL) and many of its equivalent formulations over RCA(0) from Reverse Mathematics (see [21] and [22]) can be 'pushed down' into the weak theory ERNA. while preserving the equivalences, but at the price of replacing equality with equality 'up to infinitesimals'. It turns out that ERNA plays the role of RCA(0) and that transfer for universal formulas corresponds to WKL
Erna van Duren and Michael Cox
No full textErna van Duren and Michael Cox holding their publication "Responsible Leadership and Strategic Management" at the Campus Author Recognition Program annual reception, October 27, 2011
Memorandum : betr. die Sicherung und Erschliessung der Quellen zur juedischen Kulturgeschichte und Familienkunde.
No full textDocument about the proposed establishment of a center for German Jewish culture and genealogy in Berlin or HamburgdigitizedThe manuscript has been removed from the ‘Lehranstalt fuer die Wissenschaft des Judentums Collection’, AR 11844Born in Hamburg on February 26, 1896, Erna Magnus was a social worker who was engaged in an historical study of the Jewish community of Hamburg during the 1930s. She emigrated to the United States in 1939, where she held various social work and teaching position
The Public Land System of Norwalk, Connecticut, 1654-1704: A Structural Analysis of Economic and Political Relationships
No full textErna Green's thesis for a master of history on the history and examination of the public land system in the city of Norwalk, CT.This thesis is being archived as a Digitized Shelf Copy for campus access to current students and staff only. We currently cannot provide this open access without the author's permission. If you are the author of this work and desire to provide it open access or wish access removed please contact the Wahlstrom Library to discuss permission
14th annual John Perkins Lecture
Get PDFDr. John Perkins returns to campus Tuesday, April 30, 11 a.m., at First Free Methodist Church, for the 14th annual John Perkins Lecture Series. This year’s morning event features Erna Kim Hackett, executive pastor at The Way Berkeley. Later that day, Hackett and Dr. Perkins will continue the morning’s topic, “Words Have Power,” at 7:30 p.m., also in First Free Methodist Church.
John Perkins is one of the leading evangelical voices to come out of the American civil rights movement and an internationally known author, speaker, and teacher. His is the co-founder of SPU’s John Perkins Center for Reconciliation, Leadership Training, and Community Development and the author of the new book One Blood: Parting Words to the Church on Race and Love. Erna Kim Hackett served with InterVarsity for 18 years in Black Ministries and Urban Programs. She is a preacher, pastor, writer, activist, and singer
PERTUMBUHAN DAN PRODUKSI TANAMAN TOMAT (Lycopersium esculentum Mill) PADA PEMBERIAN BERBAGAI DOSIS BUBUK CANGKANG TELUR
Get PDFPenelitian ini dilaksanakan di kelurahan Takkalala Kecamatan Wara Selatan Kota Administratif Palopo, Provinsi Sulawesi Selatan yang mulai bulan Agustus hingga November 2020. Tujuan penelitian untuk mengetahui pertumbuhan dan produksi tanaman tomat terhadap pemberian berbagai dosis pupuk cangkang telur.
Penelitian ini menggunakan percobaan lapangan dengan rancangan acak kelompok (RAK) yang terdiri atas 5 perlakuan, 3 ulangan dan setiap perlakuan terdapat 9 tanaman. Jumlah keseluruhan tanaman sebanyak 45 tanaman. Adapun perlakuan (P) sebagai berikut : P0 = kontrol, P1 = 20/gram bubuk cangkang telur, P2 = 40/gram bubuk cangkang telur, P3 = 60/gram bubuk cangkang telur, P4 = 80/gram bubuk cangkang telur.
Hasil penelitian menunjukkan bahwa pemberian bubuk cangkang telur dengan dosis 80 gram per tanaman (p4) pada tanaman tomat menghasilkan tinggi tanaman tertinggi 56,99, jumlah helaian daun terbanyak 98,66 , jumlah cabang tanaman tomat terbanyak 16,77 , waktu munculnya bunga tercepat 23, jumlah tanaman buah terbanyak 23,89 , berat buah tertinggi 23,37 , panjang buah tertinggi 3,75 dan lingkar buah terbesar 11,15
Uji Efektivitas Pemberian Fungi Mikoriza Arbuskular ( FMA ) Terhadap Cekaman Kekeringan Bibit Kakao Klon Lokal
Get PDFPenelitian ini dilaksanakan di kebun percontohan Jurusan Budidaya Tanaman Perkebunan Politeknik Pertanian Negeri Pangkajene dan Kepulauan yang dimulai pada Juni 2015 sampai September 2015. Penelitian ini bertujuan untuk mengetahui uji efektivitas mikoriza terhadap cekaman kekeringan pada bibit tanaman kakao klon lokal. Interval penyiraman A0 dilakukan setiapa hari, A1 penyiraman dilakukan berselang 1 hari, A2 penyiraman dilakukan selang 2 hari, dan A3 penyiraman dilakukan selang 3 hari. Hasil penelitian menunjukkan bahwa pada interval penyiraman setiap hari dan dengan cendawan mikoriza arbuskular cenderung memiliki tinggi tanaman tertinggi (rata-rata 51,75 cm). Interval penyiraman selang 1 hari yang diinokulasi dengan cendawan mikoriza cenderung memiliki tinggi tanaman tertinggi (rata-rata 44,67 cm). Interval penyiraman selang 2 hari dan diinokulasi dengan cendawan mikoriza cenderung memiliki tinggi tanaman tertinggi (rata-rata 30,50 cm). Interval penyiraman selang 3 hari dan diinokulasi dengan fungi mikoriza memiliki tinggi tanaman tertinggi (rata-rata 26,83 cm)
Tanggap lima varietas tomat terhadap pernberian cendawan mikoriza arbuskula dan asam humik pada sistem hidroponik
Get PDFComputational analysis of active enhancers and their functions in breast cancer patients through the study of eRNA transcription
No full textM.Phil.Enhancers specify cell identity by establishing cell-type specific gene transcription programmes through the recruitment of distinct sets of transcription factors. Aberration of enhancer activity has been linked to various pathogenic conditions including cancers. While enhancers are being widely accepted as non-coding regions in the genome that positively regulate gene expression, accumulating evidences suggest them to be transcription units themselves, producing enhancer RNAs (eRNAs) through uni- or bi-directional transcription. It is dubious whether the RNA transcript or the act of transcription contributes to enhancer activity, but the robustness of eRNA production from active enhancers and the correlation between enhancer transcription and the formation of enhancer-promoter loops suggest eRNA to be a promising signature of active enhancers, on par with, if not outperforming, classic markers such as H3K27ac and a high H3K4me1/H3K4me3 ratio. Aberration of enhancer function by mutations or structural changes in enhancer regions and/or their associated factors have been shown to contribute to tumorigenesis. Recent studies have made use of different enhancer detection methods (e.g. ChIP-Seq, Bisulfite-Seq, GRO-Seq) along with transcriptome profiling to explore the roles of enhancers in cancers. However, the use of multiple techniques is costly, and some of them require a large amount of starting materials and therefore is suitable mostly for cell lines. With growing evidence that enhancers play a major role in tumorigenesis,the field thus calls for a more accessible method to detect aberrant enhancer activities in clinical cancer samples.Making use of breast cancer as an example, a bioinformatics workflow is presented in this thesis to quantify enhancer activity from clinical samples by accurately annotating and quantifying eRNA abundance from total RNA sequencing (RNA-Seq) data. Resulting gene expression change from alteration in enhancer activity could also be detected from the same RNA-Seq data, which greatly reduces sequencing cost and at the same time ensures sample consistency. Significant differential expression between tumor and normal tissue samples was observed for breast cancer-related genes. Some differentially transcribed enhancers were also found to overlap with regions of known variants related to the disease. To evaluate the effect of aberrant enhancer activity on the expression of disease-related genes, enhancer::target regulatory network was constructed using sparse optimisation models. Consistent with previous studies, low order regularisation model was found to outperform L1 regularisation model in this type of analysis.This study potentiates the detection of enhancer malfunction along with the associated deregulation of gene expression from RNA-Seq data of clinical cancer samples, providing a universal computational method for the quantification of eRNA abundance, and also for the prediction of enhancer regulatory networks involved in disease progression. These findings shed lights onto the contribution of enhancers in cancer development, and provide insights into the use of eRNAs or enhancers in the development of cancer diagnosis and therapeutic strategies.透過招募不同的轉錄因子，增強子在不同類型的細胞中建立細胞特異性的基因轉錄程序，從而指定細胞的身份。異常的增強子活動跟癌症以及多種病症有著莫大的關係。縱使增強子一向被廣泛認為是基因組中非編碼的部份，愈來愈多證據顯示增強子能夠被轉錄並通過單向或雙向轉錄產生增強子RNA （enhancer RNA，或 eRNA）。雖然eRNA轉錄本或增強子的轉錄行為是否有助其活性仍然存疑，但活性增強子產生的大量eRNA以及增強子的轉錄與增強子—啟動子環形成的相關性均意味著eRNA是增強子活性的可靠指標，甚至比傳統的標記例如H3K27ac 及高H3K4me1/H3K4me3比例更為準確。因增強子或其相關因子的基因突變或結構改變而產生之異常增強子功能曾被發現有助腫瘤的形成。最近的研究結合轉錄組以及多種增強子檢測方法（例如ChIP-Seq，Bisulfite-Seq，GRO-Seq）探討增強子在癌症中的作用。惟多種方法的結合令實驗變得昂貴，某些技術更需要大量的組織或細胞，因此只適用於細胞系的研究。隨著更多的證據顯示增強子在腫瘤形成中擔當重要的角色，我們需要更方便的方法從臨床癌症樣本中檢測異常的增強子活性。本論文以乳腺癌為例，提出了一個適用於檢視增強子活性的生物信息分析流程。流程從total RNA-Seq數據中準確註釋和量化eRNA的表達，從而量化臨床樣本中之增強子活性。增強子活性之改變而導致的基因表達變化亦能同時從相同之total RNA-Seq數據組中獲取。此舉大大減低了測序成本，亦確保了樣本之間的一致性。分析結果顯示已知與乳腺癌有關的基因之表達在腫瘤及正常組織樣本之間有顯著差異。我們亦發現部份有顯著轉錄差異的增強子與乳腺癌相關之基因組變異出現的區域吻合。為了進一步評估異常之增強子活性對疾病相關的基因表達有何影響，我們利用了稀疏優化模型構建增強子及其靶基因的調控網絡。本研究與之前的研究一致認為低階正則化模型在這類分析中的表現比L1正則化模型表現更為理想。本研究使從臨床腫瘤樣本的RNA-Seq數據中同時檢測異常增強子功能及因此而失調之基因表達變得可能，且提供了可通用於各類型細胞的計算方法來量化eRNA及預測與疾病發展有關的增強子調控網絡。我們的研究揭示了增強子在癌症發展中的作用，並為發展eRNA或增強子作為癌症診斷及治療策略方面提供了新的見解。Cheung, Ka Man Fiona.Thesis M.Phil. Chinese University of Hong Kong 2018.Includes bibliographical references (leaves 93-110).Abstracts also in Chinese.Title from PDF title page (viewed on …)
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