1,821 research outputs found
cancerbits/lch_hierarchy can
No full textCode for Epigenomics and Single-cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis (Halbritter, Farlik, et al. 2019 Cancer Discov.
Jeunesse: Lecture suivie
No full textI am delighted to have found this little paperback in a favorite bookshop in Paris. I look forward to using it myself. It brings two of his best illustrators to a pupil's book of Florian's fables. The colored illustrations are not the only help for those of us trying to understand a sometimes difficult author. There are vocabulary notes, comments, and -- especially -- a short discussion of each fable's moral. These discussions are pleasantly candid, as in this comment on "La taupe et les lapins": "La fable de Florian est peut-être moins claire qu'elle n'y paraȋt" (55). Great work on rendering the colored illustrations!Language note: FrenchFloria
Fables de Florian, Nouvelle Edition
No full textHere is a small edition, 3¼" x 5¼," of 162 pages. It seems to be identical to Bodemann #274, published by the same people two years earlier. As Bodemann notes in a very short description, the illustrations come as three panels per page. One panel often represents two fables. My favorites among these very small illustrations are "The Blind and the Lame" (18); "Two Bachelors" (48); "Owl and Pigeon" (83); and "Ass and Flute" (111). Do not miss the gigantic crocodile on 120! Illustrations occur facing these pages: 1, 12, 18, 29, 38, 48, 66, 83, 111, and 120. There is an AI at the back.This is a hardbound book (hard cover)Language note: FrenchNo Autho
Interview with Florian Bieber
No full textInterview with Florian Bieber, lecturer in East European Politics at the University of Kent in Canterbury, England. Interview conducted in Ithaca, NY on March 13, 2009. Dr. Bieber has worked in Belgrade (Serbia) and Sarajevo (Bosnia-Herzegovina) for the European Centre for Minority Issues and has taught at the Central European University, at the University of Sarajevo and at the University of Bologna. He is also the author of a book about Serbian nationalism, entitled Nationalism in Serbia from the Death of Tito to the Fall of Milosevic (Muenster: Lit Verlag, 2005, in German), and another book, Post-War Bosnia: Ethnic Structure, Inequality and Governance of the Public Sector (London: Palgrave, 2006). He?s at Cornell this spring semester of 2009 as the Luigi Einaudi Chair in European and International Studies.Bieber's current book project (01:30)
Bieber's reflections on the 20th anniversary of 1989 (02:00)
On Bieber's background in political science and history (03:19)
When interdisciplinarity works best (5:22)
On the "ghettoization" of the Balkans and its causes/possible solutions (6:30)
Unique contribution of our field to other fields (9:38)
Addressing the ongoing perception of a division of Europe into "East" and "West" (12:04)
On Bieber's interest in the study of nationalism (16:17)
Is there such a thing as "good nationalism"? (19:12)
On Bieber's "European" upbringing and early education (21:34)
Bieber on experiences/opportunities all Europeans should ideally have (24:56)
On the future of Southeastern Europe (26:17)1_ruh0kx6
Genome-scale transcriptomic and epigenomic analysis of stem cells
Get PDFEmbryonic stem cells (ESCs) are a special type of cell marked by two key properties: The
capacity to create an unlimited number of identical copies of themselves (self-renewal) and the
ability to give rise to differentiated progeny that can contribute to all tissues of the adult body
(pluripotency). Decades of past research have identified many of the genetic determinants of
the state of these cells, such as the transcription factors Pou5f1, Sox2 and Nanog. Many other
transcription factors and, more recently, epigenetic determinants like histone modifications,
have been implicated in the establishment, maintenance and loss of pluripotent stem cell
identity.
The study of these regulators has been boosted by technological advances in the field of
high-throughput sequencing (HTS) that have made it possible to investigate the binding and
modification of many proteins on a genome-wide level, resulting in an explosion of the amount
of genomic data available to researchers. The challenge is now to effectively use these data
and to integrate the manifold measurements into coherent and intelligible models that will
actually help to better understand the way in which gene expression in stem cells is regulated
to maintain their precarious identity.
In this thesis, I first explore the potential of HTS by describing two pilot studies using
the technology to investigate global differences in the transcriptional profiles of different cell
populations. In both cases, I was able to identify a number of promising candidates that mark
and, possibly, explain the phenotypic and functional differences between the cells studied.
The pilot studies highlighted a strong requirement for specialised software to deal with
the analysis of HTS data. I have developed GeneProf, a powerful computational framework
for the integrated analysis of functional genomics experiments. This software platform solves
many recurring data analysis challenges and streamlines, simplifies and standardises data analysis
work flows promoting transparent and reproducible methodologies. The software offers a
graphical, user-friendly interface and integrates expert knowledge to guide researchers through
the analysis process. All primary analysis results are supplemented with a range of informative
plots and summaries that ease the interpretation of the results. Behind the scenes, computationally
demanding tasks are handled remotely on a distributed network of high-performance
computers, removing rate-limiting requirements on local hardware set-up. A flexible and modular
software design lays the foundations for a scalable and extensible framework that will be
expanded to address an even wider range of data analysis tasks in future.
Using GeneProf, billions of data points from over a hundred published studies have been
re-analysed. The results of these analyses are stored in an web-accessible database as part
of the GeneProf system, building up an accessible resource for all life scientists. All results,
together with details about the analysis procedures used, can be browsed and examined in
detail and all final and intermediate results are available and can instantly be reused and
compared with new findings.
In an attempt to elucidate the regulatory mechanisms of ESCs, I use this knowledge base
to identify high-confidence candidate genes relevant to stem cell characteristics by comparing
the transcriptional profiles of ESCs with those of other cell types. Doing so, I describe 229
genes with highly ESC-specific transcription. I then integrate the expression data for these ES-specific genes with genome-wide transcription factor binding and histone modification data.
After investigating the global characteristics of these "regulatory inputs", I employ machine
learning methods to first cluster subgroups of genes with ESC-specific expression patterns and
then to define a "regulatory code" that marks one of the subgroups based on their regulatory
signatures.
The tightly co-regulated core cluster of genes identified in this analysis contains many
known members of the transcriptional circuitry of ESCs and a number of novel candidates
that I deem worthy of further investigations thanks to their similarity to their better known
counterparts. Integrating these candidates and the regulatory code that drives them into our
models of the workings of ESCs might eventually help to refine the ways in which we derive,
culture and manipulate these cells - with all its prospective benefits to research and medicine
Fables de Florian
No full textNouvelle édition, ornée de figures. This diminutive but complete edition (3¼ x 5¼) is not in Bodemann. The British Library seems to have an edition of Florian published by Genets Jeune in 1808. There are four illustrations here: The Cat and the Binoculars (56); The Children and the Partridges (122); The Savant and the Farmer (138); The Countryman and the River (182). There is an AI at the back. The first title-page lists 1821 as the publication date, but the second title-page has 1820.This is a hardbound book (hard cover)Language note: FrenchJean-Pierre Claris de Floria
Jakub Deml's Letters to Josef Florian
No full textTitle: The Letters of Jakub Deml to Josef Florian Author: Igor Pejchal Department: Institute of Czech Literature and Literary Theory Thesis Supervisor: Mgr. Daniela Iwashita, Ph.D. Key Words: correspondence, Jakub Deml, Josef Florian, Josef Ševčík, Otokar Březina, František Bílek, Pavla Kytlicová, Curia of Brno, Studium edition Abstract: The diploma thesis named The Letters of Jakub Deml to Josef Florian includes the edition of all the letters of the writer Jakub Deml (1878-1961). The correspondence from 1903 to 1935 includes 346 units and exploits 6 sources: the copies of letters done by Jaroslav Staněk, handwritten letters archived in Moravian Museum in Brno and LA PNP, Prague, letters addressed to Josef Florian as edited by Jiří Olič and hand-written originals possessed by two private owners. The edition of the collected letters is accompanied by a list of letters, an editorial note and translations of excerpts which are not in Czech. An accompanying study deals with the editorial history of these collected letters, the relationship of Jakup Deml and Josef Florian in the time of their collaboration and provides an outline of the future research tasks regarding this edition. The letters of Jakub Deml to Josef Florian are published in print in..
Determination of the Fiber Orientation from low resolution Computer Tomography images using Neural Networks
No full textAuthor Florian Schininger, BScMasterarbeit Universität Linz 2023Arbeit gesperr
A discussion and improvement of Churchland's theory of connectionism
No full textauthor: Florian WundsamLiteraturverzeichnis: Seite 101-102Diplomarbeit University of Salzburg 202
Determination of the Fiber Orientation from low resolution Computer Tomography images using Neural Networks
No full textAuthor Florian Schininger, BScMasterarbeit Universität Linz 2023Arbeit gesperr
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