956 research outputs found
Reading: Amit Majmudar
No full textBecause of COVID-19 this event is canceled.
Amit Majmudar, a multi-genre author and translator, offers a Sacred Arts Festival reading that explores the concept of Building Bridges.
Co-sponsored by the Department of English and the Sacred Arts Festival
Exploring young students creativity: The effect of model eliciting activities
No full textThe aim of this paper is to show how engaging students in real-life mathematical situations can stimulate their mathematical creative thinking. We analyzed the mathematical modeling of two girls, aged 10 and 13 years, as they worked on an authentic task involving the selection of a track team. The girls displayed several modeling cycles that revealed their thinking processes, as well as cognitive and affective features that may serve as the foundation for a methodology that uses model-eliciting activities to promote the mathematical creative process
Social Stratification of the Jewish Population of Roman Palestine in the Period of the Mishnah, 70–250 CE, written by Ben Zion Rosenfeld and Haim Perlmutter
No full textA review of Social Stratification of the Jewish Population of Roman Palestine in the Period of the Mishnah, 70–250 CE, written by Ben Zion Rosenfeld and Haim Perlmutte
Loss of Inducible Nitric Oxide Synthase Expression in the Mouse Renal Cell Carcinoma Cell Line RENCA Is Mediated by MicroRNA miR-146a
No full textTumor-associated macrophages can potentially kill tumor cells via the high concentrations of nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS); however, tumor-associated macrophages actually support tumor growth, as they are skewed toward M2 activation, which is characterized by low amounts of NO production and is proangiogenic. We show that the mouse renal cell carcinoma cell line, RENCA, which, on stimulation, expresses high levels of iNOS mRNA, loses its ability to express the iNOS protein. This effect is mediated by the microRNA miR-146a, as inhibition of RENCA cells with anti-miR- 146a restores iNOS expression and NO production (4.8 ± 0.4 versus 0.3 ± 0.1 μmol/L in uninhibited cells, P < 0.001). In vivo, RENCA tumor cells do not stain for iNOS, while infiltrating tumor-associated macrophages showed intense staining, and both cell types expressed iNOS mRNA. Restoring iNOS protein expression in RENCA cells using anti-miR-146a increases macrophage-induced death of RENCA cells by 73% (P < 0.01) in vitro and prevents tumor growth in vivo. These results suggest that, in addition to NO production by macrophages, tumor cells must produce NO to induce their own deaths, and some tumor cells may use miR-146a to reduce or abolish endogenous NO production to escape macrophage-mediated cell death. Thus, inhibiting miR-146a may render these tumor cells susceptible to therapeutic strategies, such as adoptive transfer of M1-activated macrophages
Reviewing the Author-Function in the Age of Wikipedia
No full textIn Reviewing the Author-Function in the Age of Wikipedia, Amit Ray and Erhardt Graeff examine how wiki technology challenges traditional concepts of authorship and authority in knowledge production. The authors build on poststructuralist theory, particularly Roland Barthes\u27s Death of the Author and Michel Foucault\u27s concept of the author-function, to analyze how wikis destabilize individual authorship in favor of collaborative, community-driven content creation.
The essay argues that wikis represent a fundamental shift from the Romantic notion of the solitary author-genius to what they term the wiki writing process —a dynamic system where traditional roles of reader, writer, and editor blur into a unified community of users. Using Wikipedia as a primary case study, the authors demonstrate how the platform\u27s structure (article, discussion, and history pages) creates a digital palimpsest that archives all contributions while enabling continuous revision.
Through analysis of Wikipedia\u27s editing patterns and community oversight mechanisms, Ray and Graeff show how wikis embody poststructuralist principles in practice, creating what they call serial collaborations that exist in perpetual flux. The authors conclude that wikis represent an evolved form of textual production that realizes Foucault\u27s vision of discourse freed from traditional authorial constraints, offering new possibilities for collaborative knowledge creation while challenging established notions of intellectual authority and ownership
The Architecture of India
No full textBook review of "India: Modern Architecture in History" and author interview with Peter Scriver and Amit Srivastav
The complex interplay between mechanical forces, tissue response and individual susceptibility to pressure ulcers
No full textObjective: The most recent edition of the International Clinical Practice Guideline for the Prevention and Treatment of Pressure Ulcers/Injuries was released in 2019. Shortly after, in 2020, the first edition of the SECURE Prevention expert panel report, focusing on device-related pressure ulcers/injuries, was published as a special issue in the Journal of Wound Care. A second edition followed in 2022. This article presents a comprehensive summary of the current understanding of the causes of pressure ulcers/injuries (PU/Is) as detailed in these globally recognised consensus documents. Method: The literature reviewed in this summary specifically addresses the impact of prolonged soft tissue deformations on the viability of cells and tissues in the context of PU/Is related to bodyweight or medical devices. Results: Prolonged soft tissue deformations initially result in cell death and tissue damage on a microscopic scale, potentially leading to development of clinical PU/Is overtime. That is, localised high tissue deformations or mechanical stress concentrations can cause microscopic damage within minutes, but it may take several hours of continued mechanical loading for this initial cell and tissue damage to become visible and clinically noticeable. Superficial tissue damage primarily stems from excessive shear loading on fragile or vulnerable skin. In contrast, deeper PU/Is, known as deep tissue injuries, typically arise from stress concentrations in soft tissues at body regions over sharp or curved bony prominences, or under stiff medical devices in prolonged contact with the skin. Conclusion: This review promotes deeper understanding of the pathophysiology of PU/Is, indicating that their primary prevention should focus on alleviating the exposure of cells and tissues to stress concentrations. This goal can be achieved either by reducing the intensity of stress concentrations in soft tissues, or by decreasing the exposure time of soft tissues to such stress concentrations. Declaration of interest: The author has no conflicts of interest
Advancing Health Research in Humanitarian Crises
No full textAUTHOR AFFILIATION: Amit Mistry, Fogarty International Center, National Institutes of Health (NIH), United States, [email protected] media can be accessed here:
http://streaming.osu.edu/knowledgebank/PREA/PREA_Session7A_Mistry_20190325.mp4This presentation identifies the mission of the Fogarty Center at the National Institutes of Health. Within this, the Advancing Health Research in Humanitarian Crises program has been initiated recently. Specific projects within this program will be described, as well as resources and funding streams within Fogarty. Research ethics is an important cross-cutting strand across these projects
Leaders of the field: What does the future hold for single molecule technology?
No full textIn recent years, single molecule technology has experienced a rapid growth, with exciting developments in fundamental research and real-world applications. Detecting and studying biological phenomena on thesingle molecule level requires a unique synergy between researchers working on instrumentation, physics, and the life sciences. In the iScience special issue ‘‘Single Molecule Technology – From Biotechnology toBiomedical Applications’’, guest edited by Amit Meller and Chirlmin Joo (Figure 1), we are highlighting a variety of research on nanopore technology, single molecule fluorescence, and a selection of other ultra-sensitive detection methods. More content in the special issue can be found here: https://www.sciencedirect.com/journal/iscience/special-issue/10PGSBV55N0. The guest editors in this backstory share their thoughts on what is currently exciting in the field, and the advances they think will make an impact in the near future.BN/Chirlmin Joo La
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