1,397 research outputs found
STANDARD COMBINATION CHEMOTHERAPY VERSUS 2 CARBOPLATIN-CONTAINING REGIMENS IN SMALL-CELL LUNG-CANCER - A RANDOMIZED PHASE-II STUDY - PRELIMINARY-RESULTS
No full textSTANDARD COMBINATION CHEMOTHERAPY VERSUS 2 CARBOPLATIN-CONTAINING REGIMENS IN SMALL-CELL LUNG-CANCER - A RANDOMIZED PHASE-II STUDY - PRELIMINARY-RESULTS
No full textDK conjecture for Grassmannian flips
No full textPh.D.We investigate the DK conjecture on derived categories of coherent sheaves stated by Bondal-Orlov and Kawamata: there should be a derived embedding for any flip and in particular a derived equivalence for any flop. Unlike the situations for flops, there are few examples of flips proven to satisfy the DK conjecture except for some toroidal flips.We construct new examples of flips from Grassmannians, called Grassmannian flips, that satisfy the DK conjecture.我們對由彭督-奧爾洛夫（Bondal-Orlov）和川又（Kawamata）提出關於凝聚層的導出範疇相關的DK猜測進行探討：即對於任何翻轉（flip），都應該有導出（範疇的）嵌入，尤其是對於任何平轉 （flop），都應該有導出（範疇的）等價。與平轉（flop）的情況不同，除了一些環形翻轉（toroidal flips） 之外，鮮有反轉的例子證明能夠被證明滿足DK猜想。我們從格拉斯曼簇出發構造了滿足DK猜想的新例子，稱為格拉斯曼翻轉（Grassmannian flips）。Xie, Ying.Thesis Ph.D. Chinese University of Hong Kong 2020.Includes bibliographical references (leaves 84-88).Abstracts also in Chinese.Title from PDF title page (viewed on February 7, 2022)
Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: study of nine cases
No full textMorphologic, immunologic, cytogenetic, and clinical features were studied in 9 cases of acute undifferentiated leukemia (AUL). These patients were unclassifiable by FAB criteria, they were CD34+ and did not express myeloid- or lymphoid-associated antigens (CD13, CD33, CD14, CD15, CD61, CD19, CD10, CD22, CD7, CD2, CD5, CD3). Clonal abnormalities were seen in 8 of 9 cases. Del(5q) as the sole anomaly was observed in 3 cases; +13 was the primary change in 3 cases, and isolated trisomy 12 was found in 1 patient. A complex karyotype with trisomy 12q, in association with del 17p and trisomy 21q was detected in 1 case. One patient with 5q- relapsed with refractory anemia with excess of blasts; the presence of dysgranulopoiesis and a few blasts with possible monocytoid morphology in the remaining 2 patients point to a "myeloid nature" of these leukemias. Analysis of cytologic features in our 3 patients with +13, in combination with previously reported cases, suggests the occurrence of immature stem cell involvement with limited differentiation potential, possibly more along the myeloid than the lymphoid lineage. The significance of trisomy 12q in this subset of leukemia remains elusive; some clues of minimal differentiation towards the myeloid lineage in our cases are provided by positivity for the CD117 (c-kit) antigen and by relapse with acute myeloid leukemia without maturation (M1) in one patient. We conclude that, with presently available diagnostic techniques, AUL is a rare subset of leukemia, in which cytogenetic changes are confined to a few chromosomes, with prevalent involvement of 5q and of chromosomes 13 and 12. Chromosome findings may be of value in clinical practice, especially in those cases with "myeloid-oriented" karyotype
Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia
No full textAt diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3)] were detected in bone marrow samples from 71 of 153 patients with acute myelogenous leukemia (AML) (46%): in 41 patients with primary AML (pAML) (58%) and in 30 patients with secondary AML (42%). In all cases with promyelocytic leukemia (AML-M3) RAR-alpha gene rearrangements were detected (n = 9). Gene rearrangements in the Ig-JH or the TcR-beta or GM-CSF or IL-3 or MLL gene were detected in 12, 10, 16 and 12% of the cases, respectively, whereas only few cases showed gene rearrangements in the M-bcr (6%) or G-CSF gene (3%). Survival of pAML patients with TcR-beta gene rearrangements was longer and survival of pAML patients with IL-3 or GM-CSF gene rearrangement was shorter than in patients without those rearrangements. No worse survival outcome was seen in patients with rearrangements in the MLL, Ig-JH or M-bcr gene. In remission of AML (CR), clonal gene rearrangements were detected in 23 of 48 cases (48%) if samples were taken once in CR, in 23 of 26 cases (88%) if samples were taken twice in CR and in 23 of 23 cases (100%) if samples were studied three times in CR. All cases with gene rearrangements at diagnosis showed the same kind of rearrangement at relapse of the disease (n = 12). Our data show that (1) populations with clonal gene rearrangements can be regularly detected at diagnosis, in CR and at relapse of AML. (2) Certain gene rearrangements that are detectable at diagnosis have a prognostic significance for the patients' outcome. Our results point out the significance of gene rearrangement analyses at diagnosis of AML in order to identify `poor risk' patients - independently of the karyotype. Moreover, the persistence of clonal cells in the further course of AML can be studied by gene rearrangement analysis. Copyright (C) 2000 S. Karger AG, Basel
Nu-DESC DK: the Danish version of the nursing delirium screening scale (nu-DESC)
No full textAbstract Background Delirium is one of the most common complications among elderly hospitalized patients, postoperative patients and patients on intensive care units with a prevalence between 11 and 80%. Delirium is associated with higher morbidity and mortality. Reliable instruments are required to detect delirium at an early time point. The Nursing-Delirium Screening Scale (Nu-DESC) is a screening tool with high sensitivity and good specificity. However, there is currently no official translation after ISPOR guidelines of any Danish delirium assessment tools available. Thereby hampering the implementation of 2017 ESA-Guidelines on postoperative Delirium in the clinical routine. The aim of this study is to provide an official translation and evaluation of the Nu-DESC into Danish following the ISPOR process. Methods The Nu-DESC was translated after International Society for Pharmacoecomonics and Outcome Research (ISPOR) guidelines to Danish after permission of the original author, and is evaluated by medical staff and finally approved by the original author. Results All steps of the ISPOR guideline were consecutively followed, without any major problems. The evaluation of the Nu-DESC DK regarding its intelligibility and feasibility showed no statistically significant differences between nurses and medical doctors ratings. The translation was authorized and approved by the original author. Conclusion This study provides the Nu-DESC DK, an official Danish delirium screening instrument, which can detect all psychomotor types of delirium
Relativistic segmented contraction basis sets with core-valence correlation effects for atoms 57La through 71Lu : Sapporo-DK-nZP sets (n = D, T, Q)
No full textFor the 15 lanthanide atoms 57La through 71Lu, we report Sapporo-DK-nZP sets (n = D, T, Q), which are natural extensions of the Sapporo-(DK)-nZP sets for lighter atoms and efficiently incorporate the correlation among electrons in the N through P shells as well as the relativistic effect. The present sets well describe the correlation among the 4s and 4p electrons, which are important in the excitation of 4f electrons. Atomic test calculations of 57La, 58Ce, 59Pr, and 60Nd at configuration interaction with the Davidson correction level of theory confirm high performance of the present basis sets. Molecular test calculations are carried out for 57LaF and 70YbF diatomics at the coupled cluster level of theory. The calculated spectroscopic constants approach smoothly to the experimental values as the quality of the basis set increases
The Gender Gap in Political Knowledge: Is It All About Guessing? An Experimental Approach
No full textThis article analyzes the extent to which the format and the “Do not know” (DK) protocol of political knowledge questions influence the size of the gender gap. By using a set of experiments that manipulated the DK protocol and the format (open vs. closed ended) of political knowledge questions in a face-to-face representative survey of the Spanish population, we show that the format of the questions (open vs. closed ended) is not relevant in explaining the gender gap. DK protocols, however, influence outspoken levels of political knowledge differently for men and women. DK-discouraging protocols tend to encourage the emergence of hidden knowledge among women, whereas they mostly boost guessing among men. This finding suggests that the meaning and the use of the DK option appear to be gender biased
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