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No full textDetecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important immune system infection cues (Abbas et al., 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior to infection. Here we show that Drosophila melanogaster display strong aversive responses to LPS and that gustatory neurons expressing Gr66a bitter receptors mediate avoidance of LPS in feeding and egg laying assays. We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance. Furthermore, LPS stimulates Drosophila neurons in a TRPA1-dependent manner and activates exogenous dTRPA1 channels in human cells. Our findings demonstrate that flies detect bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.sponsorship: Vlaams Instituut voor Biotechnologie Alessia Soldano Luis Franco Guangda Liu Natalia Mora Emre Yaksi Bassem A Hassanr Fonds Wetenschappelijk Onderzoek G.0702.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0077.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0680.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0681.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0503.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0654.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0761.10N Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0596.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0565.07 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven GOA/14/011 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar European Commission IUAP P7/13 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekensr KU Leuven OT/12/091 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven PF-TRPLe Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talavera (Vlaams Instituut voor Biotechnologie, Fonds Wetenschappelijk Onderzoek|G.0702.12, Fonds Wetenschappelijk Onderzoek|G.0077.15, Fonds Wetenschappelijk Onderzoek|G.0680.10, Fonds Wetenschappelijk Onderzoek|G.0681.10, Fonds Wetenschappelijk Onderzoek|G.0503.12, Fonds Wetenschappelijk Onderzoek|G.0654.15, Fonds Wetenschappelijk Onderzoek|G.0761.10N, Fonds Wetenschappelijk Onderzoek|G.0596.12, KU Leuven|GOA/14/011, KU Leuven|OT/12/091, European Commission|IUAP P7/13, KU Leuven PF-TRPLe)status: Publishe
Omar Hassan, o del limite da superare
No full textIl saggio prende in esame la figura di Omar Hassan, artista classe 1987, figlio di padre egiziano e madre italiana nato e cresciuto a Milano, che rivolge il proprio interesse per il linguaggio della Street Art per poi consolidare la propria formazione all’Accademia di Belle Arti di Brera con Alberto Garutti.
Il contributo ne inquadra la figura nel panorama dell'arte del secondo dopoguerra e dell'Action Painting con particolare riferimento alla produzione più recente e alle opere site specific realizzate ad hoc per la Sala Duca Montalto del Palazzo dei Normanni a Palermo
Hassan Bakhti\u27s volunteer identification badge.
No full textPhoto of Hassan Bakhti\u27s volunteer identification badge for the 2002 Winter Olympic
Hassan Bakhti wearing his uniform in an Olympic tent.
No full textPhoto of volunteer Hassan Bakhti wearing his uniform in a tent during the 2002 Winter Olympic
Colorectal cancer risk reduction after polypectomy: evidence against the national polyp study
No full textN/
Farkhonda Hassan Oral History
No full textFarkhonda Hassan was a faculty member in science at the American University in Cairo from the 1970s to 2003, having been a graduate student there in the 1960s. Hassan outlines her family's background and her experience as a primary and secondary student at the Coptic Girl’s College. She recalls how she became interested in geology as a child, and going on to study geology at Cairo University, despite the few women in the discipline. Hassan recounts coming to AUC as a student in the first year of its solid-state science graduate program in 1964, and describes the Science Department’s faculty (like Chairman Adli Bishay) and its facilities in the 1960s, including the opening of the new Science Building. She also offers a portrait of the downtown campus and social life in those years. Hassan tells of pursuing her doctorate in geology in the United States, and her study there of moon rocks in the late 1960s. She speaks of her return to Egypt to join AUC’s Science faculty in the early 1970s, as one of several early-career science faculty hired by the university, and discusses developments in the sciences and engineering at AUC over the years. Hassan describes the response of AUC administrators, faculty, and students to the 1973 War, including volunteer work at nearby hospitals, and profiles AUC students over the course of her time at the university. Her committee service, role in seeking retirement age equity for Egyptian faculty at AUC, and research pursuits are also covered. Hassan also discusses her service in Egypt’s Parliament (including the Shura Council) and work in nongovernmental and international organizations on environmental and women’s issues
The Hassan mosque at the digital era.
No full textInternational audienceAbout ten years ago, the double behest of late Driss Aboutajdine and El Mustapha Mouad-dib permitted setting up research partnership on the use of image processing and cultural heritage. In 2015, despite his workload, Professor Driss Aboutajdine has put all his energy so a common complementary action could take place and occur, convening hence the numerical sciences, precisely 3D techniques, serving cultural heritage. This action went on to give birth to Athar-3D project, with the ambition to resolve questions pertaining to 3D modeling and computer vision having along a positive impact on cultural and architectural heritage perception. The research we carried out in this framework aims to the digitizing of Hassan Mosque, its reconstitution and the achievement of mechanism and application to heighten awareness and to better know and communicate about cultural heritage matter. To our knowledge, this is the first work of its kind and with this scientific extent on cultural and architectural heritage in Morocco. Moreover, finding an extension of academic research in the dissemination, the bringing back and mediation on this monument that stands for a symbol and emblem of Morocco's capital, is a direct valorization of research work performed in Moroccan research laboratories. This paper presents representative results of the whole project, including its historical and arts history, especially on Rabat Hassan Mosque. We are providing, for the first time, results that make possible 3D display of what Hassan Mosque might looks like. This model with the vocation to be a scientific support and medium and to which we attempted to bring all the necessary rigor. This will serve the scientific study of the monument, the popularization and awareness raising with respect to cultural heritage matters in general and Hassan Mosque in particular. We hope, therefore, to remain faithful to one of the wishes of Professor Driss Aboutajdine
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