667 research outputs found
Interleukin 1 beta recombinant vaccine for treating pulmonary fibrosis and application thereof (CN108404125B)
No full textAbstract Interleukin 1 beta recombinant vaccine for treating pulmonary fibrosis and application thereof The invention discloses an IL-1 beta vaccine for treating pulmonary fibrosis. A recombinant PfTrx-IL-1 beta vaccine established by inserting epitope of IL-1 beta into a PfTrx carrier sequence can successfully stimulate an organism to generate high-potency IL-1 beta resistant neutralizing antibody and can obviously relieve pulmonary fibrosis induced by bleomycin. Immunity of the IL-1 beta vaccine can obviously inhibit mouse pulmonary tissue collagen deposition, the vaccine can lower expression level of TGF-beta 1, CTGF and PDGFB in mouse, and these characteristics are highly conducive to slowing down the process of pulmonary fibrosis. Therefore, the IL-1 beta vaccine is expected to be developed into an effective means for treating pulmonary fibrosis
A Non-invasive Method for Removing a Non-Deflatable Bladder Catheter.mp4
No full textTitle: A Non-invasive Method for Removing a Non-Deflatable Bladder CatheterJournal: International Urology and NephrologyAuthor: Qing Cheng; Haibo Zhang; Guoren Wang; Zhenxiang Liu; Zhiming BaiCorresponding author: Zhiming BaiE-mail: [email protected] </p
Spurious OLS Estimators of Detrending Method by Adding a Linear Trend in Difference-Stationary Processes - A Mathematical Proof and its Verification by Simulation
No full textInternational audiencefirst_pagesettingsOrder Article ReprintsOpen AccessArticleSpurious OLS Estimators of Detrending Method by Adding a Linear Trend in Difference-Stationary Processes—A Mathematical Proof and Its Verification by Simulationby Zhiming LONG1,* and Rémy HERRERA21Research Center for College Moral Education, Tsinghua University, 307C Shanzhai Building, Tsinghua University, Beijing 100084, China2CNRS (National Center for Scientific Research)—UMR 8174 Centre d’Économie de la, Maison des Sciences Economiques de l’Université de Paris 1 Panthéon-Sorbonne 106-112 boulevard de l’Hôpital, 75013 Paris, France*Author to whom correspondence should be addressed.Mathematics 2020, 8(11), 1931; https://doi.org/10.3390/math8111931Received: 2 September 2020 / Revised: 23 September 2020 / Accepted: 25 September 2020 / Published: 2 November 2020(This article belongs to the Section Dynamical Systems)Download Browse FiguresVersions NotesAbstractAdding a linear trend in regressions is a frequent detrending method in economic literatures. The traditional literatures pointed out that if the variable considered is a difference-stationary process, then it will artificially create pseudo-periodicity in the residuals. In this paper, we further show that the real problem might be more serious. As the Ordinary Least Squares (OLS) estimators themselves are of such a detrending method is spurious. The first part provides a mathematical proof with Chebyshev’s inequality and Sims–Stock–Watson’s algorithm to show that the OLS estimator of trend converges toward zero in probability, and the other OLS estimator diverges when the sample size tends to infinity. The second part designs Monte Carlo simulations with a sample size of 1,000,000 as an approximation of infinity. The seed values used are the true random numbers generated by a hardware random number generator in order to avoid the pseudo-randomness of random numbers given by software. This paper repeats the experiment 100 times, and gets consistent results with mathematical proof. The last part provides a brief discussion of detrending strategies
Colistin Resistance Mechanisms and Molecular Epidemiology of Enterobacter cloacae Complex Isolated from a Tertiary Hospital in Shandong, China
No full textZaifeng Si,1,2,* Shengmei Zhao,3,* Yingying Hao,3 Qian Wang,3 Yanfa Zhong,2 Yue Liu,3 Ran Chen,3 Yan Jin,3 Zhiming Lu1,3 1Department of Clinical Laboratory, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Clinical Laboratory, Dezhou Municipal Hospital of Traditional Chinese Medicine, Dezhou, Shandong, People’s Republic of China; 3Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Jin; Zhiming Lu, Email [email protected]; [email protected]: Enterobacter cloacae complex (ECC), which includes major nosocomial pathogens, causes urinary, respiratory, and bloodstream infections in humans, for which colistin is one of the last-line drugs.Objective: This study aimed to analyse the epidemiology and resistance mechanisms of colistin-resistant Enterobacter cloacae complex (ECC) strains isolated from Shandong, China.Methods: Two hundred non-repetitive ECC strains were collected from a tertiary hospital in Shandong Province, China, from June 2020 to June 2022. Whole-genome sequencing and bioinformatics analyses were performed to understand the molecular epidemiology of the colistin-resistant ECC strains. The nucleotide sequences of heat shock protein (hsp60) were analyzed by using BLAST search to classify ECC. The gene expression levels of ramA, soxS, acrA, acrB, phoP, and phoQ were assessed using RT-qPCR. MALDI-TOF MS was used to analyse the modification of lipid A.Results: Twenty-three colistin-resistant strains were detected among the 200 ECC clinical strains (11.5%). The hsp60 cluster analysis revealed that 20 of the 23 ECC strains belonged to heterogeneous resistance clusters. Variants of mgrB, phoPQ, and pmrAB, particularly phoQ and pmrB, were detected in the 23 ECC strains. The soxS and acrA genes were significantly overexpressed in all 23 colistin-resistant ECC strains (P < 0.05). Additionally, all 23 ECC strains contained modified lipid A related to colistin resistance, which showed five ion peaks at m/z 1876, 1920, 1955, 2114, and 2158. Among the 23 ECC strains, 6 strains possessed a phosphoethanolamine (pETN) moiety, 16 strains possessed a 4-amino-4-deoxy-L-arabinose (−L-Ara4N) moiety, and one strain had both pETN and −L-Ara4N moieties.Conclusion: This study suggests that diverse colistin resistance existed in ECC, including unknown resistance mechanisms, exist in ECC. Mechanistic investigations of colistin resistance are warranted to optimise colistin use in clinical settings and minimise the emergence of resistance.Keywords: Enterobacter cloacae complex, ECC, epidemiology, colistin, resistance mechanis
Development of the DNDC model to improve soil hydrology and incorporate mechanistic tile drainage: A comparative analysis with RZWQM2
No full textThe Denitrification Decomposition model (DNDC) has known limitations for simulating soil hydrology which can strongly influence biogeochemical processes. For this study, DNDC's soil hydrological framework was enhanced by including a new sub-model for mechanistic tile drainage, improved water flux, root growth dynamics, and a deeper and heterogeneous soil profile. Comparisons were then conducted against the Root Zone Water Quality Model (RZWQM2), using measurements of soil water storage, runoff, and drainage in eastern Canada and the US Midwest. Simulation of soil water storage (DNDC 0.81 ≤ d ≤ 0.90; RZWQM2 0.76 ≤ d ≤ 0.84), daily water flow (DNDC 0.76 ≤ d ≤ 0.88; RZWQM2 0.77 ≤ d ≤ 0.90) and nitrogen loading to tile drains were improved post-development. DNDC was able to capture the observed differences in water and N losses between conventional drainage and controlled drainage management with sub-irrigation. The enhancements to DNDC's hydrological framework should enable the development of improved biogeochemical processes.This article is published as Smith, Ward, Brian Grant, Zhiming Qi, Wentian He, Andrew VanderZaag, Craig F. Drury, and Matthew Helmers. "Development of the DNDC model to improve soil hydrology and incorporate mechanistic tile drainage: A comparative analysis with RZWQM2." Environmental Modelling & Software 123 (2020): 104577. DOI: 10.1016/j.envsoft.2019.104577. Copyright 2019 The Author(s). Attribution 4.0 International (CC BY 4.0). Posted with permission
In vitro biodegradation behavior of magnesium and magnesium alloy
No full textMagnesium has the potential to be used as degradable metallic biomaterial. For magnesium and its alloys to be used as biodegradable implant materials, their degradation rates should be consistent with the rate of healing of the affected tissue, and the release of the degradation products should be within the body's acceptable absorption levels. Conventional magnesium degrades rapidly, which is undesirable. In this study, biodegradation behaviors of high purity magnesium and commercial purity magnesium alloy AZ31 in both static and dynamic Hank's solution are systematically investigated. The in vitro test results show that magnesium purification and selective alloying are effective approaches to reduce the degradation rate of magnesium. In the static condition, the corrosion products accumulate on the materials surface as a protective layer, which results in a lower degradation rate than the dynamic condition. Anodized coating can significantly further reduce the degradation rate of magnesium. This study strongly indicates that magnesium can be used as degradable implant material as long as the degradation is controlled at a low rate. Magnesium purification, selective alloying, and anodized coating are three effective approaches to reduce the rate of degradation
High symbol-rate polarization interference cancelation for satellite-to-ground remote sensing data transmission system
No full textAbstract To remove the impacts of polarization interference on satellite-to-ground high-speed data transmission systems, the major factors that affect polarization interference are concluded, the deteriorations of bit error rate (BER) of different modulation systems and channel coding modes are simulated, and the parallel adaptive filtering technology is presented to resolve the high symbol-rate signal transmission polarization interference. It has been verified by experiments that the effects of this method is remarkable. In the situation of QPSK system, 500MSPS symbol rate and 10 dB polarization isolation, the BER performance can be improved 4.5 dB by using this method
Enhancing machining accuracy reliability of multi-axis CNC Indexed by: machine tools using an advanced importance sampling method
No full textThe purpose of this paper is to propose a general precision allocation method to improve machining performance of CNC machine tools based on certain design requirements. A comprehensive error model of machine tools is established by using the differential motion relation of coordinate frames. Based on the comprehensive error model, a reliability model is established by updating the primary reliability with an advanced importance sampling method, which is used to predict the machining accuracy reliability of machine tools. Besides, to identify and optimize geometric error parameters which have a great influence on machining accuracy reliability of machine tools, the sensitivity analysis of machining accuracy is carried out by improved first-order second-moment method. Taking a large CNC gantry guide rail grinder as an example, the optimization results show that the method is effective and can realize reliability optimization of machining accuracy
On-chip time and frequency modes for the generation and processing of complex photon states
No full textWe exploit the time and frequency modes generated on integrated quantum platforms for the practical generation and coherent processing of complex photon states (two-level time-entangled photons, d-level frequency-entangled photon pairs, and d-level cluster states), by using only standard silicon-based chips and fiber telecommunications components
Telecom-compatible, on-chip generation and processing of complex photon states in time and frequency
No full textWe exploit the time and frequency modes of light generated on integrated platforms for the practical generation and coherent processing of complex photon states (2-level time-entangled photons, d-level frequency-entangled photon pairs, and 3-level discrete cluster states), by using standard silicon-based chips and fiber telecommunications components
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