1,720,954 research outputs found
PERBANDINGAN EFEK PEMBERIAN COENZYME Q10 DAN CITICOLINE TERHADAP DENSITAS SEL GANGLION RETINA PADAETHAMBUTOL INDUCED OPTIC NEUROPATHY
Full text linkPendahuluan: Neuropati optik etambutol merupakan neuropati optik yang muncul
akibat efek toksik etambutol. Gejala dapat ringan hingga berat yang mengancam
penglihatan. Terapi definitif berupa menghentikan etambutol serta adjuvan untuk
mencegah kerusakan sel ganglion retina. Coenzyme Q10 sebagai anti oksidan dan
citicoline sebagai neuroprotektor dapat diberikan untuk melindungi sel ganglion retina.
Tujuan: Mengetahui perbandingan efek pemberian coenzyme Q10 dan citicoline
terhadap densitas sel ganglion retina pada neuropati optik etambutol.
Metode: Merupakan suatu studi eksperimental terhadap 32 tikus putih galur wistar yang
dikelompokkan menjadi empat kelompok: tanpa perlakuan, induksi etambutol 35
mg/kgBB, induksi etambutol 35 mg/kgBB dan coenzyme Q10 100 mg/kgBB, serta
induksi etambutol 35 mg/kgBB dan citicoline 1 g/kgBB selama 4 minggu. Densitas sel
ganglion retina dihitung berdasarkan jumlah sel ganglion retina secara histopatologi dan
analisis data dilakukan dengan uji one-way ANOVA dilanjutkan uji post hoc Bonferroni.
Hasil: Rerata densitas sel ganglion retina paling tinggi didapatkan pada kelompok tanpa
perlakuan (32,08 8,72), diikuti kelompok perlakuan induksi etambutol dan coenzyme
Q10 (29,28 7,18), etambutol dan citicoline (27,37 5,39) dan paling rendah pada
kelompok induksi etambutol saja. (20,53 4,25). Pemberian coenzyme Q10 dan
citicoline pada kelompok induksi etambutol meningkatkan densitas sel ganglion retina
secara signifikan dibandingkan kelompok yang hanya diinduksi etambutol (p < 0,05).
Densitas sel ganglion retina pada kelompok coenzyme Q10 lebih tinggi dibandingkan
kelompok citicoline, meskipun tidak signifikan secara statistik (p > 0,05).
Kesimpulan: Coenzyme Q10 dan citicoline berpotensi protektif terhadap kerusakan sel
ganglion retina akibat etambutol, dengan efek yang lebih menojol daripada Coenzyme
Q1
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A Case of Infectious Keratitis Associated with Rigid Gas Permeable Contact Lens Use in a Keratoconus Patient
Full text linkBackground: Keratoconus is a non-inflammatory corneal ectatic disorder characterized by progressive corneal thinning and ectasia, leading to irregular astigmatism and visual impairment. Rigid gas permeable (RGP) contact lenses are often prescribed to manage keratoconus; however, improper use can lead to complications such as infectious keratitis.
Case presentation: We present a case of a 25-year-old female with keratoconus who developed infectious keratitis after three months of RGP lens wear. The patient presented with ocular discomfort, pain, photophobia, and redness in the left eye. Clinical examination revealed conjunctival and ciliary injection, a paracentral corneal infiltrate, and decreased visual acuity. Corneal pachymetry confirmed bilateral corneal thinning. The patient was diagnosed with bilateral keratoconus, bilateral compound myopic astigmatism, and left-eye infectious keratitis. Treatment included discontinuation of RGP lens wear, topical antibiotic therapy, and artificial tears. After two weeks of treatment, the corneal infiltrate resolved, and the patient was allowed to resume RGP lens wear with strict adherence to hygiene protocols.
Conclusion: This case underscores the importance of patient education and meticulous lens hygiene in preventing infectious keratitis and other complications associated with RGP lens wear in keratoconus patients. Regular follow-up examinations are crucial to monitor for signs of complications and ensure optimal lens fit. By adhering to these guidelines, clinicians can help to ensure the safe and effective use of RGP lenses in keratoconus patients
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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