95 research outputs found
Early Left Ventricular Structural Changes With Preserved Function in Overweight and Obese Adolescents: A Speckle-Tracking Echocardiography Study
No full textBackground: Overweight and obesity in adolescents are associated with dyslipidemia and may contribute to early cardiovascular remodelling. Speckle-tracking echocardiography (STE) is a sensitive imaging technique capable of detecting early myocardial functional alterations before the onset of clinical symptoms. This study aimed to evaluate the correlation between cardiac chamber dimensions, left ventricular (LV) geometry and function, and lipid profiles in overweight and obese adolescents. Methods: A cross-sectional study was conducted from June to September 2023, involving 51 overweight and obese adolescents aged 15–18 years in Bandung, Indonesia. Anthropometric measurements, fasting lipid profiles (triglycerides, total cholesterol, LDL, HDL), and transthoracic echocardiography were obtained. LV dimensions, LV mass index (LVMI), ejection fraction (EF), fractional shortening (FS), and global longitudinal strain (GLS) were assessed. Associations were analyzed using Pearson correlation.Results: Participants were predominantly male (64.7%) with a mean age of 16.3±0.6 years. Overweight (47.1%) and obesity (52.9%) were almost equally distributed with a mean BMI of 29.6±4.1 kg/m². LVMI correlated negatively with total cholesterol (r=−0.356; p=0.005), HDL (r=−0.351; p=0.006), and LDL (r=−0.280; p=0.023). The LV posterior wall thickness and LV end-diastolic diameter were also inversely correlated with selected lipid parameters. Interventricular septal thickness in systole correlated positively with triglycerides (r=0.270; p=0.028). No significant correlations were found between lipid profiles and LV function parameters, including EF, FS, and GLS (p>0.05).Conclusions: In overweight and obese adolescents, lipid profiles are associated with early alterations in LV structural dimensions while LV systolic function remains preserved. These findings support the importance of early cardiovascular screening and lifestyle modification to reduce future cardiometabolic risk
Reduced Left Ventricular Global Longitudinal Strain in Obese Adolescents
No full textBackground: Obesity in adolescents is associated with early cardiac structural and functional alterations that may progress to ventricular dysfunction later in life. Two-dimensional speckle-tracking echocardiography (2D STE) enables early identification of subclinical ventricular dysfunction. Nevertheless, its application in the adolescents remains limited. This study aimed to assess differences in left ventricular (LV) function among well-nourished, overweight, and obese adolescents using 2D STE.Methods: A cross-sectional study was conducted among adolescents aged 15–18 years from five senior high schools in Bandung, Indonesia between June and August 2023. Participants were randomly categorized into well-nourished, overweight, and obese groups. Transthoracic echocardiographic using M-mode and 2DSTE was performed to evaluate LV function, particularly global longitudinal strain (GLS). Statistical analyses were performed using SPSS with significance defined as p<0.05.Results: Sixty adolescents were included, 65% were male with a mean age of 16.4±0.6 years. Conventional echocardiography showed no significant differences in systolic or diastolic function among groups. However, obese adolescents demonstrated significantly greater LV posterior wall thickness and larger LV and right ventricular basal volumes compared with other groups. GLS analysis revealed significantly reduced LV deformation in obese group compared with overweight and well-nourished groups (–20.0±1.9 vs. –22.3±1.4 vs. –22.7±1.9, respectively; p<0.001).Conclusion: Reduced LV GLS detected by 2D STE indicates early subclinical myocardial dysfunction in obese adolescents despite normal conventional echocardiographic findings. Early cardiovascular screening and lifestyle interventions, including balanced nutrition and regular physical activity, may help reduce future cardiometabolic risk
Correlation between Health Perception, Body Image, and Eating Habits in High School Students
No full textBackground: Mental disorders, including eating disorders, mostly begin during youth. Moreover, negative body image is found to cause unhealthy eating habits in the context of several cross-cultural settings. This study aimed to examine the correlation between health perception and body image with eating habits
among high school students.
Methods: A structured, anonymous questionnaire was distributed to students of a private high school in Bandung, Indonesia in June-October 2014. The questionnaire included questions about health perception, body image, eating habits, body weight and height, and also other demographic parameters. The school was selected as the study object through purposive sampling, and 140 high school students (72 male and 68 female) were ramdomly selected.
Results: Male and female did not show considerable differences in health perceptions. Out of 13 statements, 12 statements of male respondents showed better body image than female. While in eating habits statements, female respondents seemed to maintain healthier eating habits than male respondents. No significant correlation was observed between body image and eating habits (r=-0.015, p=0.858). There was significant correlation between health perception and eating habits (r=0.374, p<0.001). Correlation between sex and
eating habits was found (p=0.020), there was not significant relationship between eating habits and Body Mass Index (BMI) (p=0.368).
Conclusions: The negative relationship between body image and eating habits is not significant. However there was a significant positive relationship between health perception and eating habits. Furthermore, there was correlation between sex and eating habits, while the positive relationship between eating habits and BMI was still not found
Pattern of Energy and Protein Intake among Stunted Children Aged 3–5 Years in Jatinangor
No full textBackground: A child’s optimal growth can be indicated by many factors, among them is body height, therefore stunting is one of the evidences of undergrowth. Nutrition, on the other hand, is one of variables affecting growth. This study aimed to examine the nutrition intake, in the form of energy, carbohydrate, protein, and fat in stunted children aged 3–5 years in Jatinangor.
Methods: This cross sectional study was carried out in September to October 2014 using the random sampling method. Dietary data from 70 stunted children aged 3–5 years in pre–school and kindegarten located in 9 urban areas in Jatinangor were collected through 3x24 Recall and Food Frequency Questionaire and analyzed.
Results: Mean energy intake was 1113.6 kcal and mean carbohydrate intake was 137.4 grams. Mean protein intake was 38.4 gram and mean fat intake was 38.2 gram. Types of food highly consumed as the source of carbohydrate were white rice and biscuit, and as the source of protein were meatball, sausage, and egg. Highest consumed vegetables, fruits and snack were water spinach, cabbage, watermelon, banana, and milk respectively.
Conclusions: Mean energy intake, mean carbohydrate intake, and mean fat intake are all below the recommended dietary allowance (RDA) 2013 with individual value of mean energy intake is below RDA 2013 for all subjects. Mean protein intake is slightly above RDA 2013
Pengaruh sistem pemesanan makanan digital terhadap ketepatan waktu pemberian makanan dan kepuasan pasien
No full textEffect of digital food ordering system on timeliness of feeding and patient satisfactionBackground: Computer-based information systems simplify food ordering, speed up the calculation of order data, and reduce operational costs for patient food ordering processes to reduce the time lag between ordering food and serving it to consumers. Only a few studies have examined the effect of digital food ordering applications on feeding accuracy and patient satisfaction.Objective: This study aims to determine the relationship between the digital food ordering system and the timeliness of feeding, and the relationship between timeliness of feeding, taste, menu variety, staff appearance, and food service with patient satisfaction.Methods: This study uses a mixed design design with a parallel concurrent mixed method. Quantitative research uses the one-group pretest-posttest pre-experimental design without a control group design and qualitative research uses the social constructivism–interpretation paradigm. The research was conducted in July 2022 at the Bayu Asih Hospital in Purwakarta. The study population consisted of 91 inpatients using a sampling technique, namely total sampling, while the number of samples for qualitative data was five persons using purposive sampling. Bivariate analysis used the Wilcoxon and Chi-Square tests, while the qualitative analysis used a deductive approach.Results: The average time for serving food with manual ordering tends to be greater, namely 181.5 seconds, which decreases to 156.62 seconds after using a digital food ordering system. Most of patients (73.6%) were satisfied with the timeliness of feeding, the taste of the food provided, the varied menu, and the neat appearance of the servers. The results of the analysis showed a significant relationship between the timeliness of food serving (p=0.006); food taste (p=0.001); menu variety (p=0.001); and the appearance of the waitress (p=0.001) with patient satisfaction.Conclusion: The timeliness of feeding increases after using a digital food ordering system. Timeliness of feeding, food taste, variety of food menus, appearance of food serving staff, and food service are significantly related to patient satisfaction
Korelasi Kadar Albumin Serum dengan Persentase Edema pada Anak Penderita Sindrom Nefrotik dalam Serangan
No full textNephrotic syndrome (NS) is a glomerular disorder characterized by massive proteinuria, hypoalbuminemia, edema, and hyperlipidemia. The aim of this study was to evaluate the correlation between serum albumin levels and percentage of edema during nephrotic stage in children with NS. Cross-sectional design with correlational analytic was used in this study. The subjects of this study were outpatients and inpatients with NS during nephrotic stage, aged between 1 and 14 years old, admitted to Dr. Hasan Sadikin General Hospital Bandung, Cibabat Hospital, and Ujung Berung Hospital from August 2009 to January 2010. Percentage of edema was calculated by substracting total body water (TBW) during illness to ideal TBW, then divided the result by ideal TBW. Subjects were 29 children, consisted of 26 boys and 3 girls. Mean serum albumin levels was 1.45 g/dL and percentage of edema was 21.6%. Analysis using Spearman correlation test showed a highly significant correlation (p=0.006) between serum albumin levels and percentage of edema in children with NS during nephrotic stage (r=-0.501). In conclusion, there is a negative correlation between serum albumin levels and percentage of edema during nephrotic stage in children with NS
Molecular markers in breeding of crops: recent progress and advancements
No full textAbstract: A convectional plant breeder faces the challenge of how to more effectively and efficiently perform selection and accelerate breeding progress to satisfy the requirements of changing demands for crop cultivars. However, with the development and advancement of molecular marker technology, the fate of plant breeding has shifted from year to year. Recently, different types of molecular markers have been developed, and advancements in sequencing technologies have greatly increased plant improvement. To further our understanding of molecular markers, several reviews have been published in recent decades. However, with the advancement of newly emerging technologies and techniques, the reviewers did not discuss several recently emerged technologies and techniques in plant breeding. Therefore, this article is intended to be reviewed as an overview of recent breakthroughs in DNA markers and their applications in breeding of crops for early and senior researchers with little or no experience with molecular markers. The progress made in molecular plant breeding, genetics, genomic selection, gene pyramiding, MAS, and gene mapping has contributed to a deeper understanding of molecular markers, provided deeper insights into the variability available for crops, and considerably supplemented current breeding techniques. Next-generation sequencing technologies assist in the identification of novel molecular markers for complex and unstructured populations through genotyping-by-sequencing, gene mapping, QTL mapping, and association mapping. Altogether, the classification of molecular markers and their potential application in plants are discussed.
Keywords: Molecular marker, QTL mapping, MAS, genomic selection, genetic marker.
Title: Molecular markers in breeding of crops: recent progress and advancements
Author: Gudeta Dida
International Journal of Novel Research in Life Sciences
ISSN 2394-966X
Vol. 9, Issue 5, September 2022 - October 2022
Page No: 10-21
Novelty Journals
Website: www.noveltyjournals.com
Published Date: 07-September-2022
DOI: https://doi.org/10.5281/zenodo.7057206
Paper Download Link (Source)
https://www.noveltyjournals.com/upload/paper/Molecular%20markers%20in%20breeding%20of%20crops-07092022-2.pdfInternational Journal of Novel Research in Life Sciences, ISSN 2394-966X, Novelty Journals, Website: www.noveltyjournals.co
Perbedaan Kadar Vitamin D antara Hipotiroid Kongenital dan Anak Sehat
No full textLatar belakang. Pertumbuhan dan perkembangan yang optimal pada anak dengan hipotiroid kongenital ditunjang oleh nutrisi yang seimbang dan adekuat. Salah satu mikronutrien yang dibutuhkan adalah vitamin D. Di Indonesia, belum ada data kadar vitamin D pada anak dengan hipotiroid kongenital.
Tujuan. menentukan perbedaan kadar vitamin D antara hipotiroid kongenital dan anak sehat.
Metode. Studi comparative dengan rancangan potong lintang kriteria inklusi anak berusia 1 bulan–5 tahun yang tidak mendapat suplementasi vitamin D. Periode penelitian bulan Juli hingga Desember 2015. Pemeriksaan kadar vitamin D dilakukan dengan metode ELISA. Perbedaan kadar vitamin D pada kedua kelompok dianalisis dengan Mann Whitney.
Hasil. Didapatkan 70 subjek yang memenuhi kriteria inklusi terdiri atas 35 anak dengan hipotiroid kongenital dan 35 anak sehat. Kadar vitamin D rerata pada kelompok hipotiroid kongenital adalah 85,87 nmol/L dan pada kelompok anak sehat adalah 97,74 nmol/L. Kadar vitamin D pada hipotiroid kongenital berbeda bermakna dengan anak sehat (p<0,001).
Kesimpulan. Kadar vitamin D pada hipotiroid kongenital lebih rendah daripada anak sehat
Perbandingan Fungsi Kognitif Bayi Usia 6 Bulan yang Mendapat dan yang Tidak Mendapat ASI Eksklusif
No full textLatar belakang. Salah satu faktor yang mempengaruhi tumbuh kembang anak adalah faktor nutrisi terutama
pemberian ASI eksklusif. Hubungan antara ASI eksklusif dan perkembangan kognitif telah diketahui pada
anak usia sekolah tetapi pada bayi belum banyak diketahui dan belum ada penelitian yang mengukur IQ
pada bayi khususnya di Indonesia.
Tujuan penelitian. Membandingkan fungsi kognitif bayi berusia 6 bulan yang diberi ASI eksklusi dan
bukan ASI eksklusif.
Metode. Penelitian cohort ini dilakukan pada bulan Mei-Juli 2007. Subjek penelitian bayi usia 4 bulan
yang mendapat ASI eksklusif dan noneksklusif yang bertempat tinggal di lingkungan Puskesmas Cigondewah
Bandung diikuti sampai usia 6 bulan. Perkembangan kognitif dinilai dengan skala Griffith dan dikonversikan
menjadi nilai IQ. Dampak ASI eksklusif terhadap perkembangan kognitif dianalisis dengan uji t.
Hasil. Dari 86 bayi yang diteliti, 8 bayi drop out, 39 ASI eksklusif dan 39 bayi noneksklusif. Tidak ada
perbedaan karakteristik subjek dan karakteristik orangtua subjek. Rata-rata IQ bayi ASI eksklusif 128,3
(8,8), rentang IQ bayi ASI eksklusif 112-142 sedangkan bayi ASI noneksklusif rata-rata 114,4 (12,1), rentang
IQ 82-137. Kelompok ASI eksklusif IQ di atas rata-rata 32 bayi dan di bawah rata-rata 7 bayi sedangkan ASI
noneksklusif IQ di atas rata-rata 19 bayi dan di bawah rata-rata 20 bayi. Pemberian ASI noneksklusif berpeluang
terjadinya IQ di bawah rata-rata 1,68 kali lebih besar dibandingkan di atas rata-rata (x2=9,57; p=0,002).
Kesimpulan. Dari aspek fungsi kognitif pemberian ASI eksklusif memberikan hasil lebih baik dibanding
dengan yang tidak mendapat ASI eksklusi
FAKTOR- FAKTOR YANG BERASOSIASI PADA KEJADIAN STUNTING PADA BAYI DI BAWAH DUA TAHUN DI WILAYAH KERJA PUSKESMAS PANDRAH KABUPATEN BIREUEN
No full textStunting is a condition of physical growth failure characterized by height for age under -2 SD from the WHOchart growth standard. This study used adesign cross sectional with variables of birth weight, non-exclusive breastfeeding, maternal education, education. father, history of ANC visits, socio-economic history, and work history of parents.  This study used a sample of 56 baduta who were stunting. The sample in this study, namely mothers who have baduta. This study uses instruments in the form of a questionnaire and an infantometer. Data analysis used univariable analysis, bivariable analysis with chi square test and multivariable with logistic regression analysis.  The results showed that the prevalence of stunting in the study site was 31.8%, the factor most associated with stunting in the ANC visit was POR = 10.54 (95% CI: 4.20-25.03) p value
- …
