15 research outputs found
Sürükleyici sanatta somaestetik yaklaşımlar; (un)balance xr deneyimi örneği
No full textBu araştırma, sürükleyici sanatta (immersive art) somaestetik yaklaşımın önemini ortaya çıkarmayı amaçlamaktadır. Bir başka ifade ile sürükleyici sanat olayları gerçekleşirken, gerçeklik algılarının, bedenle bir bütün olarak dönüşüp değiştiğini ortaya koymayı amaçlamaktadır. Somaestetik, bedenin bir algı merkezi olarak önem taşıdığı bir felsefedir. Beden anlamına gelen soma, geleneksel olarak zihin ve beden olarak ayırt edilen (ve bölünen) şeyleri içerir. Yani soma, beden ve zihin birlikteliğini içerir. Zihin terimi ayrı bir tözden ziyade bedenin önemli bir fiil veya işlevi olarak kavrandığında soma kavramını anlamak mümkündür. Somaestetik felsefeye göre gerçeği anlamak beden ve duyusal algı yoluyla gerçekleşir. Algıların değişkenliğinde de beden deneyimi önemlidir. Bedenin bütünselliğinin deneyimlenebildiği en üst mertebe sanattır. Sürükleyici sanatta beden, sanal çevreyi insan duyularını taklit edebilen çeşitli teknolojik cihazlarla algılayabilmekte ve sanatsal deneyimi kişi ancak bedeni ile sağlayabilmektedir. Beden, sürükleyici teknoloji donanımları ile bazı sürükleyici sanat olaylarında sanal bedenlere de dönüşebilmektedir. Bu çalışmada, Elyne Legarnisson’un XR (genişletilmiş gerçeklik) deneyimi (Un)Balance, örnek olay seçilmiş ve bu durumun analizi yapılmıştır. 20. yüzyıl başlarından itibaren sanatta beden, özne ve nesne olarak öne çıkmıştır. Bununla birlikte bedensel algılar değiştikçe farklı deneyimlerin yaşandığı, neticesinde farklı gerçekliklerin ortaya çıktığı bir dönem olarak 21. yüzyıl ve sürükleyici sanat karşımızda durmaktadır
Glocal touches in digital art
No full textDigitalization, it generally refers to a social process of transition from analog to digital technology. The ability of digital technology to transmit, protect, compress and reproduce information/data in a very short time has initiated digitalization processes by transforming the concepts of time, space and speed. In this process, art types, exhibition and presentation techniques based on digital technology have emerged in art. The acceleration of digitalization processes has also accelerated globalization processes, and it has been emphasized by thinkers that globalization is based on digital technology. Globalization is economic, cultural, political, social, etc. It has affected all areas of life. In the cultural field, types of globalization as cultural homogenization and cultural heterogeneization have been discussed. The resemblance of cultures to each other has been examined under the heading of homogenization, and the recognition and discovery of cultural differences has been examined under the heading of heterogeneity. Sociologist Roland Robertson proposes the term 'glocalization', a linguistic mixture of globalization and localization, instead of the term globalization, and use of the term increases in the 1990s. In glocalization, both globalizing and localizing tendencies coexist simultaneously. In order to talk about a glocal approach in the art discipline, the work of art must consist of global and local components, which are the two key elements of glocalization. From an art perspective, glocal approaches are a synthesis that combines local identity or local values with contemporary art elements. In this study, the Gates of Infinity NFT Exhibition, in which artists Hakan Y & imath;lmaz and Seyd Ahmet combined traditional tile patterns with special algorithms and turned them into a collage, was chosen as an example. Two components of glocalization; Traditional motifs, which are local design elements, and global presentation techniques are brought together in the exhibition. In the Gates of Infinity exhibition exhibited at the Metropolitan Museum, Side Ancient Theater and Bursa Zindankap & imath; Gallery, the combination of traditional elements with global communication tools and presentation techniques was considered as a glocal approach in digital art. It has been seen that glocal touches in art are instrumental in the protection, promotion and dissemination of cultural values
Identifying Unsafe Locations for Pedestrians in Konya With Spatio-Temporal Analyses
No full textIdentifying the locations of pedestrian crashes in cities contributes to the full implementation of sustainable transportation for all road users. This study examines the pedestrian crash data of Konya, T ; uuml;rkiye, from 2017 to 2022. First, the dangerous and safe road networks in Konya province were identified. Then, spatial and temporal analyses were performed. Kernel density estimation analysis was used to identify five critical locations with high pedestrian crash density. Hotspot analysis was used to identify roads where crashes showed clustering characteristics. Buffer analysis was used to analyse the effectiveness of traffic lights in preventing crashes and three locations where traffic lights were inadequate in preventing crashes were identified. According to the temporal evaluation, pedestrian crashes increased the most at 8 am and 6 pm. Locations where the number of crashes decreased over time were identified by examining the temporal changes in pedestrian crashes using space-time cube analysis. This study highlights the positive effects of improvements in the pedestrian environment on pedestrian safety. New hotspots have emerged in several areas. Therefore, this approach is valuable for early prevention. With the methodology used in the study, the locations of pedestrian crashes and the cause-and-effect relationships of crashes can be evaluated.The author appreciates the Turkish National Police Traffic Presidency for supporting this research.Turkish National Police Traffic Presidenc
Bibliometric analysis of studies conducted within the scope of the principle of secularism with vosviewer
No full textBu çalışmayla Türkiye Cumhuriyeti’nin temel ilkelerinden olan laiklik il-kesi kapsamında akademik literatürün gelişimini bibliyometrik analiz ile incelemek, araştırmacılara yol gösterici özellikte literatür bilgisi sunmak amaçlanmaktadır. Türkiye Cumhuriyeti Devleti’nin muasırlık seviyesine ulaşmasının hedeflendiği Atatürk İlkeleri konusunda Türkiye’de alanda bibliyometrik analiz çalışmaların azlığı literatüre katkı sağlanması açısından çalışmayı önemli kılmaktadır. Bu amaçla Web of Science veri tabanında 1975-2013 yılları arasında “secularism” ile ilgili erişilen ve “secularism”, “post-secularism”, “laicite”, “political secularism”, “laicism”, “Turkish Secularism”, “religious freedom” anahtar kelimeleri ile bulunan 4.412 makale incelenmiştir. Bu makaleler alanlarına, yayın yıllarına ve atıf sayılarına göre analiz edilmiştir. Söz konusu makalelerden tarih alanında olan 326 makalenin; ortak yazar analizi, yazar atıf analizi, ülke atıf analizi, anahtar sözcük analizi VOSviewer (Versiyon 1.6.19) paket programında bibliyometrik haritalama ile yapılmıştır. Bulgular; laiklik kavramının en çok din, İslam, sekürlerleşme, modernlik, Katoliklik ve dini özgürlük kavramları ile ilişkili olduğunu göstermektedir. İncelenen makaleler arasında diğer alanlara kıyasla tarih alanında yapılan çalışmaların azlığı dikkat çekicidir.This study aims to examine the development of academiz literature wit-hin the scope of the principle of secularism, one of the fundamental principles of the Rupublic of Türkiye, through bibliometric analysis and to provide guiding literature information to researchers. The scarcity of bibliometric analysis tools in the field in Türkiye makes it important to contribute to the literatıre on Atatürk’s policies, which target the modern contemporary performance of the Republic of Turkey. For this purpose, 4, 412 articles on“secularism” and found with the keywords “secularism”, “post-secularism”, “laicite”, “political secularism”, laicism”, “Turkish Secularism”, “religious freedom” accessed in the Web of Science database between 1975 and 2013 were analyzed. The articles were analyzed according to their fields, publication years and citation numbers. Co-author analysis, country citation analysis, keyword analysis of 326 articles in the field of history were performed by bibliometric mapping in the VOSviewer (Version 1.6.19) package program. The findings shows that the concept of secularism is mostly associated with the concept of religion, Islam, secularization, modernity, Catholicism and religious freedom. Among the articles examined, it is noteworthy that there are fewer studies in the field of history compared to other fields
Muâheze, Tenkîd ve Eleştirinin Geçişkenliğinde: Türk Edebiyatında Edebî Eleştirinin Başlangıç Metinleri
No full textThe necessity of recognizing Nâmık Kemâl’s Tahrîb-i Harâbât and Ta‘kîb as the first original works of late Ottoman-Turkish literary criticism has been emphasized by major figures such as Mizancı Murat and Ahmet Hamdi Tanpınar and has gradually become a point of consensus among modern Turkish literary scholars. Despite their divergence from the tezkire tradition by shifting their focus to literary texts and being regarded as the foundation of modern criticism, the fact that these works have not been examined as critical texts in their own right produces a paradoxical space of silence in which critical thought has been delayed in interrogating its own foundations. Both texts present themselves as muâheze while also demonstrating a fluidity between criticism and the early Ottoman-Turkish literary conventions of tenkîd and muâheze. In response to Harâbât, Kemâl at times approaches criticism as the identification of a work’s deficiencies and the regulation of its flaws, occasionally shifting toward muâheze by targeting the author rather than the text itself. At the same time, by adopting the role of a nâkkad (a critic who discerns genuine poetry from false poetry), he embodies the etymological essence of tenkîd. However, the aspects of judgment, reasoning, and ruling inherent in the concept of muhâkeme, which he used as an equivalent for criticism before adopting muâheze, continue to influence his criticism. This study, while considering the historical evolution of the concept of criticism, discusses the early forms of criticism in the late Ottoman-Turkish literary sphere and the issues of naming and conceptualizing it through the first original critical texts.Nâmık Kemâl’in Tahrîb-i Harâbât ve Ta‘kîb adlı eserlerinin, geç Osmanlı-Türk edebî eleştirisinin ilk telif metinleri olarak değerlendirilmesi gerekliliği, Mizancı Murat ve Ahmet Hamdi Tanpınar gibi isimler tarafından vurgulanmış; zamanla bu görüş, modern Türk edebiyatı araştırmacıları arasında genel kabul görmüştür. Edebiyat metinlerine yönelme dikkatiyle tezkire geleneğinden ayrışan ve modern eleştirinin başlangıcı addedilen bu eserlerin birer eleştiri metni olarak bizatihi kendilerinin incelenmemiş olması, eleştirel düşüncenin kendi temellerini sorgulamakta geciktiği çelişkili bir suskunluk alanı üretir. Her iki metin, birer muâheze olarak sunulmalarının yanı sıra, eleştiri ve eleştirinin geç Osmanlı-Türk edebiyatındaki erken teamülleri olan tenkîd ve muâheze türleri arasında sergiledikleri geçişkenliklerle dikkat çeker. Harâbât karşısında Kemâl, bir taraftan eleştiriyi “bir eserin noksanlarının ifadesi, kusurlarının tanzimi” olarak görür ve zaman zaman metinden ziyâde yazarı hedef alan yönleriyle muâheze türüne yaklaşır, aynı zamanda sahte şiiri hakikisinden ayıran bir nâkkad konumuyla da tenkîd kavramının etimolojik kökeniyle uyumlu hareket eder. Öte yandan, muâhezeden önce eleştiri karşılığında kullandığı muhâkeme kavramı, yargılama, akıl yürütme ve hükmetme boyutlarıyla eleştirel yaklaşımını etkilemeye devam eder. Bu çalışma, eleştiri kavramının tarihsel gelişimini de göz önünde bulundurarak geç Osmanlı-Türk edebî alanında eleştirinin erken biçimlerini, onu adlandırma ve anlamlandırma sorunlarını söz konusu ilk telif eleştiri metinleri üzerinden tartışmayı amaçlamaktadır
Comparison of diagnostic performances of three different software packages in detecting coronary artery disease
No full textQuantification of myocardial perfusion scintigraphy is frequently performed to assist physicians in detecting coronary artery disease (CAD). Software packages provide automated quantification of perfusion data. We aimed to compare the three commonly used software packages, Emory Cardiac Toolbox (ECT v2 and ECT v3), 4D-MSPECT (4DM v2 and 4DM v4) and Quantitative Perfusion SPECT (QPS v3 and QPS v4)
Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines
No full textBayram, Cem/0000-0001-8717-4668; Elmazoglu, Zubeyir/0000-0003-4527-8834WOS: 000375574200007PubMed: 26183715The epidermal growth factor receptor (EGFR) associated with signaling pathways, such as Janus kinase (JAK)/signal transducer and activator of transcription (STAT), plays an important role in colorectal cancers (CRCs). Gefitinib (Gef) is an orally active inhibitor targeting the adenosine tri phosphate-binding domain of EGFR, and cucurbitacin B (CuB) is a selective inhibitor of JAK/STAT signaling with potent antitumor activity via suppression of STAT3 phosphorylation, but the underlying mechanism is not clear. We aimed to investigate the apoptotic and antiproliferative effects of CuB as a single agent and in combination with Gef on both HT-29 and HCT-116 cell lines. Cell proliferation, cell cycle distribution, and apoptosis were evaluated using viability assay, fluorescent microscopy, cytotoxicity assay, proliferation, DNA fragmentation, and cleaved caspase 3 levels. Real-time polymerase chain reaction and Western blot analyses were performed to determine the expression of relevant genes and proteins including antiapoptotic, proapoptotic, and cell cycle regulation. EGFR, phosphorylated EGFR (pEGFR), STAT3, and pSTAT3 proteins were evalutaed with Western blot analysis. Our results showed that, compared to CuB alone, CuB plus Gef treatment caused a significant growth and cell cycle inhibition and induced apoptosis in both cell lines. Also CuB plus Gef treatment decreased DNA synthesis rate more effectively than CuB alone. Treatment with CuB alone and in combination with Gef decreased the expression levels of B-Cell CLL/Lymphoma 2 (Bcl-2), BCL2-like 1 (BCL2L1), cyclin D1, pSTAT3, and pEGFR and increased the expression levels of Bcl-2-like protein 4, Bcl-2 homologous antagonist/killer, Bcl-2-associated death promoter, Bcl-2-like protein 11, and p27kip1 levels. Our results suggest that treatment with CuB alone and more likely in combination with Gef may be a considerable alternative therapeutic approach for CRC, at least in vitro.Gazi University Research FoundationGazi University [01/2011-56]The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Gazi University Research Foundation, with the project code number 01/2011-56
An open-source framework of neural networks for diagnosis of coronary artery disease from myocardial perfusion SPECT
No full textThe purpose of this study is to develop and analyze an open-source artificial intelligence program built on artificial neural networks that can participate in and support the decision making of nuclear medicine physicians in detecting coronary artery disease from myocardial perfusion SPECT (MPS)
Investigation Covering the Effect of Boron plus Taurine Application on Protein Carbonyl and Advanced Oxidation Protein Products Levels in Experimental Alzheimer Model
No full text© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Alzheimer’s disease (AD) is the most common form of dementia that occurs in the brain. This is a chronic neurodegenerative disease which is valid in 60–70% of all dementia patients. Boron, regarded as a potential antioxidant, has the effect of reducing oxidative stress. Taurine, as one of the thiol-containing amino acids, exists at different concentrations in both the neurons and glial cells of the central nervous system. It plays an important role in the protective and adjuvant therapies as an antioxidant due to its characteristics of maintaining the oxidant-antioxidant balance of the body as well as cell integrity and increasing body resistance. Based on this information, our objective was to reveal the effect of boron alone, taurine alone plus co-administration of taurine and boron application on brain tissue protein carbonyls (PC) and serum advanced oxidation protein products (AOPP) levels in the experimental Alzheimer’s model. For this purpose, 5 groups were formed in our study which consisted of 30 Wistar albino male rats. The rats were given a single dose of STZ stereotaxically. At the end of this period, the rats were decapitated, plus their brain tissues and blood were removed. Our findings suggested that taurine alone and co-administration of boron and taurine had a decreasing effect on AOPP and PC levels of the experimental Alzheimer model of the rats
Deterioration of different stones used in historical buildings within Nigde province, Cappadocia
No full textThe Cappadocia region hosts various historical buildings constructed by several civilisations from long in the past until more recently. Some of these are big and significant buildings and their artistic, cultural and aesthetical features are quite attention-grabbing. The stones used in most of these buildings have deteriorated due to various effects. The correct identification of the deterioration mechanisms is of fundamental importance to design retrofitting and restoration procedures. In this study we aimed to determine the engineering properties and deterioration of the stones widely used in the different historical buildings in the Nigde region that forms the southern boundary of Cappadocia. 17 block samples (2 marble, 2 travertine, 6 tuff, 5 ignimbrite and 1 andesite) were taken - in accordance with the obtained permits - from stones that had fallen from the buildings and could not be used again as part of any restoration. With the purpose ofidentifying the deterioration of the building stones due to their geological structure and external effects, chemical and petrographic analyses were conducted along with detailed field observations. To determine the geomechanical properties (dry unit weight, water absorption, effective porosity, P-wave velocity, uniaxial compressive strength, slake durability index, capillary water absorption, Bohme abrasion value and Schmidt hammer rebound value) of the stones comprehensive laboratory research was carried out. The main cause of the deterioration observed in ignimbrites (UK3) and tuffs (AK3) with low strength and high porosity was humidity, especially at the capillary level. Significant deterioration observed on some stone samples was also due to the use of stones that exhibited poorer properties than the rest, although they came from the same quarry. Adding the negative effects of ground and surface water on top of these, severe damage on the stones in the formof flaking, discolouration and loss of strength were observed.Scientific and Technological Research Council of Turkey. (TUBITAK) [106Y220]This study was financially supported by the Scientific and Technological Research Council of Turkey. (TUBITAK, Projects number: 106Y220). The author would like to express his thanks to Prof. Dr. Atiye TUGRUL for her comments and suggestions
