4 research outputs found
QUYI MOLEKULYAR BIOREGULYATORLAR KURSINI O‘QITISHDA KUMARINLAR SINTEZI USULLARINI YORITISHNING METODOLOGIK AHAMIYATI HAQIDA
No full textThis article presents literature-based recommendations on coumarin synthesis methods for teaching the "Low-Molecular WeightBioregulators" course and their application in laboratory work.В статье представлены методические рекомендации основанные на литературных данных по методам синтеза кумариновдля преподавания курса «Низкомолекулярные биорегуляторы» и их применению в лабораторных работах.Maqolada “Quyi molekulyar bioregulyatorlar” kursini o‘qitishda adabiyotlarga asoslangan kumarinlar sinteziga bag‘ishlanganusullar va ulardan laboratoriya mashg‘ulotlarida foydalanish bo‘yicha ishlab chiqilgan metodik tavsiyalar keltirilgan
KIMYOVIY EKOLOGIYA KURSIDA «YASHIL KIMYO PRINSIPLARI»NI O‘QITISH
No full textThe article discusses specific aspects, methodological approaches, content and significance of the principles of “Green Chemistry” in a new educational course Сhemical ecology, developed for the field of chemistry of natural physiologically active compounds.В статье рассматриваются конкретные аспекты, методические подходы, содержание и значение принципов «зеленой химии» в новом учебном курсе Химическая экология, разработанном для образовательного направления химия природных физиологически активных соединений.Maqolada Tabiiy fiziologik faol birikmalar kimyosi yo‘nalishi uchun ishlab chiqilgan yangi o‘quv kursi – Kimyoviy ekologiya kursida “yashil kimyo” prinsiplarini o‘qitishning o‘ziga xos taraflari, uslubiy yondoshishlari, ushbu prinsiplarning mazmuni va ahamiyati ko‘rib chiqilgan
A recent bottleneck of Y chromosome diversity coincides with a global change in culture
No full textabstract: It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males
The genetic history of admixture across inner Eurasia
No full textThis is the author accepted manuscript. The final version is available from Nature Research via the DOI in this record.Data Availability. Genome-wide sequence data of two Botai individuals (BAM format) are available at the European Nucleotide Archive under the accession number PRJEB31152 (ERP113669). Eigenstrat format array genotype data of 763 present-day individuals and 1240K pulldown genotype data of two ancient Botai individuals are available at the Edmond data repository of the Max Planck Society
(https://edmond.mpdl.mpg.de/imeji/collection/Aoh9c69DscnxSNjm?q=).The indigenous populations of inner Eurasia, a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra, harbor tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine, and Uzbekistan. We furthermore report additional damage-reduced genome-wide data of two previously published individuals from the Eneolithic Botai culture in Kazakhstan (~5,400 BP). We find that present-day inner Eurasian populations are structured into three distinct admixture clines stretching between various western and eastern Eurasian ancestries, mirroring geography. The Botai and more recent ancient genomes from Siberia show a decrease in contribution from so-called “ancient North Eurasian” ancestry over time, detectable only in the northern-most “forest-tundra” cline. The intermediate “steppe-forest” cline descends from the Late Bronze Age steppe ancestries, while the “southern steppe” cline further to the South shows a strong West/South Asian influence. Ancient genomes suggest a northward spread of the southern steppe cline in Central Asia during the first millennium BC. Finally, the genetic structure of Caucasus populations highlights a role of the Caucasus Mountains as a barrier to gene flow and suggests a post-Neolithic gene flow into North
Caucasus populations from the steppe.Max Planck SocietyEuropean Research Council (ERC)Russian Foundation for Basic Research (RFBR)Russian Scientific FundNational Science FoundationU.S. National Institutes of HealthAllen Discovery CenterUniversity of OstravaCzech Ministry of EducationXiamen UniversityFundamental Research Funds for the Central UniversitiesMES R
