1,722,380 research outputs found
ngenol mebutate treatment in keloids. De Felice B, Guida M, Boccia L, Nacca M. BMC Res Notes. 2015 Sep 22;8:466. doi: 10.1186/s13104-015-1429-9.
No full textIngenol-mebutate has been used for the treatment of actinic keratosis. It has been shown that ingenol-mebutate inhibits the growth of cancer cells or induces tumor cell death through pro-apoptotic effects. Keloids are benign skin tumours and are the effect of a deregulated wound-healing process in genetically predisposed patients. Increased cell proliferation, which accounts for the progressive and hypertrophic nature of keloids, correlates with the failure of apoptosis and plays a role in the process of pathological scarring. Keloid cells show a mutated p53 gene resulting in functionally inactive p53 protein which cannot control genomic integrity. They tend to escape from apoptosis which leads to keloid development by means of accumulation of continuously proliferating cells. Currently, the treatment of keloids remains a challenge for high recurrence rates. However, the design and the development of pro-apoptotic therapeutic strategies would be beneficial to keloids treatment.
CASE PRESENTATION:
A 55-year-old caucasian woman presented recurrent keloids on a presternal scar. Standard surgical intervention was used to treat the scar. However, this was unsuccessful and a year later the patient sought treatment again, but only by alternative means as the patient refused further surgical intervention. Consequently, based on past research and experience, the authors attempted to treat these lesions with ingenol mebutate gel, due to the pro-apoptotic effects.
CONCLUSION:
After 1 month, there was a clinical resolution of lesions, with a slightly squamous, post-inflammatory erythema. A cutaneous biopsy proved the absence of residual keloids and deregulated expression of molecular markers. The last follow-up of the patient, 1 year after treatment, showed that the patient was still free of keloids recurrence
Special issue MEDYNA 2020
No full textMechanical systems such as vehicle suspensions, robot manipulators, and spacecraft are often required to operate with high performances and shock and vibrations, which may quickly cause unacceptable system states, are perceived as the most important problems in mechanical system design. The development of methods for vibro-acoustic characterization and control has become an important topic of research and several methods, with analytical, numerical and experimental approaches, have been proposed to identify the vibro-acoustic and impact characteristics of different types of structure belonging to different engineering fields.
This Special Issue of Journal of Mechanical Engineering Science (JMES) contains selected, extended and peer-reviewed papers that were initially presented at the 3rd in the series Euro-Mediterranean Conference on Structural Dynamics and Vibroacoustics (MEDYNA 2020) in Napoli, Italy, from February 17th to February 19th, 2020 (https://medyna2020.sciencesconf.org/). The emphasis of the conference series is on methods, techniques and technologies – under theoretical, numerical and experimental approaches – in acoustics, vibration, impacts and structural health monitoring and the present Special Issue highlights the current state-of-the-art of this fields and innovative ideas applied in several engineering applications, such as: aeronautics, automotive, building, etcetera
Tables for exact lower confidence limits for reliability and quantiles based on least-squares estimators of Weibull parameters
No full textTables for exact lower confidence limits for reliability and quantiles based on least-squares estimators of Weibull parameters
No full textAlgebraic properties of grids of fat lines
No full textIn this paper we consider the generator of the ideal I defining a grid X of fat lines in the projective space P^n. We compute a minimal set of generators in the homogeneous and quasi-homogeneous cases in P^3
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