8 research outputs found
Long-term morphological model of Poole Harbour
No full textThe study focuses on the impact of human interventions on the natural behaviour of estuaries in response to sea-level rise. In particular it focuses on the affect of managed realignment on the critical sea level rise (SLRcrit) for the Poole Harbour. Numerical model ASMITA (Aggregated Scale Morphological Interaction between a Tidal inlet and the Adjacent coast, Stive and Wang, 1996) is used to study the response of the system to the external forcing (both natural and anthropogenic). ASMITA model schematises the tidal-inlet system and characterises each model element by a single variable volume. Volumetric data of the Poole harbour inlet elements obtained through the digitisation of the historical admiralty charts was used to calibrate the model. The model assumes that the each inlet elements tends towards an equilibrium volume which can be defined using the empirical equations. These equilibrium equations consist of equilibrium parameters that depend on the regional properties like hydrodynamics and topography of the Poole harbour. Once the model is calibrated, simulations were performed with various sea level rise scenarios (historic and future SLR) to observe the natural behaviour of the Poole harbour. Managed realignment is being introduced in the model and a range of values of critical sea-level rise was obtained and compared with the predicted sea-level rise rate given in the literature for the next century. Results suggest that the “hold the line” management scenario (current situation) would not result in the complete loss of inter-tidal flats and the coastal flooding is unlikely to occur over the next century, as a result of critical sea-level rise values exceeds the predicted rate. However research suggests, introducing realignment (coastline retreat management scenario) reduces SLRcrit values for the estuary; thus making the estuary more sensitive to the predicted future SLR rates.CoMEMHydraulic EngineeringCivil Engineering and Geoscience
5G Wireless Mesh Network 802.11s Load Balancing Architecture for 802.11 Bgn Radio-PCI Interface
No full textAbstractThe real time verification and validation process for WLAN is becoming essential for the users whose data falls on wide characteristics requirements such as video centric and high bandwidth. Nature of channel being broadcast and presence of MAC in AP makes proper infrastructure and sharing among hosts. This makes research paper about MAC case study and research development with proper verification and validation. This enhances in DLL gives wireless data link and sustains its link with corresponding MAC address 100%, which never bottlenecks OSI layer realization. Among the entire required parameters, only selected parametric dependent layered characteristics such as codes for enhancing data rate, selection of different radio in MIMO and channel, modes of WLAN are verified and validated by constructing clouddatabase in the slottime margin of 24hours in real-time scenario. The type of data for specific application towards effective use of network capacity under various situations in real-life scenarios are considered upon optimizing the selection of wifi device from lab testing results. This paper further develops a MAC architecture for 30% of internet traffic is video centric and its evaluation under PHY 54Mbps and 512 Mbps with 4 times better throughput than previous one
Fibrotic encapsulation of orthodontic appliance in palate
No full textIatrogenic trauma though not serious is very common in dental practice. Orthodontic treatment can inflict such injuries as they are prolonged over a long period of time. Ill-fabricated orthodontic appliances, such as wires and brackets, or the patients' habits such as application of constant pressure over the appliance can traumatize the adjacent oral soft tissues. In rare cases, these appliances can get embedded into the mucosa and gingival tissues. This case report describes one such case of iatrogenic trauma to the palatal mucosa due to entrapment of a tongue spike appliance and its surgical management
An adaptive user interface for open educational content
No full textThesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2011.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student submitted PDF version of thesis.Includes bibliographical references (p. 67).For my Masters of Engineering thesis project, I have developed a framework of meta- data around open educational resources that are used by students to master a given concept. Based on the assumption that a course can be broken down into specfic concepts and that there are several resources available to students both on sites such as OpenCourseWare and also peer-managed resources like Wikipedia, I develop a model for "relevance" of a resource to the learning of a given concept, where relevance is defined by assignment to a concept by a teacher as well as usage data from students viewing the resources. I combine both active feedback (clicking a "like" button) and passive feedback (view duration and count across all users) to score each resource for a given concept. This score is then used to create an adaptive user interface that indicates which resources may be the most relevant for students learning a given concept based on their peers' feedback. In addition to designing this framework, I provide an implementation of the adaptive user interface on Apple's iPad device, and I provide an evaluation of the educational benefits of this adaptive interface by designing and executing a controlled user study on students in MIT's introductory physics course.by Vijay Umapathy.M.Eng
Species delimitation of Melia dubia Cav. from Melia azedarach L. complex based on DNA barcoding
No full textThe genus Melia L., which belongs to the â Mahoganyâ family Meliaceae, is a source of important phytochemicals with marked medicinal properties. Species identification in Melia is complex due to the existence of overlapping morphological features. Though Melia dubia Cav. is listed as a synonym of Melia azedarach L., it is not clear from the available literature whether they are the same species or different, and the species complexity still remains unresolved. In the present study, ten accessions of M. dubia and M. azedarach were analysed by DNA barcoding using three chloroplast DNA markers (rbcL, matK, and trnH-psbA), and one nuclear marker (ITS2). Intra-specific divergence was not found in any of the four markers. However, the inter-specific divergence between M. azedarach and M. dubia ranged between 0.3% (rbcL) and 4.7% (ITS2) for individual markers, and for the combined dataset, it was 8.5%. Among the four markers, ITS2 was found to be the most suitable marker for differentiating M. azedarach and M. dubia. Parsimony analysis of the DNA barcoding data showed a clear segregation between M. azedarach and M. dubia as distinct monophyletic clades in all the markers, except the rbcL marker. Our results based on Bayesian analysis of the concatenated dataset strongly support the view that M. dubia be considered a distinct species; not a synonym of M. azedarachThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Anaplastic lymphoma kinase activity, a therapeutic target, suppresses neuroblastoma cell differentiation
No full textNeuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed differentiation of precursor cells of the developing sympathetic nervous system. NB accounts for about 15% of childhood cancer-related deaths. Treatment failure and relapse are common in NB patients despite intensive chemotherapy and immunotherapy interventions, suggesting the need for new and effective treatment options. Common genetic aberrations associated with NB include MYCN amplification, chromosome 11q deletion, 1p deletion, 17q gain, 2p gain, and recurrent mutations in Anaplastic Lymphoma Kinase (ALK). While treatment of some categories of ALK-positive pediatric cancer patients such as non-Hodgkin lymphoma and inflammatory myofibroblastic tumour (IMT) with the first-generation ALK tyrosine kinase inhibitor (TKI), crizotinib, produced promising results, the outcome for ALK-positive NB patients was less encouraging, hence the need for more potent ALK TKIs for treatment of NB patients. This thesis aimed to further our understanding of ALK signalling and its role in NB differentiation and explore novel ALK TKIs in a neuroblastoma setting.
In the first study, we investigated the therapeutic efficacy of the second-generation ALK TKI, brigatinib, in an NB preclinical setting. Brigatinib was reported to be effective against ALK fusion-positive non-small cell lung tumours. We found that brigatinib potently inhibited both the activity of ALK full-length and growth of ALK-addicted NB cells in-vitro, in xenograft and Drosophila models. Compared to crizotinib, brigatinib inhibited the activities of different ALK-mutant alleles more effectively and potently inhibited crizotinib resistant ALK mutants in vitro.
In the second study, we characterized a novel ALK-I1171T mutant allele which we identified in a tumour from a 16 month old NB patient. We showed that ALK-I1171T is a gain-of-function mutation, which is resistant to crizotinib, but can be effectively inhibited by second- and third-generation ALK TKIs such as brigatinib, ceritinib and lorlatinib. Based on these results and the severe toxic side effect of the initially administered chemotherapy, ceritinib monotherapy was chosen for this child. After 7.5 months of ceritinib treatment, the primary tumour shrunk in size and was removed surgically. The patient showed complete metastatic remission and remains in remission at 58 months post-treatment.
In the third and last study, we investigated Disk large homologue 2 (DLG2), a gene reported to be uniquely upregulated in transient intermediary cells during Schwann cell precursor (SCP) differentiation to adrenal chromaffin cells. We found that DLG2, a gene located on the frequently deleted chromosome 11q in NB, is an NB tumour suppressor gene whose expression is lost in NB cell lines. Restoration of DLG2 expression inhibited NB cell growth and promoted NB cell differentiation. High expression of DLG2 in NB tumours is associated with good prognosis. Mechanistically we showed that oncogenic ALK maintains an undifferentiated NB cell phenotype by repressing DLG2 expression via the ERK1/2-SP1 signalling cascade.
In summary, these findings highlight the role of ALK in differentiation and therapeutic potential of targeting ALK in ALK-positive NB tumours
Information Systems Education Journal In this issue: 4. Full Flip, Half Flip and No Flip: Evaluation of Flipping an Introductory Programming Course The Relative Efficacy of Video and Text Tutorials in Online Computing Education 44. Use of Failure in IS De
No full textThe Information Systems Education Journal (ISEDJ) is a double-blind peer-reviewed academic journal published reviewed published by ISCAP, Information Systems and Computing Academic Professionals. The first year of publication was 2003. ISEDJ is published online (http://isedj.org). Our sister publication, the Proceedings of EDSIGCon (http://www.edsigcon.org) features all papers, panels, workshops, and presentations from the conference. The journal acceptance review process involves a minimum of three double-blind peer reviews, where both the reviewer is not aware of the identities of the authors and the authors are not aware of the identities of the reviewers. The initial reviews happen before the conference. At that point papers are divided into award papers (top 15%), other journal papers (top 30%), unsettled papers, and non-journal papers. The unsettled papers are subjected to a second round of blind peer review to establish whether they will be accepted to the journal or not. Those papers that are deemed of sufficient quality are accepted for publication in the ISEDJ journal. Currently the target acceptance rate for the journal is under 40%. Information Systems Education Journal is pleased to be listed in the 1st Edition of Cabell's Directory of Publishing Opportunities in Educational Technology and Library Science, in both the electronic and printed editions. Questions should be addressed to the editor at [email protected] or the publisher at [email protected]. Special thanks to members of AITP-EDSIG who perform the editorial and review processes for ISEDJ. AITP Education Special Interest Group (EDSIG) Board of Directors Abstract This paper discusses how cloud computing can be leveraged to add value to academic programs in information systems and other fields by improving financial sustainment models for institutional technology and academic departments, relieving the strain on overworked technology support resources, while adding richness and improving pedagogical delivery of course content. A literature review on cloud definitions and how cloud paradigms are being implemented in academia is conducted. The author suggests that for smaller programs and institutions, cloud hosting of applications, services and platforms in support of information systems programs may be the only financially viable solution to course technology requirements. The impact of transitioning core information systems courses to a cloud paradigm is discussed, and examples of how the transition can improve course content and delivery are provided. Finally, details are presented on how a transition to the cloud is being accomplished in the information systems program of the school of continuing studies at the author's small liberal arts university
Identification of constrained sequence elements across 239 primate genomes.
No full textNoncoding DNA is central to our understanding of human gene regulation and complex diseases , and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in the human genome . Identifying the genomic elements that have become constrained specifically in primates has been hampered by the faster evolution of noncoding DNA compared to protein-coding DNA , the relatively short timescales separating primate species , and the previously limited availability of whole-genome sequences . Here we construct a whole-genome alignment of 239 species, representing nearly half of all extant species in the primate order. Using this resource, we identified human regulatory elements that are under selective constraint across primates and other mammals at a 5% false discovery rate. We detected 111,318 DNase I hypersensitivity sites and 267,410 transcription factor binding sites that are constrained specifically in primates but not across other placental mammals and validate their cis-regulatory effects on gene expression. These regulatory elements are enriched for human genetic variants that affect gene expression and complex traits and diseases. Our results highlight the important role of recent evolution in regulatory sequence elements differentiating primates, including humans, from other placental mammals. [Abstract copyright: © 2023. The Author(s).
