1,773 research outputs found
Progetti per l'Isola dei granai, Danzica
No full textPresentazione del progetto redatto dal gruppo diretto da G. Polesello per la ricostruzione dell'Isola dei Granai a Danzica come nuovo centro-città, 1989
Genetic and Viral landscape in B-Cell Lymphomas : Insights on the EBV Role and Associated Shifts in The Tumour Microenviroment.
No full textThe cellular milieau in which lymphoma cells thrive has solely recently become a relevant focus of investigation. The functions of what was belived to be passive bystanders are rapidly becoming elucidated in order to explore potential targets for immunotherapy. Albeit our comprehension of cytogenetic abnormalities and molecular pathways in lymphoma are in advance of solid organ tumors, the same cannot be asserted of the tumor microenvironment. Viruses, being obligate parasites, are under continuous burden in order to survive in front of strong host immune responses. To preserve a replicative advantage , they employ manifold tricks to turn themselves immunologically undetectable. Indeed , EBV may actively reshape lymphoma microenvironment, which is coming into view as a pivotal constituent of the tumor. This talent is at least to some extent due to the elegant strategy evolved by this herpes virus to establish a latent infection in memory B lymphocytes. In point of fact , EBV orchestrates a variety of complex mechanisms facilitating the escape of lymphoma cells from anti-tumor immune responses while sustaining the creation of niches in which tumor cells may survive and prosper. Enlightenment of the contribution of tumor microenvironment in lymphomagenesis is providing the fabric for detecting and validating new therapies that aim both lymphoma cells and crucial microenvironmental components
Isola dei Granai, Danzica
No full textPresentazione del progetto per la trasformazione dell'Isola dei granai in centro città, redatto da G. Polesello con i suoi allievi (R. Fein, M. El Daccache, A. Dal Fabbro, M. Iori, S. Maffioletti, M. Montuori, P. Valle) in occasione del Seminario internazionale organizzato dall'Ordine degli Architetti della Polonia, Danzica 1989
Un progetto veneziano per Danzica sull'Isola dei granai
No full textPresentazione del progetto redatto in occasione di un concorso internazionale dal gruppo diretto da G. Polesello per l'Isola dei granai a Danzica come nuovo centro-città, 1989
Xanthomatous Inflammatory Infiltrate Involving the Spleen: An Unusual Presentation of Erdheim-Chester Disease and Review of the Literature
No full textBACKGROUND Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by foamy histiocytes, Touton-like giant cells, and fibrosis, typically affecting the diaphyseal and metaphyseal region of the long bones but that can involve any organ or tissue. ECD is usually associated with the BRAF V600E mutation or with other molecular mutations inserted in the MAPK cascade. CASE REPORT We present the case of a 63-year-old man with a previous history of myocardial infarction who underwent an emergency splenectomy for splenic rupture after an accidental fall. Histological examination of the spleen showed a diffuse xanthogranulomatous proliferation (CD68+, CD163+, S100-, CD1a-) with rare Touton-like giant cells in the red pulp. Based on the histologic findings, a diagnosis of ECD was made. However, skeletal involvement and BRAF V600E mutation were not detected. CONCLUSIONS Cases of non-Langerhans cell histiocytosis that are histologically consistent with ECD in unusual sites have been increasingly described. There is also anecdotal evidence for cases being associated with mutations besides BRAF V600E or with no genetic alteration and no skeletal involvement. Likewise, the spectrum of clinical and molecular features of ECD can be broader than previously considered. Furthermore, there is evidence that various phases of the disease can show different clinical presentations with distinct prognostic impact, according to the mutational spectrum. Recognizing ECD at an early stage allows more effective patient management, and pathologists and clinicians should be aware of the unusual clinical presentations of this rare condition
Recuerdos de Massimo.
No full textEl presente ensayo recuerda la rica relación personal e intelectual entre Massimo Pavarini e Iñaki Rivera Beiras desde que el segundo conoció siendo muy joven a Pavarini. En ese sentido, el trabajo recuerda los inicios de su fecunda relación en la ciudad de Bologna cuando Iñaki Rivera acudía a presentar a Massimo Pavarini los desarrollos de lo que sería su tesis doctoral. Las contribuciones de Pavarini al proceso de aprendizaje de Rivera, en el terreno de una epistemología crítica en la penología contemporánea, son analizados como un homenaje a la memoria y a la obra del autor italiano, tras su fallecimiento en septiembre de 2015.This paper recalls the rich personal and intellectual relationship between Massimo Pavarini and Iñaki Rivera Beiras. In that sense , the work recalls the beginning of his fruitful relationship in the city of Bologna when Iñaki Rivera came to present Massimo Pavarini’ developments in what would be his PhD thesis. Pavarini contributions to the learning process of Rivera, on the ground of a critical epistemology in contemporary penology , are analyzed as a tribute to the memory and to the work of Italian author, after his death in September 2015 .El presente ensayo recuerda la rica relación personal e intelectual entre Massimo Pavarini e Iñaki Rivera Beiras desde que el segundo conoció siendo muy joven a Pavarini. En ese sentido, el trabajo recuerda los inicios de su fecunda relación en la ciudad de Bologna cuando Iñaki Rivera acudía a presentar a Massimo Pavarini los desarrollos de lo que sería su tesis doctoral. Las contribuciones de Pavarini al proceso de aprendizaje de Rivera, en el terreno de una epistemología crítica en la penología contemporánea, son analizados como un homenaje a la memoria y a la obra del autor italiano, tras su fallecimiento en septiembre de 2015
Between Participatory Approaches and Politics, Promoting Social Innovation in Smart Cities: Building a Hum–Animal Smart City in Lucca
No full textIn recent decades, the interest in social innovation and nature-based solutions has spread in scientific articles, and they are increasingly deployed for cities’ strategic planning. In this scenario, participatory approaches become pivotal to engaging the population and stakeholders in the decision- making process. In this paper, we reflect on the first year’s results and the strengths and weaknesses— of the participatory activities realized in Lucca to co-design and co-deploy a smart city based on human–animal relationships in the framework of the European project Horizon 2020 (IN-HABIT). Human–animal bonds, as nature-based solutions, are scientifically and practically underestimated. Data were collected on the activities organized to implement a public–private–people partnership in co-designing infrastructural solutions (so-called Animal Lines) and soft nature-based solutions to be implemented in the city. Stakeholders actively engaged in mutual discussions with great enthusiasm, and the emergent ideas (the need to improve people’s knowledge of animals and develop a map showing pet-friendly services and places and the need for integration to create innovative pet services) were copious and different while showing many connections among the various points of view. At the same time, a deeper reflection on the relationships among the participatory activities and institutionally integrated arrangements also emerged
Predoni a casa nostra e il geografo solidale: Massimo Quaini tra terra e acqua
No full textIn accordance with the main goals of this collection of essays in honour of Massimo Quaini, the text focuses on a peculiar character of the Ligurian geographer’s sensibility, his attention to landscape protectionresearch activity developed in the context of the humanistic geography. Starting from a personal narrative based on his own reminiscences and neglected memories, the author tries to shed light on the relationships between civil commitment and cultural reflection which characterize environmental sensitivity, bringing together his interests with Quaini’s emotional geographies. Finally, some of Quaini’s everyday practicalities are highlighted as the easiest doorway to improve the cognitive procedures of cultural geography
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