7 research outputs found
The behavioural, toxicological, and biochemical effects of caffeine on Lumbriculus variegatus
No full textLumbriculus variegatus is increasingly used in environmental toxicology and pharmacology, yet the behavioural, toxicological and biochemical effects of caffeine in this species remain poorly defined. Here, we characterised caffeine’s effects on stimulated behaviours, locomotor activity, toxicity, and energy stores. Exposure to ≥5.0 mM caffeine for 10 minutes or ≥3.0 mM for 24 hours significantly reduced stimulated behaviours, with locomotor activity similarly suppressed at ≥5.0 mM (10 minutes) and ≥1.0 mM (24 hours) (p < .05, n = 8) with impairment persisting 24 hours after exposure to 10 mM (10 minutes) or 3.5 mM (24 hours). A 24-hour LC50 of 4.7 mM (95% CI: 4.60–4.70 mM) was observed, with significant lethality after seven days at 4.5 mM (p < .0001). These findings provide the first characterisation of caffeine’s behavioural and toxicological effects in L. variegatus and contribute to the environmental risk assessment of caffeine contamination in freshwater systems
Orchestra and Choir Concert
No full text8:00 P.M. | Orchestra and Choir Concert
Faculty Mentor: Katie Gardiner College Choir
Sopranos Alanna Mahar ‘26 Angela Connelly ‘28 Ava Bucci ‘28 Caroline Guravage ‘28 Carolyn Curtin ‘25 Claudia Rolle Leis ‘28 Emerson Lyons ‘25 Emily Fox ‘26 Emily Karlson ‘28 Emma Crain ‘25 Emma Hatem ‘27 Erin Melley ‘25 Grace Conroy ‘25 Haley Labdon ‘28 Janna Hindawi ‘28 Maria Kelly ‘28 Mary Powers ‘27 Meredith Brady ‘26 Meredith Shaw ‘27 Onora Healey ‘27 Rebekah Powers ‘28 Rory Gilles ‘28 Sophie Sundaram ‘26
Altos Beverly Riley ‘25 Ceci Massaua ‘27 Elizabeth Nompleggi ‘25 Erin O\u27Donovan ‘25 Greyson Brady ‘26 Jango Janigian ‘25 Junyi Wu ‘26 Kate Novack ‘28 Katherine Quinn ‘26 Lila Pasquarello ‘28 Mary Hatt ‘27 Regina Palladino ‘27 Rhiannon Hurst ‘25 Brooks Scholar and Fenwick Scholar Sophia Olbrysh ‘28
Tenors and Basses Benjamin Roe ‘27 Billy Suter ‘25 Brennan DeCourcey ‘26 Christian Healy ‘28 Dan Hanlon ‘25 Fletcher Hohn ‘28 Frank Amuso ‘26 Matt Hollatz ‘28 Matthew Walsh ‘27 Max Côté ‘26 Patrick Brown ‘28 Patrick Lombard ‘28 Raymond Borawski ‘28 Ronan Flanagan ‘28 Victor Matheson Holy Cross Community Victor Torres ‘27 Zack Sneeringer Holy Cross Community
Orchestra Director: Michael Carney College Orchestra
Ari Kiirikki ‘25 Flute/Brooks Scholar Amanda Masse ‘27 Flute Brendan Robinson ‘26 Oboe Ella Murray ‘27 Clarinet Jasmine Bridger ‘27 Clarinet Simone Cooke ‘27 Trumpet Riley Listengart ‘28 Horn Andrei Chura ‘25 Trombone Lucas Villaseñor ‘27 Tuba Matthew Jaskot Piano/Holy Cross Community Elliot Barron ‘25 Percussion Hans Christian Dinter ‘27 Percussion John Greco ‘28 Percussion Norah Riad ‘27 Percussion Rebecca Buckley ‘26 Violin Lucio Garcia ‘28 Violin Rosemary Guida ‘28 Violin Joshua Love ‘28 Violin Emerson Lyons ‘25 Violin/Concert Master Matthew MacDonald ‘27 Violin Isabella O’Connor ‘26 Violin Sophia Olbrysh ‘28 Violin McKenzie Sefah ‘28 Violin Emily Seiler ‘26 Violin Anna Baker ‘25 Viola Pietro Fosco Romussi ‘27 Cello/Brooks Scholar Julianna Stratton ‘26 Cello Alex Papa ‘28 Cello Iris Frost ‘28 Cello Wesley Smith ‘25 Bass Laura Arciniegas ‘28 Bas
The behavioural, toxicological, and biochemical effects of caffeine on Lumbriculus variegatus
Get PDFCaffeine is an emerging contaminant of concern frequently detected in freshwater systems, yet the behavioural, toxicological and biochemical effects of caffeine in aquatic invertebrates remain poorly characterised. Here, we investigate the effects of caffeine exposure on survival, behaviour, locomotion, and energy stores in the freshwater annelid Lumbriculus variegatus. Exposure to ≥ 5.0 mM caffeine for 10 min or ≥ 3.0 mM for 24 h reduced stimulated behaviours, with locomotion suppressed at ≥ 5.0 mM (10 min) and ≥ 1.0 mM (24 h) (p < .05, n = 8), which persisted 24 h after exposure to 10 mM (10 min) or 3.5 mM (24 h). A 24-hour LC50 of 4.7 mM (95% CI: 4.60–4.70 mM) was observed, with significant lethality after seven days at 4.5 mM (p < .0001). These findings provide the first characterisation of caffeine’s effects in L. variegatus and inform environmental risk assessment of caffeine in freshwater systems
The behavioral, physiological, and biochemical responses of Lumbriculus variegatus exposed to cannabidiol and its metabolites
Get PDFCannabidiol (CBD) is a major non-psychoactive cannabinoid that has been detected in environmental samples, but the ecotoxicological effects remain unknown. In this study, Lumbriculus variegatus are exposed to CBD, and its metabolites 7-hydroxy-cannabidiol (7-OH-CBD) and 7-carboxy-cannabidiol (7-COOH-CBD). In this study, toxicity, tactile stimulation to elicit stereotypical behaviours and locomotor activity are measured after 24-hour exposure of L. variegatus to CBD and its metabolites. We also describe the impacts on dorsal blood vessel pulsation and oxygen consumption after 24-hour exposure to CBD and 7-OH-CBD, and the effects on regenerative capacity and total energy reserves after 72 hours of exposure to CBD and 7-OH-CBD. We observe CBD, 7-OH-CBD and 7-COOH-CBD display toxicity in 50% of test populations at 14.12 µM, 11.29 µM and 15.36 µM, respectively. 24-hour exposure to CBD decreases tactile stimulation response to elicit body reversal at ≥ 2.5 µM and helical swimming at ≥ 0.5 µM and reduces locomotor activity. L. variegatus oxygen consumption was not affected by CBD but ≥2.5 µM significantly reduced dorsal blood vessel pulse rate. We observe that exposure to 7-OH-CBD does not affect the regenerative capacity of L. variegatus while CBD is shown to reduce regeneration. Exposure to CBD also results in a significant decrease in carbohydrates, increased lipid, and no effect on protein levels in L. variegatus. We determined that CBD can reduce L. variegatus behaviours, decrease pulse rates and regenerative capacity, and disrupt energy reserves. Our findings show that CBD is toxic to this common aquatic organism and the increased availability and use of CBD, and related substances, warrants further study of their environmental impact
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Scattering and sublimation: A multiscale view of μm-sized dust in the inclined disc of HD 145718
No full textWe present multi-instrument observations of the disc around the Herbig Ae star, HD 145718, employing geometric and Monte Carlo radiative transfer models to explore the disc orientation, the vertical and radial extent of the near-infrared (NIR) scattering surface, and the properties of the dust in the disc surface and sublimation rim. The disc appears inclined at 67-71°, with position angle, PA =-1.0 to 0.6°, consistent with previous estimates. The NIR scattering surface extends out to ∼ 75 au and we infer an aspect ratio, hscat(r)/r ∼0.24 in J band; ∼0.22 in H band. Our Gemini Planet Imager images and VLTI + CHARA NIR interferometry suggest that the disc surface layers are populated by grains λ/2πin size, indicating these grains are aerodynamically supported against settling and/or the density of smaller grains is relatively low. We demonstrate that our geometric analysis provides a reasonable assessment of the height of the NIR scattering surface at the outer edge of the disc and, if the inclination can be independently constrained, has the potential to probe the flaring exponent of the scattering surface in similarly inclined (i 70°) discs. In re-evaluating HD 145718's stellar properties, we found that the object's dimming events-previously characterized as UX Or and dipper variability-are consistent with dust occultation by grains larger, on average, than found in the ISM. This occulting dust likely originates close to the inferred dust sublimation radius at 0.17 au. © 2022 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society.Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Interferometric Detections of sdO Companions Orbiting Three Classical Be Stars
No full textClassical Be stars are possible products of close binary evolution, in which the mass donor becomes a hot, stripped O- or B-type subdwarf (sdO/sdB), and the mass gainer spins up and grows a disk to become a Be star. While several Be+sdO binaries have been identified, dynamical masses and other fundamental parameters are available only for a single Be+sdO system, limiting the confrontation with binary evolution models. In this work, we present direct interferometric detections of the sdO companions of three Be stars - 28 Cyg, V2119 Cyg, and 60 Cyg - all of which were previously found in UV spectra. For two of the three Be+sdO systems, we present first orbits and preliminary dynamical masses of the components, revealing that one of them could be the first identified progenitor of a Be/X-ray binary with a neutron star companion. These results provide new sets of fundamental parameters that are crucially needed to establish the evolutionary status and origin of Be stars. © 2022. The Author(s). Published by the American Astronomical Society.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
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The orbit and stellar masses of the archetype colliding-wind binary WR 140
No full textWe present updated orbital elements for the Wolf-Rayet (WR) binary WR 140 (HD 193793; WC7pd + O5.5fc). The new orbital elements were derived using previously published measurements along with 160 new radial velocity measurements across the 2016 periastron passage of WR 140. Additionally, four new measurements of the orbital astrometry were collected with the CHARA Array. With these measurements, we derive stellar masses of and . We also include a discussion of the evolutionary history of this system from the Binary Population and Spectral Synthesis model grid to show that this WR star likely formed primarily through mass-loss in the stellar winds, with only a moderate amount of mass lost or transferred through binary interactions. © 2021 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society.Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
