1,001 research outputs found
Technology of Activation of Regenerative Rehabilitation: Mechanisms and Neuroendocrine Modulation - A Narrative Review
No full textModern tissue regeneration activation technology is based on two complementary and synergistic therapeutic strategies. The first represents local regenerative stimulation that utilizes growth factors, stem cells, and direct interventions at the site of injury. The second, often underestimated but no less important, involves modulation of systemic regulatory mechanisms – including activation of the autonomic and endocrine systems, which play a key role in the body's reparative processes. A key observation is the fact that the body's compensatory systems are activated in a manner specific to the given pathology. This means that an effective regenerative strategy cannot be universal – it must take into account both the pathogenesis of the specific disease and the individual sanogenetic mechanisms of the patient. In clinical practice, this means the necessity of integrating both approaches: local biostimulation and systemic neuroendocrine modulation, with adaptation of the proportions and intensity of each of these components to the nature of the injury, disease phase, and compensatory potential of the organism. Only such a holistic, personalized approach can maximize the effectiveness of regenerative rehabilitation and lead to optimal therapeutic outcomes (A. Gozhenko). (Gozhenko et al., 2019; Gozhenko et al., 2021).
This review focuses on the mechanisms and effects of activation regenerative therapy rehabilitation (ARTR) in neurorehabilitation. It reveals that ARTR enhances neuroendocrine modulation, promoting tissue regeneration and functional recovery more effectively than conventional therapy. Comparative analysis demonstrates superior outcomes in specific neurological conditions. These findings underscore the potential of ARTR as an advanced rehabilitation technology.
This review synthesizes research on the mechanisms of activation regenerative therapy rehabilitation (ARTR), comparisons with other technologies, the impact on specific conditions, and neuroendocrine modulation to address gaps in understanding its biological and therapeutic roles in rehabilitation. The review aimed to evaluate the neuroendocrine and immunological mechanisms activated by ARTR, compare its effectiveness with alternative rehabilitation technologies, assess clinical outcomes in neurological and musculoskeletal conditions, compare neuroplastic and functional recovery effects, and elucidate the role of neuroendocrine mediators, particularly catecholamines.
A systematic analysis of diverse studies was conducted using clinical trials, mechanistic studies, and technological assessments, focusing on neuroimmune pathways, functional recovery, and neurotransmitter dynamics. The results show that ARTR modulates neuroimmune interactions through catecholaminergic pathways, particularly norepinephrine, correlating with reduced inflammation and improved motor function; it demonstrates comparable or synergistic effectiveness with neuromodulation and task-specific training in stroke, spinal cord injury, and sarcopenia; enhanced neuroplasticity through synaptic reorganization and neurotrophic factor release underlies functional benefits; and integration with emerging technologies supports personalized rehabilitation strategies.
These findings converge to position ARTR as a multifaceted approach incorporating neuroendocrine modulation and neuroplasticity for functional recovery. The synthesis emphasizes the need for standardized protocols and large-scale trials to optimize clinical translation and advance regenerative rehabilitation paradigms
“TO VICTORY” FOR VOCAL SEXTET AND SYMPHONY ORCHESTRA BY OLENA ILNYTSKA: MYTHOPOETICS OF THE WORK
No full textThe works of the Ukrainian composer Olena Ilnytska (born in 1977) are well known not only in Ukraine, but also abroad. Her works are performed by both domestic and foreign musicians. The piece “To Victory” for vocal sextet and symphony orchestra is an example of contemporary Ukrainian symphonism, combining Western European and national traditions with techniques of contemporary musical language. In it, as in other genres, the author\u27s mythopoetic thinking is evident. She reflects on a complex, historically established genre that has a philosophical basis in the history of world musical culture. “To Victory” is indicative both for understanding of mythopoetics of symphony music and the author’s symphonic thinking, which revealed itself in the skill of large-scale thinking, combining different musical-semantical intonation models, uniting them in an integrate structure. Mythologization takes place on genre, thematic, and timbre levels
Features of neuro-endocrine and immune reactions to various water-salt loads in female rats
No full textGozhenko Olena A, Zavidnyuk Yuriy V, Korda Mykhaylo M, Mysula Igor R, Klishch Ivan M, Zukow Walery, Popovych Igor L. FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS. Journal of Education, Health and Sport. 2018;8(9):11-31. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1323491
http://ojs.ukw.edu.pl/index.php/johs/article/view/5729
https://pbn.nauka.gov.pl/sedno-webapp/works/872545
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017).
1223 Journal of Education, Health and Sport eissn 2391-8306 7
© The Author(s) 2018;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.06.2018. Revised: 28.06.2018. Accepted: 30.07.2018.
FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS
Olena A Gozhenko1, Yuriy V Zavidnyuk1,2, Mykhaylo M Korda2, Igor R Mysula2,
Ivan M Klishch2, Walery Zukow3, Igor L Popovych4
1Ukrainian Scientific Research Institute of Transport Medicine, Odesa, Ukraine, [email protected]
2IY Horbachevs’kyi State Medical University, Ternopil’, Ukraine, [email protected]
3Nicolaus Copernicus University, Torun, Poland, [email protected]
4OO Bohomolets’ Institute of Physiology, Kyiv, Ukraine, [email protected]
Abstract
Background. Previously, we have shown that the weekly load of rats with water-salt solutions of different chemical compositions causes both general and specific reactions of the parameters of metabolism. The purpose of this study is to identify under these conditions specific neuroendocrine and immune responses. Materials and methods. Experiment was performed on 58 healthy female Wistar rats 240-290 g divided into 6 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Instead, the other rats received the same tap water as well as waters Sophiya, Naftussya, Gertsa and its artificial salt analogue through the probe at a dose of 1,5 mL/100 g of body mass for 6 days. The day after the completion of the drinking course in all rats some neuroendocrine and immune parameters were registered. Results. The method of discriminant analysis revealed 29 parameters of the neuroendocrine-immune complex (10 of them reflect the neuroendocrine regulation, 4 thymus mass and thymocytogram elements, 5 elements of splenocytogram, 10 elements of immunocytogram and leukocytogram of blood and parameters of phagocytosis), according to which the reaction on various water-salt loads are identified with an accuracy of 98.3%. Conclusion. The peculiarities of the reactions of the parameters of the neuroendocrine-immune complex are due to the content of water in sulfate, bicarbonate and magnesium, as well as organic carbon and nitrogen.
Key words. Water-salt loads, neuroendocrine and immune parameters, female rats.Gozhenko Olena A, Zavidnyuk Yuriy V, Korda Mykhaylo M, Mysula Igor R, Klishch Ivan M, Zukow Walery, Popovych Igor L. FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS. Journal of Education, Health and Sport. 2018;8(9):11-31. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1323491
http://ojs.ukw.edu.pl/index.php/johs/article/view/5729
https://pbn.nauka.gov.pl/sedno-webapp/works/87254
Functional–Metabolic Continuum: A Novel Perspective on the Pathogenesis of Stress-Induced Metabolic Disorders. A problem-oriented review
No full textBackground: The global epidemic of metabolic diseases demands novel theoretical frameworks for understanding their pathogenesis. The functional–metabolic continuum (FMC) concept, first articulated by Gozhenko in 2010, offers an integrative model connecting stress physiology, metabolic regulation, and cardiovascular disease.
Objective: To present a comprehensive review of the FMC concept—its evolutionary foundations, pathophysiological mechanisms, clinical manifestations, and therapeutic implications—with particular emphasis on the standardized regulatory–metabolic response that evolved to support physical function.
Key Concepts: The FMC postulates that health depends on temporal and quantitative coupling between metabolic mobilization of energy substrates by neuroendocrine systems and their utilization by somatic functions, especially muscular activity. Evolution shaped a standardized regulatory–metabolic response—uniform in direction and magnitude—that was inseparably linked with physical function. This response is stereotypical and cannot be flexibly downregulated; regulatory activation invariably produces standard metabolic mobilization, regardless of whether physical activity will actually occur. Modern conditions disrupt this coupling via two principal mechanisms: (1) psychoemotional stress activates neuroendocrine systems and mobilizes substrates in the ancestral "fight-or-flight" pattern, yet social constraints prevent the physical activity that would consume these substrates; (2) dietary excess supplies substrates in quantities chronically exceeding utilization capacity, especially when combined with sedentary lifestyles. Both mechanisms result in chronic or recurrent hyperglycemia and hyperlipidemia, damaging vascular endothelium through glycosylation, oxidative stress, inflammation, and lipid accumulation. Endothelial dysfunction represents the central pathogenetic link between metabolic derangements and clinical cardiovascular disease. Our studies of circulating desquamated endothelial cells demonstrate progressive endothelial damage across a continuum—from apparently healthy individuals through isolated arterial hypertension and ischemic heart disease to comorbid states—correlating with the severity of metabolic disturbance.
Therapeutic Implications: Restoration of the FMC through physical activity (consumption of mobilized substrates) or dietary approaches (reduction of substrate availability) represents pathogenetically grounded therapy. Temporal coupling is critical: physical activity should follow stress exposure or meals to consume mobilized substrates before they exert pathological effects. Time-restricted eating and avoidance of late-evening meals reduce substrate availability during circadian phases when utilization capacity is minimal.
Conclusions: The FMC concept provides a novel integrative approach to understanding metabolic diseases as consequences of a mismatch between ancient physiology (a standardized regulatory–metabolic response inseparably linked with physical function) and modern conditions (psychoemotional stress without muscular work, dietary excess with sedentary lifestyle). Recognizing that regulatory activation invariably evokes standard metabolic mobilization, independently of functional need, explains why modern stressors become pathogenic. Restoration of functional–metabolic balance through targeted interventions may prevent or halt progression of metabolic diseases
Reforming the agricultural land market: EU experience for Ukraine
No full textCHYGRYN, Olena, IVAKHNENKO, Olena. Reforming the agricultural land market: EU experience for Ukraine. CSIE Working Papers Series. December 2018, issue 10, pp. 17-29. ISSN 2537-6187.The need to introduce a full-fledged land market is conditioned by the realities of today. Land, a significant component of the productive forces, is still not integrated into a civilized market exchange in Ukraine. The paper is devoted to the substantiation of the need to reform the agricultural land market in Ukraine. The state of the agricultural land market in Ukraine is analyzed. The author emphasizes that in this connection the creation and functioning of a civilized agricultural land market requires the strengthening of state regulation in this area. It can stop not only the agrarian crisis, but also the economic crisis in general. The main features of the land market in other European countries are described. The author emphasizes that the EU has vast experience in this area that Ukraine can use to reform the agricultural land market. The author emphasizes that before removing the moratorium a number of problems related to the introduction of the land market in Ukraine have to be solved
Water, Proteins, and Volume Regulation: Molecular Mechanisms of Hydration and Oncotic Balance
No full textBackground: Water is the fundamental basis of life and an absolute prerequisite for the existence of proteins and all biological structures. During evolution, an extraordinarily complex multilevel system of water homeostasis has developed in the human body, with diverse executive mechanisms at each level of biological organization.
Objective: Comprehensive analysis of molecular, cellular, and systemic mechanisms of water-protein interactions in the context of human physiology, with particular emphasis on the role of urea as a regulator of protein hydration, the function of plasma proteins in maintaining oncotic pressure, and the pathophysiology of hepatic hypoproteinemia.
Methods: Narrative literature review with systematic search in PubMed, Scopus, and Web of Science databases for the period 1980-2025. Over 80 scientific sources were analyzed, including original research, systematic reviews, and clinical studies. Special attention was paid to the works of Professor A.I. Gozhenko and co-authors on water-salt homeostasis.
Results: Protein hydration layers consist of several zones with varying degrees of ordering (first layer 0.25-0.35 nm, second layer 0.35-0.6 nm), with the rotational relaxation time of water molecules in the first layer being 2-5 times longer than in bulk water. Urea demonstrates a concentration-dependent dichotomy: at physiological concentrations (5-500 mM) it functions as a compatible osmolyte, while at high concentrations (6-8 M) it acts as a denaturant. Albumin, comprising 60% of plasma protein mass, generates 75-80% of oncotic pressure (25-28 mmHg) due to the Donnan effect and nonlinear dependence π = RT·C·(1+kC). Aquaporins transport up to 3×10⁹ water molecules/s, while Na⁺/K⁺-ATPase creates ionic gradients by exporting 3 Na⁺ and importing 2 K⁺ per ATP molecule. Vasopressin, via V2 receptors, activates the cAMP-PKA cascade, leading to AQP2 phosphorylation at Ser256 and its translocation to the apical membrane. Hepatic hypoalbuminemia (<25-30 g/L) disrupts Starling balance, activating RAAS and ADH, which paradoxically exacerbates edema.
Conclusions: Water homeostasis is maintained through hierarchical integration of molecular (protein hydration, urea role), cellular (aquaporins, Na⁺/K⁺-ATPase), tissue (Starling balance, oncotic pressure), and systemic (hypothalamic-pituitary-renal axis) mechanisms. Disruption at any level leads to a cascade of pathological changes, emphasizing the need for an integrative approach to the diagnosis and treatment of water balance disorders
Author and reader or authoress and lady reader? Gender and narrative of Olena Pchilka’s fiction
No full textУ статті досліджено специфіку моделювання образів автора, наратора і читача у художній прозі Олени Пчілки, визначено гендерний аспект даної проблеми. Доводиться, що комунікативні стратегії авторки враховували гендерну ідентичність свого наратора і читача. Створено власну модель читача («любої читальниці») й оповідачки як прогресивних жінок, які прагнуть до освіти і професійної самореалізації. Іронічний наратив визначив близькість світоглядних орієнтирів авторки та її читачок, які розвінчували міфи патріархального суспільства.В статье исследуется специфика моделирования образов автора, нарратора и читателя в художественной прозе Олены Пчилки, определен гендерный аспект данной проблемы. Доказывается, что коммуникативные стратегии автора включали гендерную идентичность своего нарратора и читателя. Создана собственная модель читателя («дорогой читательницы») и рассказчицы как прогрессивных женщин, которые стремятся к образованию и профессиональной самореализации. Иронический нарратив определил близость мировоззренческих ориентиров писательницы и ее читательниц, которые развеивали мифы
патриархального общества.The article explores simulation of images of the author, the narrator and the reader in the fiction by Olena
Pchilka. The problem of gender is investigated as well. The author’s communication strategy is included in the gender identity of the narrator and the reader (“dear reader”). The own model of the reader and the narrator is created: they are progressive women who strive to education and professional fulfillment. Ironic narrative determines the adjacency of the world view of the author and the readers who dispelled myths of a patriarchal society
Постать Миколи Стороженка в рецепції Олени Пчілки / Figure of Mycola Storozhenko in the Recipe of Olena Pchilka
No full textThe article deals with the reception by Olena Pchilka the person and activity of Mykola Ilyich Storozhenko (1836–1906), a well-known literary critic, professor, head of the department of world literature at Moscow University, originally from Poltava region. Olena Pchilka is the author of an essay about him (1902) and a well-known obituary (1906), which was published in the magazine «Kievskaya Staryna». The peculiarity of the reception in these memoirs is caused by the installation on the reader: mentions of specific events in the essay-memoir (acquaintance in Moscow and celebration in 30th anniversary of Mykola Storozhenko's scientific and pedagogical activity) and, after the death, a summary of all the activities of the person, which takes the form of a literary portrait. First of all, it draws attention to the biographical dimension of Olena Pchilka's memoirs about Mykola Storozhenko, in which the tributes to a fellow countryman who has succeeded beyond the homeland are clearly traced. Mykola Storozhenko's letter to Olena Pchilka is first introduced into scientific circulation. The senior and authoritative M. Storozhenko was a recognized scientist, and this is always emphasized by the author of his memoirs, comprehending his life path. The heroes of her memoirs are not only M. Storozhenko, but also his scientific works, the environment in which he was, common acquaintances, days of which he was a part. In the memoirs there is a description of the appearance, psychological observations of the character of the protagonist and vivid episodic characters. It is a creative portrait of a scientist and public figure. Substantial information about Mykola Storozhenko's relations with fellow countrymen is provided. Not only the literary criticism but also the socio-cultural context of its activity is emphasized. Unconditional respect for the scientific work of Mykola Storozhenko in memoirs is combined with an indication of his merits for his native land
Improvement of the water resources management system at the territorial level
No full textСтаття присвячена вдосконаленню системи управління водними ресурсами на територіальному рівні. У статті висвітлюються проблеми в різних країнах світу, які описані у водопостачанні із збільшенням кількості суворого клімату. Сьогодні існуюча тенденція свідчить про те, що з початку 20 століття втрачено або деградовано близько двох третин лісів і заболочених земель, ґрунт зруйнований і погіршився в якості. Ці тенденції передбачають повені та посуху, що, в свою чергу, впливає на нашу здатність адаптуватися до змін клімату. Здійснено аналіз літератури щодо особливостей визначення основних елементів впливу на використання водних ресурсів у світі. У статті використано діалектичний метод, який зумовлений необхідністю аналізу та узагальнення окремих аспектів наукових знань, які аналізують наявність водних ресурсів у різних куточках світу. Застосовано структурно-функціональний аналіз принципу систематичного вивчення явищ та процесів. За допомогою системно-аналітичного методу утримання територій (районів) України місцевими водними ресурсами розраховується, в середньому, на рік, це м3 на людину, виходячи з ресурсу поверхневих вод, а також розвідка та водозбір ґрунтових вод. Розроблено декомпозицію критеріїв оцінки ефективності управління водними ресурсами на територіальному рівні на основі інтегрального територіального показника. Відповідно до числового значення інтегрованого індексу територіальної ефективності пропонується об'єднати регіони в однорідні групи залежно від близькості чи відстані від середнього значення цього показника.The article is devoted to the improvement of the water resources management system at the territorial level. The article covers problems in different countries of the world, which are described in the water supply with an increase in the population of a harsh climate. Today, the existing trend shows that about two-thirds of forests and wetlands have been lost or degraded since the early 20th century, the soil was destroyed and deteriorated in quality. These trends predict floods and droughts, which in turn affects our ability to adapt to climate change. The analysis of the literature on the peculiarities of determining the main elements of influence on the use of water resources in the world is carried out. The article used a dialectical method, which is due to the need for analysis and generalization of certain aspects of scientific knowledge that analyze the availability of water resources in different parts of the world. Structural-functional analysis of the principle of systematic study of phenomena and processes is applied. With the help of the system-analytical method, the maintenance of the territories (areas) of Ukraine by local water resources is calculated, on average, per year, this m3 per person, based on the resource of surface water, as well as the exploration and catchment of groundwater. The decomposition of criteria for assessing the effectiveness of water resources management at the territorial level based on the integral territorial index is developed. According to the numerical value of the integrated territorial efficiency index, it is proposed to combine regions into homogeneous groups depending on the proximity or distance from the average value of this index
"Oh, My Thoughts, My Thoughts...": Olena Pchilka's and Lesia Ukrainka's Contributions to Epigraphic Embroidery
No full textThe article focuses on the role of Olena Pchilka and Lesia Ukrainka in epigraphic embroidery development. Undoubtedly, Olena Pchilka was an ardent proponent of folk art purity. Following from this, there is a tendency to think that she was against all novelty in Ukrainian embroidery. Many researchers and antiquity enthusiasts refer to her authority when arguing against inscriptions on textile as a phenomenon resulting largely from printed cross-stitch on paper. However, not all embroidered verbal texts have been of print origin. Most of them were folkloric (or folklorized) texts. What is more, Olena Pchilka to some extent provided her own comment on epigraphic embroidery in approving Lesia Ukrainka’s rushnyk (embroidered runner) containing the inscription “Oh, my thoughts, my thoughts, woe is with you! Love one another, brethren, love Ukraine” (devoted to Taras Shevchenko). In modern embroidery, embroideresses reproduce the citation with new connotations of these words, thereby continuing the epigraphic embroidery tradition. The author illustrates the folklorization of oft-cited lines from Taras Shevchenko’s poetry with examples of epigraphic embroidery from her own Interactive Index of Folklore Formulas (Epigraphic Embroidery)
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