1,721,065 research outputs found
CIRCADIAN RHYTHMS AND THEIR IMBALANCE AS ONE OF THE MECHANISMS OF HEALTH DISRUPTION IN MODERN PEOPLE
No full textGozhenko A. I., Hryshko Yu. M. CIRCADIAN RHYTHMS AND THEIR IMBALANCE AS ONE OF THE MECHANISMS OF HEALTH DISRUPTION IN MODERN PEOPLE. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2018;4(54):172-184. ISSN 1818-9385
DOI http://dx.doi.org/10.5281/zenodo.2526928
http://aptm.org.ua
CIRCADIAN RHYTHMS AND THEIR IMBALANCE AS ONE OF THE MECHANISMS OF HEALTH DISRUPTION IN MODERN PEOPLE
A.I. Gozhenko, Yu.M. Hryshko
Ukrainian Medical Stomatological Academy, Poltava
Summary
The paper examines the issues of circadian rhythms functioning and their significance in the regulation of physiological processes. The author discusses the role of physiological biorhythms and melatonin as a universal bioregulator, adaptogen, and stabilizer of the CNS functions. Metabolic circadian rhythms are among the most important processes in the body. The paper analyzes the molecular and genetic aspects of the biological clock and its interrelation with lipid metabolism. The modern views on the biological rhythms of carbohydrate metabolism and its role in the etiology and pathogenesis of diabetes mellitus have been summarized. The influence of circadian rhythms on the LPO parameters has been discussed.
The paper focuses on the issues of desynchronosis, its causes and consequences. The imbalance of circadian rhythms, caused either by external or internal factors, may lead to the disruption of the body’s regulatory systems, which consists in the development of metabolic disorders. This, in its turn, may cause disorders of the modern person’s health.
Key words: circadian rhythms, desynchronosis, melatonin, metabolism
THE ROLE OF SYSTEMIC INFLAMMATION IN THE PATHOGENESIS OF METABOLIC DISORDERS. PART I. CONCEPT OF SYSTEMIC INFLAMMATION AND ITS PATHOGENESIS
No full textGozhenko A. I., Hryshko Yu. M., Gramatiuk S. M. THE ROLE OF SYSTEMIC INFLAMMATION IN THE PATHOGENESIS OF METABOLIC DISORDERS. PART I. CONCEPT OF SYSTEMIC INFLAMMATION AND ITS PATHOGENESIS. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2019;3(84):91-100. ISSN 0049-6804.
DOI http://dx.doi.org/10.5281/zenodo.3465995
http://www.herald.com.ua
УДК 616-002:616-098
DOI http://dx.doi.org/10.5281/zenodo.3465995
THE ROLE OF SYSTEMIC INFLAMMATION IN THE PATHOGENESIS OF METABOLIC DISORDERS. PART I. CONCEPT OF SYSTEMIC INFLAMMATION AND ITS PATHOGENESIS
Gozhenko A. I., Hryshko Yu. M., Gramatiuk S. M.
Ukrainian Research Institute for Medicine of Transport of Ukrainian Ministry of Health Care, Odessa;
Ukrainian Medical Stomatological Academy, Poltava;
Limited Liability Company Institute of Cell Biorehabilitation, Kharkіv
e-mail: [email protected].
Summary. In recent years, the concept of systemic inflammation has emerged - as a typical, pathological process. The development of systemic inflammation as a form of response to systemic alteration is accompanied by functional activation of cells of the lymphoreticular system, which is ensured by changes in metabolism, which further causes the development of insulin resistance, type 2 diabetes mellitus (CD2), atherosclerosis resulting from impaired functional-metabolic continuum (FMC), the concept of which has been formulated in recent years, which indicates the relatively constant nature of metabolism and its parameters in the intercellular environment. Thus, in its turn, is closely connected to the functional activity of organs and cells, thus forming a single system – the continuum. It has been shown that along with the well-known systemic manifestations observed in classical inflammation, as a predominantly local process, there are phenomena inherent in the body that are inflammatory but not local but systemic. Further studies should identify systemic inflammation as a distinct typical pathological process.
Key words: systemic inflammation, metabolism, diabetes mellitus, cytokines, insulin resistance
ENERGY SUPPLY OF INSULIN DEPENDENT AND INSULIN INDEPENDENT TISSUES IN DIFFERENT PERIODS OF BODY FUNCTIONING
No full textGozhenko A. I., Hryshko Yu. M., Gramatyuk S. M. ENERGY SUPPLY OF INSULIN DEPENDENT AND INSULIN INDEPENDENT TISSUES IN DIFFERENT PERIODS OF BODY FUNCTIONING. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2019;2(83):116-127. ISSN 0049-6804.
DOI http://dx.doi.org/10.5281/zenodo.3267478
http://www.herald.com.ua
UDК 616.379-008.64
ENERGY SUPPLY OF INSULIN DEPENDENT AND INSULIN INDEPENDENT TISSUES IN DIFFERENT PERIODS OF BODY FUNCTIONING
A. I. Gozhenko,Yu. M. Hryshko, S. M. Gramatyuk
Ukrainian Medical Stomatological Academy, Poltava;
Summary
The major condition for the human body existence is the constant energy supply of each cell in the organism. Thus, in the process of joint evolution of the brain and gastrointestinal tract, central and peripheral mechanisms aimed at maximizing the conservation of energy resources were improved. Regulatory systems provide energy homeostasis of insulin-dependent and insulin-independent tissues in different periods of body functioning: depending on food intake, fasting, stress, physical activity. Thus, the existing systems of energy homeostasis regulation provide adequate needs of the body depending on both the energy supply and the use of energy. Moreover, organization of energy supply has its own characteristics in insulin-dependent and insulin-independent tissues.
Key words: insulin-dependent tissues, insulin-independent tissues, energy supply, metabolism, insulin resistance
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
INTEGRATION OF PRIVATE BUSINESS PRINCIPLES IN MEDICAL INSTITUTIONS ON THE EXAMPLE OF A BUSINESS MODEL OF ORGANIZATION OF POPULATION'S PLANNED VACCINATION = ІНТЕГРАЦІЯ ПРИНЦИПІВ ПРИВАТНОГО БІЗНЕСУ У МЕДИЧНІ ЗАКЛАДИ НА ПРИКЛАДІ ПОБУДОВИ БІЗНЕС-МОДЕЛІ ОРГАНІЗАЦІЇ ПЛАНОВОЇ ІМУНІЗАЦІЇ НАСЕЛЕННЯ
No full textGozhenko A. I., Gumeniuk A. V., Gumeniuk R. V. INTEGRATION OF PRIVATE BUSINESS PRINCIPLES IN MEDICAL INSTITUTIONS ON THE EXAMPLE OF A BUSINESS MODEL OF ORGANIZATION OF POPULATION’S PLANNED VACCINATION = ІНТЕГРАЦІЯ ПРИНЦИПІВ ПРИВАТНОГО БІЗНЕСУ У МЕДИЧНІ ЗАКЛАДИ НА ПРИКЛАДІ ПОБУДОВИ БІЗНЕС-МОДЕЛІ ОРГАНІЗАЦІЇ ПЛАНОВОЇ ІМУНІЗАЦІЇ НАСЕЛЕННЯ. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2020;4(89):12-17. ISSN 0049-6804.
DOI http://dx.doi.org/10.5281/zenodo.4430734
http://www.herald.com.ua
УДК 614.47:658
DOI http://dx.doi.org/10.5281/zenodo.4430734
INTEGRATION OF PRIVATE BUSINESS PRINCIPLES IN MEDICAL INSTITUTIONS ON THE EXAMPLE OF A BUSINESS MODEL OF ORGANIZATION
OF POPULATION’S PLANNED VACCINATION
A. I. Gozhenko, A. V. Gumeniuk, R. V. Gumeniuk
SE “Ukrainian research Institution for Medicine of Transport”, Odessa;
e-mail: [email protected]
ІНТЕГРАЦІЯ ПРИНЦИПІВ ПРИВАТНОГО БІЗНЕСУ У МЕДИЧНІ ЗАКЛАДИ НА
ПРИКЛАДІ ПОБУДОВИ БІЗНЕС-МОДЕЛІ ОРГАНІЗАЦІЇ ПЛАНОВОЇ
ІМУНІЗАЦІЇ НАСЕЛЕННЯ
А. І. Гоженко, А. В. Гуменюк, Р. В. Гуменюк
ДП Укр НДІ медицини транспорту МОЗ України, м. Одеса
Summary
Denial of vaccination is becoming a problem for countries that intend to close the immunization gap. One in five children in the world does not receive routine immunizations with vital vaccines. The WHO estimates that about 1.5 million children still die each year from diseases that can be prevented with today's vaccines. Vaccination is one of the most effective means of protection against deadly diseases. Objective: to develop a strategy to achieve vaccination coverage, which will help build public confidence in vaccination and health professionals based on the principles of private business and build a business model in the Canvas template. Using the business model in the Canvas template, in the form of nine interconnected blocks, allows the medical institution to clearly describe the activities of the institution and find "bottlenecks" and possible growth points. The peculiarity of the model is the focus of all aspects of the organization's activities on the patient and his needs.
Key words: vaccination of the population; business model in Canvas template; private business
Stages of development of streptozotocin-induced experimental diabetes mellitus
Full text linkBoychuk T. M., Grytsiuk M. I., Gozhenko A. I. Stages of development of streptozotocin-induced experimental diabetes mellitus. Journal of Education, Health and Sport. 2017;7(9):585-593. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1000402
http://ojs.ukw.edu.pl/index.php/johs/article/view/4925
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Authors 2017;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 15.08.2017. Revised: 10.09.2017. Accepted: 10.09.2017.
UDK 616.379-008.64-036-019:615.252.349.7
STAGES OF DEVELOPMENT OF STREPTOZOTOCIN-INDUCED
EXPERIMENTAL DIABETES MELLITUS
Boychuk T. M.*, Grytsiuk M. I.*, Gozhenko A. I. **
*Higher Education Establishment of Ukraine "Bukovinian State Medical University"
**"Ukrainian Research Institute of Transport Medicine" Ministry of Public Health of Ukraine
Abstract
The article presents data about the stages of experimental diabetes mellitus under conditions of the streptozotocin administration. It is noted that in the early development of experimental diabetes, changes in the kidneys proceeds in three stages: physiological adaptation; increasing morphological and functional changes and maladaptation; pathophysiological stage. The data related to changes in glomerular filtration rate, acid excretion, individual morphological alterations, etc. are given. The indicated changes in the opinion of the authors indicate an adaptive reaction of the system of regulation of water-salt metabolism and its main effector organ - the kidneys - to hyperosmia, caused by hyperglycemia with the subsequent formation of diabetic nephropathy.
Key words: diabetes mellitus, streptozotocin, kidneys, hyperglycemia, glomerular filtration
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Відновлення м’язового корсету обличчя при естетичній реабілітації = Restoration muscular face of rehabilitation aesthetic
Full text linkBadyin I. Yu., Gozhenko A. I., Holodkova O. L. Відновлення м’язового корсету обличчя при естетичній реабілітації = Restoration muscular face of rehabilitation aesthetic. Journal of Education, Health and Sport. 2015;5(4):264-272. ISSN 2391-8306. DOI: 10.5281/zenodo.16937
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%284%29%3A264-272
http://dx.doi.org/10.5281/zenodo.16937
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Deklaracja.
Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.
Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 15.02.2015. Revised 27.03.2015. Accepted: 10.04.2015.
відновлення м’язового корсету обличчя ПРИ ЕСТЕТИЧНІЙ РЕАБІЛІТАЦІЇ
RESTORATION muscular FACE OF REHABILITATION aesthetic
І. Ю. Бадьїн, А. І. Гоженко, О. Л. Холодкова
I. Yu. Badyin, A. I. Gozhenko, O. L. Holodkova
ДП Український НДІ медицини транспорту МЗ України, м. Одеса
Ukrainian Research Institute for Medicine of Transport, Odessa, Ukraine
Abstract
Age-related changes of the skin of a face are part of the biological process of aging. The author writes about the improvement of the functional state of the facial muscular system the restoration ways with PRP-therapy. The mesotherapeutic and intra-muscular injection of the patient’s blood plasma, enriched by platelets in the facial muscles and/or subcutaneously is the essence of the therapy. The advantages and the results of these therapeutical methods use are discussed in the article presented..
Keywords: PRP-therapy, stem cell, platelet, aesthetic medicine.
Резюме. Возрастные изменения кожи лица являются частью общего биологического процесса старения. В работе описан усовершенствованный способ восстановления функционального состояния мышечного корсета лица путем проведения PRP-терапии. Суть терапии состоит в мезотерапевтическом и внутримышечном введении препарата – плазмы крови пациента, обогащенной тромбоцитами в мимические мышцы и/или подкожно. В статье приводятся преимущества и результаты описанных методов терапии.
Ключевые слова: PRP-терапия, стволовые клетки, тромбоциты, эстетическая медицина.Badyin I. Yu., Gozhenko A. I., Holodkova O. L. Відновлення м’язового корсету обличчя при естетичній реабілітації = Restoration muscular face of rehabilitation aesthetic. Journal of Education, Health and Sport. 2015;5(4):264-272. ISSN 2391-8306. DOI: 10.5281/zenodo.16937
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%284%29%3A264-272
http://dx.doi.org/10.5281/zenodo.1693
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