16,057,098 research outputs found
Introduction [a I centri linguistici: approcci, progetti e strumenti per l’apprendimento e la valutazione]
No full textMary Beth Gotti interview, 23 July 2008
No full textMary Beth Gotti, of GE Home & Business Solutions, discusses the impact, importance, and development of Nela Park and describes the impact and future of electrical lighting, and the designation of Nela Park as a historic landmark
Mary Beth Gotti interview, 23 July 2008
No full textMary Beth Gotti, of GE Home & Business Solutions, discusses the impact, importance, and development of Nela Park and describes the impact and future of electrical lighting, and the designation of Nela Park as a historic landmark
Legal discourse in multilingual and multicultural contexts: arbitration texts in Europe
No full textThe article presents the main results of the international research project on ‘Generic Integrity
in Legal Discourse’, coordinated by the City University of Hong Kong led by proff. Vijay Bhatia
and Christopher Candli(http://gild.mmc.cityu.edu.hk), in which the unit of the University of Bergamo (led by prof. Maurizio Gotti) took part
In silico design of agonists targeting the alpha7 nicotinic acetylcholine receptors, their synthesis and preliminary pharmacological evaluation
No full textAs an extension of previous molecular modeling studies on nicotinic acetylcholine receptor (nAChR) ligands,[1] we now adopted the LIR (Linear Interaction Response) approach to reach a realistic compromise between accuracy and calculation rate, during the delta(G)bind value estimation of a training set of known agonists for the alpha7 nAChR subtype.
The same strategy was applied to a text set of potential alpha7 nAChR agonists, which allowed identification of general structures A and B as the most promising ligands in the series. Thus, some of these derivatives were synthesized along with procedures previously utilized by us,[2] and were then assayed for binding affinity at alpha7 and alpha4beta2 nAChR subtypes.
[1] Grazioso, G.; Cavalli, A.; De Amici, M.; Recanatini, M.; De Micheli, C. J. Comput. Chem. 2008, 29, 2593-2602. [2] Rizzi, L.; Dallanoce, C.; Matera, C.; Magrone, P.; Pucci, L.; Gotti, C.; Clementi, F.; De Amici, M. Bioorg. Med. Chem. Lett. 2008, 18, 4651-4654
Novel bicyclic Delta2-isoxazoline and 3-oxo-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic receptor subtypes
No full textNeuronal nicotinic acetylcholine receptors (nAChRs) are involved in various processes such as cognition, learning and memory, cerebral blood flow and metabolism, as well as an array of pathological conditions such as Alzheimer’s and Parkinson’s diseases, mild cognitive impairment (MCI), schizophrenia, epilepsy, Tourette’s syndrome, anxiety, depression, attention-deficit hyperactivity disorder (ADHD), and nicotine addiction. As an extension of our studies focused on new Delta2-isoxazoline derivatives and their affinity/efficacy profiles at alpha4beta2 and alpha7 nAChRs [1, 2], we synthesized the group of derivatives 4-9, which may be related to (-)-Cytisine 1 and (-)-Norferruginine 3.
The target chiral compounds, obtained by means of pericyclic reactions, were prepared and tested as racemates. The synthetic details and the results of the pharmacological investigation will be presented and discussed.
[1] Dallanoce, C.; Bazza, P.; Grazioso, G.; De Amici, M.; Gotti, C.; Riganti, L.; Clementi, F.; De Micheli, C. Synthesis of Epibatidine-related 2-Ixoxazoline Derivatives and Evaluation of their Binding Affinity at Neuronal Nicotinic Acetylcholine Receptors. Eur. J. Org. Chem. 2006; 3746-3754.
[2] De Micheli, C.; De Amici, M.; Dallanoce, C.; Clementi, F.; Gotti, C. Preparation of Azabicyclic Spiro Compounds as Agonists of 7 Nicotinic Acetylcholine Receptors. PCT Int. Appl. WO 2008000469 (2008)
Jamario Harper / Rio, Antwain Steward / Twain Gotti and Make It Rain Flamez oral history interviews, 2012
No full textJamario "Rio" Harper, Twain Gotti, and Make It Rain Flamez oral history conducted by Kevin Kosanovich on 11/30/2012. Topics include: mixtapes; Moreshells Entertainment; Venues; Newport News.Jamario "Rio" Harper, Antwan "Twain Gotti" Steward, and Make It Rain Flamez oral history conducted by Kevin Kosanovich on November 30, 2012. Topics include: mixtapes; Moreshells Entertainment; Venues; Newport News
Translating international arbitration norms into the Italian language and culture
No full textThe last few decades have witnessed a great development in the process of globalization in the legal field, where an international perspective has become more and more widespread (Gotti and Williams 2010). Nowadays many of the texts in use at a local level are the result of a process of translation or adaptation of more general documents formulated at an international level. This is the consequence of the fact that in the context of co-operation and collaboration in international trade, law too is fast assuming an international perspective rather than remaining a purely domestic concern
ESP Across Cultures. Special issue 'Legal English across cultures'
No full textVolume 7 of ESP Across Cultures is the first issue to be devoted to a specific theme within the world of English for Specific Purposes. The theme chosen here is ‘legal English across cultures’. In many ways this issue complements the volume that we co-edited on Legal Discourse across Languages and Cultures published by Peter Lang in 2010 (vol. 117 of the Linguistic Insights series edited by Maurizio Gotti). One difference between the two volumes is that all of the contributions in this special issue of ESP Across Cultures are concerned with legal English seen from a cross-cultural perspective, whereas three of the papers comprising the volume on Legal Discourse across Languages and Cultures referred to languages other than English.
Of the seven papers constituting this special issue, five are of an essentially theoretical nature, while two are more concerned with pragmatic matters
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