1,013 research outputs found
Scientometric portrait of Ram Gopal Rastogi
Get PDFPublication productivity of Indian scientist (R.G. Rastogi) has been documented.
Scientometric analysis of 312 papers by Ram Gopal Rastogi published during 1954 to 1992 in various domains: (a) Luni -solar activity and quiet -time E & F- region (57); (b) Equatorial electric field and low and mid latitude iof:osphere (78); (c) Ionospheric E- region irregularities (19); (dj Ionospheric F- region irregularities (32); and (e) Magnetic disturbance effects on the equatorial low and mid latitude ionosphere (23) were analysed. Interdomainery contents and of the number of papers: a+b were 36; b+c and b+d were 20 each; b+e were 16;. c+e were 5; a+e were 3; d+e were 2; and a+d had only one publication. Highest collaborations were with H. Chandra (61), M.R. Deshpande (42), and G. Sethia (19) out of his total 97 collaborators. His highest productivity was during 1978 with 28 papers followed by 19 papers during 1977. The core journals preferred by him for publishing papers were: Indian Journal of Radio & Space Physics, India, and Journal of Atomic & Terrestrial Physics, UK (59 each), followed by Proceedings of the Indian Academy of Sciences, India (34). Most prolific title keywords with their frequencies were: Ionosphere (92); Equatorial (61); F-region (53); Equatorial electrojet region (40), and Magnetic equator (30)
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
Get PDFThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
Scientometric portrait of Nobel laureate Leland H. Hartwell
Get PDFLeland H. Hartwell was honoured with the Nobel Prize in Physiology or Medicine (2001) at his 62 years age and at 41 years of research publishing career. The first contribution of the author was in 1961 at the age of 22. The number of his contributions in a year peaked in 1997 when it touched 8. He had 108 publications during 1961 – 2001 in domains: Molecular Biology of Cell Cycle Regulation (43), Genetics of Cell Division (48), Genomic Re-arrangement and DNA Repair (9), Molecular Genetics of Yeast Cell Fission (5), and Drug Target Interaction (3) which were analysed for authorship pattern with his 101 collaborators. Most active researchers having number of publications with Leland H. Hartwell were : Weinert, T. A. (10), Garvik, B. M. (8), McLaughlin, C. S. (8), Jenness, D. D. (5). His productivity coefficient was 0.76 which clearly indicates that his productivity increased after 50 percentile age. Highest collaboration coefficient (1) for Leland H. Hartwell was found during 1963-1965, 1968-1969, 1977, 1981-1983, 1985-1990, 1996 and 1998-2001. Journals have been the most preferred channel of communication where, as many as 96 papers out of 108 have been published. The core journals publishing his papers were: Cell (14), Genetics (12), Mol. Cell Biol. (8), J. Bactariol. (7), J. Cell Biol. ( 7), Science (7) J. Mol. Biol.(6), Exp. Cell Res. (5), and Proc. Nat. Acad. Sci.(5). Publication density is 2.63 and Publication concentration is 14.63. Most prolific keywords in titles of publications were: Saccharomyces cerevisiae , Yeast , Cell division cycle , RAD9, DNA Damage , Genes , Cell cycle, Genetic control , Check point (s) , Cell division , Mutant of Yeast
Visualization of plasma edges using VTK and Adobe Flash
No full textVisualization is a very useful tool in the study and analysis of huge experimental or simulation datasets. It converts vast amount of numerical data into graphical images, extracts important hidden information and aids scientists in hypothesis building. This thesis focuses on migrating visualization module of Plasma Edge from commercial visualization software AVS to open source visualization library VTK. The VTK visualization module will be integrated in new plasma edge simulation code package at the Center for Plasma Edge Simulation for the study of plasma edge region relevant to both existing magnetic fusion facilities and next generation burning plasma experiments. VTK visualization module generates two set of images: 2D images representing cross-sectional view of 3D torroidal plane, and 3D images representing whole torroidal plane.
Two Adobe Flash modules were also developed using open source Adobe Flex to integrate the VTK visualization module with eSimMon dashboard, a front-end tool for simulation monitoring. Using these modules, virtual 3D visualization capability was provided in the dashboard for viewing generated plasma images.M.S.Includes bibliographical referencesby Lavesh Kumar Gupt
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No full textNot AvailableSearch; Personalize: Your alerts; Your baskets; Your searches. Your alerts; Your baskets; Your searches. login. login. Home > Management of early blight disease of tomato cv 'Kashi Amrit' through fungicides, bioagents and cultural practices in India. World Vegetable Center. Information; Usage statistics; Files; Holdings. Record Details. Title: Management of early blight disease of tomato cv 'Kashi Amrit' through fungicides, bioagents and cultural practices in India. Author(s): Kumar, V. Gupta, RC Singh, PC Pandey, KK Kumar, R. Rai, AB Rai, M. Publication date: 2007. Subject(s): TOMATOES EARLY BLIGHT PLANT DISEASES FUNGICIDES PLANT DISEASE CONTROL DISEASE RESISTANCE ALTERNARIA SOLANI ALTERNARIA ALTERNATA GROWTH India IN …Not Availabl
Supplemental Material, sj-docx-1-ptd-10.1177_08968608221091023 - Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study
No full textSupplemental Material, sj-docx-1-ptd-10.1177_08968608221091023 for Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study by Sidharth Kumar Sethi, Sanjay Wazir, Jagdish Sahoo, Gopal Agrawal, Naveen Bajaj, Naveen Parkash Gupta, Shishir Mirgunde, Binesh Balachandran, Kamran Afzal, Anubha Shrivastava, Jyoti Bagla, Sushma Krishnegowda, Ananth Konapur, Azmeri Sultana, Kritika Soni, Nikhil Nair, Divya Sharma, Prajit Khooblall, Avisha Pandey, Khalid Alhasan, Mignon McCulloch, Timothy Bunchman, Abhishek Tibrewal and Rupesh Raina in Peritoneal Dialysis International</p
Supplemental Material, sj-docx-2-ptd-10.1177_08968608221091023 - Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study
No full textSupplemental Material, sj-docx-2-ptd-10.1177_08968608221091023 for Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study by Sidharth Kumar Sethi, Sanjay Wazir, Jagdish Sahoo, Gopal Agrawal, Naveen Bajaj, Naveen Parkash Gupta, Shishir Mirgunde, Binesh Balachandran, Kamran Afzal, Anubha Shrivastava, Jyoti Bagla, Sushma Krishnegowda, Ananth Konapur, Azmeri Sultana, Kritika Soni, Nikhil Nair, Divya Sharma, Prajit Khooblall, Avisha Pandey, Khalid Alhasan, Mignon McCulloch, Timothy Bunchman, Abhishek Tibrewal and Rupesh Raina in Peritoneal Dialysis International</p
All-norms and all-Lp-norms approximation algorithms
Get PDFwork was done while the author was at Max-Planck-Institut für Informatik, Saarbrücken, Germany
Scientometric Portrait of Homi Jehangir Bhabha: The Father of Indian Nuclear Research Programme
Get PDFQuantitative and qualitative analysis with graphic representation of the publication productivity of a scientist facilitates easy and clear perception about the work of a scientist. Bhabha’s scientific work spanned over more than three decades (1933-1967) during which he published 104 publications, which could be classified into nine fields: Interaction of Radiation with Matter (4), Quantum Electrodynamics (5), Mathematical Physics (2), Cosmic Ray Physics (18), Elementary Particle Physics (14), Field Theory (15), General Physics (2), Nuclear Physics (4) and General (40). The highest number of publications (6) were published in 1941, 1945 and 1964 respectively. The average number of publications published per year was 3.05. His productivity coefficient was 0.05 which is a clear indicates that his publication productivity was quite consistent throughout his scientific career. He was single author in 79 of his publications and the main author in 24 publications indicates that he always preferred to work himself and lead the team as ‘mentor’. Bhabha had 22 collaborators during the period. Team of research collaborators working with a successful scientist documents the sociological aspect of history of science while generating knowledge by a leader in a domain.
Bhabha became a citable author in 1937. Bhabha received 1211 citations to his 30 publications out of 104 publications. Out of 104, 74 publications did not receive any citations. Out of 74 publications, 40 publications dealt subjects mainly of general interest. Bhabha’s 86.66 percent of cited publications received their first citations within four years of their publication indicates that his publications were noticed immediately and had direct impact among the fellow researchers working all over the world. His overall citation rate was 11.64 per cited publication. The highest citations 389 were received to the domain ‘Cosmic ray physics’. The highest number of citations received were 45 in 1938. His self-citations were only 24 (1.98%) and citations by others were 1187 (98.02%). The highest self citations were six in 1946. Bhabha’s mean diachronous self-citation rate was 1.98. The highest citation rate 28.4 was to the domain ‘Quantum electrodynamics. His single authored publications have received the highest number 863 (71.26%) of citations. Bhabha’s five publications have been cited more than 100 times each. His publications have been cited by the authors working in various diverse fields like nuclear physics, mathematical physics, instrumentation, optics, geophysics and geochemistry, condensed matter physics, applied physics, electrical and electronic engineering, mechanical engineering etc., indicating a very diverse influence and impact of Bhabha’s publications. Bhabha’s publications have also been cited by the Nobel laureates like V. L. Ginzberg, Wolfgang Pauli, H. A. Bethe, M. Born, W. Bothe, E. P. Wigner, H. Yukawa, P. M. S. Blackett and C. N. Yang which is an indication of his originality of ideas and high quality of publications
Understanding intramolecular signal transduction in regulated proteases of the High Temperature Requirement A family
No full textProtein homeostasis in all organisms is a complex process involving regulatory mechanisms that govern protein synthesis, post-translational events and degradation. The protein degradation mechanism serves multiple functions ranging from maturation of cellular proteins, protein recycling and intracellular signal transduction. This mechanism, therefore, has a major role in diverse cellular and developmental contexts. In prokaryotes, the protein degradation mechanism has been shown to influence the cellular response to environmental stimuli and thus pathogenesis and virulence. The prokaryotic protein degradation machinery involves both regulated and processive proteases. Of these, the regulated proteases are particularly important as controlled and specific proteolysis are often key events in a signal transduction cascade triggered by intracellular or extracellular stimuli. The studies described in this thesis were designed to examine a specific aspect of regulated proteases wherein proteolytic activity could be either triggered or inhibited by a regulatory domain. These studies involve three regulatory proteases belonging to the High temperature requirement A (HtrA) family in Mycobacterium tuberculosis. These M. tuberculosis HtrA paralogues share common structural features with the well-characterized regulated protease E. coli DegS.
HtrA proteases, in general, have a serine protease domain that is flexibly tethered to one or more PDZ (Post synaptic density protein-95; Drosophila disc-large tumor suppressor; Zonula occludens-1) domains at the C-terminus. HtrA proteases are membrane tethered. The membrane localization has been suggested to be significant from a functional perspective. The common features noted from multiple HtrA homologous characterized thus far include changes in quaternary structure and typically two distinct conformational states of catalytic triad (referred interchangeably as the inactive or tense state and the active or relaxed state). Tightly regulated proteolytic activity is thus achieved by an enzyme that is primarily in an inactive conformation and adopts an active conformation upon a specific trigger. Characterized triggers for HtrA activity are environmental triggers (such as high temperature), peptides or other effector ligands or substrate proteins. The modular organization of HtrA enzymes relies on the interactions between the sensory (tethered PDZ) domain with an effector ligand. Information from the PDZ domain is conveyed by concerted conformational changes to activate the catalytic domain. The intramolecular signal transduction paths thus play a key role in dictating the regulatory mechanism in HtrA enzymes. This thesis describes the structural features of M. tuberculosis HtrA and characterization of its biochemical features and regulatory mechanism(s).
The first chapter of this thesis provides a brief introduction to regulated proteolytic mechanisms. Similarities and broad differences between the eukaryotic and prokaryotic mechanisms are discussed to phrase the research problem in the context of reported studies. The extensive studies performed on this enzyme, especially E. coli DegS, are summarized to place the known features and observations in the context of M. tuberculosis homologues. The characterized features of the M. tuberculosis HtrA paralogues are summarized to describe the scope of the studies reported in this thesis. A brief introduction to the diverse techniques employed in the course of these studies is also provided to place the methodology in context. The detailed methodology is included in different chapters alongside experimental information.
Chapter two describes the crystal structure of M. tuberculosis HtrA at 1.83 Å resolution. This membrane-associated protease is essential for the survival of M. tuberculosis. The crystal structure revealed that the catalytic triad in HtrA is in an inactive conformation. This finding is consistent with the proposed role of M. tuberculosis HtrA as a regulatory protease that is conditionally activated upon appropriate environmental triggers. This structure provided a basis for directed studies to evaluate the role of this essential protein and the intracellular signal transduction mechanism that governs the activity of this protease.
The intramolecular signal transduction process that is essential for regulated enzyme activity in HtrA proteases is described in chapter three. The first part of the study involves computational analysis and molecular dynamics (MD) simulations. This work is based on several ‘seed structures’ including those of E. coli DegS in peptide-bound and free forms, M. tuberculosis HtrA2 (PepD) in peptide-bound and apo forms and M. tuberculosis HtrA (HtrA1). These simulations provided multiple insights. The first was that of conformational sampling wherein the switch between the inactive (tense) arrangement of catalytic triad and the active (relaxed) arrangement of catalytic triad could be visualized. This finding, in effect, suggested that concerted conformational changes between the site in the PDZ domain that binds the effector ligand (peptide or any substrate) and the active site were essential for regulated proteolysis. While this aspect has long been discussed, the paths for intramolecular signal transduction remain poorly understood. In this study, we adopted a methodology involving difference energy calculations between the peptide bound and free forms of HtrA homologous. The emphasis in this context was on electrostatic interactions. Difference energy calculations, in turn, provided sites on the enzyme that could serve as nodes in the intramolecular signal transduction pathways. This analysis suggested multiple paths between the PDZ and the protease domain that could potentially be adopted for signal transduction. Three representative intramolecular signal transduction paths were experimentally validated by mutational analysis. Together, the computational studies and experimental observations provided a framework to understand intramolecular signal transduction paths that serve to transmit regulatory information.
Chaperone activity in HtrA enzymes was suggested to be associated with the ability of these enzymes to adopt large oligomeric assemblies. The oligomeric assemblies of M. tuberculosis HtrA paralogues were evaluated in the presence of generic substrates such as β-casein or denatured lysozyme. These studies are described in chapter four of this thesis. Size exclusion chromatography suggested that M. tuberculosis HtrA (also referred to as HtrA1) and PepD (also referred to as HtrA2) existed in hexameric, trimeric and monomeric states. PepA (HtrA3) was prominently a trimer in solution. An important experimental insight on the differences between these paralogues came from an assay to evaluate the ability of these enzymes to inhibit protein aggregation. These assays suggested that PepD (HtrA2) was perhaps the best suited amongst three paralogues to serve this function. Small angle X-ray scattering methods provided information on the oligomeric assembly. While these were not conclusive due to experimental limitations, these studies suggested that higher order oligomers (such as dodecamer or di-dodecamer in E. coli DegP and DegQ) were not likely in the case of the M. tuberculosis paralogues. We note that conformational heterogeneity is positively correlated with chaperone activity as both HtrA and PepD adopt multiple oligomeric states. PepA (HtrA3), on the other hand, is the most homogeneous (trimer) and also the least effective in inhibiting protein aggregation.
A broad summary of the findings from studies on regulated proteases is described in chapter five. The observations on the allosteric pathways also provide an insight into the mechanism of intramolecular signal transduction. These findings are likely to be useful from an enzyme engineering perspective wherein catalytic activity can be specifically triggered by effector ligand binding to the PDZ domain. Future studies based on the work reported in this thesis include identification of cognate triggers for the three M. tuberculosis HtrA paralogues. Together, the finding that the human pathogen M. tuberculosis has three paralogues of HtrA with diverse functional roles thus exemplifies how a functional diversity is embedded within a conserved structural scaffold.
This thesis has four annexures. Annexure-I summarizes the experimental details and strategies that could not be incorporated in the main text of this thesis. Annexure-II enlisted the pairs of residues having difference electrostatic energy. Annexure-III describes a collaborative study performed on the M. tuberculosis σ factor σJ. Annexure-IV describes a collaborative project on the E. coli Arginine transporter ArgO
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