5,130 research outputs found
Easter Morning: A.R. Ammons and His Poem Video Recording
No full textAudio recording of a poem entitled, "Easter Morning", recited by the poem's author, A.R. Ammons
A.R Baswedan dan PAl: Potret Nasionalisme Warga Keturunan perspektif sosiopolitik historis
No full textIn this article, the authors review about A.R. Baswedan
and his movement through the Arab Party of Indonesia (PAl).
A.R Baswedan is an Arab descendant known as the pioneer
of independence of the Republic of Indonesia. The author
through historical socio-political studies found that A.R
Baswedan is an example of Arabic descent who counter
Arabism and views between the Arab descendants and the
descendants of indigenous Indonesians are the same or
equal and the same fate. They both have one nationality,
Indonesia. This fusion attitude in the Indonesian citizenship
and nationality equation is evident in its movement within
the PAl.
Keywords: A.R. Baswedan, Biography, and Thought
(PAl
A.R. Luria: Ideas and Prospects of Their Development in Pedagogical Psychology of the Twenty-first Century
No full textA.R. Luria’s ideas are well-known and recognized both in Russia and abroad. Scientists from different countries are actively working in neuropsychology, a part of the psychological science developed by A.R. Luria. The author has shown the relevance and importance of the neuropsychological approach to the pedagogical psychology problems and the availability to choose an adequate educational and nurturing strategy from these standpoints. The study seeks to rethink and assess the importance of A.R. Luria’s main ideas from the modern pedagogical psychology’s standpoints. The characteristic of the main theoretical provisions has been set forth based on the analysis of A.R. Luria’s academic papers and the main directions and prospects for the development of A.R. Luria’s ideas in the modern psychological pedagogical science have been determined. A.R. Luria’s academic papers most sought by the modern researchers have been noted. The study is based on the materials of the thesis researches on the pedagogical psychology problems conducted in the beginning of the twenty-first century, A.R. Luria’s papers, the publications of other researchers who have studied his contribution to the psychological science. The study results show that A.R. Luria has significantly contributed to the development of the pedagogical psychology problems. A.R. Luria’s ideas on the interaction of the humanitarian and science knowledge in the human comprehensive study, the cultural and historical understanding of the psychical functions development, and the language evolution in the music language study for the musical education development seem most promising for the pedagogical psychology development. Note has been taken of the importance of A.R. Luria’s ideas for the elaboration of the relevant problems of the training and development of a person at any age; the study of individual and typical features in mastering a foreign language; the study of the semantics of speech and means of coding meanings in the context of professional training of psychologists and teachers, specialists in the field of artistic creativity. The analysis of A.R. Luria’s main ideas facilitates the deeper understanding of the modern problems of the pedagogical psychology theory and practice
Incorporation of acceleration effects into the one-dimensional-turbulence model, with application to turbulent combustion and shock-turbulence interactions
No full textOne-dimensional turbulence (ODT) is a stochastic simulation in which 3D turbulence effects are captured on a notional 1D line of sight by introducing instantaneous spatial re-arrangements (maps) that represent advection by notional turbulent eddies. These eddy events incorporate the possibility of kinetic-energy changes that are equal and opposite to changes of other forms of energy such as the gravitational potential energy change due to a re-arrangement of a vertical density profile. This illustrates that motion aligned with an applied force, in this case gravitation , can be associated with energy change. Using this principle, we 1) present a model of turbulence interaction with the dilatational acceleration caused by thermal expansion in flames and show results for a turbulent counterflow flame with comparison to DNS and 2) present a model for shock-induced turbulence and show results for mixing width growth in a shock tube with comparison to experiments
ODTLES: A multi-scale ansatz for highly turbulent flows
No full textWe use ODTLES, a multi-dimensional extension of the One-Dimensional-Turbulence model (ODT). ODT describes turbulent advection on a 1D sub-domain using a stochastic process for turbulent advection. These 1D sub-domains are coupled to obtain a 3D approach. ODTLES is applied to channel flow. Preliminary results for the pdf of the wall shear stress are compared to DNS
Impact of Exposure Duration to High-Altitude Hypoxia on Oxidative Homeostasis in Rat Brain Regions
No full textAuthor Contributions:
Conceptualization, B.L.-M., J.-L.R. and M.R.-G.; Data curation, B.L.-M. and J.- L.R.; Formal analysis, B.L.-M., A.R. and R.D.; Funding acquisition, R.C.-R. and B.L.-M.; Investigation, B.L.-M., R.C.-R., C.M., J.O.-F. and R.D.; Methodology, B.L.-M., J.-L.R., A.R. and M.R.-G.; Project administration, B.L.-M. and M.R.-G.; Resources, B.L.-M. and R.C.-R.; Software, A.R. and J.-L.R.; Validation, R.C.-R., J.O.-F., C.M. and M.R.-G.; Visualization, B.L.-M., J.-L.R. and A.R.; Writing— original draft, A.R., B.L.-M. and J.-L.R.; Writing—review and editing, A.R., B.L.-M. and J.-L.R. All authors have read and agreed to the published version of the manuscriptHypoxia at altitudes above 3000 m poses a significant threat to organ health and physiological homeostasis, particularly in metabolically active tissues such as the brain. Many of the cellular alterations induced by hypoxia are associated with the excessive generation of reactive oxygen species (ROS) and the resulting oxidative stress. In this study, we investigated the effects of exposure duration and altitude levels on oxidative homeostasis in the rat hypothalamus, cortex, hippocampus, and striatum. We assessed ROS production, malondialdehyde (MDA) levels, the antioxidant activities of superoxide dismutase (SOD), and catalase, as well as molecular biomarkers of oxidative stress, cell death, and inflammation. Our findings demonstrated that ROS, MDA and SOD levels increased across all brain regions, particularly in response to higher altitude exposure. Conversely, catalase activity decreased under the same conditions. At the molecular level, we observed overexpression of key biomarkers related to oxidative stress, cell death, and inflammation, especially at extreme altitudes. Furthermore, these effects were most pronounced in the hippocampus, cortex, and striatum. In conclusion, our data indicate that hypoxic exposure at higher altitudes significantly contributes to the oxidative disruption of brain homeostasis in ratsUniversidad Nacional Mayor de San Marcos ( Perú )PROCIENCIA-CONCYTEC ( Perú )Depto. de Farmacología y ToxicologíaFac. de VeterinariaTRUEpu
A CRISPR-associated transposase presents null cargo integration efficiency when targeting a transcriptionally highly active region
No full textCRISPR-Cas effectors (e.g. Cas9) have been widely used to perform genetic knock-outs. Performing knock-ins however, remains challenging due to the inefficiency of the endogenous pathway cells use to integrate a donor genetic cargo into its genome (homology directed repair) when compared to other repair pathways like non-homologous end joining. CRISPR-associated transposases are complexes formed by a catalysis-deficient effector and a transposase. These complexes are able to sequester a transposon, localize a genomic target specified by a CRISPR RNA (crRNA), and integrate the transposon near the targeted site; thereby bypassing homology directed repair. In this study we aimed at developing a screening method using a CRISPR- associated transposase known as CAST, to detect integration events based on the disruption of lacZ. During the development, we found that CAST is unable to integrate a cargo in this highly active gene, most likely due to RNA polymerase-mediated dislodgment of the complex, and physical impediment for transposition proteins to reach the target DNA.Applied Sciences | Nanobiolog
Author Correction: Imaging-based representation and stratification of intra-tumor heterogeneity via tree-edit distance
No full textMartina Sollini and Paola Anna Erba were omitted from the author list in the original version of this Article. The Author Contributions section now reads: “L.C. conceived the pipeline, set up the case study, analysed the results, prepared the figures, and wrote the manuscript. M.P. formulated and tuned the pruned tree edit distance, provided the mathematical proofs and the simulation study, and wrote the manuscript. A.R. contributed to implement the patient representation pipeline. M.S. segmented the Prostate Cancer lesions and extracted the radiomic features for all patients in the case study. P.A.E collected the data and enrolled the patients in the clinical study. F.I. supervised the analyses and the conception of the pipeline. L.C., M.P., A.R. and F.I. reviewed and approved the manuscript.” The original Article and accompanying Supplementary Information file have been corrected.</p
The IPHAS catalogue of H alpha emission-line sources in the northern Galactic plane
No full textWe present a catalogue of point-source H alpha emission-line objects selected from the INT/WFC Photometric Ha Survey (IPHAS) of the northern Galactic plane. The catalogue covers the magnitude range 13 <= r' <= 19.5 and includes Northern hemisphere sources in the Galactic latitude range -5 degrees < b < 5 degrees. It is derived from similar to 1500 deg(2) worth of imaging data, which represents 80 per cent of the final IPHAS survey area. The electronic version of the catalogue will be updated once the full survey data become available. In total, the present catalogue contains 4853 point sources that exhibit strong photometric evidence for Ha emission. We have so far analysed spectra for similar to 300 of these sources, confirming more than 95 per cent of them as genuine emission-line stars. A wide range of stellar populations are represented in the catalogue, including early-type emission-line stars, active late-type stars, interacting binaries, young stellar objects and compact nebulae.
The spatial distribution of catalogue objects shows overdensities near sites of recent or current star formation, as well as possible evidence for the warp of the Galactic plane. Photometrically, the incidence of Ha emission is bimodally distributed in (r' - i'). The blue peak is made up mostly of early-type emission-line stars, whereas the red peak may signal an increasing contribution from other objects, such as young/active low-mass stars. We have cross-matched our H alpha-excess catalogue against the emission-line star catalogue of Kohoutek & Wehmeyer, as well as against sources in SIMBAD. We find that fewer than 10 per cent of our sources can be matched to known objects of any type. Thus IPHAS is uncovering an order of magnitude more faint (r' > 13) emission-line objects than were previously known in the Milky Way
Hybrid simulation for health and social care: the way forward, or more trouble than it’s worth?
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