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    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Antigenicity Of Primary Endodontic Infection Against Macrophages By The Levels Of Pge2 Production

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    Introduction: Root canal contents are potent stimuli for proinflammatory cytokines involved in apical periodontitis. This study investigated target gram-negative bacterial species and endotoxins in primary endodontic infection with apical periodontitis, determined their antigenicity against macrophages through the levels of PGE2, and evaluated their relationship with clinical findings. Methods: Samples were taken from 21 root canals with primary infection and apical periodontitis by using paper points. Polymerase chain reaction (16S rDNA) was used for bacterial detection and limulus amebocyte lysate assay for endotoxin measurement. Levels of prostaglandin E2 (PGE 2) were measured by enzyme-linked immunosorbent assay (Duoset Kit; R&D, Minneapolis, MN). Results: Prevotella nigrescens (13/21), Fusobacterium nucleatum (6/21), and Porphyromonas endodontalis (6/21) were the most frequently observed species. A positive association was found between F. nucleatum and P. endodontalis (P < .05). A correlation was found between the number of gram-negative bacterial species and the levels of endotoxins, such as PGE2 (P < .05). Higher levels of endotoxin were detected in teeth with exudation, whereas elevated levels of PGE2 were found in teeth with tenderness to percussion and pain on palpation. Conclusions: Our findings imply an additive effect between the number of gram-negative bacterial species involved in endodontic infection regarding the induction of proinflammatory cytokine by macrophage cells. Moreover, teeth with clinical symptomatology were related to higher levels of endotoxins and PGE2 secretion. Copyright © 2011 American Association of Endodontists.375602607Fabricius, L., Dahlén, G., Holm, S.E., Influence of combinations of oral bacteria on periapical tissues of monkeys (1982) Scand J Dent Res, 90, pp. 200-206Rôas, I.N., Siqueira Jr., J.F., Identification of bacteria enduring endodontic treatment procedures by a combined reverse transcriptase-polymerase chain reaction and reverse-capture checkerboard approach (2010) J Endod, 36, pp. 45-52Gomes, B.P.F.A., Pinheiro, E.T., Gade-Neto, C.R., Sousa, E.L.R., Ferraz, C.C.R., Zaia, A.A., Teixeira, F.B., Souza-Filho, F.J., Microbiological examination of infected dental root canals (2004) Oral Microbiology and Immunology, 19 (2), pp. 71-76. , DOI 10.1046/j.0902-0055.2003.00116.xGomes, B.P.F.A., Lilley, J.D., Drucker, D.B., Associations of endodontic symptoms and signs with particular combinations of specific bacteria (1996) International Endodontic Journal, 29 (2), pp. 69-75Siqueira Jr., J.F., Magalhaes, F.A.C., Lima, K.C., De Uzeda, M., Pathogenicity of facultative and obligate anaerobic bacteria in monoculture and combined with either Prevotella intermedia or Prevotella nigrescens (1998) Oral Microbiology and Immunology, 13 (6), pp. 368-372Van Winkelhoff, A.J., Van Steenbergen, T.J., De Graaff, J., Porphyromonas (Bacteroides) endodontalis: Its role in endodontal infections (1992) J Endod, 18, pp. 431-434Rietschel, E.T., Brade, H., Bacterial endotoxins (1992) Scient Am, 267, pp. 54-61Horiba, N., Maekawa, Y., Abe, Y., Cytotoxicity against various cell lines of lipopolysaccharides purified from Bacteroides, Fusobacterium, and Veillonella isolated from infected root canals (1989) J Endod, 15, pp. 530-534Dahlen, G., Immune response in rats against lipopolysaccharides of Fusobacterium nucleatum and Bacteroides oralis administered in the root canal (1980) Scandinavian Journal of Dental Research, 88 (2), pp. 122-129Hanazawa, S., Sagiya, T., Kitami, H., Monoclonal antibody against Porphyromonas (Bacteroides) endodontalis lipopolysaccharide and application of the antibody for direct identification of the species (1991) J Clin Microbiol, 29, pp. 2550-2553Hong, C.Y., Lin, S.K., Kok, S.H., The role of lipopolysaccharide in infectious bone resorption of periapical lesion (2004) J Oral Pathol Med, 33, pp. 162-169Ko, H.J., Lim, S.S., Production of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta by human polymorphonuclear neutrophils stimulated with Porphyromonas endodontalis lipopolysaccharide (2002) J Endod, 28, pp. 754-757Metzger, Z., Macrophages in periapical lesions (2000) Endod Dent Traumatol, 16, pp. 1-8Garrison, S.W., Holt, S.C., Nichols, F.C., Lipopolysaccharide-stimulated PGE2 release from human monocytes. Comparison of lipopolysaccharides prepared from suspected periodontal pathogens (1988) J Periodontol, 59, pp. 684-687Garrison, S.W., Nichols, F.C., Gamma interferon modulation of prostaglandin E2 release from monocytes stimulated with lipopolysaccharides from Bacteroides intermedius, Bacteroides gingivalis, and Salmonella typhimurium (1988) Oral Microbiol Immunol, 3, pp. 138-143Schade, U., Rietschel Th., E., The role of prostaglandins in endotoxic activities (1982) Klinische Wochenschrift, 60 (14), pp. 743-745. , DOI 10.1007/BF01716568Offenbacher, S., Heasman, P.A., Collins, J.G., Modulation of host PGE2 secretion as a determinant of periodontal disease expression (1993) J Periodontol, 64, pp. 432-444McNicholas, S., Torabinejad, M., Blankenship, J., The concentration of prostaglandin E2 in human periradicular lesions (1991) J Endod, 17, pp. 97-100Shimauchi, H., Miki, Y., Takayama, S.-I., Imai, T., Okada, H., Development of a quantitative sampling method for periapical exudates from human root canals (1996) Journal of Endodontics, 22 (11), pp. 612-615Cohen, J.S., Reader, A., Fertel, R., A radioimmunoassay determination of the concentrations of prostaglandins E2 and F2 alpha in painful and asymptomatic human dental pulps (1985) J Endod, 11, pp. 330-335Horiba, N., Maekawa, Y., Abe, Y., Correlations between endotoxin and clinical symptoms or radiolucent areas in infected root canals (1991) Oral Surg Oral Med Oral Pathol, 71, pp. 492-495Jacinto, R.C., Gomes, B.P.F.A., Shah, H.N., Ferraz, C.C., Zaia, A.A., Souza-Filho, F.J., Quantification of endotoxins in necrotic root canals from symptomatic and asymptomatic teeth (2005) Journal of Medical Microbiology, 54 (8), pp. 777-783. , DOI 10.1099/jmm.0.45976-0Schein, B., Schilder, H., Endotoxin content in endodontically involved teeth (1975) J Endod, 1, pp. 19-21Martinho, F.C., Gomes, B.P.F.A., Quantification of endotoxins and cultivable bacteria in root canal infection before and after chemomechanical preparation with 2.5% sodium hypochlorite (2008) J Endod, 34, pp. 268-272Gomes, B.P.F.A., Martinho, F.C., Vianna, M.E., Comparison of 2.5% sodium hypochlorite and 2% chlorhexidine gel on oral bacterial lipopolysaccharide reduction from primarily infected root canals (2009) J Endod, 35, pp. 1350-1353Martinho, F.C., Chiesa, W.M., Leite, F.R., Antigenic activity of bacterial endodontic contents from primary root canal infection with periapical lesions against macrophage in the release of interleukin-1beta and tumor necrosis factor alpha (2010) J Endod, 36, pp. 1467-1474Brook, I., Encapsulated anaerobic bacteria in synergistic infections (1986) Microbiological Reviews, 50 (4), pp. 452-457Gomes, B.P., Drucker, D.B., Lilley, J.D., Positive and negative associations between bacterial species in dental root canals (1994) Microbios, 80, pp. 231-243Chung, Y.H., Chang, E.J., Kim, S.J., Lipopolysaccharide from Prevotella nigrescens stimulates osteoclastogenesis in cocultures of bone marrow mononuclear cells and primary osteoblasts (2006) J Periodontal Res, 41, pp. 288-296Nair, B.C., Mayberry, W.R., Dziak, R., Biological effects of a purified lipopolysaccharide from Bacteroides gingivalis (1983) Journal of Periodontal Research, 18 (1), pp. 40-49Holt, S.C., Kesavalu, L., Walker, S., Virulence factors of Porphyromonas gingivalis (1999) Periodontol 2000, 20, pp. 168-238Holt, S.C., Ebersole, J.L., Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: The 'red complex', a prototype polybacterial pathogenic consortium in periodontitis (2005) Periodontology 2000, 38, pp. 72-122. , DOI 10.1111/j.1600-0757.2005.00113.xCouturier, C., Haeffner-Cavaillon, N., Caroff, M., Binding sites for endotoxins (lipopolysaccharides) on human monocytes (1991) J Immunol, 147, pp. 1899-1904Reife, R.A., Coats, S.R., Al-Qutub, M., Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity: Differential activities of tetra-and penta-acytlated lipid A structures on E-selectin expression and TLR-4 recognition (2006) Cell Microbiol, 8, pp. 857-868Jiang, J., Zuo, J., Hurst, I.R., Holliday, L.S., The synergistic effect of peptidoglycan and lipopolysaccaride on osteoclast formation (2003) Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 96 (6), pp. 738-743. , DOI 10.1016/j.tripleo.2003.08.006Madianos, P.N., Bobetsis, Y.A., Kinane, D.F., Generation of inflammatory stimuli: How bacteria set up inflammatory responses in the gingiva (2005) Journal of Clinical Periodontology, 32 (SUPPL. 6), pp. 57-71. , DOI 10.1111/j.1600-051X.2005.00821.xRichards, D., Rutherford, R.B., The effects of interleukin 1 on collagenolytic activity and prostaglandin-E secretion by human periodontal-ligament and gingival fibroblast (1988) Arch Oral Biol, 33, pp. 237-243Martinho, F.C., Chiesa, W.M., Marinho, A.C., Clinical investigation of the efficacy of chemomechanical preparation with rotary nickel-titanium files for removal of endotoxin from primarily infected root canals (2010) J Endod, 36, pp. 1766-176

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used

    Author Under Sail The Imagination of Jack London, 1893-1902

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    In Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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