1,721,162 research outputs found
Arginine biosynthesis in Escherichia coli: experimental perturbation and mathematical modeling.
No full textA basic challenge in cell biology is to understand how interconnected metabolic pathways are regulated to provide the adequate cellular outcome when changing levels of metabolites and enzyme expression. In Escherichia coli, the arginine and pyrimidine biosynthetic pathways are connected through a common metabolite provided by a single enzyme. The different elements of the arginine biosynthetic system of Escherichia coli, including the connection with pyrimidine biosynthesis, and the principal regulatory mechanisms operating at genetic and enzymatic levels were integrated in a mathematical model using a molecular kinetic approach combined with a modular description of the system. The model was then used to simulate a set of perturbed conditions as follows: genetic derepression, feedback resistance of the first enzymatic step, and low constitutive synthesis of the intermediate carbamyl phosphate. In all cases, an excellent quantitative agreement between simulations and experimental results was found. The model was used to gain further insight into the function of the system, including the synergy between the different regulations. The outcome of combinations of perturbations on cellular arginine concentration was predicted accurately, establishing the model as a powerful tool for the design of arginine-overproducing strains.Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe
Modélisation de la dynamique du Ca2+ intracellulaire :oscillations complexes, bistabilité et codage par fréquence des signaux calciques par la CaM kinase
No full textDoctorat en Sciencesinfo:eu-repo/semantics/nonPublishe
Spatio-temporal organization of cytosolic Ca2+ signals: a modelling approach to the molecular mechanisms and physiological implications of Ca2+ oscillations and waves
No full textAgrégation de l'enseignement supérieur, Orientation sciencesThèse d'agrégationinfo:eu-repo/semantics/nonPublishe
Modélisation du mécanisme moléculaire des rythmes circadiens chez la drosophile
No full textDoctorat en Sciencesinfo:eu-repo/semantics/nonPublishe
Modélisation des oscillateurs biochimiques contrôlant la dynamique du cycle cellulaire
No full textDoctorat en Sciencesinfo:eu-repo/semantics/nonPublishe
Theoretical models for oscillations and bistability in cellular signaling involving receptor desensitization
No full textDoctorat en Sciencesinfo:eu-repo/semantics/nonPublishe
Du comportement périodique simple aux oscillations complexes dans les systèmes biochimiques
No full textDoctorat en Sciencesinfo:eu-repo/semantics/nonPublishe
Modélisation des oscillations et des ondes de calcium intracellulaire
No full textDoctorat en Sciencesinfo:eu-repo/semantics/nonPublishe
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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