1,708 research outputs found
A dedication to Alfred L. Goldberg
No full textThis article belongs to a special issue Molecular Basis of Muscle Wasting - Dedicated to Alfred L. Goldberg Edited By Didier Attaix and William E. Mitch - Document Type: Biographical-Itemabsen
Letter to Alfred L. Shoemaker, February 10, 1948
No full textA handwritten letter from an unknown author addressed to Alfred L. Shoemaker, dated February 10, 1948. Within, the author discusses the Pennsylvania Dutch word for Ash Wednesday, along with traditions associated with this day.https://digitalcommons.ursinus.edu/shoemaker_documents/1118/thumbnail.jp
Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes: Evidence for peptide-induced channel opening in the alpha-rings
No full textThe eukaryotic 20 S proteasome contains the following 6 active sites: 2 chymotrypsin-like, 2 trypsin-like, and 2 caspase-like. We previously showed that hydrophobic peptide substrates of the chymotrypsin-like sites allosterically stimulate peptide hydrolysis by the caspase-like sites and their own cleavage. More thorough analysis revealed that these peptides also stimulate peptide hydrolysis by the trypsin-like site. This general activation by hydrophobic peptides occurred even if the chymotrypsin-like sites were occupied by a covalent inhibitor and was highly cooperative, with an average Hill coefficient of 7. Therefore, this stimulation of peptide hydrolysis at all active sites occurs upon binding of hydrophobic peptides to several non-catalytic sites. The stimulation by hydrophobic peptides was not observed in the yeast Delta N alpha 3 mutant 20 S proteasomes, in 20 S-PA26 complexes, or SDS-activated proteasomes and was significantly lower in 26 S proteasomes, all of which appear to have the gated channel in the alpha-rings in an open conformation and hydrolyze peptides at much faster rates than 20 S proteasomes. Also the hydrophobic peptides altered K(m), V(max) of active sites in a similar fashion as PA26 and the Delta N alpha 3 mutation. The activation by hydrophobic peptides was decreased in K(+)-containing buffer, which favors the closed state of the channels. Therefore, hydrophobic peptides stimulate peptide hydrolysis most likely by promoting the opening of the channels in the alpha-rings. During protein breakdown, this peptide-induced channel opening may function to facilitate the release of products from the proteasome
The television work of Alfred Hitchcock
No full textThe thesis uses close textual analysis to study and evaluate the television work of Alfred Hitchcock. The corpus consists of the twenty shows personally directed by Hitchcock, including his appearances before and after those shows. In response to most previous writing, which tends to compare the programmes with Hitchcock’s films (often unfairly) the thesis emphasises them as products of television. Programmes are evaluated on the basis of their perceived success as television- if they harness conditions related to television production and integrate them with narrative themes or to create meaning. Hitchcock is considered to be the major creative force in each programme.
Chapter One provides a variety of important contexts including a brief history of US television of the 1950s, key literature on Hitchcock and analyses of contemporaneous programmes not directed by Hitchcock. The textual analysis chapters (2-8) consider aesthetic or thematic programme aspects. Chapter Two studies the various roles played by Hitchcock’s appearances as series host. Chapter Three considers the impact of censorship on programmes frequently dealing with murder, violence and insanity. Chapter Four analyses Hitchcock’s implementation of varieties of voice-over narration, a common device in short dramatic forms. Chapter Five studies Hitchcock’s use of point-of-view shots, particularly in relation to their role in the delivery of the narrative twist. Chapter Six considers the key Hitchcock theme of detachment from the world. Chapter Seven looks at moments from the programmes which demonstrate how aesthetic is influenced by television production conditions.
Hitchcock created a number of television masterpieces. His achievements in television are in many ways comparable in quality and consistency to his theatrical films. Even when considered in the context of other 1950s US anthology dramas, the Hitchcock-directed programmes are superior on many levels. Elements of his film style were highly suited to television production. Many of his greatest achievements embrace and harness television production conditions in their presentation strategies to create an integration of style and meaning
Docking of the Proteasomal ATPases' Carboxyl Termini in the 20S Proteasome's α Ring Opens the Gate for Substrate Entry
No full textLe football, un nouveau territoire de l' historien
No full textSoccer new territory for the historian Alfred Wahl Although soccer represents social and cultural fact of substantial importance French historic research has long neglected it French historians lag far behind foreign particularly British historians as well as sociologists and anthropologists While ta king stock of the present situation the author shows the emergence of soccer as historical object Emphasizing the many fa cets of that history he pleads for its growth and autonomySoccer : a new territory for the historian, Alfred Wahl.
Although soccer represents a social and cultural fact of substantial importance, French historic research has long neglected it. French historians lag far behind foreign, particularly British historians, as well as sociologists and anthropologists. While taking stock of the present situation, the author shows the emergence of soccer as a historical object. Emphasizing the many facets of that history, he pleads for its growth and autonomy.Wahl Alfred. Le football, un nouveau territoire de l' historien. In: Vingtième Siècle, revue d'histoire, n°26, avril-juin 1990. Le football, sport du siècle. pp. 127-132
Letter to Alfred L. Shoemaker, December 15, 1949
No full textA handwritten letter from a descendent of Peter Derr addressed to Alfred L. Shoemaker, dated December 15, 1949. Within, the author provides information about folk cures, Harvest Home services and the tradition of serenading newlyweds with loud music.https://digitalcommons.ursinus.edu/shoemaker_documents/1247/thumbnail.jp
Letter From Florence Baver to Alfred L. Shoemaker, August 10, 1960
No full textA typed letter from Florence Baver to Alfred L. Shoemaker, dated August 10, 1960. Within, the author provides various anecdotes from the Lehigh County region, including humor stories and naming lore.https://digitalcommons.ursinus.edu/shoemaker_documents/1276/thumbnail.jp
Letter From Nora G. to Alfred L. Shoemaker, March 17, 1948
No full textA handwritten letter from Nora G. addressed to Alfred L. Shoemaker, dated March 17, 1948. Within, the author provides a list of old weather predictions accredited to Peter Derro, as well as information about special Saints\u27 days and agricultural advice.https://digitalcommons.ursinus.edu/shoemaker_documents/1104/thumbnail.jp
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