57,897 research outputs found
Kazimierz Goebel (1940-2022)
No full textOn the 21st of July, 2022, a remarkable mathematician and a former rector of the Maria Curie-Skłodowska University in Lublin (UMCS) – prof. Kazimierz Goebel left u
[Rezension zu:] Eckart Goebel u. Elisabeth Bronfen (Hg.), Narziss und Eros
No full textRezension zu Eckart Goebel u. Elisabeth Bronfen (Hg.), Narziss und Eros. Bild oder Text? Göttingen (Wallstein Verlag) 2009. (= Manhattan Manuscripts, hg. von Eckart Goebel, Paul Fleming u. John T. Hamilton, Bandnummer: 2), 302 S.
'Narziss und Eros', Band 2 der 'Manhattan Manuscripts', die Eckart Goebel mit Paul Fleming und John T. Hamilton herausgibt, setzt literaturhistorisch bei Ovids Fassung des Narziss-Mythos an und geht zeitgemäß - kontextgebunden - einen großen Schritt über Freud hinaus. Anstatt sich an den Ungereimtheiten, Spannungen und Widersprüchen der Ausführungen Freuds abzuarbeiten, legt der Band ohne viel Aufhebens die Kriterien narzisstischer Persönlichkeitsstörung nach dem Diagnoseklassifikationssystem DSM-N ('Diagnostic and Statistical Manual of Mental Disorders', Fourth Edition) der American Psychiatrie Association zugrunde, holt Eros in den Titel und bringt damit (Un)Ordnung in Ovids und Freuds Ordnungen der Geschlechter
Friedrich Adolph Wilhelm Diesterweg: Briefe, amtliche Schreiben und Lebensdokumente aus den Jahren 1810 bis 1832. (Sämtliche Werke, II. Abteilung, Bd. 23.) Bearb. v. Sylvia Schütze u. Mitarb. v. Gaby Herchert, Elisabeth Gutjahr und Klaus Goebel. Hrsg. v. Klaus Goebel. Neuwied: Luchterhand 2003. 789 S., EUR 55,–. [Rezension]
No full textRezension zu: Friedrich Adolph Wilhelm Diesterweg: Briefe, amtliche Schreiben und Lebensdokumente aus den Jahren 1810 bis 1832. (Sämtliche Werke, II. Abteilung, Bd. 23.) Bearb. v. Sylvia Schütze u. Mitarb. v. Gaby Herchert, Elisabeth Gutjahr und Klaus Goebel. Hrsg. v. Klaus Goebel. Neuwied: Luchterhand 2003. 789 S., EUR 55,
Goebel-Quartett : Ibachsaal, Sonntag, den 27. April, vormittags 11 Uhr, 7. ordentliches Konzert ; Dittersdorff, Streichquartett - Otto Siegl, Streichquintett (Uraufführung) - Brahms, Streichsextett G dur
No full textGoebel-Quartett. MusikfreundeVermutl. Erscheinungsjahr anhand hist. Kalender u. Design geschätz
Inhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression
No full textThe obligate intracellular protozoan parasite Toxoplasma gondii has been shown to protect different cell types from apoptosis induced by a variety of pro-apoptotic treatments. However, the precise cell biological mechanisms of this inhibition remained unknown. As shown in this study, apoptosis In human-derived HL-60 and U937 cells induced by treatment with actinomycin D or TNF-alpha in combination with cycloheximide, respectively, was indeed dose-dependently downregulated by prior infection with T gondii, as determined by DNA fragmentation assays. Cleavage of caspase 3 and caspase 9 after treatment with pro-apoptotic stimuli was considerably diminished by T gondii. Furthermore, release of mitochondrial cytochrome c during apoptosis In HL-60 cells was prevented by intracellular parasites and this was correlated with the absence of DNA strand breaks on the single cell level. Inhibition of cytochrome c release coincided with a twofold upregulation of Mcl-1 protein levels in HL-60 and U937 cells, while Bcl-2 expression did not increase after infection. Parasitic interference with the caspase cascade led to a reduced proteolytic cleavage of the nuclear target molecule protein kinase C delta. In parallel, poly(ADP-ribose) polymerase protein levels were prominently downregulated by T. gondii, irrespective of whether HL-60 and U937 cells had been treated with pro-apototic stimuli or left untreated. However, poly(ADP-ribose) polymerase mRNA levels remained unchanged after infection as determined by RT-PCR analyses. These observations suggest that T gondii has evolved different mechanisms that may contribute to downregulation of host cell apoptosis, namely inhibition of cytochrome c release and subsequent caspase activation as well as downregulation of poly (ADP-ribose) polymerase protein levels
Player agency in interactive narrative: audience, actor & author
No full textThe question motivating this review paper is, how can
computer-based interactive narrative be used as a constructivist learn-
ing activity? The paper proposes that player agency can be used to
link interactive narrative to learner agency in constructivist theory,
and to classify approaches to interactive narrative. The traditional
question driving research in interactive narrative is, ‘how can an in-
teractive narrative deal with a high degree of player agency, while
maintaining a coherent and well-formed narrative?’ This question
derives from an Aristotelian approach to interactive narrative that,
as the question shows, is inherently antagonistic to player agency.
Within this approach, player agency must be restricted and manip-
ulated to maintain the narrative. Two alternative approaches based
on Brecht’s Epic Theatre and Boal’s Theatre of the Oppressed are
reviewed. If a Boalian approach to interactive narrative is taken the
conflict between narrative and player agency dissolves. The question
that emerges from this approach is quite different from the traditional
question above, and presents a more useful approach to applying in-
teractive narrative as a constructivist learning activity
A Dynamic Subfilter-scale Stress Model for Large Eddy Simulations Based on Physical Flow Scales
No full textWe propose a new definition of the length scale in an eddy-viscosity model for large-eddy simulations (LES). This formulation extends and generalizes a previous proposal [Piomelli, Rouhi and Geurts, Proc. ETMM10, 2014], in which the LES length scale was expressed in terms of the integral length-scale of turbulence determined by the flow characteristics and explicitly decoupled from the simulation grid; this approach was named Integral Length-Scale Approximation (ILSA). As in the original ILSA, the model coefficient was determined by the user, and required to maintain a desired contribution of the unresolved, subfilter scales (SFS) to the global transport. We propose a local formulation (local ILSA) in which the model coefficient is local in space, allowing a precise control over SFS activity as a function of location. This new formulation preserves the properties of the global model; application to channel flow and backward-facing step verifies its features and accuracy
Large-eddy simulation of a separated flow with a sub-filter scale model based on the integral length-scale
No full textA new sub-filter scale model for large-eddy simulations, which uses a length-scale proportional to the integral scale of the turbulence instead of the grid resolution to parametrize the modelled stresses, will be assessed in the prediction of the flow of a boundary-layer over a rough surface, which includes separation and reattachment
Near Wall PIV-Measurements on the Windward Slope of a Hill
No full textThe turbulent flow over periodic hills was measured near to the wall, using planar Particle-Image-Velocimetry (PIV) at high spatial resolution. Our focus is on the near wall turbulence structure on the windward slope of the hill. For large-eddy simulation (LES) we suspect that, if this was not predicted accurately, it affects the prediction of the velocity profiles over the hill crest which in turn will affect the recirculation length downstream of the hill. Regarding the time averaged velocities, we were able to resolve the linear viscous region of the boundary layer. The velocity distribution and also the Reynolds stress does not comply with the law of the wall as it is valid for a turbulent boundary layer at equilibrium
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