1,720,961 research outputs found
Immunohistochemical Assay of Erythropoietin Receptor Expression in Human Colorectal Cancer and its correlation to Overall Patient Survival
No full textZielsetzung:
Viele Studien deuten darauf hin, dass eine Epo-Behandlung von Patienten mit unterschiedlichen Krebsleiden das Tumorwachstum über im Tumorgewebe exprimierte Epo-Rezeptoren fördert. Diese Studie untersucht den Zusammenhang zwischen der Erythropoietin-Rezeptor-Expression in kolorektalen Karzinomen (CRC) und dem Gesamtüberleben der betroffenen Patienten.
Versuchsplan:
Für die Untersuchung wurden 426 Gewebsschnitte von CRC-Patienten unter einem Transmissionslichtmikroskop ausgewertet. Die Gewebsschnitte wurden immunhistochemisch angefärbt, um Epo-R und EPO sichtbar zu machen. Die Auswertung der Epo-R- und Epo-Expression erfolgte durch die Bewertung von „intensity“ und „extent of staining“. Anschließend wurden mehrere Cut-off-Einteilungen für die Epo-R-Expression auf eine Korrelation mit der Patientenüberlebenszeit überprüft.
Ergebnisse:
Alle 426 Gewebsschnitte zeigten eine Epo-R-Expression, während die Expression von EPO nur in ca. einem Viertel der Schnitte zu finden war. Weder in der univariaten noch in der multivariaten Analyse konnte eine positive Korrelation zwischen der Epo-R Expression in kolorektalen Tumorzellen und dem Gesamtüberleben der CRC-Patienten gezeigt werden.
Folgerung:
Die Epo-R-Expression in kolorektalen Karzinomen hat keinen Einfluss auf das Gesamtüberleben der betroffenen Patienten und kann auch nicht als Prognosefaktor für das Patienten-Outcome dienen.
Die in dieser Studie verwendeten Gewebsschnitte stammen von Patienten, die nicht mit EPO behandelt wurden. Weitere Studien müssen nun zeigen, ob die Epo-R-Expression bei mit EPO behandelten Patienten eine prognostische Relevanz hat.Purpose:
Erythropoietin (Epo) treatment in patients with different cancers has been suggested to promote tumor growth by stimulating Epo receptors (Epo-R) which are expressed by cancer cells. This study examines the correlation between Expression of Epo-R in CRC epithelial cells and overall patient survival.
Experimental Design:
We therefore studied surgical specimens of primary CRC from 426 EPO-naïve patients. EPO-R and EPO immunostaining was evaluated under a transmission light microscope and scored according to intensity and extent of staining. A follow-up study for survival assessment was performed.
Results:
All CRC specimens showed Epo-R expression, whereas (a mostly weak) EPO expression was seen only in a quarter of cases. Both Epo-R and Epo expression in tumor epithelial cells were unrelated to overall patient survival, irrespectively of the cutoff point(s) chosen. In the multivariable analysis, tumor (T), node (N), and age were good predictors of disease outcome.
Conclusions:
Epo-R and Epo expression in CRC epithelial cells does not appear to be related to overall patient survival and thus may not serve as a predictive factor for cancer prognosis in unselected CRC patient populations. Further studies may elucidate the prognostic relevance of Epo-R expression particularly in Epo-treated CRC patients
Research into neuroprotection in case of traumatic neuropathy
No full textEinleitung: Die Therapie der traumatischen Optikusneuropathie beinhaltet neben der chirurgischen Dekompression die Gabe von Substanzen mit neuroprotektiver Wirkung.
Material und Methode: An 40 Ratten wurde mittels einer Mikroläsionsapparatur ein Kompressionstrauma des Sehnerven erzeugt. Folgend wurde nach einem etablierten Injektionsprotokoll Methylprednisolon in einer Gesamtdosis von 285 mg/kg/KG/48h und Flunarizin in einer Gesamtdosis von 750 mg verabreicht.
Die Netzhäute wurden in ein zentrales, ein intermediäres und in ein peripheres Gesichtsfeld (GF) unterteilt.
Ergebnisse: In den einzelnen GF zeigt die FLU-Gruppe, sowohl hinsichtlich der Ganglienzellzahl, als auch der Ganglienzellgröße signifikant niedrigere Ergebnisse. Allerdings ist der Unterschied der absoluten Ganglienzellzahlen und –flächen so gering, dass vom klinischen Standpunkt aus beide Substanzen in Bezug auf die Wirksamkeit sich kaum unterscheiden.Introduction: alongside with surgical decompression, the treatment of traumatic optical neuropathy implies the administration of substances with neuroprotective effect.
Matherial and Methods: a compressive optic nerve trauma was generated at 40 rats by means of micro lesion equipment. Subsequently, according to an established injection protocol, totally 285 mg/kg/KG/48h of methylprednisolon and 750 mg of flunarizin were administered.
The retina was split up into a central, intermediary, and peripheral visual fields (VF).
Results: the FLU-group shows significantly worse results with respect to both the number and size of ganglion cells in separate VF. However, the difference between the absolute numbers of ganglion cells and surface areas was so minor that from the clinical viewpoint the better effectiveness of either substance was hardly to discern
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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