1,721,758 research outputs found
Giusto e gli "Amorum libri" di Boiardo
No full textIl contributo analizza i complessi rapporti esistenti tra le rime di Giusto de' Conti e gli "Amorum libri" di Boiardo, intesi sia come 'fonte' diretta sia come 'fonte' mediata, specie con il "Canzoniere" di Petrarca. Il contributo si conclude con una serie di tavole sulle frequenze massime di sostantivi, aggettivi e verbi riscontrabili nei "Fragmenta" di Petrarca, nella "Bella mano" di Giusto e negli "Amorum libri"
RISARCIMENTO GIUSTO E CERTO TRA GIUDICI E LEGISLATORE
No full text1. Premessa. 2. Risarcimento giusto. 3. Risarcimento certo. 4. L'alternativa Giudici e Legislatore nell'attuazione del risarcimento giusto e certo: le varie stagioni attraversate dal sistema italiano. 5. La fase del modello equitativo basato sul solo reddito. 6. Il riconoscimento del danno biologico e la comparsa delle tabelle. 7. La lettura "costituzionale" dell'art. 2059, l'allargamento delle voci di danno e le nuove tabelle
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Pathways to Parkinson's disease: a spotlight on 14-3-3 proteins
Full text link14-3-3s represent a family of highly conserved 30 kDa acidic proteins. 14-3-3s recognize and bind specific phospho-sequences on client partners and operate as molecular hubs to regulate their activity, localization, folding, degradation, and protein-protein interactions. 14-3-3s are also associated with the pathogenesis of several diseases, among which Parkinson's disease (PD). 14-3-3s are found within Lewy bodies (LBs) in PD patients, and their neuroprotective effects have been demonstrated in several animal models of PD. Notably, 14-3-3s interact with some of the major proteins known to be involved in the pathogenesis of PD. Here we first provide a detailed overview of the molecular composition and structural features of 14-3-3s, laying significant emphasis on their peculiar target-binding mechanisms. We then briefly describe the implication of 14-3-3s in the central nervous system and focus on their interaction with LRRK2, α-Synuclein, and Parkin, three of the major players in PD onset and progression. We finally discuss how different types of small molecules may interfere with 14-3-3s interactome, thus representing a valid strategy in the future of drug discovery
Understanding Logical-Shift Error Propagation in Quanvolutional Neural Networks
Full text linkQuanvolutional Neural Networks (QNNs) have been successful in image classification, exploiting inherent quantum capabilities to improve performance of the traditional convolution. Unfortunately, the qubit's reliability can be a significant issue for QNNs inference, since its logical state can be altered by both intrinsic noise and by the interaction with natural radiation. In this paper we aim at investigating the propagation of logical-shift errors (i.e. the unexpected modification of the qubit state) in QNNs. We propose a bottom-up evaluation reporting data from 13,322,547,200 logical-shift injections. We characterize the error propagation in the quantum circuit implementing a single convolution and then in various designs of the same QNN, varying the dataset and the network depth. We track the logical-shift error propagation through the qubits, channels, and subgrids identifying the faults that are more likely to cause misclassifications. We found that up to 10% of the injections in the quanvolutional layer cause misclassification and even logical-shifts of small magnitude can be sufficient to disturb the network functionality. Our detailed analysis shows that corruptions in the qubits' state that alter their probability amplitude are more critical than the ones altering their phase, that some object classes are more likely than others to be corrupted, that the criticality of subgrids depends on the dataset, and that the control qubits, once corrupted, are more likely to modify the QNN output than the target qubits
Brain clearance of protein aggregates: a close-up on astrocytes.
Full text linkProtein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types, thus spreading between connected brain districts. Although microglia perform a predominant role in the removal of extracellular aggregated proteins, mounting evidence suggests that astrocytes actively contribute to the clearing process. However, the molecular mechanisms used by astrocytes to remove misfolded proteins are still largely unknown. Here we first provide a brief overview of the progressive transition from soluble monomers to insoluble fibrils that characterizes amyloid proteins, referring to α-Synuclein and Tau as archetypical examples. We then highlight the mechanisms at the basis of astrocyte-mediated clearance with a focus on their potential ability to recognize, collect, internalize and digest extracellular protein aggregates. Finally, we explore the potential of targeting astrocyte-mediated clearance as a future therapeutic approach for the treatment of neurodegenerative disorders characterized by protein misfolding and accumulation
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